Egilok pressure tablets. The correct dosage of the antihypertensive drug Egilok. Interaction with other drugs

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The site provides background information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Composition, names, varieties and forms of release Egilok

Accordingly, tablets with a normal duration of action in everyday speech are simply called "Egilok" and a number is added corresponding to the dosage of the active ingredient, for example, "Egilok 50" or "Egilok 25", etc. Long-acting tablets are called "Egilok Retard" and, as a rule, do not add a figure indicating the dosage. Egilok S tablets in everyday speech are often called "Egilok with succinate", since in this type of drug active substance is contained precisely in the form of succinate, and in Egilok Retard and Egilok with the usual duration of action in the form of tartrate. Egilok S and Egilok Retard have a prolonged action, but just Egilok has a regular one.

The three listed varieties of the drug Egilok are produced by the Hungarian pharmaceutical concern EGIS Pharmaceuticals PLC. In addition to these drugs, there is another cheaper option on the pharmaceutical market called Egilok SR (Egilok SR) and is produced by the Indian pharmaceutical plant Intas Pharmaceuticals Ltd under license. Egilok SR is a cheaper version of Egilok S.

All three varieties of Egilok are available in the form of tablets for oral administration. Egilok tablets with normal duration of action have a round biconvex shape and are colored white or almost white. Tablets of 25 mg on one side have a cross-shaped line, and on the other engraved "E 435". The 50 mg and 100 mg tablets are scored on one side and engraved "E 434" and "E 432" on the other, respectively.

Egilok Retard tablets of all dosages are white coated, have an oblong biconvex shape and a risk on both sides. Tablets Egilok C of all dosages are painted white, have an oval biconvex shape and a risk on both sides.

Egilok and Egilok Retard contain as an active substance metoprolol tartrate, and Egilok C - metoprolol succinate. Both substances are different salts of metoprolol, which actually represents the active ingredient of the drug. In the body, salt breaks down and metoprolol is released from it, which has a direct therapeutic effect. Therefore, all varieties of Egilok can be considered exactly the same, because metoprolol tartrate and succinate differ only slightly in the rate of absorption into the blood and the development of a therapeutic effect.
Auxiliary components of the three varieties of Egilok are shown in the table.

Egilok - recipe

After the letters "Rp." the full name of the drug and the dosage of the active substance are indicated (in this example, Egilok 25 mg). Then they write the letter "N" and indicate after it a number indicating the number of tablets that need to be sold to a person in a pharmacy. On the second line of the recipe, after the letters "D. S." the schedule for taking the tablets is indicated.

Therapeutic effect of the drug

By blocking adrenergic receptors, Egilok reduces heart rate, the force of contractile movement of the myocardium and the volume of blood ejected into the aorta, and also moderately reduces blood pressure. Egilok lowers blood pressure in people standing and lying down. Long-term use of Egilok in hypertension has a beneficial effect on the heart, reducing its load and, thereby, reducing the risk of sudden cardiac death, heart attack and stroke.

In addition, Egilok reduces the heart's need for oxygen by lowering blood pressure, heart rate and the strength of myocardial contractile movements. Reducing the heart rate and lengthening the period of relaxation of the heart (diastole) improves the blood supply to the myocardium itself and the uptake of oxygen by its cells. That is why Egilok provides improved nutrition and oxygen supply to the heart, which prevents angina attacks and increases human performance.

Regular use of Egilok can reduce the risk of sudden cardiac death in the development of myocardial infarction. The use of the drug after a heart attack prevents repeated attacks.

When using Egilok in complex therapy IHD drug normalizes the heart rhythm, preventing the appearance of extrasystoles and tachycardia. This effect creates a stable heart rhythm, which, even during attacks, is not disturbed with the development of deadly ventricular fibrillation. That is why the regular use of Egilok reduces the risk of death in heart failure and coronary artery disease.

Thus, we can say that Egilok is a drug for angina attacks and heart failure, because it improves the functioning of the heart and increases its stability and endurance, which allows a person to calmly endure physical and emotional stress. Egilok does not cure angina pectoris, coronary artery disease and heart failure, it only ensures the normal functioning of the heart in adverse conditions, relieving and stopping the painful symptoms of diseases and allowing a person to lead a normal life. That is, Egilok is a drug to eliminate symptoms cardiovascular diseases and prevention of angina attacks, hypertensive crises, heart attacks and strokes.

Egilok - indications for use

Egilok - instructions for use

General admission rules

The dosage of Egilok, Egilok Retard and Egilok S is selected individually, gradually increasing it to the required value. Such a gradual increase in dosage to therapeutic is necessary in order to avoid bradycardia at the beginning of treatment. The maximum allowable daily dosage is 200 mg. When choosing a dosage for angina pectoris, it is necessary to focus on the pulse, which should be 55-60 beats per minute at rest, and no more than 110 during exercise.

It is not required to change the dosage in the elderly, as well as those suffering from renal or hepatic insufficiency. Reduction of the recommended dosage is required only in case of severe hepatic insufficiency. In addition, it is necessary to reduce the dosage of Egilok with the development of bradycardia with a pulse of less than 50 beats per minute, a strong decrease in pressure, AV blockade, bronchospasm, ventricular arrhythmia, or severe liver dysfunction.

Egilok is canceled slowly, reducing the dosage within 10-14 days to the minimum (25 mg for Egilok and Egilok Retard and 12.5 mg for Egilok C). The minimum dosage should be taken within 4 to 5 days, after which the drug should be completely canceled. With a sharp discontinuation of the drug, a withdrawal syndrome develops, which is manifested by increased angina pectoris and increased pressure.

Egilok treatment of various diseases

With angina pectoris and arrhythmias, they begin to take Egilok 25-50 mg 2-3 times a day, if necessary, increasing the dosage to 100 mg 2 times a day.

Prevention re-infarction consists in taking Egilok 50-100 mg twice a day.

To stop tachycardia in hyperthyroidism, it is recommended to take Egilok 50 mg 3 to 4 times a day.

At functional disorders accompanied by tachycardia (for example, vegetovascular dystonia, panic attack, etc.), Egilok is taken 50 mg 2 times a day. With inefficiency, the dosage is increased to 100 mg 2 times a day.

Egilok can provoke an increase in allergic reactions, so people prone to allergies should take this aspect into account. Egilok also reduces the production of tears, which is important for people who use contact lenses. To prevent dry eye, they will have to use artificial tears or refuse contact lenses in favor of points.

In the presence of heart failure, Egilok can be taken only after the compensation stage has been reached. With a gradual increase in the dosage of Egilok in heart failure, an increase in symptoms may first be observed, which gradually decreases within two weeks. Because of this feature, it is impossible to increase the dosage of Egilok sharply.

Against the background of the use of Egilok, peripheral circulation may worsen.

Egilok should be used simultaneously with beta-2-agonists in people with bronchial asthma, or with alpha-blockers in pheochromocytoma. In addition, while taking Egilok, it is impossible to administer intravenously drugs from the group of calcium channel blockers, for example, Verapamil and others.

To carry out any surgical operations, it is not necessary to cancel Egilok, but the anesthesiologist should be told that the person is taking this drug. In some cases, in the absence of the necessary range of drugs for anesthesia, it may be necessary to cancel Egilok 48 hours before surgery.

Egilok must be canceled when a person develops depression.

Egilok Retard should not be used by people suffering from fructose or galactose intolerance, as well as sucrose or isomaltase deficiency, since the tablets contain sucrose.

Egilok during pregnancy and breastfeeding

When using the drug during pregnancy, it should be canceled 2 to 3 days before delivery, because otherwise the newborn may experience growth retardation, bradycardia, low blood pressure, respiratory depression and hypoglycemia after birth. If Egilok was not canceled on time, then after birth, the child's condition should be monitored for 48 to 72 hours.

Despite the fact that Egilok passes into breast milk in small quantities, it has the effects of adrenergic blockers on the baby's heart. Therefore, if necessary, taking Egilok should be canceled breast-feeding and transfer the child to artificial mixtures.

Compatibility with other drugs

Do not use Egilok in combination with the following medicines:

• Barbiturates (Phenobarbital, Phenazepam, etc.);
• Propafenone;
• Verapamil.

• Adrenaline (epinephrine);
• amiodarone;
• Class I antiarrhythmics;
• Beta-blockers (such as atenolol, propranolol, and pindolol);
• Hydrazalin;
• Guanfacine;
• Diphenhydramine;
• Diltiazem;
• clonidine;
• Methyldopa;
• Non-steroidal anti-inflammatory drugs (for example, Aspirin, Paracetamol, Ibuprofen, Nimesulide, Indomethacin, Diclofenac, etc.);
• norephedrine (phenylpropanolamine);
• Reserpine;
• Theophylline;
• Quinidine;
• Cimetidine;
• Estrogen hormones (including combined oral contraceptives);
• Ergotamine.

Cardiac glycosides (Strophanthin and others), when used simultaneously with Egilok, can provoke bradycardia. Drugs acting on the central nervous system (hypnotics, tranquilizers, antidepressants, neuroleptics and ethyl alcohol), while used with Egilok, increase the risk sharp decline blood pressure.

Egilok prolongs the effects indirect anticoagulants(for example, Warfarin, Dicoumarin, etc.).

The risk of allergic reactions increases significantly when using special solutions for skin allergy tests and iodine-containing radiopaque substances simultaneously with Egilok.

In smokers, the effects of Egilok may be much less pronounced.

Influence on the ability to control mechanisms

Overdose

• A strong decrease in blood pressure;
• Severe bradycardia with a heart rate of less than 50 beats per minute;
• Dizziness;
• Cyanosis (blue lips, nails, fingertips);
• Arrhythmia;
• Extrasystole;
• Spasm of the bronchi;
• Cardiogenic shock;
• AV blockade (up to complete cardiac arrest);
• Pain in the heart (cardialgia);
• respiratory depression;
• fatigue;
• Increased sweating;
• Violation of sensitivity (feeling of goosebumps, etc.);
• myasthenic syndrome.

Treatment of an overdose with Egilok is carried out in intensive care, since intensive care measures and constant monitoring of the person's condition are necessary. If the tablets were taken within the next 40 minutes, then gastric lavage is performed and a sorbent is given to the person (for example, activated carbon, Polysorb, Polyphepan, etc.). In the future, carry out symptomatic therapy aimed at normalizing the main performance indicators cordially- vascular system and maintaining the functioning of vital organs.

Egilok - side effects

• fatigue;
• Dizziness;
• Headache;
• Excitability;
• convulsions;
• Paresthesia (sensation of crawling and other disturbances of sensitivity);
• Depression;
• Deterioration of concentration;
• Nightmares;
• depression;

• bradycardia;
• Orthostatic hypotension (a sharp drop in pressure when moving to a standing position);
• fainting;
• Cold feet;
• palpitations;
• Temporary increase in symptoms of heart failure;
• Cardiogenic shock in people who have had a myocardial infarction;
• AV block I degree;
• Arrhythmia;
• Pain in the region of the heart;
• Edema on the extremities (for Egilok Retard and Egilok C).

• Nausea;
• Vomit;
• Dry mouth;
• Violation of the liver (darkening of urine, yellowness of the sclera or skin, stagnation of bile);
• Hepatitis (for Egilok C);
• Increased activity of AsAT and AlAT;
• An increase in the concentration of bilirubin in the blood.

• Increased sweating;
• Alopecia (baldness);
• Photosensitivity (sensitivity to sunlight);
• Exacerbation of psoriasis;
• Skin itching;
• redness of the skin;
• Exanthema.

• Shortness of breath on exertion;
• Bronchospasm;

• visual impairment;
• Dryness and irritation of the surface of the eye;
• Taste disorder.

• Weight gain;
• Joint pain (arthralgia);
• Thrombocytopenia of platelets in the blood);
• Leukopenia (decrease in the total number of white blood cells);
• Agranulocytosis (decrease in the content of neutrophils, eosinophils and basophils in the blood);
• Decreased levels of high density lipoproteins (HDL) in the blood;
• An increase in the level of triglycerides (TG) in the blood.

Contraindications for use

To absolute contraindications The use of Egilok includes the following conditions:

• Hypersensitivity, intolerance or allergic reactions to drug components;
• Atrioventricular (AV) block II or III degree;
• Sinoatrial blockade;
• Bradycardia with a heart rate of less than 50 beats per minute;
• Sick sinus syndrome;
• Cardiogenic shock;
• Severe disorders of the peripheral circulation (for example, trophic ulcers, marble coloration of the skin of the extremities, etc.);
• Heart failure in the stage of decompensation;
• Age under 18;
• Severe course of bronchial asthma;
• Simultaneous intravenous administration Verapamil;
• Acute myocardial infarction with a pulse less than 45 beats per minute, a PQ interval of more than 240 ms, and an upper pressure of less than 100 mm Hg. Art.;
• Simultaneous use of drugs-inhibitors of the CYP2D6 enzyme;
• Pregnancy and the period of breastfeeding;
• Long-term use of inotropic drugs and beta-blockers or mimetics (for Egilok C);
• Prinzmetal's angina (for Egilok);
• Fructose intolerance, galactose intolerance or sucrose or isomaltase deficiency (for Egilok Retard).

• Diabetes;

Synonyms of Egilok are the following drugs:
• Betaloc solution and tablets;
• Betaloc Zok tablets of prolonged action;
• Vasocardin and Vasocardin Retard tablets;
• Corvitol 50 and 100;
• Lidaloc tablets;
• Metozok tablets;
• Metocard tablets;
• Metocor Adifarm tablets and solution;
• metoprolol tablets;
• Serdol tablets.
Analogues of Egilok are the following drugs:
• Aritel and Aritel Core tablets;
• Atenolol tablets;
• Betak tablets;
• Betacard tablets;
• Betaxolol tablets;
• Bidop tablets;
• Binelol tablets;
• Biol tablets;
• Biprol tablets;
• Bisogamma tablets;
• Bisocard tablets;
• Bisomor tablets and lyophilizate;
• bisoprolol tablets;
• Breviblok solution;
• Vero-Atenolol tablets;
• Concor and Concor Cor tablets;
• Corbis tablets;
• Kordanum tablets;
• Cordinorm tablets;
• Coronal tablets;
• Lokren tablets;
• Nebivator tablets;
• Nebivolol tablets;
• Nebicor tablets;
• Nebilan Lannacher tablets;
• Nebilet tablets;
• Nebilong tablets;
• Nevotens tablets;
• Niperten tablets;
• OD-Neb tablets;
• Tirez tablets;
• Estecor tablets.

Egilok - reviews

Most of the reviews about Egilok are related to its use to reduce pressure and eliminate palpitations (tachycardia). Less commonly, Egilok is used for arrhythmias in order to normalize the heart rhythm. In both cases, almost all reviews of the drug are positive (more than 90%), due to its high efficiency, good tolerance and ease of use. In the reviews, people note that the drug helps to eliminate tachycardia caused by various reasons quite quickly, which normalizes general state and enables a person to lead a normal life. Egilok in order to eliminate tachycardia can be taken both as a course and as needed. This possibility of a single use of the drug is very convenient and is a definite plus from the point of view of people.

Also in the reviews, people note good efficiency Egilok with course use to lower blood pressure. According to people, the advantages of the drug are the rapid development of the effect, good tolerance and the possibility of long-term use for several years in a row.

In reviews of the use of Egilok for arrhythmias, people note that the drug very quickly and literally perfectly aligns the rhythm, relieving painful symptoms and restoring normal health.

Negative reviews about Egilok are associated with the development of side effects and the need to stop taking the drug. That is, negative reviews are usually left by people who did not fit Egilok for some reason.

Concor or Egilok?

Egilok contains metoprolol as an active substance, and Concor - bisoprolol, but both drugs belong to the same pharmacological group of selective beta1-blockers. This means that they have an almost identical mechanism of action and a similar range of side effects. Both Concor and Egilok can provoke visual impairment, dryness of the mucous membrane of the eye, conjunctivitis and other side effects with the same frequency.

In principle, the therapeutic effect of Concor and Egilok is practically no different, but one drug is better for someone, and the second for another person. There is only one way to find out which drug is best for you - try taking both. If desired, you can easily replace one drug with another, knowing that 5 mg of Concor correspond to 50 mg of Egilok. However, Egilok has a slightly stronger effect compared to Concor, so it is recommended to choose the first drug if the second is ineffective.

In general, the only significant difference between Concor and Egilok is the possibility of its use with severe bradycardia (pulse less than 55 beats per minute). Therefore, with a tendency to bradycardia, Egilok is preferable.

Egilok, Egilok Retard and Egilok S - price

All three varieties of the drug Egilok are imported into the countries of the former USSR, and therefore the differences in their cost in different pharmacies are due to wholesale prices, customs duties, exchange rates and overhead costs. This means that there is no difference between a more expensive and cheaper drug, and you can buy Egilok, which is sold at the lowest cost.

Prices for all varieties of Egilok are shown in the table.

There are contraindications. Before use, you should consult with a specialist.

A medicine for the treatment of pathologies of the cardiovascular system is Egilok. Instructions for use indicate that tablets 25 mg, 50 mg and 100 mg, retard, help to reduce the frequency of ventricular heart rate in supraventricular tachycardia, ventricular extrasystole and atrial fibrillation. At what pressure to take this medicine, you can learn from the reviews of doctors and patients.

Release form and composition

The drug is produced in the following dosage forms:

1. Tablets 25 mg, 50 mg and 100 mg.
2. Long-acting film-coated tablets 50 mg and 100 mg (Retard).
3. Long-acting film-coated tablets 25 mg, 50 mg, 100 mg and 200 mg (Egilok C).

One tablet of Egilok (Retard) contains 25, 50, 100 mg of the active substance (metoprolol tartrate), respectively.

One tablet of Egilok C, the active substance (metoprolol succinate), accounts for 23.75, 47.5, 95, 190 mg, respectively.

pharmachologic effect

Egilok instruction refers to beta1-adrenergic blocking agents. Main active substance- metoprolol. It has antianginal, antiarrhythmic, pressure-lowering effects. By blocking beta1-adrenergic receptors, the drug reduces the excitatory effect of the sympathetic nervous system on the heart muscle, quickly reduces heart rate and blood pressure.

The hypotensive effect of the drug is long-lasting, as peripheral vascular resistance decreases gradually. On the background long-term use Egilok with high blood pressure significantly reduces the mass of the left ventricle, it relaxes better in the diastolic phase.

According to reviews, the drug is able to reduce mortality from cardiovascular pathology in males with a moderate increase in pressure. Like analogues, Egilok reduces the heart's need for oxygen due to a decrease in pressure and heart rate.

Due to this, diastole is lengthened - the time during which the heart rests, which improves its blood supply and the absorption of oxygen from the blood. This action reduces the frequency of angina attacks, and against the background of asymptomatic episodes of ischemia, the patient's physical condition and quality of life are significantly improved.

The use of Egilok reduces the frequency of ventricular heart contractions in atrial fibrillation, ventricular premature beats and supraventricular tachycardia. Compared with non-selective beta-blockers of Egilok's analogues, it has less pronounced vasoconstrictor and bronchial properties, and it also has less effect on carbohydrate metabolism. Against the background of taking the drug for several years, blood cholesterol is significantly reduced.

Indications for use

What helps Egilok (Retard, C)? Tablets are prescribed if the patient has:

• angina;
• myocardial infarction;
• impaired functional cardiac activity;
• disturbed heart rhythm (supraventricular tachycardia and bradycardia with ventricular extrasystoles and atrial fibrillation);
• high blood pressure;
• prophylactic prevention of migraine attacks.

Indications for the use of tablets also apply to people over 60 years of age.

Instructions for use (at what pressure it helps)

Egilok tablets should be taken orally during or immediately after a meal at a pressure of more than 140 to 90. They can be divided in half, but not chewed.

• With angina pectoris, supraventricular arrhythmias, for the prevention of migraine attacks, a dose of 100-200 mg per day is prescribed in 2 divided doses (morning and evening).
• For secondary prevention of myocardial infarction, an average daily dose of 200 mg is prescribed in 2 divided doses (morning and evening).
• At functional disorders cardiac activity, accompanied by tachycardia, is prescribed in a daily dose of 100 mg in 2 divided doses (morning and evening).
• At arterial hypertension prescribed in a daily dose of 50-100 mg per day in 1 or 2 doses (morning and evening). With insufficient therapeutic effect, a gradual increase is possible daily dose up to 100-200 mg.

In elderly patients, patients with impaired renal function, and if hemodialysis is necessary, changes in the dosing regimen are not required. In patients with severe liver dysfunction, the drug should be used in smaller doses, due to a slowdown in the metabolism of metoprolol.

Contraindications

The use of Egilok is unacceptable for:

• breastfeeding;
• angiospastic angina;
• persons under 18 years of age;
• cardiogenic shock;
• severe arterial hypotension;
• heart failure in the phase of decompensation;
• SSSU;
• severe bradycardia;
• AV blockade of the second and third degree;
• hypersensitivity to metoprolol and other components of the drug Egilok, from which these tablets can cause side effects;
• sinoatrial blockade.

With extreme caution, this medicine is prescribed for the following pathologies: metabolic acidosis, diabetes, bronchial asthma obliterating peripheral vascular disease, chronic obstructive pulmonary disease, chronic kidney failure, myasthenia gravis, psoriasis, depression, chronic liver failure and thyrotoxicosis.

Side effects

According to the reviews given by doctors, Egilok is sometimes able to cause:

• stomach ache;
• headache, fatigue;
• decrease in heart rate;
• allergic reactions;
• decreased concentration;
• rhinitis, nausea;
• dizziness;
• shortness of breath, bronchospasm;
• diarrhea, vomiting;
• depression, insomnia;
• increased sweating.

Children, during pregnancy and lactation

The use of Egilok during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to prescribe the drug during this period, it is necessary to carefully monitor the condition of the fetus and newborn within 48-72 hours after birth, since intrauterine growth retardation, bradycardia, arterial hypotension, respiratory depression, hypoglycemia.

The effect of metoprolol on the newborn during breastfeeding has not been studied, so women taking Egilok should stop breastfeeding. With caution, the drug should be prescribed to children and adolescents under the age of 18 years.

special instructions

Before starting therapy and during treatment, blood pressure and heart rate should be monitored. If the heart rate drops below 50 beats per minute health care.

Sick diabetes glucose levels should be regularly monitored and insulin dosage adjusted if necessary. Egilok should be discontinued gradually, reducing the dosage over two weeks to avoid withdrawal syndrome, coronary disorders and angina pectoris.

Patients wearing contact lenses may experience decreased tear secretion. Caution is advised when driving vehicles and when engaging in potentially hazardous activities that require increased concentration.

drug interaction

The list of prohibited drugs for simultaneous use with Egilok is wide. Therefore, special care should be taken to combine this medicine with third party medications.

• When mixed with ethanol, the pumping effect on the central nervous system is enhanced.
• When mixed with oral hypoglycemic drugs and insulin, the likelihood of hypoglycemia increases.
• When mixed with verapamil, it can cause cardiac arrest.
• When mixed with beta-blockers (estrogens, theophylline, indomethacin), the hypotensive property of metoprolol decreases.

Egilok's analogs

According to the structure, analogues are determined:

1. Metocard.
2. Egilok Retard.
3. Corvitol 100.
4. metoprolol succinate.
5. Betaloc.
6. Vasocardin.
7. Emzok.
8. Corvitol 50.
9. Metoprolol.
10. Metozok.
11. Metoprolol tartrate.
12. Metolol.
13. Egilok S.
14. Metokor Adifarm.

Or Egilok - which is better?

The exact answer can be given only with an individual examination. However, in general, Concor has slightly fewer side effects compared to its analogue, and its use with a low pulse in more admissible. Egilok has a stronger drug effect compared to Concor.

Holiday conditions and price

The average cost of Egilok (tablets 25 mg No. 60) in Moscow is 136 rubles. The price of a dosage of 100 mg is 131 rubles for 30 tablets, 50 mg is 146 rubles. for 30 pcs. Released by prescription.

The medicine for the treatment of pathologies of the cardiovascular system is Egilok. Instructions for use indicate that tablets 25 mg, 50 mg and 100 mg, retard, help to reduce the frequency of ventricular heart rate in supraventricular tachycardia, ventricular extrasystole and atrial fibrillation. At what pressure to take this medicine, you can learn from the reviews of doctors and patients.

Caution is the key to effective therapy

As folk wisdom says, with the right dose, even poison becomes an indispensable medicine, and the most useful and harmless substance in excess threatens a person with death. When it comes to medicines, this wisdom is of particular importance, since excessive (as well as insufficient) intake of a drug into the body may either not improve the patient's condition, or aggravate it. Before use, it will not be superfluous to carefully read the instructions for "Egilok". Even if the attending doctor explained in detail how to use the drug.

"Egilok" is designed for people suffering from high blood pressure, which means that it has a rather strong effect on the functioning of blood vessels, the heart muscle. Not only the state of health of the patient, but also his very life often depends on the correct use of the medication.

Reviews of doctors

Andrey (therapist), 45 years old, Voronezh

Pharmacological agent Egilok is prescribed in the treatment of hypertension, which is accompanied by a violation of the heart rhythm. The drug acts quickly when applied sublingually. It is well suited as a first aid drug for hypertensive crisis and psychiatric disorders. Egilok effectively eliminates panic attacks and makes it possible to reduce the dose of tranquilizers.

The selective effect of the drug is low. Therefore, undesirable effects often appear.

Margarita (therapist), 32 years old, Astrakhan

I believe concor effective tool for the treatment of hypertension of the initial degree, complicated by vegetative disorders. With its use, blood pressure and heart rate return to normal. It is included in the complex therapy of IHD.

Well tolerated by patients, one-time use per day is convenient for use. Application not recommended medication for the treatment of young men due to its negative effect on erection with prolonged use.

How it works?

As can be seen from the instructions, "Egilok" reduces pressure, bringing it to normal indicators. The drug fights arrhythmia, normalizes the heart rhythm, normalizes muscle contractions, and also stabilizes the sequence of contractions and excitations. Due to the slowing of the conduction of impulses, the excitability of the heart muscle decreases, which leads to a decrease in the frequency of contractions. Speaking about how much Egilok works, doctors usually mention an hour and a half - it is during this time period that the activity of the drug reaches its peak, after which it remains for some more time.

The predominant part of the substance that enters the body is completely processed in the liver. Here is the accumulation of metabolic products. Five percent leave the body through the urinary system.

Pharmacokinetics

Suction

Rapidly and completely (95%) absorbed from the gastrointestinal tract. Cmax in plasma is achieved 1.5-2 hours after ingestion. Bioavailability is 50%. During treatment, bioavailability increases to 70%. Eating increases bioavailability by 20-40%.

Distribution

Vd is 5.6 l / kg. Binding to plasma proteins - 12%. Penetrates through the BBB and the placental barrier. It is excreted in breast milk in small amounts.

Metabolism

Metoprolol is biotransformed in the liver. Metabolites do not have pharmacological activity.

breeding

T1 / 2 averages 3.5-7 hours. Metoprolol is almost completely excreted in the urine in 72 hours. About 5% of the dose is excreted unchanged.

Pharmacokinetics in special clinical situations

With severe violations of liver function, the bioavailability and T1 / 2 of metoprolol increases, which may require dose adjustment.

In case of impaired renal function, T1 / 2 and systemic clearance of metoprolol do not change significantly.

What's on sale?

Reviews of "Egilok" contain references to three types of funds. People treat drugs differently. Medicines are on sale under the trade names "Egilok", "Egilok S", "Egilok Retard". A distinctive feature is the composition, although the main active ingredient in all three drugs is the same. "Egilok", "Egilok Retard" are made using metoprolol tartrate, but the third variety is based on a compound of the same metoprolol, but called succinate. In addition, each tablet contains auxiliary components that simplify the absorption of the drug and increase its activity.

In the basic "Egilok" cellulose and silicon dioxide, several other compounds are used as additional compounds. "Egilok Retard" is made with inclusions of magnesium stearate and molasses, talc. Finally, the third option, that is, "Egilok C", contains, among others, stearic acid and several varieties of cellulose, glycerol. When choosing a specific drug, you need to be guided not only by the question "what are these pills from." "Egilok" effectively eliminates pressure, but individual intolerance to any component is possible, prohibiting the use of the agent in question. If, when studying the composition, the patient discovered a substance that his body does not tolerate, it is urgent to notify the doctor about this and select an effective replacement.

Which is better - Egilok or Concor?

It is difficult to say which drug is best for treatment. Both drugs have many contraindications and side effects. Therefore, before conducting a course of therapy, they should be carefully studied in order to choose the best option.

The use of the drug only once a day makes it more convenient for patients.

When to apply?

Indications "Egilok": arterial hypertension, also known as hypertension. Since the regular use of the drug reduces and normalizes blood pressure, it becomes a permanent inhabitant of the hypertensive first aid kit. The drug can be used as a prophylactic to prevent myocardial infarction. Such use is reasonable if the person belongs to a risk group for pathology.

In some cases, as can be seen from the reviews, "Egilok" is prescribed for migraine, as the remedy prevents headache attacks and reduces their frequency. All of the above indications apply to the three previously mentioned types of medication.

Therapeutic properties

The medicine "Egilok", from which it helps to normalize pressure, is an effective beta-blocker. The drug creates an antianginal, antiarrhythmic, hypotensive effect. The active component reduces the excitability of the nervous system, quickly reduces pressure and heart rate. Due to the smooth decrease in vascular resistance, a long-term hypotensive effect is observed.

Prolonged use of the drug in hypertension causes a decrease in the weight of the left ventricle of the heart. Doctors indicate that the drug reduces mortality among men with moderate high blood pressure. The drug "Egilok", from which angina attacks occur less often, reduces the need for myocardium in oxygen. With its systematic use, the amount of cholesterol in the blood decreases.

Features of use

"Egilok", "Egilok Retard" are effective in hyperthyroidism, with increased activity heart muscle. The tool is used as part of complex therapy to combat the disease. "Egilok", "Egilok S" are effective in supraventricular arrhythmias. Release forms "C", "Retard" are relevant if there is a failure of the functioning of the heart muscle in chronic form. The tool is also used as one of the elements in an integrated approach to solving the problem.

Since it is necessary to use the described component together with other drugs to prevent complications, exacerbations, as well as eliminate symptoms chronic diseases heart and blood vessels, the question of compatibility is especially acute. "Egilok" enhances the effectiveness of some groups of drugs and is not combined with others. In complex therapy, this group of drugs is usually used together with diuretics, while the pressure drug activates diuretics. PAF inhibitors can be used. A common approach is to combine the drug and glycosides to support the work of the cardiovascular system. But "Egilok" and alcohol categorically do not combine. Therefore, with problems with pressure, it is necessary to refrain from alcoholic beverages, even in small doses. With diagnosed heart failure acute form, associated with problems in the functioning of the ventricle on the left, Egilok C gives the greatest efficiency in combination with the above groups of medicines.

Contraindications

The use of Egilok is unacceptable for:

• breastfeeding;
• angiospastic angina;
• persons under 18 years of age;
• cardiogenic shock;
• severe arterial hypotension;
• heart failure in the phase of decompensation;
• SSSU;
• severe bradycardia;
• AV blockade of the second and third degree;
• hypersensitivity to metoprolol and other components of the drug Egilok, from which these tablets can cause side effects;
• sinoatrial blockade.

With extreme caution, this medicine is prescribed for the following pathologies: metabolic acidosis, diabetes mellitus, bronchial asthma, obliterating peripheral vascular disease, chronic obstructive pulmonary disease, chronic renal failure, myasthenia gravis, psoriasis, depression, chronic liver failure and thyrotoxicosis.

Prevention is the best cure

Reviews of "Egilok" demonstrate that the drug is often used as a prophylactic. Known for its effectiveness in the program for the prevention of extrasystoles. In addition, "Egilok C" gives good results in myocardial infarction. The drug can be used even at a late stage, thereby reducing the likelihood of death. At correct application"Egilok S" allows you to leave in the past tachycardia, problems of the functioning of the heart muscle.

Effects

But even without such terrible results, taking alcohol-containing drinks and drugs aggravates the course of the disease and causes various complications from other organs. Adrenaline produced in the human body contributes to the rapid processing of alcohol. Egilok blocks its action, which can lead to an overdose of ethyl and subsequent intoxication.

Taking any medication has a toxic effect on the liver, and combining them with alcohol increases the load on the organ and causes a violation of its functions. Liver diseases are usually asymptomatic, so the consequences of taking Egilok and alcohol can be expressed both in mild malaise and in the acquisition of one of the toxic hepatitis, which can later turn into cirrhosis.

In case of heart disease, the use of alcoholic beverages is not recommended, especially while taking medications such as Egilok and its analogues.

izlechenie-alkogolizma.ru

Release Features

The composition of "Egilok" can be found in the instructions for use. This information is always contained on the leaflet in the carton with blisters in which the tablets are packed. The main active components of all three forms of release are indicated earlier, the effectiveness of the agent is due to the presence of metoprolol in it in the form of derivatives.

Reviews of "Egilok" contain a mention that the tool usually has a convex shape on both sides. Only type "C" is usually oblong. The color is always white. One tablet contains the active ingredient in the amount of 25 mg, 50 mg, 100 mg. An indication of this is on the packaging of the drug. Also on sale is "Egilok Retard" with a content of the main active ingredient of 200 mg. The pack contains 30 tablets or twice as many.

Egilok price

The cost of the drug on the Internet and pharmacies is different and depends on the number of tablets in the package and the concentration of the active substance. Approximate prices for Egilok produced in Hungary in Moscow are as follows:

When not?

Egilok's contraindications are a rather extensive list, and all of them must be strictly observed, since the drug has a strong effect on the heart muscle. First of all, the ban on the use establishes bradycardia, that is, a slow rhythm of contraction of the heart muscle. If the frequency of contractions decreases to 50-60 per minute, "Egilok" is not applicable.

"Egilok" can not be used with a weak sinus node, sinoatrial blockade. The drug is not applicable for problems with peripheral circulation. The medication should not be used with chronically low blood pressure. The use of Egilok is associated with a certain health hazard if there is a possibility of an allergic reaction. During pregnancy, the use of the described drug must be agreed with the attending physician. There is a possibility of a negative effect on the fetus, so the drug can be used only if the benefit from its use is significantly higher than the risk. If any contraindications are identified, the doctor decides to replace the drug or adjust the dosage of Egilok. You cannot change anything in the program on your own, you must urgently seek advice from a specialist.

drug interaction

The list of prohibited drugs for simultaneous use with Egilok is wide. Therefore, it is necessary to combine this drug with third-party medicines with special care.

• When mixed with ethanol, the pumping effect on the central nervous system is enhanced.
• When mixed with oral hypoglycemic drugs and insulin, the likelihood of hypoglycemia increases.
• When mixed with verapamil, it can cause cardiac arrest.
• When mixed with beta-blockers (estrogens, theophylline, indomethacin), the hypotensive property of metoprolol decreases.

How to be treated?

"Egilok" is intended for oral use. The drug is used for violations in the work of the heart and blood vessels on the recommendation of the attending doctor. The dosage, the scheme of application is also determined by the doctor, focusing on the patient's diagnosis, concomitant diseases and other drugs in the therapy program. Below are several options for using Egilok for common diseases. Please note: these are standard programs recommended by the manufacturer, but you cannot prescribe a medication for yourself according to these schemes, you must first undergo a doctor's examination to identify all significant factors.

With arterial hypertension, Egilok is used twice a day, usually in the evening, in the morning. The dosage of the drug is from 25 mg or more. With insufficient effectiveness, the dose is increased to 100 mg per 24 hours. Arrhythmia is treated similarly, the same program is used for angina pectoris. Sometimes the remedy is used three times a day, at a time taking from 25 mg or more. With absence positive effect the dose is increased to 100 mg divided into two divided doses 24 hours apart.

Registration numbers

tab. 100 mg: 30 or 60 pcs. P N015639/01 (2017-03-09 - 0000-00-00) tab. 25 mg: 30 or 60 pcs. P N015639/01 (2017-03-09 - 0000-00-00) tab. 50 mg: 30 or 60 pcs. P N015639/01 (2017-03-09 - 0000-00-00)

• BETALOC
• ISOPTIN
• LASIX
• VICTOEL
• UREGIT
• VERAPAMIL SOPHARMA
• MELOXICAM
• DIBICOR
• CARVEDIGAMMA
• ORNIDAZOL
• METOPROLOL
• LEVOFLOXACIN

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ATX code for EGILOK

C07AB02 (Metoprolol)

Experimental determination of suitable drugs:

• BETALOC 01.003 (Beta1-adrenergic blocker) , White, round, biconvex tablets,…
• ISOPTIN 01.015 (Calcium channel blocker) , Coated tablets…
• LASIX 01.040 (Diuretic), White or almost white tablets…
• VICTOEL 02.001 (Antipsychotic drug (neuroleptic)), Tablets, film-coated…
• UREGIT 01.040 (Diuretic) , White or grayish-white tablets,…
• VERAPAMIL SOPHARMA 01.015 (Calcium channel blocker) , Tablets, film-coated…
• MELOXIKAM 05.001 (NSAIDs) , Tablets from…
• DIBIKOR 16.039 (Medication that improves metabolism and energy supply of tissues), composition and…
• CARVEDIGAMMA 01.002 (Beta1-,beta2-blocker. Alpha1-blocker), Tablets, coated film sheath…
• ORNIDAZOL 07.001 (Antiprotozoal drug with antibacterial activity), Tablets,…
• METOPROLOL 01.003 (Beta1-blocker) , Film-coated tablets against…
• LEVOFLOXACIN 06.038 ( Antibacterial drug group of fluoroquinolones) , Tablets, coated…

Drug programs: what else is there?

When using an agent for the prevention of a heart attack, Egilok is taken every day in an amount of 50 mg (if necessary, the dose is doubled).

If vegetovascular dystonia was detected, if panic attacks were diagnosed that provoked a violation of the rhythm of the heartbeat, Egilok is used in a standard amount, that is, 50 mg. In the absence of a pronounced effect, the amount of the drug is doubled. It is assumed that "Egilok" is drunk twice a day. In the prevention of migraine, the agent is used in the same way.

What is the difference between Egilok and Concor

There are some features of the reception and treatment of pharmaceuticals that must be considered.

Metoprolol tartrate as part of Egilok acts for a short time. To get a lasting effect during therapy, it is necessary to take the medicine several times a day.

Bisoprolol provides a prolonged action. It is taken only once a day.

Egilok has a good effect in eliminating migraine attacks, but its use should be approached with caution if there are problems with the liver. Failures in the functioning of the body lead to the accumulation of metoprolol in the body. In this case, dosage adjustment is required.

The drugs differ in cost. Concor is more expensive.

Overdose: what to do?

When the permissible dose is exceeded, Egilok quite strongly affects the cardiovascular system. Bradycardia develops, dizziness, the patient feels sick. There is a high probability of hypotension, fainting, extrasystole. The rhythm of the heartbeat may be disturbed. In the most severe situations, cardiogenic shock develops, leading to loss of consciousness, up to coma. In rare cases, an overdose provokes cardialgia, atrioventricular blockade. In the absence of help, there is a chance of a complete stop of the heartbeat. Pronounced overdose symptoms appear half an hour or several hours (up to two) after the drug enters the patient's body.

In case of an overdose, it is necessary to urgently wash the stomach, take activated charcoal and conduct symptomatic therapy to eliminate the primary manifestations of the effect of the drug on the body. With a sharp decrease in pressure, the patient is placed in such a way that the level of the head is below the level of the hips. With bradycardia, acute hypotension, with insufficient functioning of the heart muscle, an urgent intake of beta-adrenergic stimulants and a number of specific medications is necessary. In the absence of a quick effect, they resort to drugs containing dopamine, dobutamine. In some cases, the effectiveness shows the use of from a gram to ten grams of glucagon. Depending on the symptoms, diazepam, beta-2-agonists, and an intracardiac electrical stimulator may help. As clinical studies have shown, it is impossible to remove excess drug from the body by hemodialysis.

Characteristics of the drug

In the medical classification, the presented tablets were classified as beta-blockers. But such pharmaceutical terms do not mean anything to ordinary people. In simple words the term means a medicine aimed at improving and stabilizing the work of the heart.

People suffering from diseases in terms of cardiovascular abnormalities, as well as all patients at risk, must be warned to give up drinking. If you ignore the rule, then undesirable compatibility can provoke a sharp deterioration in well-being, up to a coma.

The main indications for the appointment of this drug are called hypertension. Moreover, tablets are prescribed not only as a mono-prophylaxis. They are often included in a rehabilitative or preventive course, along with related medications.

In addition to reducing the risk of exacerbation of hypertension, Egilok can often be found in the appointment of patients complaining of arrhythmia. It can not do without it with a medical complex to correct the lack of hormone production thyroid gland. And if the patient complains of migraines from time to time, he can be prescribed a remedy for preventive purposes.

Such a wide spectrum of action is explained by the capabilities of the active substance, which is metoprolol tartrate. To make it more convenient to divide the tablet, the manufacturer created a strip in the middle.

"Egilok": side effects

And that's not it. Some patients (and this is confirmed by reviews on the World Wide Web) when taking Egilok often feel tired, others complain of increased excitability. Sometimes there is a feeling of anxiety, a depressed state, there are difficulties with concentration. There is a possibility of headaches, the head may be spinning.

"Egilok" in rare cases provokes sleep disturbances - nightmares, insomnia or drowsiness. Clinical studies have shown that taking the drug can adversely affect cognitive abilities (first of all, memory suffers), the general condition becomes depressed. With an extremely low probability (and yet it exists), hallucinations, paresthesia, convulsive states. The reviews on the Internet contain references to weight gain with the systematic treatment of Egilok. Laboratory tests may show an increase in the concentration of bilirubin in the blood. There may be problems with the gastrointestinal tract, stool, decreased visual acuity. As it was revealed during the official trials of the drug, side effects accompany the drug intake quite rarely, most patients tolerate the drug well. This is also evidenced by the reviews of doctors and patients.

special instructions

Before starting therapy and during treatment, blood pressure and heart rate should be monitored. If the heart rate falls below 50 beats per minute, medical attention is required.

Patients with diabetes should regularly monitor their glucose levels and, if necessary, adjust the dosage of insulin. Egilok should be discontinued gradually, reducing the dosage over two weeks to avoid withdrawal syndrome, coronary disorders and angina pectoris.

Patients wearing contact lenses may experience decreased tear secretion. It is recommended to exercise caution when driving vehicles and when engaging in potentially hazardous activities that require increased concentration.

"Egilok": analogues

If an individual intolerance to the drug is detected, it can be replaced with another, similar medication. Be sure to coordinate the replacement with your doctor. Most often, the reason for adjusting the prescribed drug is allergic reaction. There are quite a lot of drugs for hypertension in pharmacies, so there is plenty to choose from. Most often prescribed:

• "Metoprolol";
• "Metocard";
• "Metozok".

When studying the analogues of Egilok, it is necessary to be guided, first of all, by efficiency, health benefits, and only then evaluate the cost. The drug is relatively inexpensive (from a hundred rubles per pack), therefore, just for the sake of economy, it is categorically not recommended to replace it with cheaper drugs. Diseases of the heart and vascular system are dangerous not only for everyday activity, but also for life, which requires that the issue be treated very responsibly and coordinate all adjustments to the therapeutic program with the attending physician.

Negative sides

The appointment of such a serious medication should be made only by an experienced specialist, excluding any attempts at self-treatment. After treatment, the doctor will prescribe a clinical examination. Also, the expert needs to voice possible chronic, genetic ailments, talking about the accompanying complaints.

Only after that, a competent specialist will say whether it is possible to prescribe this remedy to the patient. Separately, the factors of the main contraindications will be taken into account:

• myocardial infarction with concomitant acute insufficiency;
• types of heart block;
• bradycardia;
• deviations in the work of the circulatory system;
• childhood;
• bronchial asthma.

There are several other contraindications that are atypical. So, joint reception with Verapamil is prohibited. This also included a dangerous interaction with strong drinks, which only exacerbates the manifestation of symptoms.

But pregnancy is not a strict contraindication. It depends on the current condition of the woman and her concomitant diseases. In some cases, the medicine is still allowed, but canceled immediately after the birth of the baby, if the mother is going to breastfeed the baby.

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Responsibility as an aspect of successful treatment

High blood pressure is always a danger, even if the disease is not chronic, but only manifests itself from time to time. Often, hypertension is accompanied by other health disorders, which in combination creates a danger to human life. This obliges you to take your health with the utmost responsibility. As a rule, the described drug is chosen by people to whom the attending doctor advised him. If you are going to take the remedy, you need to be prepared for the possible side effects indicated in the instructions (they are listed above). If we systematize the information collected from reviews of the drug, we can see that of the most unpleasant and strong phenomena that occur relatively often, people were worried about problems with the stool.

Feedback on Egilok from experts is mostly positive, since the drug effectively fights the main problem, is inexpensive and accessible to most people. With proper use, interruptions in the work of the heart muscle become a thing of the past, pressure stabilizes. True, Egilok gives a good result only when it really suits the patient. You can’t experiment on yourself, and it won’t work: the drug is dispensed from pharmacies strictly with a prescription from the attending physician.

Possible consequences of the combined effects of Egilok and ethanol on the body

Once in the body, alcohol stimulates the production of adrenaline, which ensures its processing and oxidation. Egilok also reduces the activity of enzymes, as a result of which the ethanol molecules remain unchanged and have an increased toxic effect on most organs.

Based on this, the compatibility of Egilok and alcohol is prohibited, despite the similar effect of both substances. Such categoricalness is due to three main factors that can cause many problems and affect human health. They look like this:

• alcohol collapse;
• ethanol overdose;
• increased toxic load on the liver.

The above factors in at its best describe the incompatibility of Egilok with alcohol. and each of these factors can lead to serious damage to organs and the development various pathologies. The greatest danger to the cardiovascular system and health in general is alcohol collapse. Egilok is prescribed for diseases of the cardiovascular system associated with hypertension and violation of the frequency of contractions. This category of people is not recommended to drink alcohol in principle. At the same time, under the action of the drug, blood pressure gradually decreases, the load on the vessels decreases, and the heart rhythm returns to normal. Taking alcohol against the background of such efficiency leads to a sharp drop in pressure and a deterioration in the course of the main processes.

A sharp drop in blood pressure provokes the development of cerebral hypoxia and leads to inhibition of the vital functions of the body. This happens due to a lack of oxygen, the supply of which decreases in proportion to the expansion of blood vessels. As a result, a person begins to feel weakness and dizziness, up to loss of consciousness. At the same time, without timely assistance, everything can end sadly and in best case a person will be disabled, and in the worst case, will die right on the spot as a result of brain failure. Adrenaline is a biologically active enzyme that increases the rate of ethanol oxidation in the body. In turn, the use of Egilok reduces the effectiveness of adrenaline, which cannot fully process alcohol and leads to an increase in the amount of toxins, up to their accumulation in tissues and the development of an overdose. An increased toxic load affects the functionality of the central nervous system, inhibiting its activity. alcohol and alcohol have an enhanced effect on the body, primary signs which are lethargy, depression, weakness, lack of coordination and slowing down of speech. To avoid toxic shock, the body stimulates the stomach to cleanse itself by causing vomiting. As a rule, after it the condition improves for a short time, and the progression of poisoning leads to impaired consciousness and respiratory dysfunction, which can result in coma and even death. The joint use of Egilok and alcoholic beverages provokes the development of transient disorders of the liver. It's no secret that most of the toxic effects of alcohol are neutralized by this particular organ. At the same time, blocking the action of adrenaline makes it impossible to process ethanol in a timely manner, increasing its toxic effect on the liver. In most cases, in the absence of any pathologies in its work, the joint use of the drug with alcohol will in no way affect the human condition. However, in the presence of diseases, the consequences of such a decision can be quite strong, starting with mild functional disorders and ending with the formation of severe hepatitis lesions of a toxic nature.

Hypertension: the first signs

The sooner the treatment of the disease is started, the less blood can be dispensed with, figuratively speaking. When should I go to the doctor, when is it reasonable to start taking Egilok? The first symptoms of hypertension are often ignored - people simply cannot appreciate the full significance of what is happening. As a rule, at the beginning, the disease marks itself with an increase in irritability, frequent dizziness and a state of fatigue. Over time, pressure provokes memory impairment, headaches and weakness.

Noticing such manifestations in oneself, it is necessary to introduce a clear control over the level of blood pressure as a rule. By conducting statistics over a relatively long time period (weeks or even months), you can identify how often the indicators go beyond the norm (120/80), how strong the deviations are. With this information, you can seek help from a doctor.

Combining Egilok and alcohol: dangerous consequences

It is impossible to take Egilok and alcohol at the same time, in a categorical form. This will cause complications, the consequences of which can adversely affect human health in general, death is not excluded.

Opposite action

First, the effect that medicine and alcoholic beverages have is diametrically opposed. Therefore, their simultaneous use can cause sudden cardiovascular failure. Its outcome may be death. In medicine, this phenomenon is called collapse. It is characterized by a sudden drop in blood pressure, the typical symptoms of which are exhaustion and severe dizziness. Often the patient loses consciousness. The collapse requires immediate medical attention. Delay threatens a person with death.

Overdose

Secondly, an overdose of ethanol is a fairly common occurrence when trying to combine Egilok with alcohol. For the decay process ethyl alcohol in the body requires adrenaline. This biological substance actively influences the rate of ethanol oxidation. As a result, alcohol breaks down faster and is excreted naturally, without lingering in the internal organs and blood. Metoprolol, the main component of Egilok, counteracts adrenaline by blocking its work. This causes a slow oxidation of alcohol. As a result, there is an accumulation of ethanol, which leads to an overdose.

First of all, the central nervous system will suffer, which will be reflected in the deterioration of the general state of health: inhibited speech, lack of vigor and mobility, difficulty in determining one's location. As intoxication worsens, additional signs of complications appear: difficulty breathing, a drop in blood pressure, impaired consciousness. The patient may fall into a coma or die if medical assistance is not provided.

Consequences for the liver

Thirdly, the effect on the liver. This is another reason to avoid combining Egilok and alcohol. Taking the medicine significantly affects the functioning of the gland. Alcohol not only enhances this load, but also poisons the liver with toxic substances. Consequently, there is a double negative effect on the body, which accelerates the formation of diseases, for example, toxic hepatitis. All liver diseases are initial stages without obvious symptoms. This increases the risk of missing the development of an anomaly and seriously threatens human health.

For reference: Toxic hepatitis is a liver disease that is formed under the influence of various harmful substances, including chemicals: drugs; alcoholic drinks; poisons contained in plants and so on.

Price for Egilok, where to buy

The average price for Egilok Retard, set in Moscow pharmacies: 215 and 275 rubles. for a pack of 30 pcs. 50 mg and 100 mg tablets.

The average price for Egilok in Moscow: 125 and 150 rubles. for 25 and 50 mg tablets in the amount of 60 pcs. in the bank.

The average price for Egilok S in Moscow: 175, 215, 275 rubles. for a pack of 30 pcs. 25, 50, 200 mg tablets.

• Internet pharmacies in RussiaRussia
• Internet pharmacies of UkraineUkraine
• Internet pharmacies of KazakhstanKazakhstan

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• Egilok 50 mg n60 tablEgis Pharmaceutical plant JSC
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• Egilok 100 mg No. 30 tablets ZAT FZ Egis, Ugorshchina
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• Egilok tablets Egilok tablets 50mg №60 Hungary, Egis

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Medical instructions for use

On our website you can find medical instructions for more than 20 thousand medicines!

All instructions are classified according to pharmacological groups, active substance, form, indications, contraindications, method of application and interaction.

In this medical article, you can read drug Egilok. Instructions for use will explain at what pressure tablets can be taken, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Egilok, from which you can find out if the drug helped in the treatment of coronary artery disease and hypertension in adults and children, for which it is also prescribed. The instructions list the analogues of Egilok, the price of the drug in pharmacies, as well as its use during pregnancy.

The medicine for the treatment of pathologies of the cardiovascular system is Egilok. Instructions for use indicate that tablets 25 mg, 50 mg and 100 mg, retard, help to reduce the frequency of ventricular heart rate in supraventricular tachycardia, ventricular extrasystole and atrial fibrillation.

Egilok refers to complex drugs that regulate heart rate and normalize blood pressure. Migraine, heart rhythm disturbance, high blood pressure - this is a short list of symptoms for which Egilok is prescribed.

This is an indispensable medicine for the elderly and all those who suffer from cardiovascular pathologies, both in acute and chronic form. With long-term use, it reduces the content of cholesterol in the blood serum.

The drug belongs to the group of cardioselective beta1-blockers. The drug has antihypertensive, antianginal, antiarrhythmic action.

Influencing the beta1-adrenergic receptors of the heart muscle, it normalizes the formation of catecholamines cAMP from ATP, reduces the intracellular current of calcium ions, has a negative chrono-, dromo-, batmo- and inotropic effect (slows heart rate, inhibits conductivity and excitability, reduces myocardial contractility).

The active substance of the drug Egilok - metoprolol tartrate, reduces the effect of the excitability of the sympathetic system on the heart muscle, additionally causing a rapid decrease in heart rate, cardiac output and blood pressure.

With hypertension, long-term use of Egilok leads to a significant decrease in the mass of the left ventricle of the heart and an improvement in its diastolic function.

Metoprolol is almost completely excreted in the urine in 72 hours. About 5% of the dose is excreted unchanged. Well reduces blood pressure, especially when combined with tachycardia, tachysystole. The action is fast especially when taken sublingually.

1. Egilok tablets of the usual duration of action, 25 mg, 50 mg and 100 mg of the active substance metoprolol tartrate.

2. Tablets Egilok Retard with prolonged action of 50 mg and 100 mg.

• angina pectoris, unstable angina;
• myocardial infarction (acute phase, as well as secondary prevention);
• CHF (compensated) in combination with diuretics, ACE inhibitors and cardiac glycosides;
• arterial hypertension (increased blood pressure), including in patients over 60 years of age, hypertensive crisis;
• rhythm disturbances associated with an increase in heart rate (supraventricular arrhythmias, extrasystoles);
• prophylactic prevention of migraine attacks;
• IHD - ischemic heart disease;
• heart failure.

Indications for the use of tablets also apply to people over 60 years of age.

The dosage of the drug depends on the stage and symptoms of the manifestation of the disease and is selected by the attending physician in each individual case individually.

In case of arterial hypertension, it is prescribed in a daily dose of 50-100 mg / day in 1 or 2 doses (morning and evening).

The maximum allowable daily dosage is 200 mg.

When determining the dosage for angina pectoris, it is necessary to focus on the pulse, which should be 55-60 beats per minute at rest, and no more than 110 beats per minute during exercise.

Egilok tablets should be taken orally during or immediately after a meal. Tablets can be divided in half, but not chewed.

Application features

Care must be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration, as there is a risk of dizziness, weakness and increased fatigue.

When mixed with ethanol, the pumping effect on the central nervous system increases, therefore it is contraindicated to combine alcoholic beverages with tablets.

The interaction of Egilok with alcohol-containing substances leads to a sharp decrease in blood pressure, which in turn can cause cerebral hypoxia.

The list of prohibited drugs for simultaneous use with Egilok is wide and fully presented in the official instructions for use attached to the medication, which you should definitely read before taking the remedy. Therefore, it is necessary to combine the drug with third-party medicines with special care and take it exclusively as prescribed by the attending physician.

Patients with diabetes need to constantly monitor the level of sugar in the blood.

Possible side effects that may occur when taking Egilok:

• shortness of breath, bronchospasm;
• allergic rhinitis, mucus discharge from the nasal passages;
• pain in the epigastric region, nausea, vomiting, diarrhea and other dyspeptic disorders;
• insomnia;
• dizziness, headache, decreased concentration, deterioration of cognitive functions of the brain;
• decrease in heart rate;
• increased sweating - hyperhidrosis;
• allergic reactions;
• excessive fatigue, lethargy, apathy, melancholy.

In relation to the sense organs (rarely), visual impairment may be observed.

It should be noted that a sharp refusal to take Egilok is not recommended. This can cause an angina attack. The drug should be discontinued gradually, consistently reducing its dose over 10 days.

With a sharp cessation of treatment, a withdrawal syndrome may occur (increased angina attacks, increased blood pressure). During the period of drug withdrawal, patients with angina pectoris should be under close medical supervision.

In most cases, the medication is well tolerated.

Overdose

It is not recommended to increase the dose indicated in the annotation.

Symptoms of oversaturation of the body with metoprolol: arterial hypotension, acute heart failure, bradycardia, cardiac arrest, AV blockade, cardiogenic shock, bronchospasm, impaired breathing and consciousness / coma, nausea, vomiting, generalized convulsions, cyanosis (manifested 20 minutes - 2 hours after taking ).

From the digestive system: nausea, vomiting.

Treatment: gastric lavage, symptomatic therapy.

Contraindications:

• breastfeeding (lactation period);
• age up to 18 years;
• heart failure in the phase of decompensation;
• cardiogenic shock;
• hypersensitivity to metoprolol and auxiliary ingredients of the drug;
• severe bradycardia;
• sinoatrial blockade, AV - blockade of 2 or 3 degrees;
• Prinzmetal's angina.

With caution: diabetes mellitus; metabolic acidosis; bronchial asthma; COPD; renal/liver failure; myasthenia gravis; pheochromocytoma (when used simultaneously with alpha-blockers); thyrotoxicosis; AV block I degree; depression (including history); psoriasis.

1. Betaloc;
2. Vasocardin;
3. Lidaloc;
4. Corvitol;
5. Metozok;
6. Metocard;
7. Metokor Adifarm;
8. Metolol;
9. metoprolol;
10. metoprolol succinate;
11. Egilok Retard;
12. Emzok.

It is important to understand that the instructions for use of Egilok, the price and reviews of the drug do not apply to analogues and cannot be used as a guide to the use or prescription for other drugs, even similar ones. For any replacement of Gordox with an analogue or other changes, a specialist consultation is necessary.

It should be understood that drug analogues cannot always fully replace the originally prescribed prescription. Therefore, when replacing a drug with a similar drug, be sure to consult with a cardiologist, therapist, neuropathologist and other specialized specialists.

Compound

Active ingredient: one 50 mg film-coated tablet contains metoprolol (in the form of 47.5 mg of metoprolol succinate, which corresponds to 50 mg of metoprolol tartrate), 100 mg contains metoprolol (in the form of 95 mg of metoprolol succinate, which corresponds to 100 mg of metoprolol tartrate ), 200 mg contains metoprolol (in the form of 190 mg metoprolol succinate, which corresponds to 200 mg metoprolol tartrate), respectively.

Excipients: microcrystalline cellulose PH 101, methylcellulose, glycerol, cornstarch, ethylcellulose, magnesium stearate. Tablet shell: microcrystalline cellulose, hypromellose, stearic acid, titanium dioxide (E171).

Tablets are taken orally, washed down with a small amount of water. Reception is allowed both during meals (recommended), and on an empty stomach.

Instructions for Egilok Retard and Egilok: the dose is divided into two doses per day, morning and evening.

Instructions for Egilok C: take 1 time per day, in the morning.

How to take (the final dose size and number of doses) the medicine is determined by the doctor individually. Maximum dose 200 mg. With impaired renal function and with advanced age, redistribution of the volume of the drug consumed is not required.

• Heart failure with compensation: 25 mg per day.
• Hyperthyroidism: 50-200 mg per day.
• Arrhythmia: 50-200 mg per day.
• Angina pectoris: 50 mg per day.
• Migraine attacks (prevention): 100-200 mg per day.
• Tachycardia: 50-200 mg per day.
• Myocardial infarction (secondary prevention): 200 mg per day.

Interaction of egilok with strong drinks

How does alcohol work? It is rapidly expanding blood vessels and as a result, blood pressure decreases. Then there is their sharp narrowing with a jump in pressure upwards. Alcohol also negatively affects the brain and liver. All strong drinks lead to an increase in the level of adrenaline in the body.

The interaction of egilok and alcohol is a threat of collapse. This condition often occurs when blood pressure drops sharply. A person has a lack of oxygen in the brain, and the result of this is a violation of vital important functions. Without timely assistance to the patient, loss of consciousness and the need to resuscitation. After all, the energy resources of the brain are depleted. That is why the instructions for egilok talk about the prohibition of the joint use of alcohol, even in small quantities.

An equally dangerous aspect of this interaction is an overdose. This happens quite often. When taking strong drinks, the amount of adrenaline in the body increases. And the drug egilok blocks the effects of adrenaline. The result of this is manifested by a slowdown in the process of alcohol oxidation. The latter accumulates in the patient's body, and this leads to an overdose. It negatively affects the state of the central nervous system. And as a result, a person experiences difficulties in orientation, his speech slows down and becomes slurred, weakness occurs. Excessive sweating is also possible, the appearance of vomiting as a protective function of the body, which slightly alleviates the condition of a person.

If the intoxication of the body is aggravated, then breathing will become rare, the voice will be hoarse, and blood pressure will drop. This leads to a coma and the risk of death.

Another danger of such combinations is a violation of the liver. A serious load on the organ occurs as a result of exposure to egilok, and alcohol also aggravates it. The work of the liver will deteriorate, even if it is completely healthy in a person. And if alcohol during the course of treatment with this drug is used even only occasionally and in small doses, then the liver can react to this with severe toxic hepatitis.

Based on the foregoing, the instructions for the drug knowingly prohibits combining it with alcoholic beverages. That's why the best solution- refuse to use them during treatment with Egilok. Such a serious drug treats serious health problems. Why interfere with the body to recover? Be patient and be responsible. And the holidays and booze never end!

vsegdazdorov.net

Often patients ask if it is possible to take alcohol while taking this or that drug. The answer is unambiguously negative: alcohol is a substance that actively affects all organs and systems, and if it is taken simultaneously with another substance that actively affects the body, then it is clear that nothing good will come of it.

How does egilok affect the body?

Egilok is a drug that suppresses the action of adrenaline on the heart (and partially on other organs). Under the action of Egilok, the coronary (feeding the heart muscle) arteries expand, as a result, additional nutrients and oxygen, which helps to reduce angina attacks and reduce the risk of myocardial infarction. The transmission of nerve impulses through the causative system of the heart is also inhibited - this restores cardiac arrhythmias and reduces the number of heartbeats. In this regard, Egilok is contraindicated in bradycardia, when the number of heartbeats is less than fifty per minute.

At the same time, under the action of Egilok, blood pressure decreases, so people prone to hypotension (low blood pressure) should not take Egilok.

Of the side effects of egilok, one can note its inhibitory effect on the central nervous system, the patient may experience lethargy, depression, and confusion while taking it. Egilok can also have side effects on the liver in the form of transient disorders of its function.

How alcohol affects the body

Alcohol acts on the blood vessels in two stages: first, it expands them sharply (blood pressure decreases, the pulse slows down), and then causes a persistent constriction (blood pressure may increase). Alcohol also has a direct toxic effect on brain and liver cells.

Some substances contribute to the rapid inactivation of alcohol, its decomposition in the liver. One of these substances is adrenaline.

The main danger of combining egilok and alcohol is collapse

The main and immediate danger will be a sharp decrease in blood pressure (BP) - that is why egilok cannot be combined with alcohol. As is known, healthy people Egilok is not taken, only those who have heart problems take it. For them, combining the intake of Egilok with alcohol can end in disaster - collapse.

Collapse occurs as a result of a sharp decrease in blood pressure, which leads to hypoxia (lack of oxygen) of the brain and inhibition of vital body functions. The patient at the same time feels weakness, dizziness, sometimes loses consciousness. If medical assistance is not provided to him in time, he will die from the depletion of the energy resources of the brain.

The second danger is an overdose of alcohol.

Adrenaline is a biologically active substance that increases the rate of alcohol oxidation in the human body. And since Egilok blocks the action of adrenaline, alcohol will oxidize slowly, it may accumulate in the body and overdose.

First of all, an overdose will affect the state of the central nervous system (CNS): large doses of alcohol depress the activity of the central nervous system. That is, in this case, alcohol acts in the same way as egilok, so a person develops lethargy, weakness, speech slows down, orientation in the environment is lost. As a protective reaction of the body, vomiting may appear, after which the condition improves. With an increase in intoxication, disturbances of consciousness deepen, breathing becomes rare, hoarse, blood pressure drops, all this can end in coma and death of the patient.

The third danger is toxic effects on the liver.

When taking Egilok, transient liver dysfunction may occur, so taking even small doses of alcohol can dramatically increase the negative effect on the liver. If a person does not have any liver diseases, then, most likely, such a combination will not affect the liver in any way if you drink a small amount of a weak alcoholic drink.

But, unfortunately, many liver diseases are asymptomatic, so it is difficult to say how the simultaneous intake of Egilok and alcohol will affect the liver of a particular patient. The consequences are quite possible from mild transient liver dysfunction to severe toxic hepatitis.

What to do for patients taking egilok

Do not drink in any case, even on a birthday and New Year It's life-threatening, not to mention the health consequences.

There are medications during which it is allowed to drink a certain amount of weak alcohol, but egilok does not apply to them.

Tachycardia and low blood pressure

With a combination of symptoms of tachycardia and hypotension, you should immediately contact a specialist and look for the cause of the pathological condition. A similar condition may indicate the presence of serious abnormalities in the body. Low blood pressure and rapid pulse appear with significant blood loss, low body temperature, acute inflammatory processes internal organs, diabetes mellitus, vegetovascular dystonia and heart damage. A similar phenomenon is often observed in pregnant women and is associated solely with changes in hormonal levels.

Drugs for tachycardia at low pressure are prescribed with extreme caution. It is extremely dangerous in this situation to self-medicate. Antiarrhythmic drugs, designed to reduce the frequency of heart beats, are not allowed to be taken with hypotension. In addition to the main therapeutic effect, this group of medicines can also lower blood pressure.

To normalize the condition and eliminate signs of tachycardia and hypotension, it is recommended to take only herbal sedatives. It can be a tincture (or tablets) of valerian, hawthorn or motherwort.

Types of illness

Pathological changes in the heart rhythm pose a serious danger, and therefore it is important to choose the right drugs for arrhythmia and tachycardia. Before determining the treatment regimen, the doctor must establish the type of syndrome. The classification of the disease is based on determining the primary source of heart contractions. AT medical practice There are the following subspecies of tachycardia:

• ventricular;
• sinus (nodal);
• supraventricular;
• atrioventricular.

An attack of tachycardia is characterized by the appearance of such signs as lack of air, pulsation of large arteries (carotid, temporal), general weakness, increased sweating, compressive pain in the chest.

Release form and medicinal composition

"Egilok" is available in the form of tablets of 0.025; 0.05 and 0.1 g. Packages are packaged in 20, 30, 60 or 100 tablets, which is quite convenient if you have a long-term treatment. Medicinal action drug due to its high quality composition. The components of the tool are:

• metoprolol tartrate;
• starch;
• cellulose;
• silicon dioxide;
• magnesium stearate;
• povidone.

After absorption into the bloodstream through the mucous membrane of the digestive tract, the drug affects the structures of the sinus node of the heart. A gradual decrease in its activity leads to a decrease in contractions, as well as the normalization of blood pressure levels. Another positive therapeutic property is the antiarrhythmic effect.

The purpose of the drug is possible in the presence of obstructive processes in the lung tissue, since due to its selective action, there is practically no effect on the muscles of the bronchi. The maximum concentration in blood serum is observed one and a half hours after ingestion, and the active substance is metabolized directly in the liver tissue.

High blood pressure and tachycardia

An attack of tachycardia and high blood pressure are a serious danger to life. Drugs for tachycardia high pressure should not only normalize the pulse, but also eliminate tension in the vessels. Medicines such as Enap, Normodepin, Corinfar, Diroton will help to correct the heart rate and stop the hypertensive syndrome.

It is impossible to ignore such attacks. Discovering pathological condition, you should contact a specialist (cardiologist) who can choose the best drug to prevent the onset of similar symptoms and relieve seizures.

How to sleep after drinking? Why do sleep problems occur? Alcohol negatively affects the central nervous system, destroying and causing some deviations. Therefore, often an alcoholic says: “I can’t sleep, what should I do?”

Types of insomnia

Depending on the state of the human body, after prolonged libations, several types of insomnia are distinguished:

• Complete lack of desire to sleep due to the occurrence of hallucinations, both visual and auditory.
• Sensitive and short sleep, often accompanied by a desire to drink. This is caused by constant dryness in the mouth. Also, this condition is characterized by an unusually high sensitivity to bright light and loud sounds.
• The process of falling asleep is long, which is often accompanied by joint, headache or other pains arising from nervous tension. Also, anxious thoughts and various fears may appear.

The main cause of insomnia after a long binge is the various effects of alcohol on the body, as well as severe intoxication. To completely and as quickly as possible get rid of this condition, it is recommended to take various drugs sedative effect. In some cases, doctors may prescribe a drug from the group of benzodiazepan tranquilizers, in particular diazepam.

Medications to normalize sleep

The choice of drugs to help the body and solve the problem of insomnia after a long binge is quite wide. Doctors toxicologists for the problem "I can not sleep" recommend taking one of the following sedatives which have a mild effect.

• Valerian;
• Motherwort;
• Grandaxin;
• Herbal preparations of sedative (sedative action);
• Glycine. Dosage - take two tablets no more than 5 times a day;
• Novopasit. Take after detoxification of the body, one tablet every 7 hours;
• Mexidol. Drink 2-3 times a day.
• Picamilon - the dosage is 150-200 mg. during the day.

When you receive medical preparations for the treatment of insomnia after a long binge, you should follow certain rules:

1. do not mix different sedatives;
2. strictly adhere to the indicated dosage;
3. be sure to conduct a general detoxification of the body.

Sedatives that should not be taken after drinking

You should be aware that there are a number of sedative medicines that should not be taken to solve the problems of "can not sleep" after a long binge. These include:

• Phenazepam. This is due to the fact that it is not compatible with alcohol, which can be in the blood of a person and increase side effects. this drug- the occurrence of hallucinations, memory impairment, the appearance of suicidal tendencies, disorientation, depressed mood, fear, outbreaks of aggression, and others. All of them are listed in the instructions. Also, when interacting with alcohol, it significantly increases the likelihood of these same side effects.
• Phenibut. It has a nootropic and weak tranquilizing effect. Doctors do not advise taking it during an acute hangover. It can be used during rehabilitation and exit from such a state after detoxification of the body. It is recommended to take if anxiety continues to remain before bedtime.
• Valoserdin and Corvalol. Both drugs contain phenobarbetal. And it is completely incompatible with alcohol. Therefore, their intake can lead to impaired brain function and even a coma. Moreover, Corvalol is rather weak in this regard.
• Afobazol. Effective only when taken regularly. The effect of the drug begins no earlier than on the third or fifth day after the start of administration. Naturally, for an emergency solution to the problem of poor falling asleep after a long binge, it simply does not fit.

You can improve the general condition on your own, using folk methods. It is important in this Special attention turn on the occurrence of hallucinations. In such cases, you should seek medical help as soon as possible.

When answering the question of how to fall asleep after drinking, you must firmly grasp the important rule - do not poison your body with alcohol. For effective treatment it is required to remove it from the body as soon as possible. To do this, you need to drink plenty of water (at least 3 three liters per day) and adjust healthy eating at home. As the main medicinal drink regular black tea with valerian or motherwort has proven itself well. You can also use various herbal preparations that have a calming effect. They can be easily purchased at any pharmacy.

If sleep disturbances are observed long time- you need to see a doctor.

If a person has certain difficulties in falling asleep after a sufficiently long binge, it is recommended to physically tire yourself a little before going to bed. Any kind of load is suitable here. For example, walking the dog, doing a set of exercises, or just doing housework or other household chores. Good way full recovery after a long binge - this, of course, is a bath. In addition, the steam room relaxes the body well and generally has a beneficial effect. It is important to make sure that the pressure is normal before visiting a bath or sauna. With high blood pressure, it is better to refuse the procedure.

The drug is contraindicated in pregnancy.

The appointment and use of Egilok tablets during pregnancy is an individual matter. In the first trimester of pregnancy, the appointment of the drug is contraindicated. It is also not recommended to use it while breastfeeding.

Treatment with the drug is possible when the intended effect and benefit for the woman outweighs the possible risk to the development of the child. Therefore, if the attending physician attributed Egilok to a pregnant woman, he must carefully monitor the intrauterine state of the fetus. In addition, observe the newborn for several days after his birth, thus identifying early stages baby health problems.

The main active ingredient of Egilok metoprolol is able to penetrate the placental barrier. But at the same time, there were no threatening signs of the drug.

Metoprolol is excreted in mother's milk in small doses. And, nevertheless, if there is a need to prescribe the drug to a nursing mother, breastfeeding should be stopped for this time.

Hangover use

With a hangover, a person suffers from symptoms alcohol poisoning- nausea with vomiting, diarrhea, dehydration, migraine, dizziness, confusion, dry mouth.

If alcohol has not completely left the blood, then taking the medicine will only aggravate the symptoms. In addition, the risk of developing other adverse reactions, dangerous to death.

The drug with a hangover syndrome can be used to normalize the work of the heart. However, it is required to wait for the body to be completely cleansed of toxins. It is best if you feel unwell to drink special hangover pills, pickle or call ambulance.

Children, during pregnancy and lactation

For pregnant women, the drug is prescribed only according to strict indications, taking into account the benefit / risk ratio, since under the influence of Metoprolol the development of bradycardia, hypoglycemia and arterial hypotension in the fetus is possible.
It requires careful monitoring of the development of the fetus, as well as the newborn in the first 48-72 hours after delivery. If necessary, the use of the drug during breastfeeding, breastfeeding should be discontinued.

According to the instructions, metoprolol is contraindicated in children and adolescents under 18 years of age, since its effectiveness and safety when used in childhood not installed.

The correct dosage of the antihypertensive drug Egilok

Among heart diseases, a special place is occupied by supraventricular paroxysmal, or supraventricular, tachycardia. Pathology is dangerous because it affects not only the elderly, but also young people and is the cause of death. It is necessary to find out how the disease manifests itself and what factors cause malfunctions in the heart.

Description

Supraventricular tachycardia is manifested by seizures, during which the heart rate reaches 100-250 beats per minute. An attack can last from a few seconds to several days, and disappears on its own without taking medication. hearth paroxysmal tachycardia located in the atrial zone, namely, above the ventricles of the heart. Therefore, tachycardia got its name.

Now the disease occupies a leading position among the pathologies of the cardiovascular system. Every year, the disease causes the death of 300,000 people. In this case, the disease most often affects people of working age, since among the causes of tachycardia are not only violations in the work of the heart, but also external factors such as leading an unhealthy lifestyle. Every fifth inhabitant of the planet and every second newborn is subject to pathological crises.

Paroxysmal tachycardia includes all types of tachycardia, the source of which is localized above the cardiac ventricles. Depending on the location of the pathology focus, it is AV-reciprocal, atrioventricular nodal, atrial and sinoatrial.

If we talk about the threat to life, then in most cases the disease is not fatal, but significantly worsens the quality of life. The patient cannot predict the onset of an attack, he does not know when he will become ill, therefore he is in constant fear. And this fear is no better than the attack itself.

Risk factors

The causes that provoke supraventricular tachycardia can be conditionally divided into cardiac and non-cardiac.

Cardiac factors include:

1. Congenital malformations of the cardiac system that arose in utero.
2. Heart disease, which is associated with a violation of the process of blood supply.
3. Heart defects, expressed in the wrong structure of the organ.
4. Inflammatory processes in the heart muscle.
5. Cardiomyopathy is a disease that is expressed in a change in the shape of the heart muscle and a violation of its functions.
6. Heart failure, manifested as a decrease in the contractility of the heart.

Non-cardiac reasons include:

1. Chemical poisoning or an overdose of certain drugs.
2. Violations in the work of the endocrine organs, in connection with which there is an increased production of hormones.
3. Alcohol and drug addiction.
4. Blockage of the lumen of the pulmonary artery by blood clots.
5. Diseases of the lungs and bronchi.
6. Disorders in the work of the nervous system.

In addition, stressful situations, emotional stress, smoking, physical abuse and excessive coffee have a strong effect on the work of the heart and the general condition of a person.

Basically, the provoking factors that lead to an increase in heart rate do not depend on the person or are influenced by the patient's lifestyle. Therefore, it is worth reviewing your daily routine, abandoning bad habits.

How does the disease manifest itself? Supraventricular tachycardia occurs suddenly and can last from a few seconds to several days. In medicine, cases of heart palpitations lasting several months have been recorded. As for the intervals between attacks, they can be quite long or short.

Stressful situations, excessive physical exercise, smoking or alcohol. Before the crisis, the patient may feel a jolt in the region of the heart, and then dizziness and tinnitus join it.

EGILOK

Tablets white or almost white, round, biconvex, with a cross-shaped dividing line and a double bevel (“double step” shape) on one side and an engraving “E435” on the other side, odorless.

Excipients: microcrystalline cellulose - 41.5 mg, sodium carboxymethyl starch (type A) - 7.5 mg, anhydrous colloidal silicon dioxide - 2 mg, povidone K90 - 2 mg, magnesium stearate - 2 mg.

20 pcs. - blisters (3) - packs of cardboard.

Tablets white or almost white, round, biconvex, with a notch on one side and an engraving “E434” on the other side, odorless.

Excipients: microcrystalline cellulose - 83 mg, sodium carboxymethyl starch (type A) - 15 mg, anhydrous colloidal silicon dioxide - 4 mg, povidone K90 - 4 mg, magnesium stearate - 8 mg.

15 pcs. - blisters (4) - packs of cardboard.
60 pcs. - dark glass jars (1) - cardboard packs.

Tablets white or almost white, round, biconvex, chamfered, with a notch on one side and engraving “E432” on the other side, odorless.

Excipients: microcrystalline cellulose - 166 mg, sodium carboxymethyl starch (type A) - 30 mg, colloidal anhydrous silicon dioxide - 8 mg, povidone K90 - 8 mg, magnesium stearate - 8 mg.

30 pcs. - dark glass jars (1) - cardboard packs.
60 pcs. - dark glass jars (1) - cardboard packs.

pharmachologic effect

Cardioselective blocker of β-adrenergic receptors.

Metoprolol suppresses the effect of increased activity of the sympathetic system on the heart, and also causes a rapid decrease in heart rate, contractility, cardiac output and blood pressure.

With arterial hypertension, metoprolol reduces blood pressure in patients in a standing and lying position. The long-term antihypertensive effect of the drug is associated with a gradual decrease in OPSS.

In arterial hypertension, long-term use of the drug leads to a statistically significant decrease in the mass of the left ventricle and an improvement in its diastolic function.

In men with mild or moderate hypertension, metoprolol reduces mortality from cardiovascular causes (primarily sudden death, fatal and non-fatal heart attack and stroke).

Like other beta-blockers, metoprolol reduces myocardial oxygen demand by reducing systemic blood pressure, heart rate and myocardial contractility. The decrease in heart rate and the corresponding lengthening of diastole when taking metoprolol provide improved blood supply and oxygen uptake by the myocardium with impaired blood flow.

Therefore, in angina pectoris, the drug reduces the number, duration and severity of attacks, as well as asymptomatic manifestations of ischemia, and improves the patient's physical performance. In myocardial infarction, metoprolol reduces the mortality rate by reducing the risk sudden death.

This effect is primarily associated with the prevention of episodes of ventricular fibrillation. A decrease in the mortality rate can also be observed with the use of metoprolol in both the early and late phases of myocardial infarction, as well as in patients of the group high risk and patients with diabetes.

The use of the drug after myocardial infarction reduces the likelihood of non-fatal re-infarction.

In chronic heart failure against the background of idiopathic hypertrophic obstructive cardiomyopathy, metoprolol tartrate, taken in low doses (2 × 5 mg / day) with a gradual increase in dose, significantly improves heart function, quality of life and physical endurance of the patient.

With supraventricular tachycardia, atrial fibrillation and ventricular premature beats, metoprolol reduces the frequency of ventricular contractions and the number of ventricular extrasystoles.

At therapeutic doses, the peripheral vasoconstrictor and bronchoconstrictor effects of metoprolol are less pronounced than the same effects of non-selective beta-blockers.

Compared with non-selective beta-blockers, metoprolol has less effect on insulin production and carbohydrate metabolism, and does not increase the duration of hypoglycemia attacks.

Metoprolol causes a slight increase in the concentration of triglycerides and a slight decrease in the concentration of free fatty acids in the blood serum. There is a significant decrease in the total concentration of serum cholesterol after the use of metoprolol for several years.

Pharmacokinetics

Suction

Metoprolol is rapidly and completely absorbed from the gastrointestinal tract. The drug is characterized by linear pharmacokinetics in the therapeutic dose range. Cmax in plasma is achieved 1.5-2 hours after ingestion. Bioavailability is approximately 50% with a single dose and approximately 70% with regular use. Taking the drug simultaneously with food can increase bioavailability by 30-40%.

Distribution

Metoprolol slightly (about 5-10%) binds to plasma proteins. Vd is 5.6 l / kg.

Metabolism

After absorption, metoprolol is largely subject to the effect of "first pass" through the liver. It is metabolized in the liver by cytochrome P450 isoenzymes. Metabolites do not have pharmacological activity.

breeding

T1 / 2 averages 3.5 hours (from 1 to 9 hours). The total clearance is approximately 1 l / min. Approximately 95% of the administered dose is excreted by the kidneys, 5% - in the form of unchanged metoprolol. In some cases, this value can reach 30%.

Pharmacokinetics in special clinical situations

Significant changes in the pharmacokinetics of metoprolol in elderly patients have not been identified.

Impaired renal function does not affect the systemic bioavailability or excretion of metoprolol. However, in these cases, there is a decrease in the excretion of metabolites. In severe renal failure (GFR

Source: https://health.mail.ru/drug/egilok/

At what pressure do they drink Egilok: instructions for use (tablets 25 mg, 50 mg and 100 mg, retard)

In this medical article, you can get acquainted with the drug Egilok. Instructions for use will explain at what pressure tablets can be taken, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Egilok, from which you can find out if the drug helped in the treatment of coronary artery disease and hypertension in adults and children, for which it is also prescribed. The instructions list the analogues of Egilok, the price of the drug in pharmacies, as well as its use during pregnancy.

The medicine for the treatment of pathologies of the cardiovascular system is Egilok. Instructions for use indicate that tablets 25 mg, 50 mg and 100 mg, retard, help to reduce the frequency of ventricular heart rate in supraventricular tachycardia, ventricular extrasystole and atrial fibrillation.

Release form and composition

The drug is produced in the following dosage forms:

1. Tablets 25 mg, 50 mg and 100 mg.
2. Long-acting film-coated tablets 50 mg and 100 mg (Retard).
3. Long-acting film-coated tablets 25 mg, 50 mg, 100 mg and 200 mg (Egilok C).

One tablet of Egilok (Retard) contains 25, 50, 100 mg of the active substance (metoprolol tartrate), respectively.

One tablet of Egilok C, the active substance (metoprolol succinate), accounts for 23.75, 47.5, 95, 190 mg, respectively.

pharmachologic effect

Egilok instruction refers to beta1-adrenergic blocking agents. The main active ingredient is metoprolol. It has antianginal, antiarrhythmic, pressure-lowering effects. By blocking beta1-adrenergic receptors, the drug reduces the excitatory effect of the sympathetic nervous system on the heart muscle, quickly reduces heart rate and blood pressure.

The hypotensive effect of the drug is long-lasting, as peripheral vascular resistance decreases gradually. Against the background of long-term use of Egilok with high blood pressure, the mass of the left ventricle significantly decreases, it relaxes better in the diastolic phase.

According to reviews, the drug is able to reduce mortality from cardiovascular pathology in males with a moderate increase in pressure. Like analogues, Egilok reduces the heart's need for oxygen due to a decrease in pressure and heart rate.

Due to this, diastole is lengthened - the time during which the heart rests, which improves its blood supply and the absorption of oxygen from the blood. This action reduces the frequency of angina attacks, and against the background of asymptomatic episodes of ischemia, the patient's physical condition and quality of life are significantly improved.

The use of Egilok reduces the frequency of ventricular heart contractions in atrial fibrillation, ventricular premature beats and supraventricular tachycardia.

Compared with non-selective beta-blockers of Egilok's analogues, it has less pronounced vasoconstrictor and bronchial properties, and it also has less effect on carbohydrate metabolism.

Against the background of taking the drug for several years, blood cholesterol is significantly reduced.

Indications for use

What helps Egilok (Retard, C)? Tablets are prescribed if the patient has:

• angina;
• myocardial infarction;
• impaired functional cardiac activity;
• disturbed heart rhythm (supraventricular tachycardia and bradycardia with ventricular extrasystoles and atrial fibrillation);
• high blood pressure;
• prophylactic prevention of migraine attacks.

Indications for the use of tablets also apply to people over 60 years of age.

Instructions for use (at what pressure it helps)

Egilok tablets should be taken orally during or immediately after a meal at a pressure of more than 140 to 90. They can be divided in half, but not chewed.

• With angina pectoris, supraventricular arrhythmias, for the prevention of migraine attacks, a dose of 100-200 mg per day is prescribed in 2 divided doses (morning and evening).
• For secondary prevention of myocardial infarction, an average daily dose of 200 mg is prescribed in 2 divided doses (morning and evening).
• With functional disorders of cardiac activity, accompanied by tachycardia, a daily dose of 100 mg is prescribed in 2 divided doses (morning and evening).
• With arterial hypertension, a daily dose of 50-100 mg per day is prescribed in 1 or 2 doses (morning and evening). With insufficient therapeutic effect, a gradual increase in the daily dose to 100-200 mg is possible.

In elderly patients, patients with impaired renal function, and if hemodialysis is necessary, changes in the dosing regimen are not required. In patients with severe liver dysfunction, the drug should be used in smaller doses, due to a slowdown in the metabolism of metoprolol.

Contraindications

The use of Egilok is unacceptable for:

• breastfeeding;
• angiospastic angina;
• persons under 18 years of age;
• cardiogenic shock;
• severe arterial hypotension;
• heart failure in the phase of decompensation;
• SSSU;
• severe bradycardia;
• AV blockade of the second and third degree;
• hypersensitivity to metoprolol and other components of the drug Egilok, from which these tablets can cause side effects;
• sinoatrial blockade.

With extreme caution, this medicine is prescribed for the following pathologies: metabolic acidosis, diabetes mellitus, bronchial asthma, obliterating peripheral vascular disease, chronic obstructive pulmonary disease, chronic renal failure, myasthenia gravis, psoriasis, depression, chronic liver failure and thyrotoxicosis.

Side effects

According to the reviews given by doctors, Egilok is sometimes able to cause:

• stomach ache;
• headache, fatigue;
• decrease in heart rate;
• allergic reactions;
• rhinitis, nausea;
• dizziness;
• shortness of breath, bronchospasm;
• diarrhea, vomiting;
• depression, insomnia;
• increased sweating.

Children, during pregnancy and lactation

The use of Egilok during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to prescribe the drug during this period, careful monitoring of the condition of the fetus and newborn within 48-72 hours after birth is necessary, since intrauterine growth retardation, bradycardia, arterial hypotension, respiratory depression, hypoglycemia are possible.

The effect of metoprolol on the newborn during breastfeeding has not been studied, so women taking Egilok should stop breastfeeding. With caution, the drug should be prescribed to children and adolescents under the age of 18 years.

special instructions

Before starting therapy and during treatment, blood pressure and heart rate should be monitored. If the heart rate falls below 50 beats per minute, medical attention is required.

Patients with diabetes should regularly monitor their glucose levels and, if necessary, adjust the dosage of insulin. Egilok should be discontinued gradually, reducing the dosage over two weeks to avoid withdrawal syndrome, coronary disorders and angina pectoris.

Patients wearing contact lenses may experience decreased tear secretion. It is recommended to exercise caution when driving vehicles and when engaging in potentially hazardous activities that require increased concentration.

drug interaction

The list of prohibited drugs for simultaneous use with Egilok is wide. Therefore, it is necessary to combine this drug with third-party medicines with special care.

• When mixed with ethanol, the pumping effect on the central nervous system is enhanced.
• When mixed with oral hypoglycemic drugs and insulin, the likelihood of hypoglycemia increases.
• When mixed with verapamil, it can cause cardiac arrest.
• When mixed with beta-blockers (estrogens, theophylline, indomethacin), the hypotensive property of metoprolol decreases.

Egilok's analogs

According to the structure, analogues are determined:

1. Metocard.
2. Egilok Retard.
3. Betalok ZOK.
4. Corvitol 100.
5. metoprolol succinate.
6. Betaloc.
7. Vasocardin.
8. Emzok.
9. Corvitol 50.
10. Metoprolol.
11. Metozok.
12. Metoprolol tartrate.
13. Metolol.
14. Metokor Adifarm.

Concor or Egilok - which is better?

The exact answer can be given only with an individual examination. However, in general, Concor has somewhat fewer side effects compared to its counterpart, and its use with a low pulse is more acceptable. Egilok has a stronger drug effect compared to Concor.

Holiday conditions and price

The average cost of Egilok (tablets 25 mg No. 60) in Moscow is 135 rubles. The price of a dosage of 100 mg is 130 rubles for 30 tablets, 50 mg is 145 rubles. for 30 pcs. Released by prescription.

Source: https://instrukciya-po-primeneniyu.ru/egilok.html

Egilok: instructions for use, at what pressure?

Egilok is a drug of the group of beta1-adrenoblockers that produces antianginal (myocardial oxygen saturation), antiarrhythmic and hypotensive effect.

It reduces the heart's need for oxygen, increases endurance in coronary artery disease, reduces the risk of angina attacks, the risk of a heart attack. The drug is used in complex therapy coronary disease, arrhythmias, angina pectoris, heart failure, in the treatment of migraine and hyperthyroidism.

Egilok is prescribed for conditions caused by increased blood pressure and hypoxia (oxygen starvation) of cardiac tissues, which is due to its complex positive influence on the heart and hypotensive effects. Recommended for arrhythmia, migraine, high blood pressure, if there are no contraindications.

Release form and composition

Available in the form of white tablets for oral administration:

• Egilok of normal action: round, biconvex tablets with a dosage of 25 mg - with a cross-shaped line on one side and the number "E 435" on the other;
• Egilok of usual action: with a dosage of 50.100 mg of risk - on the one hand, and "E 434" and "E 432" - on the other;
• Egilok Retard all strengths: oblong, biconvex, white film-coated tablets scored on both sides.
• Egilok From all dosages: white oval biconvex tablets with a notch on both sides.

The active substance is metoprolol tartrate. In one capsule Egilok and Egilok Retard - 25, 50, 100 mg of the active substance (metoprolol tartrate). In Engilok C, the active substance is metoprolol succinate (25-200 mg). Excipients: microcrystalline cellulose, povidone, sodium carboxymethyl, starch, magnesium stearate, colloidal silicon dioxide (titanium), etc.

Store 5 years at room temperature. Apply according to a prescription from a cardiologist.

Egilok has the usual action, and Egilok S and Egilok Retard - prolonged (extended), which reduces the likelihood of side effects.

All varieties of the drug are produced by the pharmaceutical concern EGIS Pharmaceuticals PLC (Hungary).

There is another variety - cheap analogue Egilok C - Egilok SR (Egilok SR), manufactured under license by the pharmaceutical plant Intas Pharmaceuticals Ltd (India).

All forms of the drug are considered the same, in which the active substance is different salts of metoprolol (tartrate and succinate), which decompose in the body and secrete metoprolol. The difference is only in the speed of absorption and the onset of the effect, as well as in the composition of the excipients.

The cost of the drug: in Russia 125 rubles, in Kyiv - 57-90 UAH.

Pharmacological properties

The active substance of the drug blocks beta 1 - adrenoreceptors of the heart, which gives a decrease in the frequency of heart contractions, the strength of myocardial contractions and the volume of blood pushed into the aorta.

Egilok reduces pressure. With prolonged use of Engilok, the risk of sudden death from stroke, heart attack, hypertensive crises, cardiac pathologies. By improving the supply of oxygen to the heart, the drug increases human activity, reduces the risk of angina attacks.

Egilok and Egilok Retard are used if the patient has hyperthyroidism or hyperkinetic cardiac syndrome for the complex treatment of the disease.

Egilok and Egilok C are prescribed to avoid supraventricular arrhythmias. These drugs are indicated for heart failure.

Egilok Retard is used in conjunction with diuretic (diuretic) drugs, cardiac glycosides and ACE inhibitors.

In violation of the left ventricle (systolic phase) and heart failure, Egilok C is more effective. This form of the drug reduces the likelihood of death in the later stages of a heart attack, eliminates tachycardia, and myocardial dysfunction.

Egilok prevents repeated attacks of angina pectoris, tachycardia, repeated attacks after a heart attack. The medicine does not cure these heart diseases, but increases the patient's endurance during physical, emotional stress, maintaining the normal functioning of the heart.

By eliminating the symptoms of heart disease, a person can lead a normal life.

The active component of Egilok, metaprolol, reduces the stimulating effect on the heart of the sympathetic nervous system, reduces heart rate and blood pressure.

Gradually reduces the resistance of peripheral vessels and gives a hypotensive effect. Due to the decrease in blood pressure and heart rate, myocardial oxygen demand decreases.

Due to this, the patient's condition improves, angina attacks become less frequent.

Instructions for use

Read the instructions for use of Egilok: at what pressure it is prescribed, doses, features and contraindications of the drug.

Egilok tablets are taken regardless of the meal time, preferably at the same time of day. The dose is selected individually, taking into account the indications of the patient, increasing gradually, but not more than 200 mg / day.

The medicine is prescribed for such pathologies:

1. At elevated pressure.
2. Angina pectoris (pain behind the sternum - "angina pectoris").
3. Migraine (throbbing headache in any area of ​​the head - occipital, temporal, frontal).
4. Tachycardia (increased heart rate - 90 and>).
5. Bradycardia (slow heart rate).
6. Functional disorders in the work of the heart.
7. atrial fibrillation.
8. Myocardial infarction.

To protect yourself from the risk of harming your health, using a drug for pressure, you must carefully read the instructions, familiarize yourself with the features of the drug (contraindications, side effects, compatibility with other drugs) and follow the doctor's recommendations. Do not exceed the allowable dose, monitor changes in condition.

To reduce blood pressure, the initial dose is 25-50 mg in 2 divided doses (morning and evening). In the absence of the desired effect, the dose may be increased by the attending physician.

Treatment of angina involves 25-50 mg/day with a possible increase to 200 mg and the addition of a 2nd drug to obtain the desired result. It is necessary to ensure that the heart rate at rest and under load does not go beyond: 55-60 - 110 beats / min.

After myocardial infarction for maintenance therapy, 100-200 mg / day is prescribed, with arrhythmia 25-50 mg 2-3 rubles / day. With insufficient effectiveness, the dose is increased to 200 mg or the 2nd drug against arrhythmia is additionally connected.

For migraine attacks, Egilok is prescribed 100 mg per day in 2 divided doses. In elderly patients and patients with pathology of the liver or kidneys, the dose of the drug is not increased.

The maximum therapeutic effect occurs 1.5 hours after administration. About 95% of the drug is biotransformed (processed) by the liver, 5% is excreted by the kidneys.

When treated with Egilok, it reduces the release of lacrimal fluid and discomfort may occur in patients using contact lenses. If during the reception surgical intervention, it is necessary to warn the anesthesiologist about this so that he can choose an adequate anesthesia.

It is necessary to complete the treatment smoothly, reducing the dose (every 2 weeks). Abrupt withdrawal may worsen the patient's condition.

Contraindications

With a wide range of indications, the drug has a number of contraindications. You can use it only after making sure that there are no contraindications.

It is dangerous for patients with a slow heartbeat (50-60 beats / min. or less), sick sinus syndrome.

It is undesirable to use in cases of sinoatrial blockade and in violation of peripheral circulation. Do not take hypotensive patients (low blood pressure)

If the patient has contraindications, it is necessary to reduce the dose of the drug, control the body's response to taking Egilok in small doses, or select another drug.

The drug is prohibited to take with:

• bradycardia;
• heart failure during decompensation;
• cardiogenic shock;
• during breastfeeding;
• hypersensitivity to the components of the drug;
• sinoatrial and atrioventricular blockade (2-3rd degree);
• arterial hypotension (marked decrease in blood pressure);
• angiospastic angina.

Side effects

Studies, medical observations and patient reviews made it possible to compile a list of possible side effects from various human organs and systems.

Side effects in the treatment of Egilok:

The cardiovascular system:

• pain in the region of the heart;
• palpitations, arrhythmia;
• swelling of the extremities (Egilok Retard, Egilok C);
• increased signs of heart failure;
• cardiogenic shock in patients after a heart attack;
• bradycardia;
• orthostatic hypotension (a sharp drop in blood pressure when standing up);
• fainting;
• coldness in the lower extremities.

Nervous system:

• dizziness and headache;
• anxiety;
• fatigue;
• depression;
• decreased concentration;
• excitability;
• convulsions;
• Paresthesia (impaired sensitivity, "goosebumps").

• nausea, vomiting;
• abdominal pain;
• dryness of the oral mucosa;
• constipation or diarrhea;
• liver pathology (stagnation of bile, yellowing of the skin, whites of the eyes, dark urine);
• increased bilirubin in the blood;
• hepatitis (Egilok C).

Respiratory system:

• shortness of breath on exertion;
• rhinitis;
• bronchospasm;

Skin covers:

• excessive sweating;
• hives (blistering and itching);
• rash, skin itching;
• photosensitivity (increased sensitivity of the skin to sunlight);
• exanthema (skin rash);
• redness of the skin.

Sense organs:

• visual impairment;
• taste disorder;
• dryness, eye irritation;
• tinnitus;
• conjunctivitis (inflammation of the mucous membrane of the eyes).

In the initial stages of taking the medicine, there is a feeling of fatigue.

These effects are temporary and weak. If any of the effects manifests itself brightly and for a long time, you should stop taking the drug and consult a doctor.

Overdose

If the dose of the drug is mistakenly exceeded, dizziness and bradycardia, sometimes nausea and vomiting, may occur. Blood pressure may drop. Sometimes in a patient, when the dose of Egilok is exceeded, arrhythmia, ventricular extrasystole are observed, and fainting may occur.

In severe cases, with cardiogenic shock, the patient may lose consciousness and fall into a coma, cardiac arrest may occur. With an excessive dose of the drug, such symptoms appear in the period from 20 minutes to 2 hours after ingestion.

If this happens, the patient should:

• wash the stomach;
• give adsorbents;
• put horizontally, raising the legs above the head (if the pressure has dropped);
• enter beta-agonists intravenously (if bradycardia, heart failure has developed);
• Dopamine, Dobutamine, Norepinephrine are used if the measures taken have not helped.

Doctors apply different types therapy, focusing on the symptoms and condition of the patient. If this happened at home, you should immediately call an ambulance, explaining the essence of the problem.

Egilok's analogs

There are many analogues of the drug, but before using them, you need to consult a cardiologist, but they cannot fully replace the original. Analogues: Vasocardin, Betalok, Corvitol, Lidalok, Metocard, Metozok, Metolol, Emzok, Metoprolol.

Forbidden simultaneous use Egilok with some drugs:

• the hypotensive effect of metoprolol may decrease with the combined use of Angiloc and beta-blockers (theophylline, indomethacin, estrogens);
• when taken simultaneously with Verapamil, it can lead to cardiac arrest.
• enhance the negative effect on the central nervous system simultaneous reception with Ethanol;
• the likelihood of hypoglycemia will increase when Egilok is mixed with insulin and hypoglycemic agents.

Instructions for use:

Egilok is a remedy for the treatment of pathologies of the cardiovascular system.

pharmachologic effect

Egilok, according to the instructions, refers to beta1-adrenergic blocking agents. The main active ingredient is metoprolol. It has antianginal, antiarrhythmic, pressure-lowering effects. By blocking beta1-adrenergic receptors, Egilok reduces the excitatory effect of the sympathetic nervous system on the heart muscle, quickly reduces heart rate and blood pressure. The hypotensive effect of the drug is long-lasting, as peripheral vascular resistance decreases gradually.

Against the background of long-term use of Egilok with high blood pressure, the mass of the left ventricle significantly decreases, it relaxes better in the diastolic phase. According to reviews, Egilok is able to reduce mortality from cardiovascular pathology in males with a moderate increase in pressure.

Like analogues, Egilok reduces the heart's need for oxygen due to a decrease in pressure and heart rate. Due to this, diastole is lengthened - the time during which the heart rests, which improves its blood supply and the absorption of oxygen from the blood. This action reduces the frequency of angina attacks, and against the background of asymptomatic episodes of ischemia, the patient's physical condition and quality of life are significantly improved.

The use of Egilok reduces the frequency of ventricular heart contractions in atrial fibrillation, ventricular premature beats and supraventricular tachycardia.

Compared with non-selective beta-blockers of Egilok's analogues, it has less pronounced vasoconstrictor and bronchial properties, and it also has less effect on carbohydrate metabolism.

Against the background of taking the drug for several years, blood cholesterol is significantly reduced.

Release form Egilok

Egilok is produced in tablets of 25, 50 and 100 mg.

Indications

The drug is used to treat angina pectoris, myocardial infarction, arterial hypertension, including in elderly patients, rhythm disturbances, in complex treatment migraine.

Contraindications

According to the instructions, Egilok can not be used in case of atrioventricular blockade of 2 and 3 degrees, weakness of the sinus node, lowering blood pressure below 90-100 mm Hg. Art., at sinus bradycardia with a heart rate below 50-60 beats per minute.

Hypersensitivity to the components of the drug is also a contraindication.

Instructions for use Egilok

The drug in tablets is taken regardless of food, dose selection is strictly individual and should be carried out gradually. More than 200 mg / day Egilok can not be taken. To achieve the effect, regular intake of the drug is important.

To lower blood pressure, start with a dose of 25-50 mg 2 times a day (morning, evening), if necessary, increasing the dose.

For the treatment of angina, take 25-50 mg 2-3 times a day, if the effect is insufficient, the dose is increased to 200 mg / day or another drug is added to the treatment regimen. It is advisable to maintain a heart rate of 55-60 beats / min at rest and no more than 110 beats / min during exercise while taking the medication.

As maintenance therapy after myocardial infarction, 100-200 mg / day is prescribed in 2 divided doses.

With cardiac arrhythmias, the initial dose is 25-50 mg 2-3 times a day, in case of insufficient effectiveness, increase it to 200 mg / day or add another antiarrhythmic agent to the treatment regimen.

If there are indications for Egilok in the treatment of migraine attacks, its dose in this case is 100 mg / day in 2 divided doses.

With concomitant pathology of the kidneys and liver, as well as in elderly patients, changes in the dose of Egilok are not required.

When a patient uses contact lenses, the patient should be aware of possible appearance discomfort due to a decrease in the production of tear fluid during treatment with this agent.

If planned surgery against the background of taking Egilok, it is necessary to warn the anesthetist about this so that he can choose adequate means for anesthesia with a minimal inotropic effect. It is not required to cancel the drug.

It is necessary to complete the treatment with the drug gradually, reducing the dose every 2 weeks. Abrupt withdrawal of the drug may worsen the patient's condition.

Side effects

According to reviews, Egilok is sometimes able to cause headache, fatigue, depression, insomnia, dizziness, decreased concentration, decreased heart rate, shortness of breath, bronchospasm, rhinitis, nausea, diarrhea, vomiting, abdominal pain, increased sweating, allergic reactions.