How to drink wix active. Vicks for colds - indications and features of use. International nonproprietary or grouping name

Prohibited at breastfeeding

Forbidden to children

Has restrictions for the elderly

Forbidden for liver problems

Forbidden for kidney problems

Acute respiratory diseases occur with severe symptoms of a cold and a characteristic clinical picture: acute onset, fever, chills, weakness. When infected, the head is spinning, because the pathogen poisons the body. After a couple of days, a runny nose begins. Frequent sneezing injures the nasal mucosa, causes nosebleeds, and a runny nose causes headaches.

To reduce discomfort, drugs that relieve symptoms are used. Vicks Active Symptomax is popular as it effectively relieves the symptoms of a cold, returns the patient to working capacity and interest in life. Further, the article describes in detail the instructions for using the drug, indications and contraindications, as well as side effects.

general information

The combined drug based on paracetamol has antipyretic, analgesic and decongestant properties. Eliminates symptoms of colds and viral diseases. The citrus flavor of a warm drink and the simple preparation make taking the drug easy and pleasant.

medicinal group

Vicks active (Vicks Active SymptoMax) belongs to the group of anilides in combination: a non-narcotic analgesic, including NSAIDs. ATC code: N02BE51. The effectiveness of the drug is associated with the analgesic and antipyretic properties of paracetamol.

Release forms and prices

Available as a free-flowing yellow powder with a taste and smell of citrus, which dissolves in warm water for oral administration. One sachet (5 g) contains 1 g of paracetamol and 12.2 mg of phenylephrine.

The table shows the average cost of the drug in the territory of the Russian Federation.

Composition and pharmacological properties

The main active ingredients of the drug:

1. Paracetamol is a metabolite of phenacetin, which is formed when taking the drug and acts as an analgesic with a low level of anti-inflammatory activity. The main advantages are low toxicity and little effect on the production of methemoglobin. Paracetamol relieves pain and reduces fever.
2. Phenylephrine hydrochloride (mezaton)- synthetic adrenomimetic, stimulator of α-adrenergic receptors. Weakly affects the β-receptors of the heart. Constricts arterioles and raises blood pressure. Phenylephrine, narrowing blood vessels, relieves swelling and hyperemia of the nasal cavity.

The composition also includes additional components that do not have a therapeutic effect, but affect the absorption of the drug, give it shape and taste (sucrose, citric and tartaric acids, sodium cyclamate, sodium citrate, aspartame, potassium acesulfame, flavors).

The pharmacokinetics of the drug is presented in the table.

Varieties

Vicks preparations come in various directions:

1. On sale you can find a rubbing balm with menthol and eucalyptus oils. It is used for colds and coughs.
2. Vicks Active Sinex is a nasal spray that relieves congestion and swelling of the nasal cavity.
3. From the symptoms of a cold, we offer Vicks Medinight Syrup with a taste of honey and chamomile.
4. Vicks Active Symptomax Plus also contains guaifenesin.

Indications and contraindications

Feverish syndrome on the background of acute respiratory infections and influenza, weak and moderate pain syndrome- all these symptoms are indications for the use of the drug. But it does not affect the cause of the disease itself.

It is strictly forbidden to take medicine for children under 15 years of age, during pregnancy and lactation. Elderly people should be consulted with a doctor before taking. With caution, the drug is prescribed to patients with concomitant chronic diseases. With the simultaneous intake of alcohol, the risks of toxic liver damage and hypertensive crisis increase.

Instructions for use and drug compatibility

Before starting treatment, you must read the instructions for using Vicks Active. Or consult with a specialist. As a rule, the drug is taken according to the following rules:

1. To prepare the medicine, dissolve one sachet in warm boiled water (250 ml), the finished drink should be drunk at a time.
2. The medication should be repeated after six hours.
3. A maximum of four sachets per day can be used.
4. Treatment lasts no more than five days.

Since the drug is combined, it is worth considering both of its components when joint admission with other medicines. The medicine contains paracetamol and phenylephrine. These are active chemical substances, which can react with drugs taken in parallel. A number of serious complications and worsening of the general condition of the patient are possible.

The table shows examples of the interaction of the components of the drug active substances with other drugs.

Before taking the drug, you need to carefully study these interactions if other medications have been previously prescribed. Perhaps the doctor will advise a more acceptable analogue of the drug that relieves symptoms.

Possible side effects and overdose

Individual intolerance to the drug or concomitant diseases can cause unpleasant consequences (Table 3). If you feel unwell, stop taking the medication and seek medical advice.

With an overdose of paracetamol, a person turns pale, feels sick, and starts vomiting. There may be a violation of glucose metabolism. With cerebral edema, the patient may die. If symptoms of an overdose appear, you should immediately call for medical help.

With an excess of phenylephrine, a headache, convulsions, tachycardia, and vomiting may appear. It is necessary to wash the stomach, drink plenty of alkaline water, take activated charcoal.

Analogues

Popular analogues of the drug may contain additional substances:

There may also be a variety of flavors in analogue preparations: orange, lemon, honey, blackcurrant, lime, so you should pay attention to dyes in their compositions.

). Vicks Active SymptoMax is combined remedy in the form of a powder for preparing a hot drink. Its use helps bring down the temperature, reduce pain and.

Composition and dosage form

Powder Vicks Active SymptoMax is supplied in laminated bags of 5 g. A single dose contains 1 g (analgesic-antipyretic) and 12.2 mg of phenylephrine hydrochloride (sympathomimetic).

Each sachet of Vicks Active SymptoMax Plus contains 0.5 g of paracetamol and 10 mg of phenylephrine. The composition additionally includes the mucolytic Guaifenesin (0.2 g).

When should I take Vicks Active?

A pharmacological agent is prescribed to relieve or reduce the severity of the following symptoms:

• (and rhinorrhea);
• high body temperature and febrile reaction;
• against the background of inflammation (and);

Important:Vicks Active drugs do not affect the cause of the disease in any way and do not speed up the healing process.

When is Vicks Active SymptoMax contraindicated?

Vicks Active should never be taken by patients with individual hypersensitivity to active ingredients.

Contraindications include the following diseases and pathological conditions:

Note:patients are not recommended to take this medicine, because one of its auxiliary ingredients is a source of phenylalanine - aspartame.

Vicks Active SymptoMax is not intended for children and adolescents under 18 years of age. Vicks Active SymptoMax Plus is approved for use from the age of 12.

How to take medicine?

Powder from one sachet must be diluted in 200-250 ml of hot water (not boiling water!), Before ingestion, and allow the solution to cool. Permissible daily dose- 4 sachets (20 g). Between doses, it is necessary to maintain time intervals of 4-6 hours.

As an antipyretic, Vicks Active can be taken 3 days in a row, and as an analgesic - no more than 5 days. If there is a need to continue treatment, it is necessary to consult with your doctor. Long-term use of paracetamol requires control of the picture of peripheral blood and periodic monitoring of liver function.

Side effects

With intolerance to the active components, the development of allergic reactions is possible - skin itching, rashes (""), bronchospasm and. In severe cases, it is not excluded.

Most patients tolerate Vicks Active SymptoMax very well.

Side effects of paracetamol:

• (reduction or disappearance of appetite);
• dyspeptic disorders;
• intestinal disorders;
• pain in the epigastric region (in the projection of the stomach);
• pupil dilation;
• violation of the clarity of visual perception near;
• dysuria (impaired urine output);

Note:paracetamol can cause damage to the liver (hepatonecrosis) and kidneys (interstitial).

Side effects of phenylephrine hydrochloride:

• cardiopalmus;
• sleep disorders;
• unmotivated feeling of anxiety;
• high nervous excitability;
• shiver;
• irritability;
• confusion;
• disorientation in space;

Overdose

With a significant excess of single and daily doses, signs of poisoning appear. paracetamol. Ingestion of ≥ 10 g of this substance causes damage to the liver and kidneys. TO clinical symptoms overdoses (develop after 12-48 hours) include abdominal discomfort or pain in the abdominal region and.

Important:severe poisoning causes progressive encephalopathy. Coma and death are not ruled out.

In case of overdose, call " ambulance» or contact your nearest medical institution. Within 2 hours, you need to rinse the stomach and take (). In the first 8-9 hours, the introduction of a specific antidote, methionine, is indicated, and at a later date (12 hours or more) - acetylcysteine ​​for detoxification. Further medical tactics are determined by the severity of the lesion. internal organs. In a hospital, hardware blood purification is indicated - hemodialysis.

Large doses of guainefesin can cause respiratory depression, digestive disorders and confusion.

pharmachologic effect

Paracetamol indiscriminately blocks the cyclooxygenase enzyme in the central nervous system, thereby reducing the production of pain and inflammation mediators - prostacyclins and prostaglandins. Antipyretic properties are due to its direct effect on the hypothalamic center of thermoregulation.

Phenylephrine is a sympathomimetic that stimulates α-adrenergic receptors. It causes constriction of the vessels of the nasal mucosa, which helps to reduce its swelling and rhinorrhea.

The guaifenesin present in Vicks Active SymptoMax Plus is a mucolytic. This component helps to thin the sputum in the bronchi and increase its volume. Thanks to this, the secret is easier to remove from the upper respiratory tract, and coughing attacks develop much less frequently.

After taking a hot drink, the components of the drug are absorbed in the gastrointestinal tract quickly and in full. They penetrate the bloodstream and act systemically, freely penetrating the blood-brain barrier. The therapeutic effect develops within 15-25 minutes and lasts for 6-12 hours. Biotransformation of phenylephrine and paracetamol occurs in the liver. Unchanged substances and their metabolic products are excreted mainly in the urine.

Vicks Active SymptoMax during pregnancy

during pregnancy (especially duringI and III trimesters), drugs containing paracetamol should not be taken, although the substance does not have teratogenic and embryotoxic properties. If necessary symptomatic therapy during lactation, the child must be temporarily transferred to artificial feeding.

Interaction with other drugs

The hepatotoxic effect of paracetamol, even when consuming relatively small doses (5 g), can develop while taking Primidone, Rifampicin, Carbamazepine, Phenytoin and Phenobarbital.

Vicks Active Symtomax should not be taken simultaneously with drugs from the group of monoamine oxidase inhibitors, β-blockers and tricyclic antidepressants.

Efficiency indirect anticoagulants and antiplatelet agents increases, and uricosouric drugs - decreases.

Paracetamol is able to potentiate the action of sedatives.

Simultaneous use steroid hormones increases the risk of developing glaucoma.

Phenylephrine in combination with and antipsychotics can provoke intestinal motility disorder () and slow urine output.

Additionally

Particular care must be taken by persons who are diagnosed with:

• chronic obstructive pulmonary disease;
• hyperoxaluria;
• hyperbilirubinemia (congenital).

At the time of treatment, you should refrain from taking alcoholic beverages and pharmacy tinctures, since ethanol enhances the toxic effect on the liver.

Trade name of the drug

Vicks Active SymptoMax

International nonproprietary or grouping name

Paracetamol + Phenylephrine

Dosage form

powder for solution for oral administration [blackcurrant, lemon].

Vicks Active SymptoMax Composition (per sachet)

Active substances- paracetamol 1000 mg, phenylephrine hydrochloride 12.20 mg.
Excipients in blackcurrant powder - vitamin C 100 mg, sucrose 2351 mg, citric acid 812 mg, sodium citrate 501 mg, aspartame 53 mg. acesulfame potassium 51 mg, blackcurrant flavor S-133747 56 mg, blackcurrant flavor 1007348 60 mg. blackcurrant dye 6 mg.
Excipients in citric powder - ascorbic acid 100 mg, sucrose 1936 mg, citric acid 812 mg, sodium citrate 501 mg, aspartame 25 mg, acesulfame potassium 65 mg, quinoline yellow dye 1 mg, lemon flavor F/29088 30 mg, lemon flavor F/ 29089 240 mg, lemon flavor F/28151 240 mg, lemon flavor F/501.476/AP05O4 40 mg.

Vicks Active SymptoMax Description

Blackcurrant powder: fine-crystalline powder of light violet color with a characteristic smell of black currant.
Lemon powder: light crystalline powder yellow color with a characteristic lemon scent.
A solution of blackcurrant powder: red-violet in color with a characteristic smell of blackcurrant.
Solution of lemon powder: yellow with a characteristic smell of lemon, with opalescence.

Pharmacotherapeutic group

Means for eliminating the symptoms of acute respiratory infections and "colds" (analgesic non-narcotic drug + alpha-adrenergic agonist).

ATX code

Pharmacological properties

Pharmacodynamics
Combined drug, the action of which is due to the composition of its constituent components.
Paracetamol has analgesic and antipyretic effects, these effects are due to inhibition of prostaglandin synthesis in the central nervous system. Phenylephrine is a postsynaptic alpha-adrenergic agonist with low cardioselective affinity for beta receptors. Decongestant, constricts blood vessels, eliminates swelling and hyperemia of the nasal mucosa.
Pharmacokinetics
Paracetamol is rapidly and completely absorbed into small intestine. The maximum concentration in the blood is observed 15-20 minutes after ingestion. Systemic bioavailability is determined by first pass metabolism and, depending on the dose, ranges from 70% to 90%. Paracetamol is rapidly distributed to all body tissues and has an elimination half-life of approximately 2 hours. Metabolized in the liver and excreted in the urine as glucuronides and sulfate compounds (> 80%). Phenylephrine is rapidly absorbed from gastrointestinal tract. The level of primary metabolism is quite high (~60%), so oral administration phenylephrine reduces its bioavailability (~40%). The maximum plasma concentration is observed after 1-2 hours, and the half-life varies from 2 to 3 hours. It is excreted in the urine in the form of sulfate compounds. Oral administration of phenylephrine as a decongestant should be done at intervals of 4-6 hours.

Vicks Active SymptoMax Indications for use

Symptoms of "colds" and flu: headache, pain in
throat, other types of pain, nasal congestion, fever.

Contraindications

• Hypersensitivity to paracetamol or other components of the drug;
• Arterial hypertension:
• Coronary artery disease:
• Impaired liver function and severe renal impairment:
• Hyperthyroidism;
• Diabetes;
• Phenylketonuria (because the drug contains aspartame);
• Concurrent use of tricyclic antidepressants, monoamine oxidase (MAO) inhibitors, or beta-blockers
• or taking them within the last 2 weeks;
• Pregnancy and lactation period;
• Hyperplasia of the prostate;
• Glaucoma:
• Age up to 18 lay down,
• Sucrase/isomaltase deficiency;
• fructose intolerance;
• Glucose-galactose malabsorption.

Carefully

Long-term use of the drug is not recommended. The simultaneous use of other anti-cold and / or paracetamol-containing drugs should be avoided. Do not take the drug at the same time as drinking alcohol.
Bronchial asthma, COPD (chronic obstructive pulmonary disease), glucose-6-phosphate dehydrogenase deficiency, blood diseases, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson, Rotor syndromes), hyperoxaluria.

Use during pregnancy and during breastfeeding

Do not use the drug during pregnancy and during breastfeeding.

Vicks Active SymptoMax Dosage and administration

Dissolve the contents of one sachet in hot but not boiling water (250 ml). Allow to cool to an acceptable temperature and drink. Adults and children over 18 years old - one sachet. If necessary, repeat the reception every 4-6 hours, but not more than 4 doses (sachets) per day.
The drug is not recommended to be used for more than 5 days as an anesthetic and 3 days as an antipyretic without consulting a doctor.
If symptoms persist, a doctor should be consulted.

Side effects

Paracetamol

allergic reactions
Rare: skin rash, urticaria, anaphylaxis, bronchospasm, angioedema.
From the side of the central nervous system

Rare: dizziness.
From the hematopoietic system
Rare: aplastic anemia, methemoglobinemia, increased
blood pressure.
Very rarely: pathological changes blood such as thrombocytopenia, agranulocytosis, hemolytic anemia, neutropenia, leukopenia, pancytopenia.
So sides digestive system
Rare: nausea, vomiting, dryness of the oral mucosa, hepatotoxicity
So sides of the urinary system
Rare: urinary retention, nephrotoxicity (papillary necrosis).
Other
Rarely: paresis of accommodation, increased intraocular pressure, mydriasis.
Phenylephrine
So sides of cardio-vascular system
Rare: tachycardia, increased blood pressure.
So aspects of the nervous system
Rare: insomnia, nervousness, tremor, anxiety, irritability, confusion, irritability and headache.
From the digestive system

Often: anorexia, nausea and vomiting.
From the side immune system And skin
Seldom: allergic reactions, including skin rash, urticaria, anaphylaxis and bronchospasm.

Overdose

Paracetamol
Liver damage is possible in adults who have taken 10 grams or more of paracetamol. Taking 5 grams or more of paracetamol can cause liver damage if there are risk factors: prolonged treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, or other drugs that induce liver enzymes, alcohol abuse, lack of glutanion (for example, malnutrition), cystic fibrosis, HIV infection, starvation, cachexia.
Symptoms of an overdose of paracetamol in the first 24 hours: blanching, nausea, vomiting, anorexia and pain in the abdomen. Liver damage may occur within 12 to 48 hours after the use of the drug. In case of overdose of paracetamol, despite the absence of primary symptoms of overdose, it is necessary to seek medical advice. qualified help in medical institutions. To prevent the serious consequences of an overdose, the necessary measures should be taken in a timely manner.
Symptoms may appear only partially as nausea or vomiting and may not reflect the actual degree of overdose or risk of organ damage.
In severe overdose - liver failure with progressive encephalopathy, coma, death; acute kidney failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.
Phenylephrine
Symptoms of a phenylephrine overdose include irritability, headache, increased blood pressure.
In the event of the above symptoms of an overdose, you should consult a doctor
Treatment: the introduction of donators of SH-groups and precursors of the synthesis of glutathione - methionine within 8-9 hours after an overdose and acetylcysteine ​​- within 8 hours.
The need for additional therapeutic measures (further administration of methionine, intravenous administration acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after taking it.

Interaction with other drugs

Paracetamol
Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications.
Paracetamol enhances the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.
The rate of absorption of paracetamol is increased by metoclopramide or domperidone and decreased by cholestyramine.
The anticoagulant effect of warfarin and other coumarin derivatives is enhanced with prolonged use of paracetamol,
The drug enhances the effects of MAO inhibitors, sedatives, ethanol.
Phenylephrine
With the simultaneous use of phenylephrine with antidepressants, antiparkinsonian, antipsychotic drugs, phenothiazine derivatives, urinary retention, dryness of the oral mucosa, and constipation are possible.
When used with glucocorticosteroids, the risk of developing glaucoma increases. Tricyclic antidepressants increase the adrenomimetic effect of phenylephrine, the simultaneous administration of halothane increases the risk of developing ventricular arrhythmias.

special instructions

The drug should not be combined with ethanol.
During the period of treatment, it is necessary to refrain from taking sleeping pills, anxiolytic drugs, as well as other drugs containing paracetamol.
The drug distorts the results of laboratory tests that evaluate the concentration of glucose and uric acid in plasma.
Contains sucrose. The drug is contraindicated in patients with rare congenital fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency. Contains aspartame (E951), a source of phenylalanine. May be toxic to patients with phenylketonuria.
When driving vehicles and engaging in other potentially hazardous activities, it must be taken into account that the drug can cause side effects such as dizziness and confusion.

Release form

Powder for solution for oral administration [blackcurrant, lemon]. 5.0 g of powder in a laminated sachet.
5 or 10 sachets, along with instructions for use, are placed in a cardboard box)

Storage conditions

At a temperature not higher than 25°C. Keep out of the reach of children.

Best before date

3 years. Do not use after the expiration date.

Terms of dispensing from pharmacies

Without recipe.

Registration certificate holder

OOO Procter and Gamble Distribution Company, Russia 125171, Moscow, Leningradskoe shosse, 16A, building 2.

Symptoms of "colds" and flu: headache, sore throat, other types of pain, nasal congestion, fever. Before using other Vicks Active products, read the label carefully to ensure that these products are used correctly. Get the Ultimate Cold Relief - in a Hot Drink When your cold symptoms take you by surprise, you need immediate relief to stay on track with your goals. Vicks Active Symptomax vitamin C, which has a powerful effect on the five main symptoms of the common cold: fever, headache, joint and muscle pain, sore throat and nasal congestion. Relieved symptoms Temporarily relieves cold symptoms: - Nasal congestion - Aches and fever - Sore throat

Contraindications to the use of Vicks active symptomatic plus

• Hypersensitivity to paracetamol or other components of the drug;
• Arterial hypertension;
• Coronary artery disease;
• Impaired liver function and severe renal dysfunction;
• Hyperthyroidism;
• Diabetes;
• Phenylketonuria (because the drug contains aspartame);
• Simultaneous use of tricyclic antidepressants, monoamine oxidase inhibitors (MAO) or beta-blockers or their use within the last 2 weeks;
• Pregnancy and lactation period;
• Hyperplasia of the prostate;
• Glaucoma;
• Age up to 18 years;
• Sucrase/isomaltase deficiency;
• fructose intolerance;
• Glucose-galactose malabsorption.

Bronchial asthma, COPD (chronic obstructive pulmonary disease), glucose-6-phosphate dehydrogenase deficiency, blood diseases, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson, Rotor syndromes), hyperoxaluria.

Vicks active symptomatic plus Use during pregnancy and children

Do not use the drug during pregnancy and during breastfeeding.

Vicks Active Symptomax Plus Side effects

Paracetamol

Allergic reactions - Rarely - skin rash, urticaria, anaphylaxis, bronchospasm, angioedema.

From the side of the central nervous system: Rarely - dizziness.

On the part of the hematopoietic system: Rarely - aplastic anemia, methemoglobinemia, increased blood pressure. Very rarely - pathological changes in the blood, such as thrombocytopenia, agranulocytosis, hemolytic anemia, neutropenia, leukopenia, pancytopenia.

From the digestive system: rarely - nausea, vomiting, dryness of the oral mucosa, hepatotoxic effect.

From the urinary system: Rarely - urinary retention, nephrotoxicity (papillary necrosis).

Others: Rarely - paresis of accommodation, increased intraocular pressure, mydriasis.

Phenylephrine

From the side of the cardiovascular system: Rarely - tachycardia, increased blood pressure.

From the nervous system: Rarely - insomnia, nervousness, tremor, anxiety, irritability, confusion, irritability and headache.

From the digestive system: often - anorexia, nausea and vomiting.

From the immune system and skin: Rarely - allergic reactions, including skin rash, urticaria, anaphylaxis and bronchospasm.

Dosage of Vicks active symptomatic plus

Dissolve the contents of one sachet in hot but not boiling water (250 ml). Allow to cool to an acceptable temperature and drink. Adults and children over 18 years old - one sachet. If necessary, repeat the reception every 4-6 hours, but not more than 4 doses (sachets) per day. The drug is not recommended to be used for more than 5 days as an anesthetic and 3 days as an antipyretic without consulting a doctor. If symptoms persist, a doctor should be consulted.

Overdose

Paracetamol

Liver damage is possible in adults who have taken 10 grams or more of paracetamol. Taking 5 grams or more of paracetamol can cause liver damage if there are risk factors - prolonged treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin or other drugs that induce liver enzymes, alcohol abuse, lack of glutanion (eg, malnutrition), cystic fibrosis, HIV -infection, starvation, cachexia.

Symptoms of an overdose of paracetamol in the first 24 hours are blanching, nausea, vomiting, anorexia and pain in the abdomen.

Liver damage may occur within 12 to 48 hours after the use of the drug.

In case of an overdose of paracetamol, despite the absence of primary symptoms of an overdose, it is necessary to seek qualified help from medical institutions. To prevent the serious consequences of an overdose, the necessary measures should be taken in a timely manner.

Symptoms may appear only partially as nausea or vomiting, and may not reflect the actual degree of overdose or risk of organ damage. In severe overdose - liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.

Phenylephrine

Symptoms of a phenylephrine overdose include irritability, headache, and increased blood pressure. In the event of the above symptoms of an overdose, you should consult a doctor.

Treatment - the introduction of donators of SH-groups and precursors of the synthesis of glutathione - methionine within 8-9 hours after an overdose and acetylcysteine ​​- within 8 hours. The need for additional therapeutic measures (further administration of methionine, intravenous administration of acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.