Analogue xanthinol nicotinate instructions for use. Xanthinol nicotinate is a vasodilator in the complex therapy of osteochondrosis. xanthinol nicotinate side effects

Osteochondrosis due to irritation of pain receptors is often complicated by vascular spasms, which leads to an increase in inflammatory tissue swelling and an increase in ischemic manifestations.

These processes in combination aggravate the course of the disease and increase cartilage and bone damage. That is why the complex therapy of osteochondrosis includes the use of vasodilating drugs.

One such drug is Xanthinol nicotinate. This drug improves microcirculation in peripheral tissues, increases the resistance of nerve tissues to oxygen deficiency, and promotes the development of an additional vascular network.

In addition, the drug has a positive effect on cardiac activity, increases blood flow. Similar properties significantly improve the condition of patients with osteochondrosis.

Pharmacological action of the drug

The drug belongs to the group of vasodilators. Its action is due complex impact and theophylline.

Xanthinol nicotinate improves cerebral circulation, reduces the intensity of manifestations associated with insufficient oxygen supply to the brain. As a result of treatment with the drug, metabolic processes are significantly improved. brain processes and increases the blood supply to the brain.

In addition, Xanthinol nicotinate promotes the expansion of the peripheral vascular network, normalizes tissue nutrition, improves blood circulation in the collateral network, promotes blood thinning, and has antiplatelet properties (has an antithrombotic effect). The drug has fibrinolytic abilities, in other words, promotes the resorption of blood clots.

With prolonged therapy with such a drug, fibrinolytic processes are activated, and thrombus formation decreases due to blood thinning. The drug reduces the concentration in the blood of substances such as cholesterol and certain lipids, provides an anti-atherosclerotic effect.

Among other things, medicine characterized by a nicotine-like syndrome, which is associated with an exacerbation of olfactory and gustatory sensitivity. Such sensations arise due to hypersensitivity of the mucous tissues of the nose and mouth.

Therefore, during treatment, patients note that previously favorite dishes and preferred alcohol, which were previously perceived with positive side, now they began to be perceived more sharply and acquired an unpleasant amber.

Release form and composition

Xanthinol nicotinate is produced in tablet and injectable form:

• The composition of the injections contains Xanthinol nicotinate and injection water. Each package contains 5-10 ampoules of 2 or 5 ml of solution;
• The drug is available in packs of 120, 60 or 30 tablets. Each tablet of the drug contains the main active ingredient xanthinol nicotinate, as well as auxiliary components such as:

1. corn starch;
2. milk sugar;
3. Povidone;
4. Calcium stearate (aqueous).

Indications for use

The drug helps in the treatment of many diseases such as:

• Obliterating atherosclerosis of the vessels on the legs, associated with the overgrowth of vascular lumens;
• thromboangiitis obliterans (venous inflammation);
• Trophic ulcers of the lower leg;
• Raynaud's disease associated with paroxysmal arterial circulatory disorders in the hands or feet;
• Retinopathy, which is a disorder in the blood vessels eye retina;
• Migraine pains;
• Pressure ulcers resulting from experienced thrombosis of the veins in the legs;
• With an increase in the amount of fluid in the cavity inner ear(Meniere's syndrome);
• In the treatment of thrombophlebitis;
• With vascular lesions of diabetic etiology (diabetic angiopathy);
• Pathological compaction of connective tissues (scleroderma);
• Difficult-healing wounds;
• With various kinds of circulatory disorders of the brain;
• In the treatment of atherosclerosis of various localization (coronary vessels of the brain, etc.);
• Various dermatoses;
• Vascular spasms in osteochondrosis, etc.

Contraindications

Tablets and injections of Xanthinol nicotinate are not acceptable in the treatment of every patient, since they have contraindications:

1. Heart or kidney failure;
2. The presence of acute bleeding;
3. Mitral valve stenosis;
4. heart attack;
5. Hypotension;
6. Pregnancy;
7. An aggravated ulcer of the intestine or stomach;
8. Hypersensitivity to the active ingredient of the drug;
9. Glaucoma etc.

In addition, the manufacturer states that a certain degree of caution must be observed when prescribing tablets or injections of Xanthinol nicotinate to persons taking antihypertensive drugs, drivers Vehicle working with special complex mechanisms people.

Side effects and overdose

During treatment with the drug, some side effects may occur, such as:

• sudden fever;
• An attack of hypotension;
• diarrhea;
• general weakness;
• dizziness;
• Manifestations of nausea;
• redness of the skin;
• loss of appetite;
• Stomach pain, etc.

In the event of a prolonged overdose, an excessive amount of uric acid accumulates in the blood, the content of liver enzymes increases, pressure drops sharply, and severe pain in the epigastrium and vomiting appears. Shown as a treatment symptomatic therapy and refusal to take the drug.

Xanthinol nicotinate: instructions for use

Since the drug is available in several pharmacological forms, then he has several ways of taking it: inside, intramuscular injection or intravenous infusions.

The use of tablets

Xanthinol nicotinate tablets should be swallowed completely according to the following scheme: 150 mg 3 times a day. Strictly on medical advice, the dose can be increased to 200-600 mg.

Treatment lasts at least 8 weeks. As soon as there is a clear improvement in the condition, the therapeutic dose of the drug begins to be gradually reduced.

injections

Injections of the drug are administered intravenously or intramuscularly.

Intravenous infusions are carried out by jet twice a day, 2 ml each, while the patient is recommended to be in a supine position during the infusion. Intramuscular injections put 2-6 ml daily for at least 2 weeks.

If there is an acute form of circulatory disorders, then the simultaneous administration of injections and tablets of the drug is prescribed.

During pregnancy

It is absolutely not permissible to prescribe a drug during the first trimester. In subsequent periods, the appointment is possible only by the decision of the doctor and subject to constant monitoring of the patient.

Interaction

The drug enhances the effect of Strofantin, antihypertensive drugs such as α- and β-blockers, angloblockers, etc.

Price for ampoules and tablets

Price criteria for drugs in Moscow and Russia vary depending on dosage form drug:

1. Xanthinol nicotinate No. 60 tablets, 150 mg each - 193-233 rubles;
2. Ampoules with injection solution No. 10, 2 ml each - 347-381 rubles.

Analogues

Almost everyone has medication There are analogues and synonyms.

Analogues are drugs that have an identical therapeutic effect, and synonyms are drugs with the same active substance.

Among the most common analogues that have an identical therapeutic effect, there are:

• Theoverine;
• Teminal;
• Wincanor;
• Theobromine;
• Theodibaverine, etc.

If we talk about synonyms, the main active ingredient of which is also xanthinol nicotinate, then there are also a lot of them:

• Vedrin;
• Angioamine;
• Complamin;
• Megemin;
• Sadamin;
• Theonikol;
• Xavin;
• Complamex, etc.

Xanthinol nicotinate: instructions for use and reviews

Latin name: Xantinol nicotinate

ATX code: C04AD02

Active substance: xanthinol nicotinate (xantinol nicotinate)

Producer: OAO Usolye-Sibirsky KhPZ, Irbitsky Chemical Pharmaceutical Plant, OAO Aveksima, Dalkhimfarm, Moskhimfarmpreparaty im. N. A. Semashko, Ellara LLC, Uralbiopharm OJSC, Novosibkhimfarm OJSC, Russia

Description and photo update: 13.08.2019

Expand blood vessels, promote better blood circulation, regulate redox processes - all these properties are possessed by the drug Xanthinol nicotinate.

It is prescribed in the treatment of many pathologies. IN complex treatment osteochondrosis, he takes not the last place.

What are the active ingredients of the drug, in what forms is it produced and what side effects can it give?

pharmachologic effect

The drug Xanthinol nicotinate has several important functions. It dilates the peripheral vessels, makes it possible to develop collateral circulation, and provides a better supply of cells with oxygen and nutrients.

Photo of active substances:

Theophylline. Substance-stimulator of the central nervous system, enhances myocardial contractions, has a bronchodilatory effect. Expands peripheral, coronary and hepatic vascular walls. Gives a diuretic effect.

A nicotinic acid. Belongs to the group of vitamins (vitamin B3). Directly involved in metabolism: redox processes, tissue respiration, carbohydrate and protein metabolism. It has a moderate ability to dilate blood vessels, improve the secretion of gastric juice.

The lack of nicotinic acid in the body destabilizes the activity of the central and peripheral nervous systems, provokes inflammation of the skin and mucous membranes. A more detailed review of nicotinic acid can be found in this.

The substance expands the peripheral vascular network, promotes normal blood circulation, cleanses the vascular wall of lipoprotein plaques, reduces blood pressure.

Xanthinol nicotinate is a drug whose value and effectiveness lies in the combination of the properties of its main active ingredients.

Useful video:

Composition and form of release of the drug

medicinal product Available in solid and liquid forms:

1. Injectable forms contain Xanthinol nicotinate dissolved in water for injection. Ampoules with a solution are available in dosages of 2 and 5 ml.
2. The solid tablet form contains 150 mg of xanthinol with auxiliary components.

Photo of the preparation:

Xanthinol Nicotinate in ampoules

Xanthinol Nicotinate tablets

Indications for use

Due to a fairly wide range of effects, Xanthinol nicotinate is used in a complex drug treatment many diseases:

1. angio- and retinopathy;
2. non-healing wounds and ulcers;
3. hypercholesterolemia;
4. neurogenic and muscular dystrophies;
5. obliterating atherosclerosis of vessels and obliterating endarteritis in the lower extremities;
6. pathology of impaired blood circulation of brain tissues against the background of atherosclerotic disorders;
7. dermatoses of vascular and neurogenic origin (scleroderma, neurodetitis).

Contraindications

The drug is not prescribed to patients with high sensitivity to nicotinic acid and theophylline.

The drug is not prescribed to patients with acute or uncompensated cardiovascular insufficiency.

The drug is not prescribed for bleeding, in the acute phase of myocardial infarction, with exacerbation of gastric ulcer with duodenal ulcer.

The drug is contraindicated in people with a history of acute or chronic renal failure.

side properties

To exclude undesirable consequences, it is impossible to use strong tea, coffee and alcohol during treatment with the drug.

From taking the drug, a nicotine-like syndrome may develop.

This neurotoxic state is marked by hypersensitivity of the mucous membranes.

On the mucous membrane of the nose and mouth, sensitive, olfactory, taste stimuli begin to perceive odors with tastes especially sharply, sharply, often perversely.

From Xanthinol nicotinate, a collaptoid state can develop in the form of dizziness, lowering blood pressure, headaches, epigastric pain.

Dosage and overdose

The drug is administered intravenously at a dosage of 2-4 ml every day, a course of 2 weeks

There are two ways to take Xanthinol nicotinate: orally or as an injection. The drug is administered intramuscularly or intravenously by jet.

In tablets, the drug is taken 3 times a day, 150 mg.

For special indications, the daily dosage may be increased to 600 mg.

Usually, the course of taking Xanthinol tablets lasts about 2 months. After the therapeutic effect of the drug is achieved, the dosage of Xanthinol is gradually reduced.

Injections - intravenous jet infusions of the drug at a dosage of 2 ml in the morning and evening. During the administration of the drug, the patient should take a horizontal position.

At acute forms circulatory disorders, according to indications, prescribe a combined treatment of Xanthinol nicotinate in tablets and injections.

The drug is considered one of the low-toxic, but an overdose is possible. It can manifest itself in the form of arterial hypotension with general weakness, dizziness, palpitations, epigastric pain, flushing of the skin.

All signs of drug overdose are stopped by symptomatic treatment.

Xanthinol nicotinate in the treatment of osteochondrosis

Osteochondrosis is manifested by a mass of symptoms, but almost all of them are associated with spasm and dystrophic changes in articular cartilage nerve endings and vessels.

Therefore, as a vasodilator, Xanthinol nicotinate is necessary.

In the treatment of osteochondrosis, it is also important that the drug improves peripheral circulation, gives impetus to the development of collateral circulation. Nervous tissues become more resistant to forced hypoxia.

Xanthinol nicotinate also significantly improves the properties of blood, contributing to its thinning and fluidity.

The drug is not indicated as a monocomponent of the treatment of osteochondrosis. He will give positive effect only in combination with other drugs.

Instructions for use

Application of injections

The drug is administered intramuscularly, intravenously by stream, drip.

Xanthinol nicotinate for intravenous drip is diluted in 250 ml of saline or 5% glucose solution. Drip rate: one drop per second. The course of drip administration for acute disorders is from 5 to 10 procedures.

Useful video on how to do injections:

The use of tablets

Tablets are taken only after meals, whole, three times a day. The usual dosage is 150 mg per dose. According to the indications, the dosage can be increased to 450-600 mg.

Xanthinol nicotinate during pregnancy

In the first trimester of pregnancy, the drug is not prescribed. In the second and third trimester Xanthinol nicotinate is prescribed only in extreme, special cases under the obligatory supervision of doctors.

How painful are injections of Xanthinol nicotinate

Intramuscular injections of Xanthinol nicotinate can give a burning sensation, soreness at the injection site.

The course of treatment is quite long, so in this case it is better to alternate the buttocks (right, left), injections should be at least 1.5 cm apart from each other.

To relieve pain and discomfort, an iodine mesh is applied to the injection site.

The price of the drug

According to the therapeutic effect, the following drugs belong to Xanthinol nicotinate:

1. Theoverine. Consisting of three active substances: theobromine, papaverine, barbamyl.
2. Teminal. It contains three active ingredients: theobromine, aminophenazone, phenobarbital.
3. Wincanor. Main active ingredient: vincamine.
4. Theobromine. Main active ingredient: alkaloid theobromine.
5. Theodibaverin. It contains three active ingredients: theobromine, papaverine, bendazol.

Name of the drug	Price	Purchase	Pharmacy
Xanthinol nicotinate 150 mg N60 tabl	from 195 rub.	Buy
Xanthinol nicotinate tablets 150mg 60pcs	from 187 rubles

Tablets - 1 tab.:

• Active substances: xanthinol nicotinate 150 mg.
• Excipients: lactose - 15.7 mg, potato starch - 51.3 mg, calcium stearate - 2.3 mg, povidone (polyvinylpyrrolidone low molecular weight medical) - 10.7 mg.

10 pieces. - cellular contour packings (6) - packs of cardboard.

10 pieces. - packings without cells contour (6) - packs of cardboard.

Description of the dosage form

Tablets of white or almost white color, ploskotsilindrichesky, with a facet and risk.

pharmachologic effect

Means that improves microcirculation; combines the properties of theophylline and nicotinic acid. It causes expansion of peripheral vessels, improves collateral circulation, improves microcirculation, improves oxygenation and tissue nutrition. It has an antiplatelet effect, activates the processes of fibrinolysis, improves cerebral circulation, reduces blood viscosity.

Enhances oxidative phosphorylation and ATP synthesis. By blocking adenosine receptors and PDE, it increases the content of cAMP in the cell, stimulates the synthesis of NAD and NADP as a substrate.

By reducing OPSS and increasing myocardial contractions, it helps to increase the minute volume of blood and increase cerebral circulation, and reduces the severity of the consequences of cerebral hypoxia.

It causes a nicotine-like syndrome, accompanied by hyperesthesia of the mucous membrane of the nasal cavity and mouth: it exacerbates olfactory and taste sensitivity. In this regard, the smell and taste offered during the nicotine-like reaction of alcoholic beverages and dishes is perceived as sharper and more unpleasant.

With prolonged use, it has an anti-atherosclerotic effect, activates the processes of fibrinolysis, reduces the concentration of cholesterol and atherogenic lipids, increases the activity of lipoprotein lipase, reduces blood viscosity, and reduces platelet aggregation.

Clinical pharmacology

A drug that improves microcirculation. Angioprotector.

Indications for use Xanthinol nicotinate

Raynaud's disease, obliterating endarteritis, obliterating atherosclerosis of the vessels of the extremities, obliterating thromboangiitis (Buerger's disease), diabetic angiopathy, vascular thrombosis and embolism, post-thrombophlebitis syndrome, trophic ulcers of the legs, difficult-to-heal wounds, bedsores, cerebrovascular accidents, Meniere's syndrome, atherosclerosis of the coronary vessels, atherosclerosis cerebral vessels, hypercholesterolemia, hypertriglyceridemia, intrauterine and postpartum fetal asphyxia, dermatoses due to impaired trophism of vascular origin, scleroderma, Buschke's scleredema.

Contraindications to the use of Xanthinol nicotinate

acute bleeding, acute infarction myocardium, mitral stenosis, acute heart failure, chronic heart failure in the stage of decompensation, arterial hypotension, peptic ulcer stomach and duodenum in the acute phase, acute renal failure, glaucoma, pregnancy, hypersensitivity to xanthinol nicotinate.

Xanthinol nicotinate Use in pregnancy and children

Contraindicated in pregnancy and lactation.

xanthinol nicotinate side effects

From the side of cardio-vascular system: possible decrease in blood pressure, a transient feeling of warmth, redness of the skin.

From the side digestive system: rarely - nausea, diarrhea, anorexia, gastralgia; with prolonged use in high doses, an increase in the level of transaminases and alkaline phosphatase is possible.

Other: weakness, dizziness; with prolonged use in high doses, a change in glucose tolerance, an increase in the level of uric acid in the blood serum is possible.

drug interaction

With simultaneous use with drugs that have a hypotensive effect (beta-blockers, ergot alkaloids, alpha-blockers, sympatholytics, ganglion blockers), with strophanthin, a sharp increase in their action is possible.

Dosage of Xanthinol Nicotinate

Inside - 150-600 mg 3 times / day after meals.

V / m is administered at a dose of 300-600 mg 1-3 times / day; in / in the jet is injected slowly, in the supine position, at a dose of 300-800 mg 1-3 times / day. For intravenous drip, the dose is 150-900 mg.

In acute violations of the blood supply to tissues, simultaneously with parenteral administration of xanthinol nicotinate, 300 mg 3 times / day are used orally.

Precautionary measures

Use with caution in labile blood pressure.

Use with caution simultaneously with antihypertensive drugs.

Influence on the ability to drive vehicles and control mechanisms

Use with extreme caution in drivers of vehicles, as well as in patients involved in potentially hazardous activities.

Instructions for use

Xanthinol nicotinate instructions for use

Dosage form

tablets

Composition

Xanthinol nicotinate 150 mg

Pharmacodynamics

Means that improves microcirculation; combines the properties of theophylline and nicotinic acid. It causes expansion of peripheral vessels, improves collateral circulation, improves microcirculation, improves oxygenation and tissue nutrition. It has an antiplatelet effect, activates the processes of fibrinolysis, improves cerebral circulation, reduces blood viscosity.

Enhances oxidative phosphorylation and ATP synthesis. By blocking adenosine receptors and PDE, it increases the content of cAMP in the cell, stimulates the synthesis of NAD and NADP as a substrate.

By reducing OPSS and increasing myocardial contractions, it helps to increase the minute volume of blood and increase cerebral circulation, and reduces the severity of the consequences of cerebral hypoxia.

It causes a nicotine-like syndrome, accompanied by hyperesthesia of the mucous membrane of the nasal cavity and mouth: it exacerbates olfactory and taste sensitivity. In this regard, the smell and taste offered during the nicotine-like reaction of alcoholic beverages and dishes is perceived as sharper and more unpleasant.

With prolonged use, it has an anti-atherosclerotic effect, activates the processes of fibrinolysis, reduces the concentration of cholesterol and atherogenic lipids, increases the activity of lipoprotein lipase, reduces blood viscosity, and reduces platelet aggregation.

Side effects

From the side of the cardiovascular system: a decrease in blood pressure, a transient feeling of warmth, redness of the skin is possible.

From the digestive system: rarely - nausea, diarrhea, anorexia, gastralgia; with prolonged use in high doses, an increase in the level of transaminases and alkaline phosphatase is possible.

Other: weakness, dizziness; with prolonged use in high doses, a change in glucose tolerance, an increase in the level of uric acid in the blood serum is possible.

Selling Features

prescription

Special conditions

Use with caution in labile blood pressure.

Use with caution simultaneously with antihypertensive drugs.

Influence on the ability to drive vehicles and control mechanisms

Use with extreme caution in drivers of vehicles, as well as in patients involved in potentially hazardous activities.

Indications

Raynaud's disease, obliterating endarteritis, obliterating atherosclerosis of the vessels of the extremities, obliterating thromboangiitis (Buerger's disease), diabetic angiopathy, vascular thrombosis and embolism, post-thrombophlebitis syndrome, trophic ulcers of the legs, difficult-to-heal wounds, bedsores, cerebrovascular accidents, Meniere's syndrome, atherosclerosis of the coronary vessels, atherosclerosis cerebral vessels, hypercholesterolemia, hypertriglyceridemia, intrauterine and postpartum fetal asphyxia, dermatoses due to impaired trophism of vascular origin, scleroderma, Buschke's scleredema.

Contraindications

Acute bleeding, acute myocardial infarction, mitral stenosis, acute heart failure, chronic heart failure in the stage of decompensation, arterial hypotension, peptic ulcer of the stomach and duodenum in the acute phase, acute renal failure, glaucoma, pregnancy, hypersensitivity to xanthinol nicotinate.

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

drug interaction

With simultaneous use with drugs that have a hypotensive effect (beta-blockers, ergot alkaloids, alpha-blockers, sympatholytics, ganglion blockers), with strophanthin, a sharp increase in their action is possible.

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