Benzydamine - a complex effect on inflammation and pain. Benzydamine hydrochloride, what is it? Benzydamine analogues

Benzydamine: instructions for use and reviews

Latin name: Benzydamine

ATX Code: A01AD02

Active substance: benzydamine (Benzydamine)

Manufacturer: Verteks, JSC (Russia)

Description and photo update: 11.07.2019

LP-004681

Trade name:

Benzydamine

International non-proprietary name (INN):

benzydamine

Dosage form:

topical solution

Composition

1 ml of solution contains:

active substance:benzydamine hydrochloride - 1.50 mg.

Excipients:ethanol (ethyl alcohol 95%) - 80.00 mg, glycerin - 50.00 mg; methyl parahydroxybenzoate (methyl paraben) - 1.00 mg; natural food flavor MINT - 0.30 mg; sodium saccharinate - 0.24 mg; polysorbate 20 - 0.05 mg; sodium bicarbonate - in the amount necessary to establish the pH; purified water - up to 1.00 ml.

Description

Clear, colorless solution with a characteristic odor.

Pharmacotherapeutic group

Non-steroidal anti-inflammatory drug (NSAID).

ATX code

A 01 AD 02

Pharmacological properties

Pharmacodynamics

Benzydamine hydrochloride is a non-steroidal anti-inflammatory drug, an indazole derivative without a carboxyl group. The absence of a carboxyl group gives it the following features: benzydamine is a weak base (whereas most NSAIDs are weak acids), has a high lipophilicity, penetrates well into the inflammation site along the pH gradient (where the pH is lower) and accumulates in therapeutic concentrations.

It has an anti-inflammatory and local anesthetic effect, has an antiseptic (against a wide range of microorganisms), as well as antifungal action.

The anti-inflammatory effect of the drug is due to a decrease in capillary permeability, stabilization of cell membranes due to inhibition of synthesis and inactivation of prostaglandins, histamine, bradykinin, cytokines, complement factors and other non-specific endogenous "damaging" factors. Benzydamine inhibits the production of pro-inflammatory cytokines, especially factor tumor necrosis-a(TNF-a), to a lesser extent interleukin-1p(IL-lp). The main feature of benzydamine is that, being a weak inhibitor of prostaglandin synthesis, it demonstrates a powerful inhibition of pro-inflammatory cytokines. For this reason, benzydamine can be classified as a cytokine-suppressing anti-inflammatory drug.

The local anesthetic effect of benzydamine is associated with structural features its molecules, similar to local anesthetics. The analgesic effect is due to an indirect decrease in the concentration of biogenic amines with algogenic properties and an increase in the threshold of pain sensitivity of the apparatus; benzydamine also blocks the interaction of bradykinin with tissue receptors, restores microcirculation and reduces pain sensitivity in the focus of inflammation. Benzydamine has an antibacterial effect due to the rapid penetration of microorganisms through the membranes, followed by damage to cellular structures, disruption of metabolic processes and damage to cell lysosomes. Has antifungal activity against 20 strains Candida albicans and non-albicans strains, causing structural modifications of the cell wall of fungi and their metabolic chains, thus preventing their reproduction.

Pharmacokinetics

When applied topically, it is well absorbed through the mucous membranes and quickly penetrates into inflamed tissues, is found in the blood plasma in an amount insufficient to obtain systemic effects. It is excreted mainly by the kidneys and through the intestines in the form of metabolites or conjugation products.

Indications for use

Symptomatic therapy of pain syndrome of inflammatory diseases of the oral cavity and ENT organs (of various etiologies):

Pharyngitis, laryngitis, tonsillitis;

Gingivitis, glossitis, periodontal disease, stomatitis (including after radiation therapy);

Calculous inflammation of the salivary glands;

After treatment or extraction of teeth;

After surgical interventions and injuries (tonsillectomy, jaw fractures);

Candidiasis of the oral mucosa (as part of combination therapy).

When infectious inflammatory diseases requiring systemic treatment, the drug Benzydamine is used as part of combination therapy.

Contraindications

Hypersensitivity to benzydamine or to any other component of the drug;

Children's age (up to 12 years).

Carefully

Hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs;

Bronchial asthma (including history).

Use during pregnancy and during breastfeeding

Dosage and administration

locally. After meal.

Adults (including elderly patients) and children over 12 years of ageTo rinse the throat or mouth, use 15 ml of the drug (a measuring cup is attached) 2-3 times a day. After rinsing for 20-30 seconds, the solution must be spit out. If a burning sensation occurs when using an undiluted solution, the solution should be diluted (to dilute, mix in a measured

A glass of 15 ml of the drug and 15 ml of water or in a separate container using a measuring cup). Do not exceed the recommended dose.

The duration of treatment should not exceed 7 days. If after treatment within 7 days there is no improvement or new symptoms appear, you should consult your doctor.

Use the drug only according to the method of application and in the doses indicated in the instructions. If necessary, please consult your doctor before taking the medicine.

Side effect

Classification of the incidence of side effects according to the recommendations

World Health Organization (WHO):

very often > 1/10;

often > 1/100 to< 1/10;

infrequently > 1/1000 to< 1/100;

rarely > 1/10,000 to< 1/1000;

very rarely< 1/10000. включая отдельные сообщения;

the frequency is unknown - according to the available data, it is not possible to establish the frequency of occurrence.Allergic reactions:infrequently - photosensitivity;

rarely - hypersensitivity reactions, skin rash, pruritus; very rarely - angioedema, laryngospasm; frequency unknown - anaphylactic reactions.Local reactions:

rarely - dry mouth, burning sensation in the oral cavity; the frequency is unknown - a feeling of numbness in the oral cavity. Others:

frequency unknown - laryngospasm.

Overdose

No cases of drug overdose have been reported.

When using the drug in accordance with the instructions for use, an overdose

unlikely.

Symptoms

In case of accidental ingestion of the drug, the following symptoms are possible: vomiting, abdominal cramps, anxiety, fear, hallucinations, convulsions, ataxia, fever, tachycardia, respiratory depression.

Measures to help with overdose

Treatment is symptomatic. Empty the stomach by inducing vomiting or gastric lavage using a gastric tube (under medical supervision); provide medical supervision, supportive care and necessary hydration. The antidote is not known.

Interaction

Studies of the interaction of benzydamine with other drugs have not been conducted.

Special Instructions

If a burning sensation occurs during the use of the drug Benzydamine, the solution

should be pre-diluted with water twice by bringing the water level to

risks in a graduated glass (see section "Method of application and doses").

When using the drug benzidamine, reactions may develop

hypersensitivity. In this case, it is recommended to stop treatment and

consult with your doctor to prescribe the appropriate therapy.

In a limited number of patients, the presence of sores in the throat and mouth may indicate

for more serious pathology. If symptoms do not improve within 3 days,

you need to consult a doctor.

Benzydamine is not recommended for use in patients with hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs.

Benzydamine should be used with caution in patients with bronchial asthma in history due to the possibility of developing bronchospasm in them against the background of the use of the drug.

Benzydamine contains parahydroxybenzoates, which may cause allergic reactions.

Avoid getting the solution in your eyes. If the solution gets into your eyes, rinse them with plenty of water.

Patients involved in sports: when using drugs containing ethanol, the results of anti-doping tests for the maximum permissible content of ethanol in the blood according to the standards established by some sports federations may be positive.

Drivers of vehicles should be aware that the drug contains ethanol(in one dose of the drug (15 ml) contains 1.2 g of 95% alcohol).

Influence on the ability to drive vehicles and mechanisms

The drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Release form

Solution for local use 0.15%.

100 ml or 50 ml bottles made of polyethylene terephthalate or dark glass with a screw cap with first opening control made of high density polyethylene or polypropylene.

Each vial, together with a polypropylene measuring cup and instructions for use, is placed in a cardboard box.

Storage conditions

At a temperature not higher than 25 °C. Keep out of the reach of children.

Best before date

3 years.

Do not use after the expiration date.

Holiday conditions

Released without a prescription.

Manufacturer

VERTEX JSC, Russia

Legal address: 196135, St. Petersburg, st. Tipanova, 8-100. Manufacturer's address:

St. Petersburg, road to Kamenka, 62, lit. A. Address for sending consumer claims: 199106, St. Petersburg. V. O., 24 .

Benzydamine hydrochloride is an anti-inflammatory nonsteroidal drug that has analgesic and antipyretic properties. The active substance is present in medicinal product as benzydamine hydrochloride.

pharmachologic effect

Benzydamine is used as local remedy, as it has: decongestant, antiseptic and analgesic effect. The effect of anesthesia as a result of the use of the drug is preserved within 1.5 - 2 hours. This is due to the fact that the active substance affects not only local nerve endings, but also affects the pain centers in the cerebral cortex.

The drug actively inhibits the reproduction of bacteria, fungi of the Candida species, which cause a large number of diseases.

The agent has the ability to quickly penetrate into the mucous membranes, is well excreted from the blood by the excretory system and through the digestive tract within 13 hours.

The result of use is noticeable during the first day of use.

Benzydamine reduces the activity of small blood vessels, normalizes the activity of organs at the cellular level. This drug has an adverse effect on the activity of microorganisms, slowing down their reproduction on the mucous membranes.

The drug reduces the sensitivity of pain receptors at the site of the inflammatory process. The special activity of this agent is manifested in relation to bacteria of the genus Gardnerella vaginalis.

Benzydamine is rapidly absorbed by the mucous membrane and actively affects the foci of inflammation.

Benzidanimine hydrochloride is prescribed for moderate pain syndrome various etiologies for oral administration.

This drug is widely used in dentistry for the treatment of gingivitis, stomatitis, periodontitis, inflammatory diseases of the tongue. It is effective for lesions of the mucous membranes in the oral cavity, inflammation of the salivary glands, inflammatory processes after the extraction of teeth, fractures of the facial bones and jaw bones. It is used as an adjunct in the treatment of caries.

Benzydamine is widely used for mucosal lesions after chemotherapy. It is during this period that patients need careful analgesic treatment.

In otolaryngology, the drug is used to treat tonsillitis, pharyngitis, laryngitis. It is effective after the removal of the tonsils.

In gynecology, the drug is used to treat fungal infections, with vaginitis of various origins, trichomoniasis, inflammation of the uterus, vaginal atrophy in old age.

Benzydamine is used for the treatment of inflammation of the veins, venous stasis, thrombophlebitis, post-phlebotic syndrome, with violations of the outflow of venous blood during pregnancy. The drug can be used as a decongestant medicine.

Preparations based on benzydamine can be used both externally in case of venous insufficiency, and as part of complex therapy vein diseases. In patients suffering from vascular sclerosis, it is used as a wound healing and analgesic.

Locally, the drug is used in dentistry to suppress inflammation of the oral cavity, stomatitis, tonsillitis, pharyngitis, and inflammation of the salivary glands.

Contraindications and side effects

Medicines with benzydamine not recommended to use:

Benzydamine-based drugs are well tolerated by patients of any age. but when used incorrectly may be observed:

• Numbness and burning of the oral cavity;
• Redness and small rash on the skin;
• A state of weakness, drowsiness and lethargy.

Release form

Medicinal preparations containing benzydamine hydrochloride, due to the wide range of applications, are available in various forms convenient to use.

• The solution is available in 120 ml vials and is used externally.
• The lozenges are greenish in color, mint flavored and square in shape.
• Spray with dispenser.
• Gel.

How the drug is used depends on the indications for use and the form of release of the drug. Dosage and regimen must be determined by the attending physician.

Tablets are used for oral administration 4 times a day. They should be completely absorbed.

The solution is used to rinse the mouth and throat. It is necessary to use one tablespoon of the solution for rinsing every 2-3 hours.

The spray is used to treat the oral cavity. The use of the spray is allowed only for adult patients and children after 6 years of age, 6 injections per application for adults and one dose for children. After using the spray, the medicine should not be swallowed.

Also, the spray is used for elderly patients and after surgery, if the patient cannot rinse his mouth on his own.

For the treatment of gynecological diseases drugs are used for vaginal douching. One packet of powder should be diluted in 0.5 liters of boiled water beforehand. For one application, 150 ml of such a solution is sufficient. The same composition is used for a one-time procedure, which should be carried out lying on its side. The liquid should remain in the vagina for some time.

Outwardly, a gel is used, which is applied to the affected area 2 to 3 times a day. Rub in with extreme caution until the product is completely absorbed. When using the gel should not get on the mucous membrane and eyes. Procedures are carried out according to the doctor's prescription within 7 days.

Use of the drug in childhood

The drug should be used with extreme caution children after 6 years. Before use, consultation with a specialist is necessary. The duration of treatment should not exceed one week.

When processing the oral cavity, the following recommendations should be observed:

• For children of school age, the spray is used after 3 hours, 4 injections per application 4 times a day.
• Children from 4 years old can use the drug at the rate of a dose per 4 kilograms of weight in three hours. The spray should not be sprayed down the throat, but behind the cheek.

Overdose

Cases of drug overdose are excluded.

Analogues of Benzydamine

The modern pharmacological industry presents a number of drugs based on benzydamine. The drug analogues are Oralcept, Tenflex, Novosept forte and Sage in the form of a solution and cough drops.

Dentists widely use such analogues as Dental paste Solcoseryl, Dentokind, Proposol spray, Kalgel, Salvin, Maraslavin and Yoks solutions, Stomatofit, Holisal, Dentaplus tooth drops.

The well-known drug Tantum Verde is also an analogue, which includes benzydamine. The drug is produced in the form of a spray and tablets. It is used topically to suppress an infection in the throat.

Tantum rose - an analogue produced in the form of a solution or powder, which has an antiseptic and analgesic effect. The drug is used in gynecological practice for the treatment of fungal infections.

Analogues, which include benzydamine hydrochloride, are a number of organotropic and gastrointestinal agents.

Benzydamine hydrochloride - this name is known only to a narrow circle of specialists. For patients, he is familiar as Tantum Verde. Already on the second day of its use, pain, burning, discomfort in the throat decreases.

Operating principle

To remove the inflammatory reaction, prescribe drugs from the group of non-steroidal anti-inflammatory drugs.

Unlike other drugs with a similar effect (analgesics, anesthetics, antipyretics), they have several advantages:

• They act simultaneously on pain, swelling, inflammation.
• Possess a wide range applications.
• Effective for any pathology.
• They have a minimum list of contraindications.
• Do not inhibit the work of the central and peripheral nervous system.
• Do not accumulate in the body.
• Easy to use, as they are produced in any dosage forms.

Benzydamine hydrochloride belongs to the group of indazoles and, in addition to anti-inflammatory and analgesic properties, acts as an antiseptic with specific antimicrobial properties.

The main component of benzydamine hydrochloride has several distinctive qualities:

• Possesses high speed suction.
• Quickly penetrates into epithelial structures.
• Accumulating in the required concentration, it effectively acts in the focus of inflammation.
• Local use provides a low concentration of the substance in the blood, and this, in turn, makes it possible to avoid systemic effects on the body.
• Due to the ability to quickly penetrate through cell membranes, it disrupts the metabolism of pathogenic microorganisms of 110 species, inhibits their reproduction.
• It has fungicidal properties (acts on 20 strains of fungi).
• It inhibits pain receptors locally, and at the same time affects the central parts of the brain responsible for pain sensitivity.
• Shows properties in 30 seconds and keeps local anesthesia for about 2 hours.

And, most importantly: it gives a therapeutic effect on the first day of treatment.

In the modern pharmaceutical market, there are now about 40 original patented non-steroidal anti-inflammatory drugs. But only one of them with benznidamine hydrochloride. This is Tantum Verde, a product of the Italian pharmaceutical concern ANGELINI FRANCESCO A.C.R.A.F. S.p.A.

Application

Everything dosage forms the drug is used topically, after eating with otolaryngological and dental pathologies:

1. Lozenges (one unit contains 3 mg of the active ingredient).
2. Solution for local irrigation and rinsing (in 1 ml - 1.5 mg) in a 120 ml bottle.
3. Spray (in 1 dose of 2.5 mg) in a 30 ml vial.

Dosage forms are prescribed for sore throat, pharyngitis, laryngitis, tonsillitis and candidiasis. In dentistry, they are used for periodontal disease, sialadenitis.

For the treatment of infectious diseases and inflammatory processes of the throat, larynx and oral cavity of various etiologies, it is recommended to use a tablet form of the drug for resorption every 6 hours.

With severe pain syndrome, rinsing or irrigation is indicated every one and a half to two hours.

A dosed spray is prescribed in one dose (one injection) from 4 to 6 times a day.

For the treatment of children, the calculation of the daily dosage of the spray (according to the instructions) is carried out according to the formula, taking into account body weight.

Tantum Verde does not include substances from the antibiotic group and dangerous auxiliary components, therefore it is actively used in pediatrics for the treatment of babies from 3 years old in the spray.

Form advantages:

• Aerosol overdose, ingestion of the drug by a child are excluded.
• Absorption takes place gradually.
• Convenient to use at home.

Benzydamine hydrochloride is also part of the Tantum gel, which is shown in complex treatment venous insufficiency. This is prescribed for patients with swelling and a chronic feeling of heaviness in the lower extremities, with nocturnal muscle cramps, pain syndrome, phlebitis and thrombophlebitis. Gel Tantum is allowed to use during pregnancy.

It is applied externally, locally to the area of ​​projection of pain or swelling, rubbing until completely absorbed four times a day.

The concern based on benzydamine hydrochloride produces the preparation Tantum Rose in the form of a powder for preparing a solution (1 sachet per 0.5 liter of water). It is used in gynecological practice in the complex treatment of bacterial vaginosis, nonspecific and specific vulvovaginitis, cervicovaginitis.

For preventive purposes, it is prescribed before and after surgical interventions, as well as for hygiene procedures of the postpartum period.

Advantages

All dosage forms with benzydamine hydrochloride meet the basic requirements for local preparations that treat acute and chronic pathologies oropharynx.

Advantages:

• They have a wide spectrum of antimicrobial activity.
• Do not give a systemic toxic reaction.
• Does not irritate mucous membranes.
• Hypoallergenic.
• They can be used as monopreparations and as part of combination therapy.

If the rest of the group of non-steroidal anti-inflammatory drugs are based on weak acids, then benzydamine is a weak base. Due to this, the substance penetrates well into the inflammatory focus, accumulates in the required, therapeutic concentration.

Due to the antimicrobial and antimycotic ability of the preparations, the plaque disappears, the sanitation of the mucous surfaces of the oropharynx takes place in the shortest possible time.

But despite the fact that medicine effective and safe for all age groups, only a specialist can make a rational choice in his favor and choose an adequate treatment regimen.

Included in medications

A.01.A.D.02 Benzydamine

G.02.C.C.03 Benzydamine

I.A50-A64.A59 Trichomoniasis

IX.I80-I89.I80 Phlebitis and thrombophlebitis

X.J00-J06.J02.9 Acute pharyngitis, unspecified

X.J00-J06.J03.9 Acute tonsillitis, unspecified

XI.K00-K14.K05 Gingivitis and periodontal disease

XI.K00-K14.K12 Stomatitis and related lesions

XIV.N70-N77.N76 Other inflammatory diseases of the vagina and vulva

XXI.Z100.Z100* CLASS XXII Surgical practice