Coldrex - instructions for use, composition, indications, side effects, analogues and price. Coldrex junior hotdrink instructions for use, contraindications, side effects, reviews Coldrex junior reviews

Content

Respiratory diseases are easier to treat at the first manifestations. If you have symptoms of a cold or infection, you can apply Coldrex medicine. Each of its forms is freely sold in pharmacies. Therapy with this drug, subject to the dosage regimen and manufacturer's instructions, does not cause negative reactions. To avoid adverse health effects, consult your doctor.

Instructions for use Coldrex

Coldrex is generally well tolerated by patients, so doctors often recommend it at the first sign of respiratory problems. For therapy to be effective, the drug must be taken in strict accordance with the instructions. Deviations from the recommended dosing regimen, use in the presence of contraindications can cause a number of negative consequences.

Composition of Coldrex

The drug is released in the form of tablets, syrup or water-soluble powder. Each form of the drug has a specific composition:

Name

Release form

Active ingredients

Excipients

Coldrex

Tablets

Phenylephrine, caffeine, vitamin C, paracetamol.

Corn starch, povidone, sodium lauryl sulfate, stearic acid, potassium sorbate, color.

Coldrex Hotrem

Paracetamol, ascorbic acid, phenylephrine hydrochloride.

Citric acid, sucrose, sodium cyclamate, corn starch, sodium citrate, flavor, sodium saccharin.

Coldrex Maxgripp

Vitamin C, paracetamol, phenylephrine.

Flavor, sodium citrate, citric acid, sodium saccharinate, corn starch, sodium cyclamate, color, colloidal silicon dioxide, sucrose.

Coldrex Broncho

Guaifenesin

Molasses, dextrose, glacial acetic acid, sodium cyclamate, macrogol 300, dye, sodium benzoate, red pepper tincture, flavor, sodium metabisulfite, acesulfame K, star anise seed oil, xanthan gum, levomenthol, racemic camphor, water.

Coldrex Night

Paracetamol, promethazine hydrochloride, dextromethorphan hydrobromide.

Ethanol (96%), sodium cyclamate, liquid dextrose, macrogol 300, flavored oil, acesulfame K, sodium acid citrate, colors, sodium benzoate, water.

Pharmacodynamics and pharmacokinetics

Features of the action of the drug are due to its composition. The active components of the drug have the following pharmacodynamics and pharmacokinetics:

  • Paracetamol is an analgesic, the effect of which is based on the inhibition of the synthesis of prostaglandins of the central nervous system. The substance has an effect on the hypothalamus, has an antipyretic effect. Paracetamol is absorbed into gastrointestinal tract, its biosynthesis occurs in the liver. The substance is excreted in the urine.
  • Ascorbic acid - compensates for the lack of vitamin C, characteristic of the initial stages of infectious diseases, normalizes capillary permeability, strengthens immune system organism. Absorption of the substance occurs in the gastrointestinal tract, after which it is rapidly transported through the tissues. Residues of ascorbic acid are excreted during urination.
  • Caffeine has a stimulating effect on the central nervous system and secretory function of the stomach, helps to reduce platelet aggregation, vasodilation, enhance the analgesic effect of paracetamol, increase diuresis. After oral administration, the substance is easily absorbed. The maximum concentration of caffeine in the blood plasma occurs after 60 minutes. The half-life of the substance is 3.5 hours.
  • Phenylephrine helps to ease breathing, relieve swelling of the nasal mucosa. Absorption occurs unevenly in the gastrointestinal tract. The bioavailability of the substance when taken orally is reduced. Phenylephrine is excreted in the urine.

Indications for use

The drug is prescribed to relieve symptoms of colds and flu. According to the instructions for use, the drug fights several manifestations of diseases:

  • pain in muscles and joints;
  • high body temperature;
  • nasal congestion;
  • headache;
  • chills;
  • pain in the throat, sinuses.

Method of application and dosage

All forms of Coldrex must be taken orally in the manner indicated by the instructions. The recommended duration of the course and dosage of the drug should be carefully observed to reduce the risk of side effects. If it is necessary to increase the duration of therapy, if undesirable symptoms are detected, it is necessary to consult a specialist.

Coldrex tablets

Children over 12 years of age and adults are prescribed 2 tablets of Coldrex 4 times / day. A child aged 6-12 years is shown 1 pill four times a day. The recommended dose of the drug must not be exceeded. The maximum duration of therapy for colds and flu using tablets is 5 days. If symptoms persist, it is necessary to contact a specialist to change the treatment strategy or increase the course of the medication.

Syrup

As an expectorant that promotes the secretion of bronchial glands, Broncho syrup is prescribed for elderly patients, adults and children over 12 years old, 10 ml 1-3 times / day. A viscous liquid must be poured into a measuring cup to the desired mark and drunk. For children from 3 to 6 years, the permitted single dose is 5 ml. Syrup Knight is recommended to be taken 1 time / day at bedtime. Adult patients are prescribed 4 scoops (20 ml). Children under 12 years of age are recommended to give 10 ml of medication.

Coldrex Powder

The contents of Hotrem or Maxigripp sachets must be poured with a 200 ml glass of hot water, stirred until the powder is completely dissolved. Adults are advised to take 1 sachet every 4-6 hours. The maximum quantity is 4 sachets per day. Children over 12 years of age are advised to drink a drink every 6 hours. Do not drink more than 3 sachets per day. The drug should not be used for more than 5 days.

special instructions

Patients taking the drug should refrain from drinking alcohol for the period of therapy in order to avoid toxic liver damage. Patients who are addicted to alcohol should not use the medication. The drug can cause dizziness, therefore, for the duration of treatment, you should abandon activities that require increased concentration of attention, fast psychomotor reactions (driving a car, managing complex and dangerous mechanisms).

During pregnancy

The period of bearing a child and breastfeeding is a contraindication to the use of the drug. The doctor should decide on the possibility of using the medicine for the treatment of colds and viral diseases during pregnancy. If treatment is necessary for a woman during lactation, it is recommended to stop breast-feeding, since the ingress of paracetamol into the body of a child can provoke a toxic effect.

Coldrex for children

The drug in childhood should be taken strictly according to the instructions. In the line of medicines, Coldrex Junior is produced. It is prescribed for children aged 6 to 12 years. The tool is a powder that should be dissolved in 125 ml of hot water. It is recommended to drink 1 sachet every 4 hours. In this case, the maximum dose of the drug per day should not exceed 4 sachets. Therapy is allowed to continue no more than 5 days. If the symptoms of the disease have not disappeared, you should consult a doctor.


drug interaction

Experts do not recommend the simultaneous use of the drug with beta-blockers, monoamine oxidase inhibitors, tricyclic antidepressants. Between the use of these medicines should take a break of at least 2 weeks. The combined use of Coldrex with the following drugs can have an adverse effect on the body:

  • Colestyramine - the rate of absorption of paracetamol is reduced.
  • Rifampicin, barbiturates, zidovudine, carbamazepine, other inducers of microsomal liver enzymes - the possibility of developing a hepatotoxic effect increases.
  • Isoniazid, Cimetidine, hormonal contraceptives - increases the activity of caffeine, which can cause nervous excitement, anxiety, heart palpitations.
  • Anticoagulants of indirect action, Heparin, diuretics - the effectiveness of these drugs is reduced.
  • Metoclopramide, domperidone - excessively rapid absorption of paracetamol occurs.

Side effects

When taking the recommended doses, the drug is well tolerated by patients. Long-term therapy may cause nephrotoxic or hepatotoxic effects. During treatment, it is not recommended to drink coffee or strong tea, as there is a risk of increasing the negative effects of caffeine. Coldrex tablets rarely causes adverse reactions:

  • bronchospasm (with the patient's sensitivity to non-steroidal anti-inflammatory drugs);
  • thrombocytopenia;
  • cardiopalmus;
  • dizziness, nervous tension, irritability, headache, insomnia;
  • nausea, vomiting, liver dysfunction;
  • skin rash, angioedema, dermatitis, urticaria, anaphylactic shock, Stevens-Johnson syndrome;
  • violations of the process of excretion of urine;
  • glaucoma attack.

Overdose

If the patient has exceeded the recommended dose of the drug, the medication should be stopped even if the condition does not worsen, then go to the hospital. An overdose of Coldrex can be manifested by nausea, pallor of the skin, hepatonecrosis, impaired liver function, vomiting, and a decrease in the intensity of hunger.

In adult patients, the toxic effects of paracetamol are detected after taking 10-15 g of the substance. In this case, an increase in the activity of hepatic transaminases is possible. For treatment, gastric lavage, sorbents, the introduction of N-acetylcysteine, SH-group donors are prescribed. Exceeding the dose of terpinhydrate can provoke gastrointestinal disorders - the patient will need symptomatic therapy.

An overdose of caffeine is manifested by increased urination, arrhythmia, epigastric pain, sleep disturbance, vomiting, increased nervous excitability, anxiety, tachycardia, convulsions, tremor. In the event of a severe arterial hypertension The patient requires treatment with alpha-blockers. Excess consumption ascorbic acid can provoke abdominal pain, nausea, diarrhea. A patient with an overdose of vitamin C is shown forced diuresis, symptomatic therapy.

Coldrex contraindications

  • leukopenia;
  • individual intolerance to one or more substances that make up the drug;
  • disease circulatory system;
  • dysfunction of the kidneys and liver;
  • diseases of cardio-vascular system organic genesis;
  • thrombophlebitis;
  • epilepsy;
  • insomnia;
  • severe atherosclerosis;
  • decompensated heart failure;
  • glaucoma;
  • alcoholism;
  • coronary artery disease;
  • severe anemia;
  • prostate hypertrophy;
  • pregnancy and lactation;
  • hyperthyroidism;
  • arterial hypertension in severe form;
  • thrombosis;
  • pancreatitis in acute form;
  • the presence of a tendency to vascular spasms;
  • poor cardiac conduction;
  • heavy diabetes.

Terms of sale and storage

The drug is approved as an over-the-counter drug. Store the medicine in a dry place at room temperature, keep out of the reach of children. The shelf life of the drug depends on the form of release and is 2-4 years from the date of manufacture.

Analogues

In the absence of funds on the shelves of pharmacies, it can be replaced with other medicines. There are several drugs similar to Coldrex in composition or properties:

  • Aurora Hot Sip is a drug for the treatment of colds. Produced in the form of a powder intended for the preparation of a solution. The Coldrex analog is well tolerated by patients. The medication has a number of contraindications, so before using it is necessary to carefully study the instructions. Drink a hot solution prepared from the contents of a sachet of Aurora Hot Sip and water 4 times / day, avoiding on an empty stomach.
  • Adzhikold - tablets designed to eliminate symptoms respiratory infections. The active ingredients of the product are: paracetamol, caffeine, phenylephrine hydrochloride. Tablets have analgesic, antipyretic, decongestant and anti-allergic effects. Adzhikold has a small list of contraindications - it is prohibited for children under 6 years of age, pregnant and lactating women, people with hypersensitivity to the components of the drug. Adults are prescribed 1-2 pills 3-4 times / day, children - 1 tablet 1-4 times / day.
  • Coldrin - helps to cope with febrile syndrome, acute rhinitis with colds and infectious diseases. Produced in the form of tablets, which include caffeine, paracetamol, chlorphenamine, phenylephrine. The drug has many contraindications - it is recommended to consult a doctor before use. Adults need to take 1-2 pills every 4-6 hours. Maximum dose- 12 tablets per day. Children - 1 pill with an interval of 4 hours (no more than 5 pieces / day). The maximum duration of therapy is 1 week.
  • Glycodin is a drug that has an expectorant effect. The remedy is released in the form of a syrup. The composition of Glycodine is represented by levomenthol, terpinhydrate, dextromethorphan hydrobromide. The drug has a minimum of contraindications. People with bronchial asthma it should be taken with caution. The recommended dose for children is 1/4-1/2 tsp. 3 times/day. Adults need to take 5 ml four times a day.
  • Coldkur Plus - tablets for symptomatic therapy colds and flu, contain phenylephrine, acetaminophen, caffeine, chlorphenylamine. The drug has antipyretic, analgesic, vasoconstrictive effects. The drug can not be used for arterial hypertension, during pregnancy, lactation, with individual intolerance to the components. Adults are shown 1 pill three times a day. Children need to drink 1/2 tablet 3-4 times / day. The maximum duration of therapy is 5 days.
  • Neogrip - tablets of an elongated shape, used for colds. They have anti-inflammatory, anti-allergic, vasoconstrictive effects, relieve fever. Adults are shown 1-2 pills 3-4 times / day. Dosage for children should be determined by a doctor.
  • Gripaut is an effective anti-inflammatory drug for the treatment respiratory diseases. It is recommended to take no more than 4 pills per day, the maximum duration of therapy is 5 days. The tool has a large number of contraindications and side effects.
  • Maxicold - released in the form of tablets and powder. Ingredients: phenylephrine, paracetamol, vitamin C. Maxicold is indicated for patients with flu and colds to relieve pain, fever, runny nose. Shown to drink 1-2 pills four times / day. Maxicold has many contraindications - a preliminary consultation with a specialist is necessary.
  • Flukold - sachets and pills with antihistamine, analgesic, antipyretic effects. The drug relieves swelling of the nose, myalgia, fever. The contents of the sachet must be dissolved in water and taken no more than 4 per day. Flukold tablets should be drunk 1 pc. three times a day, swallowing whole.
  • Eidrink - combined remedy against symptoms of respiratory ailments. The active substances are paracetamol and phenylephrine. It is necessary to take 1 sachet 3-4 times in 24 hours. The contents of the sachet must be diluted hot water.
  • Vicks Active - is released in the form of a powder, syrup, balm, nasal spray, effervescent tablets. Each type of medicine has a specific composition and properties. Vicks Active is designed for the symptomatic treatment of flu and colds. It is necessary to carefully follow the recommendations for admission indicated in the instructions.
  • Lemsip Max - used for high temperature, chills, headache, nasal congestion, rhinitis. It should be taken orally, previously dissolved in a glass of hot water. The recommended daily amount is 4 sachets.
  • Paralen contains caffeine and paracetamol. The medication relieves pain and fever, improves well-being with colds. Maximum daily dose Paralena - 8 tablets. The course of treatment is up to 10 days.
  • Amitsitron is an analgesic, antipyretic, vasoconstrictor powder for the treatment of influenza and ARVI manifestations. It is allowed to take no more than 3 sachets per 24 hours, after diluting the contents with hot water. It is necessary to strictly follow the instructions, since Amicitron has a large list of side effects.
  • Axagrip - contains paracetamol, guaifenesin, phenylephrine. The medication is designed to reduce fever, headache and muscle pain, nasal congestion. Adults are advised to take no more than 8 tablets per 24 hours with water. It is necessary to strictly follow the instructions of the instructions in order to prevent overdose and side effects.
  • Grippocitron - used to treat patients suffering from viral diseases. The medication relieves swelling, fever, fights sneezing, itching in the nose, headache. From the powder contained in the bags, you need to prepare a drink by mixing it with hot water. It is necessary to use the resulting liquid every 4-6 hours.
  • Multigrip is a combined anti-influenza drug containing paracetamol, ascorbic acid, phenylephrine. Eliminates headaches and muscle pain, runny nose, nasal congestion, lowers body temperature. It is recommended to drink no more than 3 doses of the drug per day. To prepare a drink, the powder is dissolved in hot, but not boiling water.
  • Theraflu - its components effectively fight fever, allergic manifestations, swelling, pain in acute respiratory viral infections. The drug has a vasoconstrictor, sedative, antitussive action. The powder is taken orally by preparing a hot solution. The interval between doses is 4 hours (no more than 4 sachets / day).

Coldrex Junior Hot Drink- combination drug.
Paracetamol has an analgesic and antipyretic effect, phenylephrine reduces swelling of the mucous membranes of the sinuses, which makes breathing easier, ascorbic acid (vitamin C) makes up for the increased need for vitamin C in colds and flu.

Indications for use:
Coldrex Junior Hot Drink is used in children 6-12 years old to eliminate the symptoms of colds and flu, such as fever, headache, chills, pain in the joints and muscles, feeling of nasal congestion, pain in the sinuses and throat.

Mode of application:
Contents of 1 sachet Coldrex Junior Hot Drink pour into a mug, pour about 125 ml of hot water, stir until dissolved.
If necessary, add cold water and sugar.
Children 6 to 12 years: 1 sachet every 4 hours. Do not exceed 4 sachets in 24 hours.
Do not give the drug to children under 6 years of age without consulting a doctor.
The drug is not recommended for more than five days without consulting a doctor. If symptoms persist, see a doctor.
Do not exceed the indicated dose. In case of overdose, seek immediate medical attention medical care even if the child feels well, because there is a risk of delayed serious liver damage.

Side effects:
In the recommended doses of the drug Coldrex Junior Hot Drink usually well tolerated.
Paracetamol rarely has side effects.
Sometimes possible allergic reactions, for example, skin rash, urticaria, angioedema.
Rarely - thrombocytopenia, leukopenia, agranulocytosis.
With prolonged use in excess of the recommended dose, hepatotoxic and nephrotoxic effects may be observed.
Phenylephrine may cause nausea, headache, slight increase blood pressure and in rare cases, palpitations that disappear after discontinuation of the drug.
In case of any adverse reactions, consult a doctor.

Contraindications:
A drug Coldrex Junior Hot Drink should not be taken concomitantly with other paracetamol-containing drugs, if hypersensitivity to the ingredients that make up the drug, with a genetic absence of glucose-6-phosphate dehydrogenase, with diseases of the blood system, with severe violations of the liver or kidneys, thyrotoxicosis, diabetes, arterial hypertension, heart disease (severe stenosis of the aortic orifice, acute infarction myocardium, tachyarrhythmia); angle-closure glaucoma, in children under 6 years of age.
With caution in benign hyperbilirubinemia.

Interaction with others medicines:
A drug Coldrex Junior Hot Drink should not be taken simultaneously with tricyclic antidepressants, beta-blockers, MAO inhibitors and within 14 days after their withdrawal.
The risk of developing a hepatotoxic effect increases with the simultaneous use of barbiturates, diphenin, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes.
Talk to your doctor if you are taking metoclopramide, domperidone (used to treat nausea and vomiting), or cholestyramine (used to lower blood cholesterol), as

Metoclopramide and domperidone increase the rate of absorption of paracetamol, while cholestyramine reduces it.
Glucocorticosteroids increase the risk of developing glaucoma.
Paracetamol reduces the effectiveness of diuretic drugs.
Halothane increases the risk of ventricular arrhythmia.
Phenylephrine reduces the hypotensive effect of guanethidine.
Guanethidine enhances the alpha-adrenostimulatory effect of phenylephrine. Paracetamol, when taken for a long time, enhances the effect of indirect and anti-coagulants (warfarin and other coumarins), which increases the risk of bleeding.

Overdose:
Signs of drug overdose Coldrex Junior Hot Drink- nausea, vomiting, stomach pain, sweating, pallor of the skin, cardiac arrhythmias.
After 1-2 days, signs of liver damage can be determined.
In severe cases it develops liver failure and coma. If you suspect poisoning, you should immediately seek medical help. The victim should do a gastric lavage during the first 4 hours of poisoning and consult a doctor. The specific antidote for paracetamol poisoning is acetyl cysteine.

Storage conditions:
Store at a temperature not exceeding 25 °C.
Keep out of the reach of children.

Release form:
Coldrex Junior Hot Drink - powder for oral solution (for children).
3 g in laminated sachets (BPFP). 10 sachets, along with instructions for use, are placed in a cardboard box.

Composition:
Powder Coldrex Junior Hot Drink contains active substances: paracetamol 300 mg, phenylephrine hydrochloride 5 mg, ascorbic acid 20 mg;
excipients: sodium saccharinate, sodium cyclamate, citric acid, sodium citrate, corn starch, sucrose, lemon flavor 610399 E, dye curcumin E 100, colloidal silicon dioxide.

Additionally:
Before taking the drug Coldrex Junior Hot Drink a doctor's consultation is necessary if it is necessary to follow a hyposodium diet (each sachet contains 0.06 g of sodium).
In order to avoid toxic damage to the liver, the drug should not be combined with ethanol-containing drugs.
Active substances Coldrex Junior does not cause drowsiness.

Composition

1 sachet contains k=active ingredients:

  • paracetamol 300 mg
  • phenylephrine hydrochloride 5 mg
  • ascorbic acid 20 mg

Release form

Powder for solution for oral administration (for children) is heterogeneous, from white to pale yellow in color, with a lemon smell; dissolves in 125 ml of hot water to form a cloudy solution from yellow to yellow-green in color, without foam on the surface, with a lemon smell; there may be some sediment.

10 sachets per pack.

pharmachologic effect

Combined drug for the symptomatic treatment of acute respiratory diseases.

Paracetamol has an antipyretic, analgesic effect.

Phenylephrine hydrochloride is a sympathomimetic, constricts the vessels of the mucous membrane of the nose and paranasal sinuses, as a result of which swelling decreases and nasal breathing is facilitated.

Ascorbic acid fills the increased need for vitamin C in colds and flu.

Indication for use

To eliminate the symptoms of acute respiratory infections and influenza in children aged 6-12 years, including:

  • elevated body temperature;
  • headache;
  • chills
  • pain in the joints and muscles;
  • feeling of nasal congestion;
  • pain in the sinuses and throat.

Methods of application and doses

Children aged 6 to 12 years are prescribed 1 sachet every 4 hours. Do not use more than 4 sachets in 24 hours. Do not exceed the indicated dose.

The maximum duration of application is no more than 5 days. If symptoms persist, a doctor's consultation is required. The doctor determines the need for continued treatment individually.

Pour the contents of 1 sachet into a mug, pour about 125 ml of hot water, stir until dissolved. If necessary, add cold water and sugar.

Contraindications

  • hypersensitivity to the components of the drug;
  • severe liver disease;
  • severe kidney disease;
  • diseases of the hematopoietic system;
  • thyrotoxicosis;
  • arterial hypertension;
  • heart disease (severe aortic stenosis, acute myocardial infarction, tachyarrhythmias);
  • prostatic hyperplasia;
  • angle-closure glaucoma;
  • diabetes;
  • genetic absence of glucose-6-phosphate dehydrogenase;
  • sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, tk. the composition of the drug includes sucrose;
  • simultaneous use of tricyclic antidepressants, beta-blockers, MAO inhibitors and a period of up to 14 days after their cancellation;
  • children's age up to 6 years.

special instructions

The drug should not be taken simultaneously with other drugs containing paracetamol, as well as other non-narcotic analgesics (metamisole sodium), NSAIDs ( acetylsalicylic acid, ibuprofen), other cold and flu medications, sympathomimetics (such as decongestants, appetite suppressants, amphetamine-like stimulants), barbiturates, anticonvulsants, rifampicin, and chloramphenicol.

When conducting tests to determine uric acid and blood glucose levels, you should inform your doctor about the use of Coldrex® Junior, because. the drug may distort the results of laboratory tests that evaluate the concentration of glucose and uric acid.

Before taking the drug, you need to consult a doctor if:

  • taking metoclopramide, domperidone (used to relieve nausea and vomiting), or cholestyramine, used to lower blood cholesterol;
  • taking drugs to reduce blood clotting (for example, warfarin);
  • low sodium diet - each sachet contains 0.12 g of sodium.

To avoid toxic liver damage, paracetamol should not be combined with preparations containing ethanol.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C.

LSR-000826/08

Trade (proprietary) name: COLDREX Junior Hot Drink

Dosage form:

powder for solution for oral administration (for children).

Description:
White to pale yellow heterogeneous powder with a lemon odour. When the contents of the sachet are dissolved in 125 ml of hot water, a cloudy solution is formed from yellow to yellow-green in color, without foam on the surface, with a lemon smell; there may be some sediment.

Composition:

active substances: paracetamol 300 mg, phenylephrine hydrochloride 5 mg, ascorbic acid 20 mg;
Excipients: sodium saccharinate, sodium cyclamate, citric acid, sodium citrate, corn starch, sucrose, lemon flavor 610399 E, coloring agent curcumin E 100, colloidal silicon dioxide

Pharmacotherapeutic group: ARI and "colds" of symptoms remedy (non-narcotic analgesic agent + alpha-adrenergic agonist + vitamin). Code ATX: N02BE51

Pharmacological properties:

Coldrex Junior Hot Drink is a combination drug.

Paracetamol has an analgesic and antipyretic effect, phenylephrine reduces swelling of the mucous membranes of the sinuses, which makes breathing easier, ascorbic acid (vitamin C) makes up for the increased need for vitamin C in colds and flu.

Indications: is used in children aged 6-12 years to eliminate the symptoms of colds and flu, such as fever, headache, chills, joint and muscle pain, feeling of nasal congestion, pain in the sinuses and throat.

Contraindications:

the drug should not be taken simultaneously with other paracetamol-containing drugs, with hypersensitivity to the ingredients that make up the drug, with a genetic absence of glucose-6-phosphate dehydrogenase, with diseases of the blood system, with severe violations of the liver or kidneys, thyrotoxicosis, diabetes, arterial hypertension, heart disease (severe aortic stenosis, acute myocardial infarction, tachyarrhythmias); angle-closure glaucoma, in children under 6 years of age. Carefully with benign hyperbilirubinemia.

Dosage and administration:

Pour the contents of 1 sachet into a mug, pour about 125 ml of hot water, stir until dissolved. If necessary, add cold water and sugar.

Children from 6 to 12 years old: 1 sachet every 4 hours. Do not exceed 4 sachets in 24 hours.

Do not give the drug to children under 6 years of age without consulting a doctor.

Do not exceed the indicated dose. In case of an overdose, seek medical attention immediately, even if the child feels well, as there is a risk of delayed serious liver damage.

Side effect:

at recommended doses, the drug is usually well tolerated.

Paracetamol rarely has side effects.

Sometimes allergic reactions are possible, for example, skin rash, urticaria, angioedema.

Rarely - thrombocytopenia, leukopenia, agranulocytosis.

Phenylephrine can cause nausea, headache, slight increase in blood pressure and, in rare cases, palpitations, which disappear after discontinuation of the drug.

In case of any adverse reactions, consult a doctor.

Overdose:

Signs of overdose - nausea, vomiting, stomach pain, sweating, pallor of the skin, cardiac arrhythmias.

After 1-2 days, signs of liver damage can be determined.

In severe cases, liver failure and coma develop. If you suspect poisoning, you should immediately seek medical help. The victim should do a gastric lavage during the first 4 hours of poisoning and consult a doctor. The specific antidote for paracetamol poisoning is acetyl cysteine.

Special instructions:

before taking the drug, a doctor's consultation is necessary if it is necessary to follow a hyposodium diet (each sachet contains 0.06 g of sodium). In order to avoid toxic damage to the liver, the drug should not be combined with ethanol-containing drugs. The active substances of Coldrex Junior do not cause drowsiness.

Interaction with other drugs:

the drug should not be taken simultaneously with tricyclic antidepressants, beta-blockers, MAO inhibitors and within 14 days after their withdrawal. The risk of developing a hepatotoxic effect increases with the simultaneous use of barbiturates, diphenin, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes.

Talk to your doctor if you are taking metoclopramide, domperidone (used to treat nausea and vomiting), or cholestyramine (used to lower blood cholesterol), as Metoclopramide and domperidone increase the rate of absorption of paracetamol, while cholestyramine reduces it.

Glucocorticosteroids increase the risk of developing glaucoma. Paracetamol reduces the effectiveness of diuretic drugs. Halothane increases the risk of ventricular arrhythmia. Phenylephrine reduces the hypotensive effect of guanethidine. Guanethidine enhances the alpha-adrenostimulatory effect of phenylephrine. Paracetamol, when taken for a long time, enhances the effect of indirect and anti-coagulants (warfarin and other coumarins), which increases the risk of bleeding.

Release form: powder for solution for oral administration (for children). 3 g in laminated sachets (BPFP). 10 sachets, along with instructions for use, are placed in a cardboard box.

Storage conditions:

Store at a temperature not exceeding 25 °C.
Keep out of the reach of children.

Best before date:

3 years. Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies:

without recipe.

Manufacturer:

SmithKline Beecham S.A., Spain. SmithKline Beecham SA, CTRA de Ajalvir, KM2500, 28802, Alcala de Henares, Madrid, Spain Carretera de Ayalvir, 2500 km, Alcala de Henares, Madrid, Spain
Address in Russia: 119180, Moscow, Yakimanskaya nab.d.2

Application for violations of kidney function

Contraindications: severe renal dysfunction.

Use in children

Contraindication: childhood up to 6 years old.

Use in children over 6 years of age is possible according to the dosing regimen.

Dosage form

Contraindications for use

Hypersensitivity to the components of the drug;

severe liver disease;

severe kidney disease;

Diseases of the hematopoietic system;

thyrotoxicosis;

Arterial hypertension;

Heart disease (severe aortic stenosis, acute myocardial infarction, tachyarrhythmia);

Hyperplasia of the prostate;

Angle-closure glaucoma;

Diabetes;

Genetic absence of glucose-6-phosphate dehydrogenase;

Sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, tk. the composition of the drug includes sucrose;

Simultaneous use of tricyclic antidepressants, beta-blockers, MAO inhibitors and a period of up to 14 days after their cancellation;

Children's age up to 6 years.

Carefully the drug should be used for benign hyperbilirubinemia, pheochromocytoma, peripheral vascular disease (Raynaud's syndrome).

Application for violations of liver function

Contraindications: severe liver dysfunction.

Representation:

GlaxoSmithKline Healthcare JSC
(Russia) ATX code: N02BE51 (Paracetamol in combination with other drugs (excluding psycholeptics))

Side effect

Determination of the frequency of side effects: very often (≥1/10), often (≥1/100 and

Paracetamol rarely has side effects.

From the hematopoietic system: very rarely - thrombocytopenia.

Allergic reactions: rarely - skin rash, urticaria, allergic dermatitis; very rarely - anaphylaxis, hypersensitivity reactions, incl. angioedema, Stevens-Johnson syndrome.

From the side respiratory system: very rarely - bronchospasm in patients sensitive to acetylsalicylic acid and other NSAIDs.

From the side digestive system: very rarely - nausea, vomiting, impaired liver function.

From the side of the central nervous system: very rarely - dizziness, headache, insomnia.

From the sense organs: rarely - mydriasis, acute attack of glaucoma in most cases in patients with angle-closure glaucoma.

From the side of the cardiovascular system: rarely - tachycardia, palpitations, increased blood pressure.

From the urinary system: very rarely - dysuria, urinary retention in patients with obstruction of the outlet Bladder with prostatic hypertrophy.

In the event of any adverse reactions, the patient should consult a doctor.

Dosing regimen

Children aged 6 to 12 appoint 1 sachet every 4 hours. Do not use more than 4 sachets within 24 hours. Do not exceed the indicated dose. The maximum duration of application is no more than 5 days. If symptoms persist, a doctor's consultation is required. The doctor determines the need for continued treatment individually.

Pour the contents of 1 sachet into a mug, pour about 125 ml of hot water, stir until dissolved. If necessary, add cold water and sugar.

Pharmacokinetics

Data on the pharmacokinetics of the drug Coldrex ® Junior are not provided.

Indications

To eliminate the symptoms of acute respiratory infections and influenza in children aged 6-12 years, including:

Increased body temperature;

Headache;

Pain in joints and muscles;

Feelings of nasal congestion;

Pain in the sinuses and throat.

ICD-10 codes

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C. Shelf life - 3 years.

Registration certificate holder:

GlaxoSmithKline Healthcare JSC(Russia)

Terms of dispensing from pharmacies

The drug is released without a prescription.

special instructions

The drug should not be taken concomitantly with other drugs containing paracetamol, as well as other non-narcotic analgesics (metamizole sodium), NSAIDs (acetylsalicylic acid, ibuprofen), other means to relieve symptoms of colds and flu, sympathomimetics (such as decongestants, appetite suppressants , amphetamine-like stimulants), barbiturates, anticonvulsants, rifampicin and chloramphenicol.

When conducting tests to determine uric acid and blood glucose levels, you should inform your doctor about the use of Coldrex ® Junior, because. the drug may distort the results of laboratory tests that evaluate the concentration of glucose and uric acid.

Before taking the drug, you need to consult a doctor if:

taking metoclopramide, domperidone (used to treat nausea and vomiting), or cholestyramine, used to lower blood cholesterol;

taking drugs to reduce blood clotting (for example, warfarin);

Compliance with a reduced sodium diet - each sachet contains 0.12 g of sodium.

To avoid toxic liver damage, paracetamol should not be combined with preparations containing ethanol.

Influence on the ability to manage vehicles and mechanisms

If dizziness occurs, the patient should refrain from driving vehicles or other potentially hazardous activities that require concentration of attention and speed of psychomotor reactions.

pharmachologic effect

Combined drug for the symptomatic treatment of acute respiratory diseases.

Paracetamol has antipyretic, analgesic effect.

Phenylephrine hydrochloride- sympathomimetic, constricts the vessels of the nasal mucosa and paranasal sinuses, as a result of which swelling decreases and nasal breathing is facilitated.

Vitamin C replenishes the increased need for vitamin C for colds and flu.

Release form, composition and packaging

Powder for solution for oral administration (for children) heterogeneous, from white to pale yellow, with a lemon smell; dissolves in 125 ml of hot water to form a cloudy solution from yellow to yellow-green in color, without foam on the surface, with a lemon smell; there may be some sediment.

Excipients: sodium saccharinate - 21.5 mg, sodium cyclamate - 31.5 mg, citric acid - 340 mg, sodium citrate - 215 mg, corn starch - 100 mg, sucrose - 1862.5 mg, lemon flavor 610399E - 100 mg, curcumin dye (E100) - 3.5 mg, colloidal silicon dioxide - 1 mg.

3 g - laminated sachets (10) - cardboard packs.

Clinico-pharmacological group: A drug for the symptomatic treatment of acute respiratory diseases Pharmaco-therapeutic group: A remedy for the elimination of symptoms of acute respiratory infections and "colds" (non-narcotic analgesic + vasoconstrictor + vitamin)

drug interaction

Paracetamol when taken for a long time enhances the effect indirect anticoagulants(warfarin and other coumarins), which increases the risk of bleeding. Episodic administration of a single dose of the drug does not significantly affect the effect of indirect anticoagulants.

Inducers of microsomal oxidation enzymes in the liver (barbiturates, diphenin, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, flumecinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxicity in overdose and concomitant use with paracetamol.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity.

Paracetamol reduces the effectiveness of diuretic drugs.

Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol.

Paracetamol enhances the effects of MAO inhibitors, sedatives, ethanol.

Phenylephrine when taken with MAO inhibitors, it can lead to an increase in blood pressure.

Phenylephrine reduces the effectiveness of beta-blockers and antihypertensive drugs, increases the risk of developing arterial hypertension and disorders of the cardiovascular system.

Tricyclic antidepressants enhance the sympathomimetic effect of phenylephrine, may increase the risk of developing
side effects from the cardiovascular system.

The simultaneous use of halothane with phenylephrine increases the risk of developing ventricular arrhythmia.

Phenylephrine reduces the hypotensive effect of guanethidine, which, in turn, enhances the alpha-adrenostimulating activity of phenylephrine.

Antidepressants, antiparkinsonian drugs, antipsychotics, phenothiazine derivatives increase the risk of urinary retention, dry mouth, and constipation.

The simultaneous appointment of GCS with phenylephrine increases the risk of developing glaucoma.

With simultaneous use with digoxin and cardiac glycosides, an increased risk of developing heart rhythm disturbances or a heart attack may be increased.

Vitamin C when used simultaneously with iron preparations, due to its reducing properties, it converts ferric iron into ferrous iron, which improves its absorption.

With simultaneous use, ascorbic acid increases the excretion of iron in patients receiving deferoxamine.

With simultaneous use with barbiturates, primidone increases the excretion of ascorbic acid in the urine.

Ascorbic acid in high doses may reduce urine pH, which, when used simultaneously, reduces tubular reabsorption of amphetamine and tricyclic antidepressants.

With simultaneous use, acetylsalicylic acid reduces the absorption of ascorbic acid by about a third.

With simultaneous use with warfarin, it is possible to reduce the effects of warfarin.

When used simultaneously with tetracycline, the excretion of ascorbic acid in the urine increases.