Spazgan or no shpa. The difference between no-shpa and spasmalgon. Spasmalgon for cephalgia: indications and contraindications

I was prescribed noshpa to relieve spasms of the gastrointestinal tract, but what about the brain? I'm not a doctor, but I think there are other drugs like spazgan. I think no.

noshpa relieves spasm of smooth muscles. but not in the brain. who told you that you have a spasm there?!

no-spa (drotaverine hydrochloride) Regardless of type autonomic innervation drotaverine relaxes the smooth muscles of the gastrointestinal tract, biliary tract, genitourinary system.

That is, if you have smooth muscles in your brain (which is typical only for the gastrointestinal tract), then it can help))

Indications for use of Baralgin

Baralgin is used for moderate and mild pain with smooth muscle spasms: intestinal, renal, biliary colic, spasms Bladder, ureter. (WITH)

That is, the same nonsense. The brain is in a different place, and if intestinal remedies helped someone, then this is a placebo effect or just a coincidence.

No-spa is an antispasmodic with myotropic action

No-shpa (international generic name– drotaverine) is an antispasmodic with myotropic action, that is, it relieves increased tone from smooth muscles. All muscles in our body are divided into skeletal muscles, which provide movement. skeletal system, and smooth, located in internal organs and blood vessels. No-spa acts only on smooth muscles, limiting the flow of calcium ions to it. Calcium ions play an important role in regulating the body's vital functions. Penetrating into cells, they activate intracellular bioenergetic processes that ensure the implementation of the physiological functions of these cells, including their contraction.

No-spa reduces smooth muscle tone internal organs, their motor activity(including intestinal peristalsis) and moderately dilates blood vessels. It relieves spasm of smooth muscles caused both by the central nervous system and by direct action on smooth muscles located in the gastrointestinal tract, biliary, urinary and vascular systems. At the same time, no-spa does not have serious cardiovascular side effects (that is, it does not inhibit the contractility of the heart muscle), does not affect the autonomic nervous system, which innervates internal organs and blood vessels, does not penetrate the central nervous system.

When administered intravenously, the effect of no-shpa appears after 2-4 minutes, and the maximum effect develops after 30 minutes.

No-spa is used for the prevention and treatment of functional conditions and pain caused by spasm of smooth muscles and is available in the form of tablets for oral administration in dosages of 40 mg and 80 mg (no-spa forte) and as an injection solution in ampoules.

Indications and contraindications for prescribing no-shpa

No-spa is used for the prevention and treatment of functional disorders and pain caused by smooth muscle spasm:

So, the difference between No-shpa and Spazmalgon: the composition of No-shpa is the same, known to many since Soviet times, drotaverine; Spazmalgon contains Metamizole sodium.

Therefore, no-spa is a strong antispasmodic, and spasmalgon, in addition to relieving spasms, also relieves pain.

If no-spa is an antispasmodic, then Spazmalgon is an antispasmodic, i.e. When taking Spazmalgon, the effect comes from the action of three drugs:

Spazmalgon is available in tablets and ampoules for intravenous and intramuscular administration of the drug.

That is, taking into account the mechanism of action of these drugs, there are some preferences when prescribing them, so to speak, “playing around” the mechanism of their action.

Noshpa is preferable for pain in the intestines, attacks of cholelithiasis (kidney stones), chronic gastritis, cholecystitis, pancreatitis.

Spasmalgon is better where, in addition to the antispasmodic effect, an analgesic (pain reliever) is also necessary: ​​the condition after surgery, an attack of renal colic with urolithiasis (urolithiasis), limb injuries, attacks of migraines and other headaches.

Spazgan

Brief characteristics of the drug

Spazgan is a combined drug, belongs to the group of analgesic and antispasmodic drugs, has an analgesic, analgesic, antipyretic effect on the human body. Due to its balanced composition, spazgan effectively relaxes the muscles of internal organs, relieves pain, and reduces elevated body temperature.

Release form and composition of the drug

Spazgan is available in tablets and as a solution for intravenous injection.

1 tablet of the drug contains 500 mg of metamizole sodium, 5 mg of pitofenone hydrochloride and 100 mcg of fenpiverinium bromide.

1 ampoule of solution contains 1 g of metamizole sodium, 400 mcg of pitofenone hydrochloride and 4 mcg of fenpiverinium bromide.

Spazgan - indications and contraindications

The drug is recommended for use for mild or moderate pain syndromes, spasms of smooth muscles and intestines, dysmenorrhea, renal and gastric colic. In some cases, spasgan is used to relieve short-term symptomatic pain syndrome, myalgia, neuralgia, and sciatica. The drug can also be used as an auxiliary drug to reduce pain after diagnostic or surgical intervention.

You should not use spazgan if you have hypersensitivity to pyrazolone derivatives or other components of the drug, as well as with pronounced impairment of kidney and liver function.

During the first semester of pregnancy and lactation, spazgan is prescribed only in cases where the expected therapeutic effect exceeds the risk of defects in the fetus.

Spazgan - application and dosage

The minimum and maximum doses of the drug depend on the age of the patient.

For children from 6 months to 1 year, spazgan is administered only intramuscularly with no more than 0.1 ml at each dose. The maximum daily dose should not exceed 1.2 ml.

Children from 1 year to 5 years are prescribed from 0.4 to 3.2 ml of the drug, depending on the child’s body weight and the severity of pain.

Children from 5 to 14 years old are prescribed 1 ml of the drug 4 times a day.

Children over 14 years of age and adults are prescribed 1-2 tablets 4 times a day (3 times before meals and before bedtime). The tablets should not be chewed or taken with large amounts of liquid.

Attention: The presented material does not constitute a recommendation for the use of drugs. Before using any of the medications described on the site, be sure to consult your doctor!

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Spazgan

Description current as of 08/16/2016

• Latin name: Spasgan
• ATX code: A03DA02
• Active substance: Metamizole sodium + Pitofenone + Fenpiverinium bromide (Metamizole sodium + Pitofenone + Fenpiverinium bromide)
• Manufacturer: Wockhardt Limited (India)

Compound

1 tablet contains: 500 mg metamizole sodium, 5 mg pitofenone hydrochloride, 0.1 mg fenpiverinium bromide.

Release form

• Spazgan tablets are packed
• in blister packs. One pack contains 2 or 10 packages of 10 tablets.
• Spazgan in the form of a solution for intravenous (IV) and intramuscular (IM) administration is sold in ampoules of 5 ml, packed in blister packs of 5 ampoules.

pharmachologic effect

Analgesic, analgesic, antipyretic, antispasmodic.

Pharmacodynamics and pharmacokinetics

Many people use a combined analgesic and antispasmodic drug - Spazgan, what helps and what the mechanism of action is has been thoroughly studied. It has been established that the active components provide analgesic, antipyretic and mild anti-inflammatory effects.

Thus, metamizole sodium is a non-narcotic analgesic, pitofenone hydrochloride is a myotropic antispasmodic that has a direct effect on the smooth muscles of internal organs, and fenpiverinium bromide is an anticholinergic blocker that complements the relaxing effect. It is in this combination that mutual reinforcement occurs pharmacological effects, which help reduce elevated body temperature and relieve pain by relaxing smooth muscles.

Pharmacokinetics of metamizole

Resorption is rapid and complete; after 30 minutes, an amount of 5% of the maximum serum concentration is in the bloodstream. Partial binding to plasma proteins occurs in the bloodstream. In general, the substance in human body undergoes intensive biotransformation, resulting in the formation of active metabolites. Only 3% that is excreted is unchanged metamizole. It has been established that individual components can be excreted in breast milk.

Indications for use of Spazgan

• reduction of pain after surgical or diagnostic interventions;
• reduction of increased body temperature in patients with colds or infectious and inflammatory diseases.

Indications for the use of Spazgan for mild or moderate pain syndrome are:

Attention!

Do not use the drug to relieve abdominal pain until the cause of its occurrence is determined.

Contraindications

Metamizole sodium, pitofenone hydrochloride, fenpiverinium bromide are included in Spazgan tablets. What are they contraindicated for:

• with hypersensitivity to pyrazolone derivatives (including Butadione, Tribuzon), and other components of the drug;
• with severe functional disorders of the kidneys or liver;
• with tachyarrhythmia;
• in the absence of glucose-6-phosphate dehydrogenase;
• with angle-closure glaucoma;
• with prostatic hypertrophy leading to urinary retention;
• with gastrointestinal obstruction;
• with megacolon;
• in the presence of various diseases blood systems;
• patients in a collapsed state;
• pregnant women in the first trimester and the last 6 weeks;
• nursing mothers;
• children under 5 years old.

Side effects

• allergic reactions, manifested in the form of skin rash, itching, and in rare cases, anaphylactic shock develops;
• tachycardia, dizziness, decreased blood pressure, cyanosis;
• Isolated cases of epigastric burning, dry mouth and headache have been reported;
• with prolonged use, the anticholinergic effect can lead to fainting and impaired accommodation;
• long-term therapy can lead to disorders of the blood system, for example, thrombocytopenia, leukopenia, agranulocytosis;
• Patients prone to bronchospasm must beware of the risk of provoking an attack.

Instructions for use of Spazgan (Method and dosage)

The maximum daily dose is 6 tablets.

Duration of therapy is up to 5 days, otherwise monitoring of peripheral blood parameters and assessment of the functional state of the liver is required.

Spazgan tablets, instructions for use in children

Use is possible only as prescribed by a doctor. The dosage differs depending on the age of the child:

• from 6 to 8 years - no more than 0.5 tablets;
• 9–12 - you can give 3/4 tablets;
• adolescents 13–15 years old are prescribed 1 tablet. up to 3 times during the day.

With intravenous or intramuscular administration of Spazgan solution

• patients with acute severe colic: 5 ml is administered slowly intravenously over 5-8 minutes, if necessary, repeated administration is allowed after 6-8 hours;
• standard single dose – no more than 2 ml;
• the maximum permissible daily dose is no more than 10 ml.

Overdose

Accompanied by the following symptoms: vomiting, convulsions, dry mouth, changes in sweating, impaired accommodation, decreased blood pressure, drowsiness, confusion, functional disorders liver and kidneys.

Treatment measures

• symptomatic therapy is prescribed;
• perform gastric lavage;
• Activated carbon is used.

Interaction

• combination with other non-narcotic analgesics causes mutual enhancement of toxic effects;
• with tricyclic antidepressants, oral contraception, Allopurinol disrupts liver metabolism and increases the toxicity of metamizole;
• with barbiturates, phenylbutazone and other inducers of hepatic microsomal enzymes, the effect of metamizole is weakened;
• with Cyclosporine - the level of the latter in the bloodstream decreases;
• with sedatives and tranquilizers, the analgesic effect of Spazgan is potentiated.

Terms of sale

To purchase Spazgan solution or tablets, you must contact a qualified physician for a prescription.

Storage conditions

• dryness;
• darkness;
• temperature up to + 25 °C.

Space out of reach of children.

Best before date

The drug can be stored for 3 years.

special instructions

Metamizole metabolites may change the urine color to red in some patients. The reaction has no clinical significance.

With alcohol

Spazgan can affect the psychophysical state of the patient, as well as in combination with other drugs that depress the central nervous system.

Spazgan during pregnancy and lactation

The drug is contraindicated during lactation and pregnancy in the first trimester and the last 6 weeks.

Analogs

Spazgan substitutes that match all 3 active ingredients:

Differences between Spazgan and Spazmalgon

Most often, patients using modern antispasmodics ask the question: which is better Spazgan or Spazmalgon?

Spazmalgon is a structural analogue of Spazgan, produced in Bulgaria, which is slightly cheaper in price. Due to the same active ingredients and their quantity in 1 tablet, the instructions for use, indications, and contraindications for these drugs are the same. However, on the forums you can find different comments in favor of one or another analogue. But this is more of a personal individual reaction of the body rather than a pattern.

The main difference between Spazgan and Spazmalgon is the price and manufacturer.

Reviews

Positive comments and reviews about Spazgan indicate its effectiveness and popularity. Many praise the drug for the fact that it relieves pain quickly and completely, and also has an antipyretic effect. It is believed that Spazgan is much better than simple analgesics and antispasmodics, which act less comprehensively or do not help some patients at all.

Spazgan price, where to buy

The average cost of Spazgan solution (5 ampoules of 5 ml each) is rubles, while the price of Spazgan in tablets differs depending on the number of tablets in the package:

• a package of tablets No. 20 costs approximately 130 rubles;
• a package of tablets No. 100 - approximately 410 rubles.

Spazgan: indications for use and specifics of prescribing the drug

The name of the drug Spazgan speaks for itself. Its action is aimed at relieving pain that occurs due to spasm. The drug has a pronounced effect, so Spazgan is classified as a potent drug. Take it with caution, as directed and under the supervision of your doctor, since the drug can cause side effects. Spazgan has a number of contraindications, and an overdose is dangerous, since the components included in the composition have a certain toxicity threshold. There is no antidote.

Indications

Spazgan for injection

Spasms can occur even in practically healthy person. It depends on the characteristics of the body, or its predisposition to a particular type of disease. The etiology of spasm is the involuntary contraction of muscle tissue of internal organs. Spasm always occurs accompanied by severe pain. Renal, intestinal, or gastric colic are antispasmodic phenomena of internal organs.

Acute pain accompanies inflammatory processes, both for gallstones and urolithiasis. The pain is long lasting. To avoid painful shock, the patient needs to take a fast-acting painkiller. Such a remedy is Spazgan. Indications for use of the drug are any acute manifestation of pain with the exception of appendicitis.

The product is endowed with medicinal qualities. It not only situationally combats acute attacks of spasms, but also prevents their further occurrence, fighting the root cause of their manifestation. Spazgan is prescribed in a course of tablets or in the form of injections for 3 to 5 days. After receiving a course of Spazgan, almost all patients noted an improvement in their well-being and the absence of recurrent pain.

Pharmacology

Spasgan (Spazgan), medicinal product non-narcotic, having analgesic, antipyretic and anti-inflammatory properties. A group of non-steroidal drugs aimed against inflammatory processes and rheumatic pain. A medicinal product with a combined composition of the Analgesic-Antipyretic group.

Pharmacodynamics

The drug Spazgan contains:

• Metamizole sodium is a non-narcotic analgesic, a derivative of pyrazolone. It is responsible for relieving pain, reducing temperature, as well as mild anti-inflammatory properties.
• Pitofena hydrochloride is a myotropic antispasmodic agent. Relaxes the smooth muscles of muscle tissue through direct action. The action extends to all internal organs
• Phenpiverinium bromide is the main choline blocker. An accompanying quality is a weak relaxing effect on muscle tissue.

These three substances, when combined, enhance pharmacological properties each component and contribute to the rapid relief of pain, relaxation of smooth muscles, active reduction high temperature bodies.

The main effect of the drug

Spazgan: tablet form

Spazgan has a strong antispasmodic effect with an analgesic effect and prolongation for a long period of time. This is facilitated by the suppression effect of prostaglandin H-synthetase caused by pyrazolone. Thanks to its effect, the new formation of prostaglandins is difficult.

Sensitivity to barricadin, which is responsible for stimulating pain sensations by nerve endings, is significantly reduced. As a result, the pain syndrome is relieved, and therefore the spasm is extinguished. Also, metamizole in moderate quantities relieves the reaction to inflammation. The release of prostaglandins into the center regulating the general temperature is inhibited, against the background of which heat transfer increases with the complete elimination of the symptom of fever. Body temperatures remain normal. Pitofenon has a relaxing effect on the smooth muscles of internal organs, resulting in an analgesic effect that relieves spasms.

Phenpiverinium bromide, which represents a group of M-anticholinergics, exhibits blocking properties nerve endings in the parasympathetic fiber. This effect is associated with a decrease in the overall tone of the smooth muscles of the gastrointestinal tract, gallbladder and urinary ducts. In addition, the action of fenpiverinium bromide is aimed at reducing intestinal motility, which is an additional analgesic effect.

Combined action of the drug. Each of the components enhances the pharmacological effects of each other with synergy dosage forms. When taken orally, the effect of Spazgan occurs within minutes, reaching an effective maximum after two hours.

The main elimination of the drug from the body is through urine, minor elimination is through bile.

Release form

Spazgan is produced in two modifications. In tablets packed in a blister in an amount of 10 pcs. A standard cardboard package contains 2 blisters. Composition of one Spazgan tablet:

1. metamizole sodiummg
2. pitofenone hydrochloride - 5 mg
3. fenpiverinium bromide mkg.

Injection solution for intravenous administration. Ampoule volume 5 ml. Cellular packaging contains 5 ampoules. Five packs are included in cardboard box. Composition of one ampoule of solution for injection:

1. metamizole sodium – 1 g
2. pitofenone hydrochloride – 400 mcg
3. fenpiverinium bromide – 4 mcg.

Analogs produced in other countries:

Indications and contraindications

Analogue of Spazgan - Spazmalgon

Spazgan is prescribed symptomatically - in cases of sudden onset of pain, as well as in general therapy in order to prevent the occurrence of spasms. For stomach, intestinal and kidney colic of mild to moderate nature. For spasms of intestinal smooth muscles, painful periods and in cases of functional or organic dysmenorrhea. Spazgan is prescribed symptomatically in cases of short-term manifestations of pain symptoms due to sciatica, neuralgia, myalgia, bursitis and arthritis.

As an adjuvant, Spazgan is prescribed to patients after surgery, as well as for certain types of diagnostics to relieve pain and for biliary dyskinesia. As the main therapy for spastic conditions of internal organs, with hyperthermia, manifestations severe forms migraine.

Contraindications exist for patients with impaired liver function and those suffering from renal failure.

• angle-closure glaucoma
• intolerance to the components of the drug or one of them
• hereditary disorders of glucose-6-phosphate dehydrogenase activity
• functional disorders of the liver and kidneys
• liver porphyria
• megacolon and intestinal obstruction
• peptic ulcers
• inability to clot and blood diseases
• adenoma and benign prostatic hyperplasia
• lactation and pregnancy.

Special recommendations apply to a group of patients prone to hypotension. The drug is not recommended for patients with a reaction to analgesics, as well as for those suffering from bronchial asthma. In the first trimester of pregnancy and when breastfeeding, the drug is prescribed with extreme caution.

Dosage of the drug

When making appointments, the table of patient age groups is taken into account:

1. For young patients up to one year old, if necessary, Spazgan is administered exclusively intramuscularly at a daily dose not exceeding 1.2 ml.
2. Age category from 12 months to 5 years. The dosage of Spazgan depends on the body weight, age of the patient and the degree of pain symptom. Daily dosage- from 0.4 to 3.2 ml.
3. Age category years. For this age category, the dosage of the drug is no more than 1 ml per injection. The number of injections per day is recommended by the attending physician, but not more than four times a day.
4. The age group from 14 years old belongs to the adult category. Patients in this group are prescribed a tablet method of treatment. The patient takes 1-2 tablets depending on body weight four times a day. Of these: in breakfast, lunch and dinner before meals and one dose before bedtime.

The tablets are not chewable, have a bitter taste with a pronounced taste of analgin and are washed down with plenty of still drinking water.

Interaction with other drugs

Spazgan: release form solution in ampoules

When combined with other non-narcotic drugs of the analgesic group, the toxic properties of any of the components of the drug may appear. The risk of a negative effect increases many times over, since each of the components of the drug is in active pharmacological form, and has a certain reaction with the release of toxins when interacting with other components of analgin-like drugs.

The simultaneous use of Spazgan with contraceptives or tricyclic antidepressants containing allopurinol or codeine can lead to disruption of the metabolism of metamizole in the liver with an increase in its toxicity. Phenylbutazone and barbiturates can weaken the effect of metamizole, increasing its toxicity, and cause adverse reactions. Derivatives of phenylbutazone and barbituric acid inhibit the effect of Spazgan as an antispasmodic agent. When Spazgan interacts with cyclosporines, their bioavailability for the body is blocked with a subsequent decrease in its level in the blood plasma.

When interacting with sedatives or tranquilizers, the effect of Spazgan as an anesthetic is significantly enhanced. Simultaneous use of H1-blockers with histamine, amantadine, tricyclic antidepressants or quinidine, the M-choline blocking properties of Spazgan are significantly enhanced. When interacting with alcohol, the effect is mutually enhanced. Antibiotics of the penicillin group are not used when consuming Spazgan.

Spazgan injections are made without mixing with other agents, since the drug is not compatible with any of them.

Drug overdose

In case of overdose, intoxication with a pronounced allergic reaction is quite often observed. Intoxication is caused by metamizole, and fenpiverinium bromide causes anticholinergic manifestations in the form of allergic manifestations. Vascular shock may occur. A more rare occurrence of drug overdose may be signs of agranulocytosis. Damage to the cerebral cortex and irreversible gastrointestinal disorders occur extremely rarely. Symptoms of an overdose of Spazgan: confusion, anxiety, sharp pain in the abdomen, vomiting, low blood pressure that cannot be corrected, convulsions, impaired renal function, anaphylactic shock.

There is no antidote. Treatment by flushing the body with hemodialysis using forced diuresis, taking sorbents.

Side effects

Under normal conditions, Spazgan is fairly well tolerated. The reaction to the drug is purely individual:

• A reaction in the form of a rash may occur on the body.
• Dry mouth is often observed.
• A common reaction from taking the drug is headache and a burning sensation in the epigastric region.
• Some patients experience dizziness, periodic tachycardia with a decrease in blood pressure.
• Taking the drug over a long period of time can lead to disorders of the circulatory system.
• With concomitant asthmatic disease, coughing attacks can be provoked.
• From the gastrointestinal tract. Constipation. In rare cases, changes in the mucous membranes may be observed.
• From the urinary system. Nephritis, redness of urine, anuria.
• From the side of the central nervous system. Accommodation disturbance, dizziness.
• Individual manifestations. Urticaria may occur, skin rashes, blockage of sweat glands.

In conclusion, it should be noted that the drug Spazgan does not tolerate self-prescription. It must be recommended by the attending physician and the drug should be taken under his supervision. The drug is prescribed with caution to patients with renal or hepatic insufficiency, bronchial asthma, a tendency to hypotension, hypersensitivity to any of the components of the drug, as well as to any non-narcotic analgesics. When taking the drug for more than seven days, it is necessary to take a peripheral blood test, which gives a complete picture of the functioning of the liver.

In the video, the pharmacist talks about the drug Spazgan, the active ingredients included in its composition, method of use, side effects and contraindications:

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What pills to take for headaches: spasmalgon, no-shpa, paracetamol

Tablets for headaches can be divided into drugs that are used by people when cephalalgia appears and those recommended by doctors. It’s interesting, but this is exactly the situation now.

Most people with migraines use medications that help them in most cases: spasmalgon, citramon, paracetamol, aspirin, analgin. Doctors prescribe other tablets that affect the etiological and pathogenetic components of the cephalgic syndrome.

What types are beneficial?

Tablets for headaches can be divided into 3 categories (according to the active ingredient):

1. Painkillers;
2. Anti-inflammatory drugs;
3. Antiplatelet agents (prevent the formation of blood clots inside blood vessels).

The group of painkillers includes amidopyrine and analgin. The mechanism of action of these drugs is to eliminate the pain center of the brain due to disruption of nerve transmission.

These medications have side effects. Analgin is prohibited for use in many European countries and the USA due to the presence of agranulocytosis. These drugs should not be used if the number of leukocytes is low or if you have diseases of the cardiovascular system. Amidopyrine and analgin are contraindicated for people with bronchial asthma. They should not be prescribed to pregnant women and children under 8 years of age.

Aspirin (acetylsalicylic acid) is one of the most popular migraine medications. The medicine helps relieve cephalalgia by improving blood supply to the cerebral vessels, but the main effect of this remedy is anti-inflammatory. The use of aspirin is rational in the presence of inflammatory changes in ligaments, muscles, and meninges.

The mechanism of action of acetylsalicylic acid is to suppress swelling, which tablets can relieve headaches, but only against the background of mild cephalgia.

You should not take aspirin in cases of gastric ulcer, bronchial asthma, or a tendency to allergies.

The safest remedy of all types used by the population for cephalgic syndrome is paracetamol. The effectiveness of the medicine is inferior to the drugs described above. It should not be used for liver or kidney diseases.

The best medicine for migraines

Looking for best medicine A number of common medications should be highlighted:

These tablets are included in the list of common folk remedies that can be used against headaches.

The popularity and effectiveness of citramon is due to its complex composition. Active ingredients of the medicine:

Additional Ingredients – lemon acid, sugar, cocoa.

Due to the presence of several ingredients, these tablets cope well with cephalgic syndrome. They have anti-inflammatory and analgesic effects. To relieve pain, take 2 tablets 3 times daily.

Tempalgin is a synthetic medicine based on gampidone and analgin. It is used for neuritis, muscle spasms, toothache, intestinal and renal colic. The spasmodic and analgesic effect of the drug allows you to eliminate cephalgia of vascular origin.

Solpadeine is a complex tablet containing codeine, caffeine, and paracetamol. To treat cephalgic syndrome, you need to take 1 tablet 4 times daily.

Pentalgin has the following composition:

To treat migraines, you need to take it 2 times a day, one tablet.

Doctors do not recommend using these medications until the cause of cephalgia is determined. In case of vascular origin of pain syndrome, it is enough to eliminate the spasm or improve the blood supply to the cerebral vessels, which will lead to the elimination of the pain syndrome.

Anti-inflammatory and antispasmodic drugs do not help with tumors and hematomas of the skull. These formations can compress brain tissue and form cephalgic syndrome.

Spasmalgon for headaches: the secret of effectiveness

Spasmalgon helps due to the combined therapeutic effect of the drug. The tablets have an anti-inflammatory, antipyretic, analgesic effect (due to the content of metamizole), antispasmodic effect (due to pitofenone). The complex composition of the drug also contains piverinium bromide, which reduces the conductivity of nerve impulses when taking 2-3 tablets per day.

Due to its numerous medicinal effects, the drug is widespread not only among the people, but also among doctors. Even pharmaceutical companies actively duplicate it and produce it under different international names:

1. Baralgetas (Serbia);
2. Spazgan (Indonesia);
3. Revalgin (India);
4. Masigan (India);
5. Bral (India).

Spasmalgon for cephalgia: indications and contraindications

Spasmalgon is prescribed in the following cases:

• Moderate pain syndrome due to spasmodic contractions of the muscles of the organs;
• Renal colic, abdominal pain;
• Joint soreness;
• After surgical interventions;
• To reduce fever (infection)

Spasmalgon is used for headaches in children, adults over 15 years old, 2 tablets three times a day; more than 6 tablets cannot be used per day. The duration of treatment is no more than 5 days. It is forbidden to increase the dosage of the drug on your own, as the medicine has side effects.

Spazmalgon against head pain in children is prescribed ½ tablet (for children under 8 years old), ¾ tablet (10–12 years old). Side effects of the medicine:

1. Burning in the epigastrium;
2. Tachycardia, decreased blood pressure;
3. Proteinuria, anuria, impaired renal function;
4. Agranulocytosis, leukopenia, thrombocytopenia;
5. Allergic reactions (Quincke's edema, anaphylactic shock, bronchospasm).

Contraindications to taking spasmalgon:

• Bone marrow suppression;
• Unstable angina;
• Impaired kidney and liver function;
• Tachyarrhythmias;
• Chronic heart failure;
• Glaucoma;
• Glucose-6-phosphatase deficiency;
• Lactation;
• Intestinal obstruction;
• Prostate hyperplasia;
• Pregnancy;
• Childhood.

Spasmalgon is not recommended during lactation, as well as while driving; alcohol should not be used.

Paracetamol

Paracetamol against headaches began to be used in the 19th century, when it was developed under the name Antifebrin. The first analogue of the drug was highly toxic, so it was processed only in the second half of the 20th century. It was sold under the name Panadol.

There are many effective tablets for cephalalgia, but paracetamol is a must-have in your medicine cabinet, as the medicine helps against many types of pain: dental, muscle, ligamentous, viral, bacterial infections.

After oral administration, the tablets dissolve in the stomach after half an hour. After this time interval, the active ingredients enter the blood and brain. In case of cephalgic syndrome, long-term use of paracetamol causes an addictive effect, so you need to take the medicine according to a certain algorithm:

1. With strong painful sensations in the head you can’t take paracetamol and spasmalgon on an empty stomach;
2. Take the tablets with water green tea, coffee, juice;
3. Caffeine can negatively affect the liver;
4. For cephalgia, the dose of the drug is from 500 to 1000 mg per day;
5. You cannot use these tablets for more than 3 days;
6. Paracetamol is contraindicated for nursing mothers and pregnant women;
7. For hepatitis, bronchospasm, and allergies, taking medication should be discussed with your doctor.

Paracetamol for migraines should be used in combination with analgesics. This combination for children should be prescribed only according to strict indications. There are more effective tablets to prevent migraine attacks. Acetylsalicylic acid It only helps with mild headaches. Severe attacks should be treated with caffeine, phenacetin, ibuprofen, or naproxen.

For children, it is rational to administer ergotamine orally. At the very beginning of the disease, you need to take the medicine several times a day, but not more than a week.

No-spa for cephalgic syndrome

No-spa is rarely used for headaches, since the drug is more aimed at eliminating spasmodic contractions of the smooth muscles of the gastrointestinal tract. Clinical studies have proven that drotaverine (no-spa) is good for tension-type pain syndrome (tension headache). This cephalalgia occurs due to psychological or physical overload, muscle tension cervical spine spine. Tension syndrome is accompanied by the following additional syndromes:

• Shingles painful sensations On the one side;
• Increased pressure in the temples (the “hoop” symptom);
• Throbbing, uniform pain.

While taking no-shpa, the severity of tension pain decreases, the risk of their transition to chronic condition. Drotaverine (no-spa) does not always bring relief, since against the background of spasm of the occipital and neck muscles persistent compression of the nerve fibers occurs.

Dosage of drotaverine release:

1. Tablets 40 mg;
2. Tablets 80 mg;
3. Intramuscular injections.

The tablets have yellow, convex shape and the signature “spa” inscription.

For vascular headaches, the symptoms begin to disappear after 12 minutes, and intravenous administration of no-shpa eliminates cephalalgia after 6-8 minutes.

Contraindications to taking no-shpa (drotaverine);

• Heart diseases;
• Kidney and liver diseases;
• Age up to 6 years;
• Lactation, pregnancy.

Drotaverine is characterized by antispasmodic and vasodilating effects, which leads to the elimination of spastic conditions.

Main indications for taking no-shpa:

1. Spasmodic constipation;
2. Spasms of the gastrointestinal tract;
3. Attack of urolithiasis and cholelithiasis;
4. Ulcer of the duodenum, stomach;
5. Constriction of peripheral vessels;
6. Angina;
7. Renal and hepatic colic.

Drotaverine (no-spa) is not an essential medicine for migraines, since there are more effective medicines(including spasmalgon, paracetamol, citramon). Only with tension pain can you use no-shpa to eliminate cephalgic syndrome.

There is experimental information confirming the effectiveness vasodilators during a migraine attack. It is somewhat erroneous, since antispasmodics cannot be used for a long time. They become addictive, limiting the duration of use of the medicine.

The second point for using no-shpa is tension pain. They occur against a background of depression or nervous experiences. Increased fatigue, nervous experiences and stress lead to compression of the brain. Such symptoms often develop in people engaged in active physical or mental labor.

However, the medicine has few side effects, so it can be used as a muscle relaxant to eliminate the pathological symptoms of cephalgic syndrome in the back of the head, temples, and forehead.

The therapeutic effect of taking no-shpa occurs quickly, so there is no doubt about the effectiveness of the drug. It takes minutes to achieve the maximum concentration of drotaverine in the blood. If the medicine is administered intravenously, a positive therapeutic effect will occur within 3 minutes.

The drug has few contraindications, so it is often used against headaches, but is prohibited for kidney, liver and heart diseases. It is difficult for pregnant women to do without drotaverine, since there is no alternative to it.

Spazgan: instructions for use, price, reviews, analogues

An anesthetic drug based on three active ingredients. Thanks to complex impact Spazgan has a quick and strong effect on pain and the mechanism of its occurrence. The drug is inexpensive and available without a prescription, but the doses indicated in the instructions should not be exceeded, as an overdose can cause dangerous symptoms.

Dosage form

Spazgan is available in two forms: tablets for oral administration and solution for injection. Tablets are round, white. Packaged in blister packs of 10 pieces. The cardboard package contains 2 blisters.

The solution for injection is available in ampoules of 5 ml. The package contains 5 or 10 ampoules. Injection ampoules are more often used in hospital settings or in acute conditions, when tablets do not bring the expected and quick effect.

Description and composition

Spazgan is a drug from the group of antispasmodics with an analgesic effect. Refers to combination drugs. It contains metamizole sodium, fenpiverinium bromide, pitofenone hydrochloride, and also excipients. Taking the drug allows not only to relieve pain, but also to have an antipyretic effect. When taken correctly, the active ingredients act in the area of ​​pain and relieve spasms of smooth muscles. The drug can be used in various areas of medicine for pain syndrome. Spazgan can be classified as a drug wide range actions. Its use will help you cope with headaches, intestinal and kidney colic, and the drug is also effective for symptoms of flu and colds, which are accompanied by muscle pain and fever.

1 tablet contains:

• metamizole sodium – 500 mg;
• pitofenone hydrochloride – 5 mg;
• fenpiverinium bromide – 0.1 mg.

1 ml of solution for injection contains:

• metamizole sodium (analgin) – 500 mg;
• pitofenone hydrochloride – 2 mg;
• fenpiverinium bromide – 0.02 mg;
• water for injections.

Pharmacological group

Spazgan – combined drug, which contains three active components, each of which has specific action on the cause and symptoms of pain.

• Metamizole is a non-narcotic analgesic that relaxes smooth muscles, inhibits the synthesis of prostaglandins, blocks acetylcholine m receptors, and reduces fever and inflammation.
• Pitophenone hydrochloride is a myotropic antispasmodic that has a direct effect on muscle tissue, relieves spasms and pain.
• Fenpiverinium bromide is an anticholinergic blocker with an analgesic and relaxing effect, which accelerates the therapeutic effect of the drug.

In combination, the components of the drug anesthetize inflammation, relieve spasms and irritation of nerve endings.

After taking the drug, its active components quickly penetrate the gastrointestinal tract, after which they penetrate the bloodstream. The effect after taking the drug is observed after 10 - 12 minutes and lasts for 3 - 4 hours. The drug is metabolized in the liver and excreted in urine, bile, and feces.

Indications for use

The medicine Spazgan is intended for the relief of pain of mild to moderate severity. The drug can be prescribed for various conditions and diseases in combination with other drugs of systemic and symptomatic action.

for adults

The main indication for use of the drug is:

• renal colic;
• intestinal spasms;
• migraine;
• myalgia;
• neuralgia;
• joint pain of unknown etiology;
• dysmenorrhea.

Indications for prescribing the drug may include other pain syndromes affecting soft fabrics internal organs and systems. Yours wide application The drug was found for pain in women during menstruation; this remedy is also often used for cramping pain in the stomach or migraines. If the nature of the pain syndrome is unknown, it is better to avoid taking Spazgan tablets or injections. Taking them can make it difficult to determine the cause when visiting a doctor.

for children

Spazgan can be used for children from 5 years old. Indications for its use may be elevated body temperature, inflammatory processes, febrile seizures, muscle pain. Despite the possibility of using the drug in pediatrics, many doctors recommend refraining from taking it, citing the risks of side effects. Spazgan for children is often replaced with drugs such as Ibuprofen or Paracetamol.

During pregnancy and breastfeeding, it is not recommended to use Spazgan in tablets or injections. An exception to the use of this drug may be conditions in which taking the medication will not harm the fetus or the course of pregnancy.

Contraindications

Spazgan recommends that you read the instructions for use of the drug before using the drug. possible contraindications, among which:

• severe kidney disease;
• obstruction of the intestines and stomach;
• liver dysfunction;
• children under 5 years old.

Applications and dosages

for adults

The injection solution can be used for intramuscular or intravenous administration. The dose of the drug is calculated individually, but should not exceed 5 ml per 1 administration. The frequency of injections is 1 – 2 per day.

for children

For children, the medicine can be used from the age of 5. The recommended dose of the drug is 0.5 tablets 2 times a day. Children over 8 years old can be given 1 tablet of the drug no more than 2 times a day. The duration of taking the drug is 2 – 5 days.

for pregnant women and during lactation

Tablets or injection solution are not used during pregnancy and lactation. Its use increases the risk of early pregnancy loss and premature birth in the late trimester. During lactation, the drug can be used only if the baby is switched to artificial formulas during the period of taking the drug.

Side effects

The drug Spazgan is well tolerated, but in some cases, after taking the drug, adverse reactions of the body may appear, including:

• heart rhythm disturbance;
• nausea, urge to vomit;
• bluish skin;
• headache, dizziness;
• signs of dyspepsia;
• skin reactions.

The appearance of the above symptoms should be a reason to discontinue the drug or reduce the dose. In any case, you need to consult a doctor who can select another medicine with a similar mechanism of action.

Interaction with other drugs

Spazgan is not compatible with others similar drugs with the same therapeutic effect. While taking the medication, it is important to adhere to the recommended doses. The effect of the drug can be enhanced by drugs containing ethanol, and such drugs can also increase the risk of side effects. Sedative drugs enhance the analgesic properties of metamizole sodium. If you are prescribing Spazgan or taking other medications, you should inform your doctor.

special instructions

1. The antispasmodic Spazgan is incompatible with alcohol.
2. During the intake process, you must strictly adhere to the dose and duration of use.
3. When taking the medicine for more than 1 week, you need to take a blood test and monitor the functioning of your kidneys and liver.
4. It is prohibited to relieve pain with a drug of unknown etiology.
5. Persons with bronchial asthma should take the drug with caution.
6. While taking the drug, the urine may turn red.

Overdose

Symptoms of a drug overdose may occur when the recommended dose is exceeded or the medication is taken for a long time. Characteristic features The following symptoms are considered contraindications:

• nausea, vomiting;
• sharp abdominal pain;
• convulsions;
• bowel dysfunction;
• fainting state.

The appearance of such symptoms requires taking a sorbent and gastric lavage. If the patient's condition is serious, an ambulance should be called.

Storage conditions

You can buy the medicine in pharmacies without a doctor's prescription. The drug should be stored out of the reach of children at a temperature not exceeding 25 degrees.

Analogs

Among analogues of Spazgan, one can distinguish drugs based on composition (structural) and drugs based on therapeutic action, that is, those that have a different composition, but are also used to relieve pain:

• Baralgetas is a non-narcotic analgesic and myotropic antispasmodic. Used to relieve pain of mild to moderate intensity.
• Metamizole is a pyrazolone derivative with analgesic, antipyretic and anti-inflammatory effects.
• Maxigan is a combined anesthetic that helps relieve muscle spasms.
• Spazmalgon is an antispasmodic analgesic for pain relief, has affordable price, is often used in practice.

The use of any analogue must be agreed with a doctor.

The cost of Spazgan is on average 171 rubles. Prices range from 45 to 520 rubles.

Antispasmodics for headaches

Tablets for headaches and migraines relieve unpleasant symptoms. Remedies provide relief, but do not treat the cause. Be patient until you see a doctor severe pain is not possible, and then antispasmodics come to the rescue. When using them, it is important to observe the dosage and take into account the characteristics of a particular drug.

Vasodilator tablets

Poor blood circulation in the brain is a common cause of headaches. The blood vessels narrow and a spasm occurs. When such pain occurs sporadically, pain medications may be effective. If the cause of the malaise is correctly determined and physical suffering is caused by vasospasm, taking vasodilating antispasmodics for headaches will help.

Myotropic antispasmodics

For vascular spasm and increased blood pressure, myotropic antispasmodics are prescribed. Some of the drugs of this type are included in the list of safe ones during pregnancy, at different stages. They have different shapes release: in addition to tablets, you can administer headache medicine intramuscularly or in the form of suppositories (rectal suppositories). This group of drugs includes:

• No-shpa (Drotaverine);
• Dibazol;
• Papaverine;
• Dexalgin;
• Revalgin.

Drotaverine

Drotaverine helps the body's tissues fill with oxygen and helps cells absorb more calcium ions. These antispasmodics for headaches do not have a negative effect on the autonomic nervous system. The dosage of the medicine depends on the person’s age, condition and diagnosis. Maximum dose, which can be taken per day for an adult – 240 mg. Children 3-6 years old can drink up to 120 mg per day (no more than 20 mg at a time), children 6-12 years old can take 200 mg, 40 mg per dose in 24 hours.

Papaverine

The drug Papaverine relieves spasms by dilating blood vessels. Additionally, it acts as a sedative, helping to sleep during severe discomfort caused by pain. These antispasmodics are taken two or four times a day, 20 or 40 mg. Papaverine injections also relieve headaches. A 1-2% solution is injected, often mixed with dibazole, nicotinic acid, phenobarbital to enhance the calming effect. Another form of the drug - suppositories - is more often used to relieve spasms of the abdominal muscles.

Neurotropic antispasmodics

Neurotropic antispasmodic drugs affect the transmission of nerve impulses to the nerves that stimulate smooth muscles. The remedies dilate narrowed blood vessels very simply. Antispasmodics work like this: they block the impulse of the sympathetic nerves. Neurotropic vasodilators include:

Buscopan

This medicine is often taken to relieve pain symptoms in the abdominal cavity, for example, to relieve intestinal, renal, biliary colic. Suppositories are prescribed to pregnant women and do not have a negative effect on the fetus. In this case, headache is not the main indication for taking the drug, but is eliminated along with other, main symptoms. Buscopan tablets are taken specifically for headaches:

Natural antispasmodics

Headaches can be treated folk remedies, natural preparations. Herbal infusions work well:

• Take anise fruits, lingonberry leaves, coltsfoot - one tablespoon each, two tablespoons each of linden flowers, raspberries. Stir, pour a tablespoon of the resulting mixture with boiling water (a glass), and boil for 5 minutes. Strain and take hot before bed.
• Mix two tablespoons of hawthorn fruit, the same amount of motherwort, bearberry herb, and a tablespoon of valerian root. Prepare a decoction, drink 0.3 cups three times a day for migraines, an hour after meals.

Other natural antispasmodics:

Unconventional ways to get rid of headaches:

• Cut a large aloe leaf lengthwise, apply to your temples, forehead, and lie down for 20 minutes in a dark room.
• Lubricate your temples and forehead with garlic juice.
• Pour 10 cloves of garlic with milk (50 ml), put on low heat, cook for 5 minutes, cool, strain. Place 5-10 drops of the resulting mixture into the ear, after a minute tilt your head so that the broth pours back out, repeat on the other ear.
• Cut raw potatoes into slices, wrap in a thin layer of gauze, and apply the resulting bandage to your forehead.
• Brew strong green tea, add a pinch of mint, drink. The slight pain goes away after drinking this tea.

What pill to take for headaches

Drugs relieve pain and alleviate suffering, but if attacks are constant and frequent, a doctor should select antispasmodics for headaches. When migraines do not subside, return and become more severe, you should tell your doctor that the medication is not suitable. When positive effect no, you should find other pills. If the remedy does not work, it means that the cause of the headache is incorrectly determined.

It can be called:

• stress, depression;
• migraines (a chronic hereditary disease);
• inflammation, infectious processes;
• heart disease;
• tumors;
• strokes;
• osteochondrosis.

Galidor

At vascular diseases that cause headaches, the antispasmodic Halidor is used. It is prescribed in whole courses, and the duration depends on the disease. For diseases accompanied by a violation cerebral circulation, the course lasts 2-3 weeks, sometimes 2-3 months, the method of administration of the drug is intravenous injections. Using a dropper, the drug is administered to the body twice a day for an hour. If necessary, after the injection cycle the patient is prescribed the same medicine in tablets.

Spazgan

The instructions for the drug indicate three components that relieve pain, relax muscles tense due to spasm, and soften existing inflammatory processes. Spazgan is able to reduce elevated temperatures. It is used as a one-time drug to relieve excruciating pain. It can be used for a maximum of three days. If pain and fever do not go away during this time, other drugs are prescribed.

Spazgan should be taken on a full stomach. You can take no more than 6 antispasmodic tablets per day, but this is not a recommendation for action. Approximate regimens:

1. The usual dosage for patients over 15 years of age is 2-3 doses per day, 1-2 tablets;
2. a child under 12 years of age is advised to take half a tablet at a time, no more than two in total per day;
3. Teenagers are recommended to take one tablet 2-3 times a day.

No-shpa

This headache medicine is effective against unpleasant symptoms that occur during nervous soil, tension type. This name comes from the word tension, in English this is tension. The cause of such pain is neurology or psychological problems. Signs of tension pain:

• a feeling of pressure in the temples, as if a hoop was put on the head;
• the girdle pain on one side intensifies;
• uniform pain sensations gradually increase, there is no pulsation.

If stress is prolonged, or exhausting physical and psychological stress does not stop, that is, the source of the impact on well-being remains, then tension pains become chronic. No-shpa, taken at the first pain symptoms, works almost immediately, discomfort weakens after 10 minutes. Intravenous administration of an antispasmodic helps quickly; the drug will begin to relieve pain within a few minutes. The full effect occurs half an hour after application.

One of the main symptoms of gastrointestinal dysfunction is pain. It provokes pain in the intestines, usually a spasm. In addition, in gynecology, for pathologies of the urinary tract and other painful manifestations associated with smooth muscles, myotropic antispasmodics have been developed to relieve these conditions.

Which antispasmodic is better?

The drugs have side effects and contraindications

Drotaverine

It differs from papaverine in its longer and stronger effect. Used in case of contraindications to anticholinergic drugs. Reduces intestinal motility, muscle tone, dilates blood vessels. Does not penetrate the brain. Has high bioavailability. Contraindications: increased sensitivity, cardiogenic shock, hypotension, cardiac, renal and liver failure. Caution during pregnancy and lactation, glaucoma, atherosclerosis coronary arteries. Side effects: hypotension, headache, insomnia, tachycardia, constipation, nausea. Advantages - low price.

Produced under the names Drotaverine (45 rubles for 20 tablets), (more expensive - 132 rubles), Spasmol, Spazoverine

"Drotaverine" 50 tablets Russian production
"No-spa" 24 tablets

Papaverine hydrochloride

Reduces muscle tone of organs and blood vessels. Increases blood flow, including in the brain. In large doses, sedation, decreased cardiac excitability and conductivity. Used to relieve muscle spasms and as a premedication. Available in the form of tablets (price from 40 rubles), suppositories, solution for injection (10 rubles per ampoule).

Mebeverine

Reduces smooth muscle contraction and tone. Prescribed for. Side effects (less compared to drotaverine and papaverine): dizziness, allergies, nausea, diarrhea. Contraindicated during pregnancy. Refrain from activities requiring concentration during the treatment period.

Hyoscine butyl bromide

Disturbs the transmission of nerve impulses in smooth muscle cells. In addition to the main effect, it normalizes (reduces) the secretion of the digestive glands. Does not affect the central nervous system. Eliminates pain and discomfort in the abdomen. Contraindications: angle-closure glaucoma, pregnancy, pulmonary edema, myasthenia gravis, cerebral atherosclerosis. Be careful in the first trimester of pregnancy. The maximum concentration of the drug is after 2 hours. Small doses are required to achieve the effect. Does not have atropine-like effect. Minimal likelihood of side effects (less than with no-shpa): tachycardia, shortness of breath, urinary retention, dry skin, dry mouth.

Tradename– Buscopan: tablets (315 rubles) and rectal suppositories(377 rub.).

Spasmalgon

Combination drug, which contains: metamizole sodium (NSAID with analgesic, anti-inflammatory, antipyretic properties), pitofenone hydrochloride (similar in action to papaverine), fenpiverinium bromide (relaxes muscles, M-anticholinergic). Active substances strengthen each other. Contraindications: angina pectoris, CHF, pregnancy and lactation, up to 6 years, intestinal obstruction, high sensitivity. During the treatment period, monitor the leukocyte count and liver function, exclude alcohol, and drive vehicles. Release form: tablets (from 136 rubles), ampoules (32 rubles per 1 piece).

Combined remedy. Contains alverine - an antispasmodic with myotropic action, simethicone - reduces gas formation. Indications: gastrointestinal disorders, preparation for abdominal examination (ultrasound, instrumental, x-ray). The cost of capsules is 416 rubles.

Dispersed medications in tablet forms are easy to carry with you, they are easy to use in the required situation.

Spazmalgon and its analogue Spazgan differ only in the different auxiliary components in the composition.

None of them the best drug for headache relief, they are almost identical. Spazgan acts more aggressively when compared to Spazmalgon.

Letters from our readers

Subject: Grandma's blood pressure has returned to normal!

From: Christina ( [email protected])

To: Site Administration

Christina
Moscow

My grandmother's hypertension is hereditary - most likely, I will have the same problems as I grow older.

The scope of application of the drugs spazgan and spasmalgon is quite wide. These funds are used in the following areas of medicine:

• gynecology;
• gastroenterology;
• nephrology.

The direction of action of spazgan and spasmalgon is the same. They are used for the following indications:

• migraine;
• toothache;
• diseases of the genitourinary system;
• hepatic colic;
• cholelithiasis;
• menstrual pain;
• neurological pain.

The agents under consideration are united by the property of pain relief. The drugs relieve pain of varying localization and intensity. The effect is achieved by using both spasmalgon and spazgan.

pharmachologic effect

The action of spasmalgon and spazgan is the same.

The differences lie in the pharmacological action. The drugs contain various auxiliary components. The ingredients of the drugs cause an individual reaction.

The active ingredient metamizole sodium has a rapid effect. Its action includes:

• decreased receptor sensitivity;
• brain cell activity.

Other effects of the drug component:

• muscle relaxation process;
• exception of spasm.

Contraindications

Both spasmalgon and spazgan have contraindications. Each drug contains auxiliary components. The ingredients of medications cause individual reactions.

An individual reaction may include an allergy. Another name for a negative reaction is a side effect. The body’s reaction is individual, just as the human body is individual.

TO general contraindications include:

• acute surgical pathology;
• kidney and liver damage;
• decreased bladder tone;
• intestinal obstruction;
• vascular insufficiency;
• adenoma;
• pregnancy status;
• children up to 3 months old.

The drug spasmalgon and spazgan are used carefully. Because negative reactions are possible. Their use is undesirable in the following cases:

• asthma;
• allergy;
• high sensitivity;
• cold.

Instructions for use

Both drugs contain the substance metamizole sodium. The direction of action of spazgan or spasmalgon is as follows:

• anesthesia;
• decreased body temperature;
• analgesic effect.

For pain, it is enough to take one tablet. Especially if you have a migraine. The effect of application is achieved after half an hour. The greatest effectiveness is achieved by using injection.

Overdose

Using the drug in excess causes a negative reaction. Overdose leads to the following:

• hematopoietic disorder;
• blood pathology;
• vascular lesions;
• heart failure.

These drugs are not used often.

Main differences

Spazgan is produced by an Indian company. And spasmalgon in Bulgaria.

Spasmalgon has a weak effect. Spazgan acts more intensely.

Less excipients contains spasmalgon. Most of the components are found in spazgan. Thanks to these substances, the effect is enhanced.

These drugs are analogues. The more additives or excipients, the greater the risk of an adverse reaction.

Additives have a negative effect on gastrointestinal tract.

What is the best treatment for headaches?

These drugs treat headaches in the same way. They have an analgesic effect.

Spazgan has higher efficiency. Headache goes by quite quickly.

The faster the effect, the better drug. This is the opinion of many patients. Although the individual reaction of the body causes adverse reactions.

special instructions

The drugs are used strictly according to the instructions. Self-medication is contraindicated! In the presence of adverse reactions the drugs are discontinued.

Use the products with extreme caution for the following pathologies:

• renal failure;
• liver pathologies;
• blood diseases.

Other analogues

There are enough analogues for the drugs. These include the following means:

• pentalgin;
• efferalgan;
• Phosicard;
• nevotens;
• selectra;
• vestibo.

These are not all analogues of drugs. The focus of the funds is the same. All products have an analgesic effect.

These drugs are used strictly for their intended purpose. Independent use of the products is contraindicated.

• use strictly according to instructions;
• compliance with dosage;
• be alert to possible side effects.

solution for intravenous and intramuscular administration, tablets

Pharmachologic effect:

A combined analgesic and antispasmodic agent, the combination of drug components leads to their mutual enhancement pharmacological action. Metamizole sodium is a pyrazolone derivative that has an analgesic and antipyretic effect. Pitophenone hydrochloride has a direct myotropic effect on smooth muscles (papaverine-like effect). Phenpiverinium bromide has an m-anticholinergic effect and has an additional myotropic effect on smooth muscles.

Indications:

Pain syndrome (mild or moderate) with spasms of smooth muscles of internal organs: renal colic, spasm of the ureter and bladder; biliary colic, intestinal colic; biliary dyskinesia, postcholecystectomy syndrome, chronic colitis; algodismenorrhea, diseases of the pelvic organs. For short-term treatment: arthralgia, myalgia, neuralgia, sciatica. As an auxiliary drug: pain syndrome after surgical interventions and diagnostic procedures.

Contraindications:

Hypersensitivity (including to pyrazolone derivatives), inhibition of bone marrow hematopoiesis, severe hepatic and/or renal failure, glucose-6-phosphate dehydrogenase deficiency, tachyarrhythmias, severe angina pectoris, decompensated CHF, angle-closure glaucoma, prostatic hyperplasia (with clinical manifestations), intestinal obstruction, megacolon, collapse, pregnancy (especially in the first trimester and the last 6 weeks), lactation. For intravenous administration - infancy (up to 3 months) or body weight less than 5 kg. For tablets - children's age (up to 5 years). With caution. Renal/liver failure, bronchial asthma, “aspirin” triad, tendency to arterial hypotension, hypersensitivity to other NSAIDs.

Side effects:

Allergic reactions: urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock. From the urinary system: impaired renal function, oliguria, anuria, proteinuria, interstitial nephritis, red staining of urine. From the cardiovascular system: decreased blood pressure. From the hematopoietic organs: thrombocytopenia, leukopenia, agranulocytosis (may be manifested by the following symptoms: unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis, as well as the development of vaginitis or proctitis). Anticholinergic effects: dry mouth, decreased sweating, accommodation paresis, tachycardia, difficulty urinating. Local reactions: with intramuscular injection, infiltrates are possible at the injection site. Overdose. Symptoms: vomiting, decreased blood pressure, drowsiness, confusion, nausea, pain in the epigastric region, impaired liver and kidney function, convulsions. Treatment: gastric lavage, administration of activated carbon, symptomatic therapy.

Directions for use and dosage:

Spazmalgon is taken orally: adults and adolescents over 15 years of age: 1-2 tablets 2-3 times a day, without chewing, with a small amount of liquid. Children 12-14 years old: single dose - 1 tablet, maximum daily dose - 6 tablets (1.5 tablets 4 times a day), 8-11 years old - 0.5 tablets, maximum daily dose - 4 tablets (1 tablet 4 times a day) , 5-7 years - 0.5 tablets, maximum daily dose - 2 tablets (0.5 tablets 4 times a day). Parenterally (i.v., i.m.). For adults and adolescents over 15 years of age with acute severe colic, 2 ml are administered intravenously slowly (1 ml over 1 minute); if necessary, re-inject after 6-8 hours. IM - 2-5 ml of solution 2-3 times a day. Daily dose should not exceed 10 ml. The duration of treatment is no more than 5 days. Dose calculation for children with IV and IM administration: 3-11 months (5-8 kg) - IM only - 0.1-0.2 ml; 1-2 years (9-15 kg) - IV - 0.1-0.2 ml, IM - 0.2-0.3 ml; 3-4 years (16-23 kg) - IV - 0.2-0.3, IM - 0.3-0.4 ml; 5-7 years (24-30 kg) - IV - 0.3-0.4 ml, IM - 0.4-0.5 ml; 8-12 years (31-45 kg) - IV - 0.5-0.6 ml, IM - 0.6-0.7 ml; 12-15 years - IV and IM - 0.8-1 ml. Before administering the injection solution, it should be warmed in your hand.

Special instructions:

During treatment with the drug, it is not recommended to take ethanol. With long-term (more than a week) treatment, monitoring of the peripheral blood picture and the functional state of the liver is necessary. If agranulocytosis is suspected or thrombocytopenia is present, the drug should be discontinued. Cannot be used for cupping acute pain in the stomach (until the cause is determined). Use in nursing mothers requires cessation of breastfeeding. Intolerance is very rare, but the risk of developing anaphylactic shock after intravenous administration of the drug is relatively higher than after taking the drug orally. Patients with atopic bronchial asthma and hay fever have an increased risk of developing allergic reactions. Parenteral administration should be used only in cases where oral administration is not possible (or absorption from the gastrointestinal tract is impaired). Special caution is required when administering more than 2 ml of solution (risk of a sharp decrease in blood pressure). The IV injection should be carried out slowly, in the lying position and under the control of blood pressure, heart rate and respiratory rate. When treating children under 5 years of age and patients receiving cytostatic drugs, metamizole sodium should only be taken under medical supervision. For intramuscular administration it is necessary to use a long needle. It is possible that the urine may turn red due to the release of a metabolite (it has no clinical significance). Drivers should be careful during treatment Vehicle and persons engaged in potentially hazardous activities that require quick physical and mental reactions.

Interaction:

The solution for injection is pharmaceutically incompatible with other drugs. When administered together with H1-histamine blockers, butyrophenones, phenothiazines, tricyclic antidepressants, amantadine and quinidine, the m-anticholinergic effect may be enhanced. Enhances the effects of ethanol; simultaneous use with chlorpromazine or other phenothiazine derivatives can lead to the development of severe hyperthermia. Tricyclic antidepressants, oral contraceptives and allopurinol increase the toxicity of the drug. Phenylbutazone, barbiturates and other hepatoinducers, when administered simultaneously, reduce the effectiveness of metamizole sodium. Sedative and anxiolytic drugs (tranquilizers) enhance the analgesic effect of metamizole sodium. Radiocontrast drugs, colloidal blood substitutes and penicillin should not be used during treatment with drugs containing metamizole sodium. With simultaneous administration of cyclosporine, the concentration of the latter in the blood decreases. Metamizole sodium, displacing oral hypoglycemic drugs from protein binding, indirect anticoagulants, GCS and indomethacin, may increase the severity of their action. Thiamazole and cytostatics increase the risk of developing leukopenia. The effect is enhanced by codeine, H2-histamine receptor blockers and propranolol (slows down the inactivation of metamizole sodium).

Before using the drug Spasmalgon consult your doctor!