Metformin and its analogues. Metformin analogues. Discounted price for diabetics

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There are many drugs with metformin, but they all work in different ways. Now I am taking Glucophage LONG, because it has the mildest effect and no adverse reactions. Given that I have to drink it every day because of my type 2 diabetes, it is very important that the drug fits perfectly.

I was assigned it because diabetes, take on a regular basis to control sugar. But it turned out to be difficult to drink it because of the side effects that constantly crawled out. I refused to take it, we decided to try to regulate the condition with a diet. The desired result did not work out, now I drink Glucophage Long. The drug has a milder effect and no adverse reactions, sugar reduces... I was prescribed it because of diabetes, take it on a regular basis to control sugar. But it turned out to be difficult to drink it because of the side effects that constantly crawled out. I refused to take it, we decided to try to regulate the condition with a diet. The desired result did not work out, now I drink Glucophage Long. The drug has a milder effect and no side reactions, sugar reduces perfectly.

Metformin was prescribed to me for hormonal problems. I didn't set a goal to lose weight. When I started taking it, I felt a whole series of side effects. I also lost my appetite. I didn't want to eat at all. Sometimes I just force myself to eat. Accordingly, she lost weight. I take Metformin once a day. I read about Metformin reviews and ... Metformin was prescribed to me for hormonal problems. I didn't set a goal to lose weight. When I started taking it, I experienced a number of side effects.
I also lost my appetite. I didn't want to eat at all. Sometimes I just force myself to eat. Accordingly, she lost weight. I take Metformin once a day.
I read reviews about Metformin and now, to be honest, I'm confused. Some write that the drug helped, while others, on the contrary, had problems with hormones.
Now I don't even know what to do.

Metformin hydrochloride appeared on the pharmaceutical market in 1957, and to this day this hypoglycemic drug is a recognized leader in the treatment of type 2 diabetes mellitus, including those complicated by obesity. How active substance Metformin increases the sensitivity of cells to insulin. Metformin derivatives are natural substances obtained from plants:

french lilac;
goat's rue (goat's rue).

According to modern scientific research, the drug Metformin is also effective in the treatment of certain types of cancer (mainly associated with diabetes) and fatty liver.

How to replace Metformin?

Sometimes patients, believing that the treatment process goes without significant results, are interested in what can replace Metformin. Let's try to find out what Metformin tablets have analogues and how effective they are in the treatment of diabetes.

Popular substitutes for Metformin

Glucophage;
Siofor;
Metfogamma;
Hexal;
Formetin.

All of them also contain the same active substance, from which the logical conclusion follows that the drugs have a similar effect on the body, and, accordingly, have the same indications, contraindications for use and methods of administration.

Which is better - Siofor or Metformin?

Siofor, like Metformin, is an oral drug that has a hypoglycemic effect. Siofor is a product of the German pharmaceutical company BERLIN-CHEMIE. Siofor and Metformin tablets are considered a good alternative to insulin injections, provided that treatment is started on time.

Which is better - Metformin or Glucophage?

Glucophage contains metformin hydrochloride as an active ingredient, and is also taken in type 2 diabetes mellitus as a single agent and for complex therapy. A variety of the drug Glucophage-Long provides an extended period of action.

Studies have shown that Glucophage is twice as likely to cause organ dysfunction digestive system than metformin. But, if we compare two pharmaceuticals by price, then the cost of Glucophage-Long is much higher.

Based on the foregoing, we can conclude that synonymous medicines can replace each other, but this requires the appointment of a specialist. But the lack of the desired effect is most often explained by:

violations when taking drugs (regime, dose or diet);
the need to use metformin-containing agents in combination with a group of drugs that improve their action.

Other analogues of Metformin

The following are the means by which you can successfully replace the drug Metformin.

Vijar

Being a dietary supplement that lowers blood glucose levels, activates immune system and is considered an excellent means of prevention against viral and bacterial infections.

BAA Spirulina

Helps in the fight against diabetes and other metabolic disorders, as well as overweight.

Glucoberry

A biologically active substance used to reduce the risk of complications from diabetes.

Glucosil

A drug that serves to correct body functions in the first and second types and optimize metabolic processes.

Guarem

An agent taken in poorly controlled diabetes mellitus and obesity, when switching to insulin therapy is not desirable.

midon

The drug is used for insulin-dependent and non-insulin-dependent diabetes mellitus, metabolic disorders of other substances in the body and severe obesity.

In this article, you can read the instructions for using the drug Metformin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Metformin in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Metformin analogues in the presence of existing structural analogues. Use to treat type 2 diabetes and obesity (weight loss) in adults, children, and pregnancy and lactation. The composition and interaction of the drug with alcohol.

Metformin- inhibits gluconeogenesis in the liver, reduces the absorption of glucose from the intestine, increases the peripheral utilization of glucose, and also increases the sensitivity of tissues to insulin. At the same time, it does not affect the secretion of insulin by pancreatic beta cells, and does not cause hypoglycemic reactions. Reduces the level of triglycerides and low density lipoproteins in the blood. Stabilizes or reduces body weight. It has a fibrinolytic effect due to the suppression of a tissue-type plasminogen activator inhibitor.

Composition

Metformin hydrochloride + excipients.

Pharmacokinetics

After oral administration, metformin is absorbed from the gastrointestinal tract. Bioavailability after taking a standard dose is 50-60%. Practically does not bind to plasma proteins. accumulates in salivary glands, muscles, liver and kidneys. It is excreted unchanged by the kidneys. With impaired renal function, cumulation (accumulation) of the drug is possible.

Indications

type 2 diabetes mellitus without a tendency to ketoacidosis (especially in obese patients) with the ineffectiveness of diet therapy;
in combination with insulin - in type 2 diabetes mellitus, especially with severe obesity, accompanied by secondary insulin resistance.

Release form

Film-coated tablets 500 mg, 850 mg and 1000 mg.

Instructions for use and regimen

The dose of the drug is set by the doctor individually, depending on the level of glucose in the blood.

The initial dose is 500-1000 mg per day (1-2 tablets). After 10-15 days, a further gradual increase in dose is possible depending on the level of blood glucose.

The maintenance dose of the drug is usually 1500-2000 mg per day (3-4 tablets). The maximum dose is 3000 mg per day. (6 tablets).

Metformin tablets should be taken whole during or immediately after a meal with a small amount of liquid (a glass of water). For decreasing side effects on the part of the gastrointestinal tract, the daily dose should be divided into 2-3 doses.

Due to the increased risk of developing lactic acidosis, the dose of the drug should be reduced in severe metabolic disorders.

Side effect

nausea, vomiting;
metallic taste in the mouth;
lack of appetite;
diarrhea;
flatulence;
stomach ache;
lactic acidosis (requires discontinuation of treatment;
hypovitaminosis B12 (malabsorption);
megaloblastic anemia;
hypoglycemia;
skin rash.

Contraindications

diabetic ketoacidosis, diabetic precoma, coma;
impaired renal function;
acute diseases occurring with a risk of developing impaired renal function: dehydration (with diarrhea, vomiting), fever, severe infectious diseases, hypoxia conditions (shock, sepsis, kidney infections, bronchopulmonary diseases);
clinical manifestations of acute and chronic diseases, which can lead to the development of tissue hypoxia (cardiac or respiratory failure, acute infarction myocardium);
serious surgical operations and trauma (when insulin therapy is indicated);
liver dysfunction;
chronic alcoholism, acute poisoning alcohol;
use for at least 2 days before and within 2 days after radioisotope or X-ray studies with the introduction of an iodine-containing contrast agent;
lactic acidosis (including history);
compliance with a hypocaloric diet (less than 1000 calories per day);
pregnancy;
lactation period;
hypersensitivity to the drug.

Use during pregnancy and lactation

When planning a pregnancy, as well as in the event of pregnancy while taking Metformin, it should be canceled and insulin therapy should be prescribed. Since there are no data on penetration into breast milk, this drug is contraindicated during breastfeeding. If necessary, the use of Metformin during the period breastfeeding, breastfeeding should be discontinued.

Use in children

Contraindicated in children and adolescents under the age of 18 years.

Use in elderly patients

It is not recommended to use the drug in people over 60 years of age who perform heavy physical work, which is associated with an increased risk of developing lactic acidosis in them. In elderly patients, the recommended daily dose should not exceed 1 g (2 tablets).

special instructions

During the period of treatment, it is necessary to monitor kidney function. At least 2 times a year, as well as with the appearance of myalgia, the content of lactate in plasma should be determined. In addition, once every 6 months, it is necessary to control the level of creatinine in the blood serum (especially in patients, the elderly). Do not prescribe Metformin if the level of creatinine in the blood is above 135 µmol/l in men and 110 µmol/l in women.

It is possible to use the drug Metformin in combination with sulfonylurea derivatives. In this case, especially careful monitoring of blood glucose levels is necessary.

48 hours before and within 48 hours after radiopaque (urography, intravenous angiography), Metformin should be discontinued.

If a patient develops a bronchopulmonary infection or infectious disease urinary organs you should immediately inform your doctor about it.

During treatment, you should refrain from drinking alcohol and medicines containing ethanol. With the simultaneous intake of alcohol, the development of lactic acidosis is possible.

Influence on the ability to drive vehicles and control mechanisms

The use of the drug in monotherapy does not affect the ability to drive vehicles and work with mechanisms.

When Metformin is combined with other hypoglycemic agents (sulfonylurea derivatives, insulin), hypoglycemic conditions may develop, in which the ability to drive vehicles and engage in other potentially hazardous activities that require heightened attention and rapid psychomotor reactions.

drug interaction

The simultaneous use of danazol is not recommended in order to avoid the hyperglycemic effect of the latter. If necessary, treatment with danazol and after discontinuation of the latter, a dose adjustment of metformin is required under the control of glycemic levels.

Combinations requiring special care: chlorpromazine - when taken in high doses (100 mg per day), increases glycemia, reducing the release of insulin.

In the treatment of neuroleptics and after discontinuation of the latter, dose adjustment of metformin is required under the control of glycemic levels.

With simultaneous use with sulfonylurea derivatives, acarbose, insulin, non-steroidal anti-inflammatory drugs (NSAIDs), MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers, the hypoglycemic effect of metformin may increase.

With simultaneous use with glucocorticosteroids (GCS), oral contraceptives, epinephrine, sympathomimetics, glucagon, hormones thyroid gland, thiazide and loop diuretics, phenothiazine derivatives, derivatives nicotinic acid it is possible to reduce the hypoglycemic effect of metformin.

Cimetidine slows down the excretion of metformin, as a result of which the risk of developing lactic acidosis increases.

Metformin can weaken the effect of anticoagulants (coumarin derivatives).

Alcohol intake increases the risk of developing lactic acidosis during acute alcohol intoxication, especially in cases of starvation or a low-calorie diet, as well as liver failure.

Analogues of the drug Metformin

Structural analogues for the active substance:

Bahomet;
Glycon;
Glyminfor;
Gliformin;
Glucophage;
Glucophage Long;
Langerine;
Metadiene;
Metospanin;
Metfogamma 1000;
Metfogamma 500;
Metfogamma 850;
Metformin;
Metformin Richter;
Metformin Teva;
Metformin hydrochloride;
Nova Met;
NovoFormin;
Siofor 1000;
Siofor 500;
Siofor 850;
Sofamet;
Formetin;
Formin Pliva.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Composition and alcohol

In this article, you can read the instructions for using the drug Metformin. Reviews of site visitors - consumers of this medication, as well as opinions of doctors of specialists on the use of Metformin in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Metformin analogues in the presence of existing structural analogues. Use to treat type 2 diabetes and obesity (weight loss) in adults, children, and pregnancy and lactation. The composition and interaction of the drug with alcohol.

Metformin - inhibits gluconeogenesis in the liver, reduces the absorption of glucose from the intestine, enhances peripheral glucose utilization, and also increases tissue sensitivity to insulin. At the same time, it does not affect the secretion of insulin by pancreatic beta cells, and does not cause hypoglycemic reactions. Reduces the level of triglycerides and low density lipoproteins in the blood. Stabilizes or reduces body weight. It has a fibrinolytic effect due to the suppression of a tissue-type plasminogen activator inhibitor.

Metformin hydrochloride + excipients.

After oral administration, metformin is absorbed from the gastrointestinal tract. Bioavailability after taking a standard dose is 50-60%. Practically does not bind to plasma proteins. It accumulates in the salivary glands, muscles, liver and kidneys. It is excreted unchanged by the kidneys. With impaired renal function, cumulation (accumulation) of the drug is possible.

type 2 diabetes mellitus without a tendency to ketoacidosis (especially in obese patients) with the ineffectiveness of diet therapy;
in combination with insulin - in type 2 diabetes mellitus, especially with severe obesity, accompanied by secondary insulin resistance.

Film-coated tablets 500 mg, 850 mg and 1000 mg.

Instructions for use and regimen

The dose of the drug is set by the doctor individually, depending on the level of glucose in the blood.

The initial dose is mg per day (1-2 tablets). Through the day, a further gradual increase in dose is possible depending on the level of blood glucose.

The maintenance dose of the drug is usually mg per day (3-4 tablets). The maximum dose is mg per day. (6 tablets).

Metformin tablets should be taken whole during or immediately after a meal with a small amount of liquid (a glass of water). To reduce side effects from the gastrointestinal tract, the daily dose should be divided into 2-3 doses.

Due to the increased risk of developing lactic acidosis, the dose of the drug should be reduced in severe metabolic disorders.

nausea, vomiting;
metallic taste in the mouth;
lack of appetite;
diarrhea;
flatulence;
stomach ache;
lactic acidosis (requires discontinuation of treatment;
hypovitaminosis B12 (malabsorption);
megaloblastic anemia;
hypoglycemia;
skin rash.

diabetic ketoacidosis, diabetic precoma, coma;
impaired renal function;
acute diseases occurring with a risk of developing impaired renal function: dehydration (with diarrhea, vomiting), fever, severe infectious diseases, hypoxia conditions (shock, sepsis, kidney infections, bronchopulmonary diseases);
clinically pronounced manifestations of acute and chronic diseases that can lead to the development of tissue hypoxia (heart or respiratory failure, acute myocardial infarction);
serious surgical operations and injuries (when insulin therapy is indicated);
liver dysfunction;
chronic alcoholism, acute alcohol poisoning;
use for at least 2 days before and within 2 days after radioisotope or X-ray studies with the introduction of an iodine-containing contrast agent;
lactic acidosis (including history);
compliance with a hypocaloric diet (less than 1000 calories per day);
pregnancy;
lactation period;
hypersensitivity to the drug.

Use during pregnancy and lactation

When planning a pregnancy, as well as in the event of pregnancy while taking Metformin, it should be canceled and insulin therapy should be prescribed. Since there are no data on penetration into breast milk, this drug is contraindicated during breastfeeding. If it is necessary to use Metformin during breastfeeding, breastfeeding should be discontinued.

Contraindicated in children and adolescents under the age of 18 years.

Use in elderly patients

It is possible to use the drug Metformin in combination with sulfonylurea derivatives. In this case, especially careful monitoring of blood glucose levels is necessary.

48 hours before and within 48 hours after radiopaque (urography, intravenous angiography), Metformin should be discontinued.

If a patient has a bronchopulmonary infection or an infectious disease of the genitourinary organs, the attending physician should be informed immediately.

During treatment, you should refrain from taking alcohol and drugs containing ethanol. With the simultaneous intake of alcohol, the development of lactic acidosis is possible.

Influence on the ability to drive vehicles and control mechanisms

The use of the drug in monotherapy does not affect the ability to drive vehicles and work with mechanisms.

When Metformin is combined with other hypoglycemic agents (sulfonylurea derivatives, insulin), hypoglycemic conditions may develop, in which the ability to drive vehicles and engage in other potentially hazardous activities that require increased attention and rapid psychomotor reactions is impaired.

Combinations requiring special care: chlorpromazine - when taken in high doses (100 mg per day), increases glycemia, reducing the release of insulin.

In the treatment of neuroleptics and after discontinuation of the latter, dose adjustment of metformin is required under the control of glycemic levels.

With simultaneous use with glucocorticosteroids (GCS), oral contraceptives, epinephrine, sympathomimetics, glucagon, thyroid hormones, thiazide and loop diuretics, phenothiazine derivatives, nicotinic acid derivatives, it is possible to reduce the hypoglycemic effect of metformin.

Cimetidine slows down the excretion of metformin, as a result of which the risk of developing lactic acidosis increases.

Metformin can weaken the effect of anticoagulants (coumarin derivatives).

Alcohol intake increases the risk of developing lactic acidosis during acute alcohol intoxication, especially in cases of starvation or a low-calorie diet, as well as liver failure.

Analogues of the drug Metformin

Structural analogues for the active substance:

What to take instead of Metformin for diabetes?

This drug has a number of serious contraindications, therefore, we will consider substitutes for the drug Metformin, whose analogues are in no way inferior to the original in terms of their effect on glucose levels, and even surpass them in some ways. A patient with diabetes requires a systematic decrease in blood glucose levels with Metformin.

The effect of metformin on the body

Thanks to Metformin in a patient with diabetes mellitus:

in the liver, the genesis of glucose is inhibited;
reduced intestinal absorption of glucose;
improves peripheral glucose absorption;
increased insulin sensitivity.

Usually, immediately after ingestion, the elements of the drug spread to the entire body. It is first absorbed into gastrointestinal tract, then after 3 hours reaches the blood plasma and begins its action.

This drug is prescribed to people whose diabetes has reached stage 2. It is especially suitable for obese people. The dose is determined by the doctor, but usually it does not exceed 1000 mg per day (these are 2 tablets of the drug). This is the maximum dose for the elderly. For other patients, it can be gradually increased to 3 grams.

Concerning original drug Metformin, instructions for use describe many side effects. Therefore, not everyone is suitable for long-term treatment. In addition, it is known that its appointment to elderly patients over the age of 60 years is not recommended. Sometimes prescribed combination therapy (Metformin and analogues).

Possible dangerous conditions during treatment with Metformin

With prolonged use this drug or in case of overdose, some dangerous states, which describes the instructions for use, Metformin analogues do not have some of the stated side effects.

So, often when using the drug, patients with impaired renal functioning develop lactic acidosis, which can lead to death. Drinking alcohol during treatment with Metformin is life-threatening, as the risk of developing lactic acidosis increases significantly.

The main signs of this complication:

a significant decrease in body temperature;
diarrhea;
muscle pain;
pain in the abdomen;
loss of consciousness;
coma.

When a patient has such conditions, he is urgently hospitalized, the tactics of treatment are promptly determined and hemodialysis is performed. Metformin is excluded from further therapy of diabetes mellitus.

It is also not recommended to combine treatment with Metformin with Danazol - the patient may develop hyperglycemia. If Danazol is needed, it should be replaced at least temporarily with Metformin analogues, and after the re-appointment of Metformin for treatment, its dose should be adjusted. Also beware simultaneous use this drug with Insulin, NSAIDs, Chlorpromazine, Clofibrate and other medicines. Their combination can lead to hypoglycemia.

During pregnancy and lactation, this drug is excluded, replaced with analogues, or insulin therapy is prescribed. It can penetrate into breast milk, so it is also excluded during breastfeeding. If it is impossible to cancel or replace Metformil, the woman should stop lactation.

Side effects caused by the drug:

nausea accompanied by vomiting;
flatulence;
diarrhea;
dizziness;
lack of appetite;
metallic taste.

These states are temporary. But if they do not go away for a long time, the doctor prescribes treatment with Atropine, antocides and antispasmodics. Other side effects include skin rash, hypovitaminosis of vitamin B, rarely megaloblastic anemia (blood disease) and lactic acidosis.

Metformin analogs

The drug is absolutely contraindicated in patients with kidney and liver diseases. Such a number of contraindications involuntarily makes you think: are there any analogues to this medicine?

The main analogue is Glibenclamide.

Its action, aimed at lowering blood glucose levels, is almost identical to the action of Metformin, only this drug has much fewer contraindications.

The drug is widely distributed throughout the world. According to experimental and clinical studies, it perfectly fights the disease at the molecular level. Its dosage affects the rate of stimulation of insulin secretion.

Other drugs that most often replace Metformin therapy, doctors include:

Gluconorm;
Insulin;
Glucovans Glibenclamide;
Galvus Med Vilda Gliptin and others.

All of the above drugs have peripheral effects on increasing tissue sensitivity. First of all, it improves in adipose and muscle tissues, then glucose uptake at the cellular level improves to the maximum.

If it is possible to replace medications, the doctor prescribes additional tests and diagnostics internal organs. This eliminates the risk of occurrence and development of side diseases.

Metformin

The description is current as of 18.09.2015

Latin name: Metformin
ATX code: A10BA02
Active ingredient: Metformin (Metformin)
Manufacturer: Atoll OOO (Russia)

Composition

The drug contains the active ingredient metformin, as well as additional substances: starch, magnesium stearate, talc.

Release form

The medicine is produced in the form of tablets, which are coated film sheath. Tablets of 500 mg and 850 mg are produced. There can be 30 or 120 pieces in a blister.

pharmachologic effect

Metformin is a substance of the biguanide class, its mechanism of action is manifested by inhibiting the process of gluconeogenesis in the liver, it reduces the absorption of glucose from the intestine, enhances the process of peripheral glucose utilization, and increases the degree of tissue sensitivity to the action of insulin. Does not affect the process of insulin secretion by pancreatic beta cells, does not provoke manifestations of hypoglycemic reactions. As a result, it stops hyperinsulinemia, which is an important factor contributing to weight gain and the progress of vascular complications in diabetes mellitus. Under its influence, body weight stabilizes or decreases.

The agent reduces the content of triglycerides and low density linoproteins in the blood. Reduces the intensity of fat oxidation, inhibits the production of free fatty acids. Its fibrinolytic effect is noted, inhibiting PAI-1 and t-PA.

The drug stops the development of proliferation of smooth muscle elements of the vascular wall. Has a positive effect on the condition of cardio-vascular system prevents the development of diabetic angiopathy.

Pharmacokinetics and pharmacodynamics

After Metformin is taken orally, the highest plasma concentration is observed after 2.5 hours. In people who receive medication in maximum doses, the highest content of the active component in plasma was not higher than 4 μg / ml.

The absorption of the active ingredient stops 6 hours after ingestion. As a consequence, the plasma concentration decreases. If the patient takes the recommended doses of the drug, then after 1-2 days in the plasma there is a stable constant concentration of the active substance in the range of 1 μg / ml or less.

If the medicine is taken with food, then the absorption of the active ingredient decreases. It accumulates mainly in the walls of the digestive tube.

Its half-life is approximately 6.5 hours. The level of bioavailability in healthy people is 50-60%. Its association with plasma proteins is negligible. Approximately 20-30% of the dose is excreted through the kidneys.

Indications for the use of Metformin

The following indications for the use of Metformin are determined:

The drug is prescribed as an additional remedy to the main treatment with insulin, as well as other anti-diabetic drugs. Also prescribed as monotherapy.

The tool is also used for polycystic ovaries, but this can only be done under the strict supervision of a physician.

Contraindications

The following contraindications for the use of Metformin are determined:

the patient's age is up to 15 years;
a high degree of sensitivity to the active ingredient or other components of the drug;
severe kidney disease (dysfunction, insufficiency);
diabetic precoma;
gangrene;
diabetic ketoacidosis;
dehydration (if constant vomiting and diarrhea)
diabetic foot syndrome;
acute myocardial infarction;
dehydration, infectious diseases in severe form, shock and other conditions that can lead to deterioration of kidney function;
insufficiency of adrenal function;
liver failure;
a diet in which a person consumes no more than 1000 kcal per day;
lactic acidosis;
alcoholism in a chronic form;
diseases in which the patient has tissue hypoxia;
fever;
intravenous or intra-arterial administration of radiopaque drugs that contain iodine;
alcohol poisoning;
pregnancy and breastfeeding period.

Side effects

Most often, when taking the drug, they manifest side effects in the functions of the digestive system: nausea, diarrhea, vomiting, abdominal pain, loss of appetite, the appearance of a metallic taste in the mouth. As a rule, such reactions develop during the first time of taking the remedy. In most cases, they disappear on their own with further use of the drug.

If a person has a high sensitivity to the drug, erythema may develop, but this occurs only in rare cases. With the development of a rare side effect - moderate erythema - it is necessary to cancel the reception.

With long-term treatment, some patients experience a deterioration in the absorption of vitamin B12. As a result, its level in the blood serum decreases, which can lead to impaired hematopoiesis and the development of megaloblastic anemia.

Tablets Metformin, instructions for use (Method and dosage)

The tablets should be swallowed whole and washed down with plenty of water. The medicine is drunk after eating. If it is difficult for a person to swallow the 850 mg tablet, it can be divided into two parts, which are taken immediately, one after the other. Initially, a dose of 1000 mg per day is taken, this dose should be divided into two or three doses to avoid side effects. The next dose is gradually increased. The maximum allowed intake is 3000 mg of medication per day.

If Metformin is taken by the elderly, you need to constantly monitor the condition of their kidneys. Full therapeutic activity can be obtained after two weeks after the start of treatment.

If you need to start taking Metformin after taking another oral hypoglycemic drug, you must first stop treatment with such a drug, and then start taking Metformin at the indicated dosage.

If the patient combines insulin and Metformin, then the usual dose of insulin should not be changed in the first few days. Further, the dose of insulin can be gradually reduced under the supervision of a doctor.

Instructions for use Metformin Richter

The dose of the drug is set by the doctor, it depends on the content of glucose in the patient's blood. When taking tablets of 0.5 g, the initial dose is 0.5-1 g per day. Further, the dose can be increased if necessary. The largest dose per day is 3 g.

When taking tablets of 0.85 g, the initial dose is 0.85 g per day. Further, if necessary, it is increased. The highest dose is 2.55 g per day.

Instructions for use Metformin Canon

Instructions for use of this medication provides similar instructions. The dose is determined by the attending physician individually.

Overdose

In case of an overdose, some side effects may occur, which is why it is recommended to take the tablets only at the indicated dose. When taking metformin at a dosage of 85 g, a case of overdose was recorded, as a result of which lactic acidosis developed, in which vomiting, nausea, muscle pain, diarrhea, and abdominal pain were noted. If help is not provided in a timely manner, dizziness, impaired consciousness and coma may develop. Most effective method removal from the body of metformin is hemodialysis. Next, symptomatic therapy is prescribed.

Interaction

Caution should be exercised when combining Metformin with sulfonylurea derivatives due to the risk of hypoglycemia.

The hypoglycemic effect is reduced when taking systemic and local glucocorticosteroids, glucagon, sympathomimetics, gestagens, adrenaline, thyroid hormones, estrogens, nicotinic acid derivatives, thiazide diuretics, phenothiazines.

With the simultaneous administration of Cimetidine, the excretion of metformin from the body slows down, as a result, the risk of lactic acidosis increases.

Hypoglycemic action is potentiated by β2-adrenergic receptor antagonists, angiotensin-converting factor inhibitors, clofibrate derivatives, monoamine oxidase inhibitors, non-steroidal anti-inflammatory drugs and oxytetracycline, cyclophosphamide, cyclophosphamide derivatives.

When using intra-arterial or intravenous contrast drugs containing iodine, which are used for X-ray studies, together with Metformin, the patient may develop renal failure, and the likelihood of lactic acidosis increases. It is important to suspend the reception before such a procedure, during it and for two days after. Further, the drug can be restored when kidney function is reassessed as normal.

High doses of the antipsychotic chlorpropamazine increase serum glucose and inhibit insulin release. As a result, it may be necessary to increase the dose of insulin. But before that, it is important to control the level of glucose in the blood.

To avoid hyperglycemia, it should not be combined with Danazol.

The absorption of metformin is slowed down by guar and cholestyramine, therefore, while taking these drugs, the effectiveness of metformin decreases.

Enhances the effect of internal anticoagulants, which belong to the class of coumarins.

Terms of sale

You can buy a prescription.

Storage conditions

The tool belongs to list B. It must be protected from children and stored at t 25 degrees.

Best before date

The shelf life of Metformin is 3 years.

special instructions

If monotherapy with Metformin is carried out, hypoglycemia is not observed. Therefore, the patient can work with precise mechanisms or control transport. However, when taking the drug in combination with insulin or with other drugs that are used to treat diabetes, hypoglycemia may occur, which, in turn, leads to a violation of mental reactions and coordination of movements.

Do not prescribe pills to people after reaching the age of 60, in the event that they work physically hard. In this case, lactic acidosis may develop.

Patients who take the drug need to determine the content of creatinine in the blood before treatment and then, during treatment, regularly. At normal rate this should be done once a year, with an increased initial level of creatinine, such studies should be carried out 2-4 times a year. With the same frequency, similar studies are carried out for older people.

If the patient is overweight, it is important to follow a balanced diet during treatment.

After the surgical interventions You can resume treatment after 2 days.

Metformin analogs

Which is better - Metformin or Glucophage?

Glucophage is the original drug produced in France, Metformin is its domestic counterpart. Which drug to prefer, should be determined only by the attending specialist.

children

There is not enough experience with this medicine in children.

With alcohol

Alcohol and Metformin should not be combined, since such a combination significantly increases the likelihood of lactic acidosis. Therefore, during the treatment process, it is important to avoid taking alcohol, as well as drugs that contain ethanol.

Metformin for weight loss

Despite the fact that reviews of Metformin for weight loss often appear on the Metformin Richter forum and other resources, this remedy is not intended for people who want to get rid of excess weight. This weight loss drug is used due to its action associated with lowering blood sugar levels and a concomitant decrease in body weight. However, you can only learn about how to take Metformin for weight loss from unreliable sources on the network, as experts do not advise practicing this. However, those who take Metformin to treat diabetes sometimes manage to lose weight with this medicine.

During pregnancy and lactation

Taking Metformin during pregnancy is contraindicated. If pregnancy occurs during treatment with this medicine, you need to stop it and start taking insulin. Natural feeding is stopped if treatment with this drug is necessary.

Reviews about Metformin

Reviews of Metformin tablets from those patients who have diabetes indicate that the drug is effective and allows you to control glucose levels. The forums also have reviews of positive dynamics after treatment with this drug in PCOS. But most often there are reviews and opinions about how drugs Metformin Richter, Metformin Teva and others allow you to control body weight.

Many users report that drugs containing metformin really helped to cope with extra pounds. But at the same time, side effects associated with the functions of the gastrointestinal tract were very often manifested. In the process of discussing how metformin is used for weight loss, doctors' reviews are mostly negative. They categorically do not advise using it for this purpose, as well as drinking alcohol during the treatment.

Metformin price, where to buy

The price of Metformin in pharmacies depends on the drug and its packaging.

The price of Metformin Teva 850 mg is an average of 100 rubles per pack of 30 pcs.

You can buy Metformin Canon 1000 mg (60 pcs.) for 270 rubles.

How much Metformin costs depends on the number of tablets in the package: 50 pcs. can be purchased at a price of 210 rubles. It should be taken into account when buying a drug for weight loss that it is sold by prescription.

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Education: Graduated from the Rivne State Basic Medical College with a degree in Pharmacy. Graduated from Vinnitsa State medical University them. M.I. Pirogov and an internship based on it.

Experience: From 2003 to 2013, she worked as a pharmacist and head of a pharmacy kiosk. Awarded with certificates and distinctions for long-term and conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.

Vita: I am very grateful to Anna (Anna, Anulya is her nickname in Vktakte) for helping me.

Dana: The drug is good, you need to take it for a long time, but due to this you are cured as it should and.

Ekaterina: Hello, I have such a problem a month ago, they cut out a purulent chic on the buttock! all .

Valeria: Zerkalin helps to relieve even severe inflammation. Maybe until the end he will not remove acne (this.

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How to replace Metformin: which is better than analogues?

Metformin analogues can be found in every pharmacy. There are a sufficient number of such medicines today.

They may differ in price, manufacturer or dosage. The main active ingredient unites all these drugs is metformin hydrochloride. It is thanks to him that the hypoglycemic effect of taking such medications is achieved.

Preparations containing metformin are included in the group of third-generation biguanide drugs. Their main advantage is that the hypoglycemic effect begins to appear gradually without reaching too low rates.

What is the active substance Metformin?

The active substance metformin (international generic name- min) is the main active ingredient in a variety of tableted products, which are often prescribed to patients diagnosed with diabetes mellitus. This is a hypoglycemic medication from the group of biguanides of the third generation.

The hypoglycemic drug inhibits the processes of gluconeogenesis, the transport of free electrons in the reactions of respiration in mitochondria.

Metformin stimulates the reactions of glycolysis processes, the cells begin to absorb glucose faster and in greater volume. The drug helps to reduce the absorption of sugars from the lumen of the gastrointestinal tract into the blood plasma. The drug does not cause a sharp decrease in the level of carbohydrates in the blood plasma, since it does not have an activating effect on the processes of insulin production.

The mechanism of action of the active ingredient on human body consists in the manifestation of the following effects:

Reduces the level of decline in glycogen from an organ such as the liver. As a result, there is a basal rise in blood glucose levels.
Slows down the process of glucose synthesis from proteins and lipids.
Favorably affects the stimulation of glucose deposition in the liver.
Helps to neutralize the manifestation of insulin resistance and increases the sensitivity of cells and tissues to this hormone, which is produced by the pancreas.
Favorably affects the reduction of glucose absorption by the intestines.
Promotes the conversion of glucose to lactate in the digestive tract.
Raises the level of lipids in the blood. In addition, at the same time there is a decrease in the amount of bad cholesterol in the body.
Causes muscles to absorb more glucose.

Drugs with metformin have one indisputable advantage over other drugs - it does not lead to the development of hypoglycemia, that is, the level of carbohydrates in the blood does not fall below the normative levels.

Instructions for use of any metformin-based drug indicates that not only developing diabetes mellitus can be an indication for admission. Tablets can also be taken in such cases:

if there is a violation of glucose tolerance or develop problems with glycemia after waking up;
with the development of insulin resistance and significant weight gain (especially in the abdomen)ꓼ
gynecology uses metformin preparations for the treatment of cleropolycystic ovariesꓼ
during manifestation of metabolic syndrome
as a prophylactic to prevent aging of the body.

The active ingredient has a positive effect on the brain and reduces the risk of developing Alzheimer's disease.

What are the trade names of the medicinal product?

Drugs with metformin in pharmacies are provided in sufficient quantities. in large numbers. Modern pharmacology and manufacturing firms produce multiple analogues in different dosage forms. It can be tablets or capsules.

The group of such a medication includes various types of medication.

The original drug Metformin Teva. In such tablets there may be from 0.5 to 1.0 grams of the active substance. Depending on the progression of the disease, the attending physician prescribes the medication with the required amount of metformin hydrochloride. The Israeli manufacturing company is responsible for the production and effectiveness of the tablets. Metformin Teva is a hypoglycemic medication. It is prescribed for the development of type 2 diabetes mellitus. In addition, in addition to the usual dosages, tablets can be presented in a form such as long-acting metformin. Price for medicine will depend on the amount of the active ingredient that is part of the tablets. The average cost, depending on the dose of the active component in the composition of the medication, varies from 77 to 280 rubles.

Metformin Canon is a representative of a foreign drug in Russia. Its manufacturer is the Russian pharmacological enterprise Canonpharma Production. Capsule tablets of such a drug may contain 500, 850 or 1000 mg of the active ingredient. The drug is effective as a sugar-lowering agent, and also contributes to the normalization of excess weight, especially if diet therapy is followed. Metformin Canon has proven itself in the pharmacological market. Its cost is relatively low and varies from 89 to 130 rubles, depending on the required dosage.

Metformin Zentiva is a more expensive representative of this group of hypoglycemic agents. The price of the drug can be from 118 to 200 rubles. The manufacturer is a Slovak company that offers its consumers a drug in the following dosages - 0.5, 0.85 or 1 gram of the active substance. As a rule, Metformin Zentiva is prescribed to normalize the level of carbohydrates in the blood, and also if there is insulin resistance in patients older than ten years of age.

Metformin Richter is included in the analogues of Metformin, produced by one of two manufacturing companies. Geographical location of the pharmaceutical company - the Russian Federation and Hungary. The composition of the drug includes from 500 to 1000 mg of the active ingredient. The mechanism of action of metformin is aimed at eliminating hyperglycemia and normalizing excess weight.

Often such a drug is prescribed as a replacement for the previous medication. The cost of the drug is from 180 to 235 rubles.

How to take medicine correctly?

Tablet preparations based on metformin hydrochloride, as a rule, are prescribed when the first signs of diabetes appear.

The initial dosage of the drug should not be higher than 0.5 grams of the active ingredient. The attending physician may recommend taking the tablets during or after meals, depending on the individual needs of the patient. The number of doses of the drug should not exceed two or three times a day. Only one to two weeks after the start of the therapeutic course, it is allowed to revise the prescribed doses upwards. The maximum possible daily dosage should not exceed two grams of the active ingredient. It should be borne in mind that if the drug is used before the start of a meal, then the effect of the active ingredient may decrease dramatically. In some cases, Metformin is combined with insulin injections. Thus, an increase in the effect of injections is achieved.

Metformin pharmacokinetics indicate that the drug, after oral administration, reaches its maximum plasma concentration in about two and a half hours.

The absorption of the active ingredient stops after six hours after the use of the tablets.

The most popular analogues of Metformin are Siofor and Glucofage

What can replace Metformin tablets? What kind pharmaceutical preparations enjoy particular popularity among consumers?

One of the most popular medicines of the biguanide group is Siofor, which is produced in tablet form. The main active ingredient medicinal substance metroformin hydrochloride acts, silicon dioxide, povidone, magnesium stearate, macrogol are used as auxiliary components.

Siofor 1000 in diabetes is used to lower blood sugar levels. At the same time, a decrease in indicators occurs not only after the main meal, but also allows you to reduce a basic level of. The main active ingredient in Siofor allows you to regulate the production of insulin by the pancreas, which has a beneficial effect on the body and does not provoke the development of hypoglycemia.

The main indications for which Siofor is prescribed are type 2 diabetes mellitus, which is not accompanied by insulin therapy. The action of Siofor is also well manifested in the ineffectiveness of diet therapy.

The active ingredient, which is part of the composition, manifests itself in slowing down the absorption of glucose in small intestine, neutralizes its production by liver cells.

Glucophage is similar in composition and is a tool based on metformin hydrochloride. To date, you can buy tablet preparations of regular or prolonged action. Medical studies have shown that taking Glucophage tablets is half as likely to lead to adverse reactions from the organs of the gastrointestinal tract.

At the same time, the cost of Glucophage Long is an order of magnitude higher than that of other tablet preparations.

What else can replace the drug?

How to replace Metformin? This question may arise in every diabetic. To date, there are more than a hundred drugs that are synonyms or generic analogues.

They may include metformin hydrochloride as the main substance or be one of them (in combination drugs). The originals are presented in the form of cheaper or more expensive tablets. The difference in price may depend on the manufacturer or dosage of the drug.

The most popular names of similar medicines:

What is best for a patient can only be decided by a specialist who manages his disease.

For example, Gliformin is also a member of the biguanide class, which includes metformin hydrochloride. Similar properties of its effect on the body are explained by the fact that it contains the same active substance. Gliformin contributes to additional stimulation of the reserve secretion of insulin by beta cells, and also has a beneficial effect on peripheral utilization. increased amount muscle glucose.

If you simultaneously take Gliformin with other hypoglycemic drugs, its effect on lowering blood sugar increases.

Is there a difference in products with a single active ingredient?

Sometimes you can find patient reviews that the use of Metformin substitutes does not bring the same positive effect. Some begin to show different adverse reactions. It should be noted that the decision on the need to replace the drug should come exclusively from the attending physician, depending on the degree of development of the pathology, as well as the individual characteristics of the patient. That is why, you should not independently engage in the search for drugs that are part of the analogues of the medicine prescribed by the doctor.

In addition, various medical devices may have a single active component, but differ in the quantitative composition of auxiliary agents. It is these additional components that can cause possible harm to the body and cause side effects.

That is why, the opinion of experts boils down to the fact that analogue drugs can replace the main drug only if such a decision was made by the attending physician. As a rule, when switching to other drugs, the absence positive result occurs when the correct regimen of administration or dose of the drug is not observed and if there is a violation in the diet.

What medicines can be used for diabetics will tell the expert in the video in this article.

Metaformin is familiar to all diabetics, because it is a sugar-burning drug. The content of the drug inhibits gluconeogenesis, which in turn stimulates glycolysis, that is, the cells absorb glucose better. The drug is popular and has many analogues.

Firms that produce analogues are located in Russia, Israel and Poland. There is also a manufacturing plant in Hungary. Therefore, the patient often has a question about the effectiveness of these drugs. Do they all work the same way? Let's try to figure it out.

When is Metformin prescribed?

The indications for prescribing this drug are the following reasons: metabolic syndrome, impaired glucose tolerance. It is also indicated for non-insulin dependent diabetes mellitus.

Do not take Metformin to children under 10 years of age, pregnant women with kidney failure or liver disease.

This drug is made in Israel. Tablets are sold with a dosage of 500, 850 and 100 mg. The cost depends on the packaging and ranges from 150-280 rubles.

Metformin MV Teva capsules can be found on the market. Their main difference from the previous drug is an increase in the duration of action. This happens due to the release of active components. Capsules are usually prescribed for people over 65 who have increased physical activity. Complex therapy with these capsules is carried out under strict control.

This sugar-liquefying drug is produced by a domestic Russian company called Canonpharma Production. The dosages are the same as in the Israeli medicine, i.e. 500, 800 or 100 mg. Released by prescription. Prescribed by an endocrinologist. Reception strictly according to the instructions. Capsule tablets, namely in this form Metformin Canon is produced, lower the amount of glucose without causing a state of hypoglycemia. They help improve fat metabolism, remove bad cholesterol.

Tablets can be taken both for mono-treatment and for complex therapy. It is often prescribed to patients with type 11 diabetes after they have gone on a low-carbohydrate diet without getting the desired results. Or those who are moderate physical exercise also do not bring results.

The dosage is selected by the doctor. Treatment usually begins with a single dose of the minimum dose. During treatment, adjustments are made.

Metformin Kanono is not prescribed for children under 10 years of age. Patients noted some side effects. We are talking about the appearance of nausea and lack of appetite. Some were bothered by the strange taste and stomach pains. Very rarely there are serious complications in the case of hepatitis or hypovitaminosis.

When prescribing this drug, the doctor must warn about the refusal to take alcohol for the period of treatment. The relationship between the development of side effects on the background of alcohol intake has been proven.

The Russian analogue is cheaper, from 110 to 140 rubles.

This drug is developed and manufactured by a Slovak company. Indications for its reception are the same as in the previous analogues. It also cannot be prescribed to children whose age is less than 10 years. The dosage is determined by the doctor depending on the severity of the disease. In the course of treatment, individual adjustments are made.

Metformin Richter

These tablets are manufactured in Hungary. Practically indistinguishable from Russian counterpart. The only difference is that Metformin Richter has only two dosage forms. These are 500 and 800 mg. It is also prescribed for the elderly, and is contraindicated in those under 10 years of age. It is excreted for a long time, so patients with kidney problems should be carefully approached with treatment.

Before use, be sure to consult a specialist

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