Isoprinosine dosage for children 5 years old. Isoprinosine - official* instructions for use. Impact on the ability to drive vehicles and other mechanisms

Isoprinosine is a drug that has a pronounced antiviral and immunomodulatory effect (acts as an immunomodulator). The RLS drug encyclopedia states that the drug helps restore the functioning of lymphocytes in immunodeficiency, increases blastogenesis, and has a beneficial effect on the expression of membrane receptors and the activity of lymphocyte cells. International name and naming medicine according to the INN - Inosine pranobex. The medicine is used for monotherapy or combination treatment of adults and children ( childhood– from 3 years and more).

The presence of papillomas, warts, condylomas, moles and spines on the body is the first sign of malignant melanoma!

We hasten to warn you that most medications “treat” warts, papillomas, moles, etc. - this is a complete deception of marketers who make hundreds of percentage points on drugs whose effectiveness is zero. They do not cure the disease, but only mask the symptoms.

The pharmacy mafia makes huge money by deceiving sick people.

But what to do? How to treat if there is deception everywhere? Doctor of Medical Sciences Anatoly Makhson conducted own investigation and found a way out of this situation. IN this article The doctor also told how to 100% protect yourself from melanoma, for only 149 rubles!
Read the article in the official source on link.

What does Isoprinosine help with and what diseases is it used to prevent? The manufacturer Teva notes that the drug is well suited for the treatment of influenza and other acute respiratory viral infections, various viral infectious pathologies.

Isoprinosine is most often prescribed for ARVI, herpes, mononucleosis, sore throat, Epstein Barr virus, colds, coxsackie viruses, thrush, rotavirus, HPV (the medicine is good at getting rid of papillomas and warts). Medicine can also be prescribed for infectious inflammation and as part of comprehensive HIV treatment.

Isoprinosine is not antibacterial drug. This is a drug that has exclusively antiviral and immunomodulatory effects, so the drug is often prescribed as part of a combination therapy using various medications. Speaking about whether it is possible to drink along with antibiotics and other drugs, theoretically there are no such restrictions, but the final decision on the type of complex treatment of a disease or infection with the help of several medications should remain with the doctor.

Important! It is a common belief that any drug that is not an antibiotic can be taken without any restrictions on the consumption of alcoholic beverages. This is a misconception, because Isoprinosine (more precisely, its active components) interacts extremely poorly with ethyl alcohol. The reaction that occurs in the body can lead to negative consequences.

Therefore, you should give up alcoholic beverages if you are undergoing Isoprinosine therapy.
Also as a drug with an immunomodulatory effect, the active ingredient of which is peptidoglycan.

Doctors' opinions on the most effective methods of treating warts and papillomas

Describes his vision on this matter chief physician Moscow City Hospital No. 62. Anatoly Nakhimovich Makhson
Medical practice: more than 40 years.

“I have been treating people’s papillomas and warts for many years. I’m telling you as a doctor, papillomas along with HPV and warts can really lead to serious consequences if they are not dealt with.

The human papillomavirus is present in everyone on whose body there are papillomas, moles, warts and other pigmented formations. According to rough estimates, 80-85% of the planet's population has it. By themselves they are not dangerous. The problem is that an ordinary papilloma can become melanoma at any time.

It's incurable malignant tumors, which kill a person in just a few months and from which there is no escape.

Unfortunately, in Russia and the CIS countries, pharmaceutical corporations sell expensive medications that only relieve symptoms, thereby hooking people on one drug or another. That is why in these countries such high percent cancer diseases and so many people suffer from “non-working” drugs.

The only one medicinal product, which I want to recommend, and it is also officially recommended by WHO for the treatment of papillomas and warts is Papinol. This drug is the only remedy that has an effect not only on external factors(that is, it removes papillomas), and also acts on the virus itself. At the moment, the manufacturer has managed not only to create a highly effective product, but also to make it accessible to everyone. Moreover, within federal program Every resident of the Russian Federation and the CIS can get it for 149 rubles.”

Instructions for use of Isoprinosine

In children and adults, Isoprinosine is prescribed for the treatment of all kinds of viral pathologies and ailments. According to the official annotation, the main substance of the drug is Inosine Pranobex.

The release form of Isoprinosine is 500 mg tablets, packaged in blisters. The official description of the drug states that the mechanism of action active substance The medicine is based on antiviral activity, which acts directly on viruses developing in the human body. There can be a huge number of these viruses, so the decision to prescribe a drug should be made by a doctor. If we talk about why Isoprinosine is prescribed, then we can distinguish several main groups of diseases and pathological conditions. Indications for use are as follows:

1. State of immune deficiency (against the background of viral pathologies in patients with a weak immune system);
2. Subacute sclerosing panencephalitis;
3. Colds, ARVI, flu;
4. Mononucleosis;
5. Severe measles;
6. Infectious skin lesions in intimate areas(growths, warts, etc.);
7. Cognitive molluscum, etc.

The active ingredient in the drug Isoprinosine is inosine pranobex.

How to take Isoprinosine

During therapy viral diseases It is recommended to use 1-4 tablets of the drug per day (for patients over 12 years of age). The use of a larger amount of the drug per day must be approved by a doctor. The dosage for young patients (no older than 12) should be no more than 50 mg per 1 kg of weight per day.

It is allowed to increase the dose for adults and children, if indicated. The entire dose should be divided between 4-5 doses per day. Therefore, when talking about how often you can take Isoprinosine, you should take into account the treatment regimen chosen by your doctor. The doctor can also clarify whether the drug should be taken before or after meals. The usual way to take Isoprinosine is to use the drug after meals.

Side effectsIsoprinosine

Taking Isoprinosine may cause certain side effects:

1. Headaches, increased fatigue, dizziness, poor health, poor sleep;
2. Decreased appetite, gag reflex, nausea, painful sensations in the upper abdomen, digestive problems;
3. Allergic reactions in the form of itching and rash;
4. Polyuria;
5. Pain in the joints.

The compatibility of Isoprinosine and alcohol is very poor, because any drugs with an immunomodulatory effect should not be taken at the same time as drinking alcohol, because the active substances of the drug will be poorly absorbed into the blood, without having the desired effect. Also, the main contraindications include the prohibition of the use of Isoprinosine for treatment during menstruation, with hepatitis B ( breastfeeding).

Reception prohibited this drug during pregnancy not only early stages, but also in the second and third semesters, before giving birth. It is strongly recommended that you stop taking this drug if you expect to become pregnant in the near future.

Isoprinosine and Allokin are often prescribed for complex treatment various infectious diseases, . The drugs combine well with each other.

Important! There is no point in considering the compatibility of Arbidol and Isoprinosine separately, because These drugs are analogues with similar composition and action, so it is worth excluding the option of taking them simultaneously.

Isoprinosine tablets

Instructions for using Isoprinosine tablets are as follows: adults are usually prescribed one, two, three, four tablets per day (depending on the patient’s condition, form and type of disease). Judging by the reviews, doctors prescribe medicine for children according to their weight (no more than 50 mg per 1 kg of weight per day). Therefore, you need to check with your doctor about how much to drink. It is strictly prohibited to independently set the dosage for yourself or your child, because the medicine is potent, and an overdose is fraught with danger. dangerous consequences. You can find out how many tablets are in a package at the pharmacy. Isoprinosine is usually available in a package containing 10 tablets (the quantity may vary depending on the manufacturer).

Contrary to popular belief, Isoprinosine does not exist in the form of suppositories, syrup for children, ointment, injection solution, suspension - the medicine is sold exclusively in tablets.

In fact, the drug Isoprinosine and its analogues (based on the main active ingredient) are prohibited in many countries of the world - they are not sold in pharmacies. This is due to the fact that the effectiveness of this medicine has not yet been proven, despite many positive feedback about it from specialists and patients.

Important! In a number of countries, Isoprinosine is also prohibited for the reason that it contains inosine pranobex, which cannot be used for medical purposes in some countries of the world.

Isoprinosine analogues

On the modern pharmaceutical market you can find many analogues of Isoprinosine. Among a number of drugs, we can distinguish some drugs that are similar in their active substance, type of effect on the human body and infections, viruses. If we talk about how to replace Isoprinosine, we note the following drugs:

1. . Generic and full synonym of Isoprinosine both in composition and in its effect on viruses and the human body as a whole. The drug is being manufactured in a number of European countries. Groprinosin is cheaper than the original, but the medicine is sold immediately in packs of 50 tablets, while Isoprinosin can be bought in quantities of 10 tablets;
2. Novirin. The production of this drug is carried out in Ukraine. It is often prescribed for complex therapy ARVI, parainfluenza, various types influenza, adenovirus. It is often used to treat viral diseases. Also noticeably cheaper than the original;
3. Normomed. The drug is presented in the form of a syrup in which the main active substance is inosine. Manufactured in an Italian pharmaceutical factory. The duration of treatment with this medicine is 7-8 days. Often prescribed for preventive purposes;
4. Amizon. The active substance is amizon. The drug provides good antiviral and anti-inflammatory effects, and also has analgesic and antipyretic properties. Amizon is prohibited from taking by people who have lactose intolerance, tuberculosis, severe kidney and liver diseases. The drug is not prescribed for treatment during pregnancy and lactation, as well as for children under the age of 5-6 years;
5. Anaferon and Giporamin. Russian analogues Isoprinosine. These drugs are antiviral medications, which are used for therapy and prophylactic purposes. Separately, it is worth noting Anaferon, which is a homeopathic remedy, so doctors prescribe it extremely rarely. Hyporamine is an antiviral drug that is sold in pharmacies in various forms: tablets, ointment, suppositories for rectal and vaginal use;
6. Arperflu. A medicine from Belarus, the main active ingredient of which is arbidol hydrochloride. Used as an immunomodulatory antiviral drug, often prescribed for colds viral diseases. Can be used during pregnancy and breastfeeding;
7. Immunal. An immunomodulatory drug made using the main active substance – echinacea. Sold in tablet and syrup form. Taking this medication allows you to increase the number of leukocytes and activate phagocytosis, which helps in destroying the viral infection.

Important! You should not buy Isoprinosine or its analogues unless prescribed by a doctor. It is strictly not recommended to start taking the medicine and prescribe the dosage yourself or your child - the remedy has many side effects, contraindications, therefore, if you have a simple cold, you should limit yourself to the usual medications.

Many of us are worried about warts, papillomas, herpes, shingles and other skin problems. But few people know that all these diseases are caused by tiny infectious particles - viruses. Unfortunately, in the arsenal modern medicine not many are effective antiviral drugs. IN Lately Everyone is hearing about one of the new drugs of this type - Isoprinosine. Of course, the question arises: how reliable and safe is this product?

Description of the medicine

The use of Isoprinosine has a long history. The drug was first used in the 1970s. last century.

The drug belongs to the class of immunostimulating and antiviral agents. The basis of Isoprinosine is a compound also known as inosine or hypoxanthine riboside. Inosine is a natural biological substance found in any cell. From a chemical point of view, inosine is a derivative of purine. Inosine is a nucleotide that is part of transfer RNA, which is necessary for the translation of some compounds important for the cell. Inosine also plays an important role in the mechanism muscle contractions and is a precursor to the ATP molecule.

Other functions performed by inosine in the body:

• anabolic effect;
• antihypoxic effect;
• stimulation of nucleotide synthesis;
• ensuring intracellular energy transport;
• stimulation of metabolism, first of all, activation of the metabolism of pyruvic acid to ensure tissue respiration;
• promotion energy level cells;
• decreased degree of platelet aggregation;
• activation of tissue regeneration, primarily the myocardium and mucous membrane gastrointestinal tract.

The role of the compound is especially important in ensuring the normal functioning of the myocardium affected by coronary disease. By improving microcirculation, the drug is able to improve the size of the necrosis zone. It also has an antiarrhythmic effect, maintains the energy balance of the myocardium, improves coronary circulation, enhances myocardial contractions, and has positive influence on metabolic processes in the heart muscle, promotes greater relaxation of the myocardium during systole. The positive effect of the drug also affects the case of ischemic kidney damage. The compound can help activate metabolism even under conditions of hypoxia and the absence of ATP.

In addition, Isoprinosine, according to some experts, is capable of performing many useful functions in the body, primarily related to the fight against infection. The therapeutic mechanism of Isoprinosine is dual. Firstly, the drug is positioned as an immunomodulatory agent. According to its developers, it is capable of:

• stimulate cellular immunity, increase the activity of monocytes and macrophages, activate the work of leukocytes and lymphocytes (primarily T-lymphocytes and NK-lymphocytes, which destroy cells affected by viruses, as well as T-suppressors and T-helpers);
• stimulate the production of antibodies by B lymphocytes and cytoplasmic cells;
• prevent a decrease in leukocyte activity under the influence of glucocorticosteroids;
• restore the functions of leukocytes in conditions of immunosuppression;
• increase the level of interferon gamma, interleukins 1 and 2;
• reduce the level of special substances – cytokines, which contribute to the development of inflammation;
• stimulate the formation and maturation of immune system cells in the bone marrow;
• improve the recognition of foreign substances and proteins by the immune system.

The immunomodulatory properties of the drug can manifest themselves both at the systemic and local levels.

But the most important thing useful property The drug is that it has direct antiviral activity and is able to prevent the proliferation of viral particles by blocking the work of viral RNA - the molecule that stores genetic code virus and the enzyme dihydropteroate synthetase, responsible for the replication of viral particles. However, this effect of Isoprinosine is not universal. It appears only in relation to the following viruses:

• Herpes simplex of various types,
• Varicella zoster,
• cytomegalovirus,
• Epstein-Barr virus,
• measles virus (Measles morbillivirus),
• T-lymphoma virus,
• influenza viruses types A and B,
• polioviruses (viruses that cause polio),
• equine encephalitis virus,
• ECHO viruses (causing a number of diseases in immunocompromised individuals),
• encephalomyocarditis virus.

The effect of the drug against these types of viruses, according to its manufacturers, was recorded in vivo, that is, inside living organisms.

When using Isoprinosine as a drug against herpes, a decrease in the severity and duration of the disease is observed, fastest healing affected surface, reducing the frequency of formation of blisters and erosions on the skin, swelling.

Isoprinosine is a complex remedy. The preparation contains not only inosine, but also a number of other substances, namely the salt of 4-acetamidabenzoic acid (acidoben) and N,N-dimethylamino-2-propanol (dimepranol). The ratio of the components inosine-acidoben-dimepranol is 1:3:3. A similar complex is called inosine pranobex. The therapeutic effectiveness is determined by inosine, and the purpose of the second and third components is to increase the level of availability of inosine for lymphocytes.

Pharmacokinetics

After oral administration, Isoprinosine is quickly absorbed into the blood from the gastrointestinal tract in almost full volume (90%). The bioavailability of the drug is also high. The maximum concentration in the blood is observed after 1 hour. When taking 1500 mg of the drug, the concentration after 1 hour will be 600 mcg/ml.
Isoprinosine is also eliminated from the body quite quickly, since 2 hours after administration it cannot be detected in the blood. The process of metabolizing the drug begins. Almost all metabolites of Isoprinosine appear in the urine 8-24 hours after administration.

The main metabolite of Isoprinosine is uric acid, which is excreted through the kidneys. However, this may result in the process of acid crystallization, which should be taken into account when prescribing the drug to patients with urolithiasis. Cumulations of active and excipients does not occur in tissues. Acetamidobenzoic acid is metabolized to o-acyl glucuronide, N,N-dimethylamino-2-propanol is metabolized to N-oxide. The half-life of acetamidobenzoic acid metabolites is 50 minutes, the N,N-dimethylamino-2-propanol metabolite is 5 hours. Complete elimination of all drug metabolites from the body occurs within 1-2 days.

Release form

To date, isoprinosine is available only in a single form - in tablets containing 500 mg of inosine pranobex. The tablets also contain a certain amount of excipients:

• mannitol – 67 mg,
• povidone – 10 mg,
• Magnesium stearate – 6 mg,
• wheat starch – 67 mg.

Isoprinosine tablets have an oblong biconvex shape, white color and a slight amine odor. In pharmacies you can find packages of Isoprinosine of 20, 30 and 50 tablets. Isoprinosine is produced by the Hungarian pharmaceutical company.

There is no special pediatric version of the drug, so the standard version must be used to treat children. The medicine is available in pharmacies with a prescription.

The drug can be stored at a temperature no higher than +25°C and for no more than 5 years in a dry place, protected from light and out of reach of children. The drug should not be used after the expiration date.

Isoprinosine analogues

To date, the only structural analogue of Isoprinosine is Groprinosin, which also contains the medicinal complex inosine pranobex and is available in the same dosage as Isoprinosine.

You can also find a number of antiviral and immunomodulating agents in pharmacies. Among them we can mention Cycloferon, Arbidol, Ergoferon, Kagocel. However, they all have a different composition and indications. Therefore, in most cases it will not be possible to replace Isoprinosine with them.

Price

The price of Isoprinosine depends on the number of tablets in the package. The price in online stores for a package of 20 tablets fluctuates around 600-700 rubles, for a package of 30 tablets – around 900-1000 rubles, for a package of 50 tablets – around 1500 rubles. Also, the price depends on the manufacturer, since there is a type of the drug produced by an Israeli pharmaceutical company, and there is a variety produced by a Hungarian company. This circumstance is the imported origin of the drug and explains its relatively high price.

Side effects

Like most other drugs, Isoprinosine is not always and not all patients tolerated equally well. The most common side effects when taking Isoprinosine are allergic reactions - skin rash, urticaria, sometimes swelling. Frequent (more than 1% of cases) side effects of Isoprinosine also include:

• headache,
• dizziness,
• increased fatigue,
• bad feeling,
• loss of appetite,
• nausea,
• vomit,
• pain in the epigastric region.

Somewhat less frequently, other symptoms may occur when taking the drug. adverse reactions from the side:

• Gastrointestinal tract (constipation, vomiting),
• liver and biliary tract (increased activity of transaminases (ALT, AST) and alkaline phosphatase, increased concentration uric acid in blood),
• nervous system (nervousness, drowsiness or insomnia).

The following side effects of Isoprinosine cannot be ruled out:

• polyuria (increased amount of urine excreted during the day);
• joint pain;
• exacerbation of gout in patients suffering from this disease;
• systemic allergic reaction- Quincke's edema.

Instructions for use of Isoprinosine

In case of acute viral diseases it is valid next principle– the earlier the use of the drug tablets began, the greater its effectiveness will be.

The dosage of Isoprinosine is calculated individually. For this, only the patient’s weight is taken into account, but the dosage does not depend on age. The optimal daily dosage is 50 mg/kg of weight (or, to make it easier to calculate, 1 tablet per 10 kg of weight). The resulting number should be divided into 3-4 doses.

In some cases daily dosage for adults, the dose can be doubled by the doctor, up to 100 mg/kg body weight. The dosage for children should not be increased under any circumstances. If the calculated dosage needs to be rounded to a whole number of tablets, always round down. For example, if the patient’s weight is 59 kg, then his total weight body will be equal to 59 * 50 mg or 2950 mg. Since one tablet contains 500 mg, the dosage will be 2950/500 mg or 5.9 tablets per day. Rounding to the whole (downwards) gives 5 tablets. They can be taken three times a day, according to the 2+2+1 scheme, or 4 times a day, according to the 2+1+1+1 scheme. The breaks between doses should be evenly spaced - 6 hours for 4 doses and 8 hours for three times a day.

The maximum daily dosage of the drug for an adult patient is 4 g. In old age, the dosage is not adjusted.

Duration of treatment

The duration of treatment depends on the disease. Diseases for which the duration of treatment is 5-14 days or until disappearance clinical symptoms plus two additional days:

• acute ARVI,
• flu,
• Infectious mononucleosis.

If you need to continue taking Isoprinosine after two weeks, you should consult a doctor

Diseases for which the course of treatment with the drug is 5-10 days, with a possible repetition of the course after 8 days:

• genital and labial herpes,
• shingles,
• cytomegalovirus infection.

Some doctors propose another scheme, according to which, for relapses of chronic diseases, the drug should be taken until the symptoms completely disappear, and then for another 2 weeks. The following regimen can also be used - after the relapse has passed, Isoprinosine should be taken one tablet per day for a month. And when acute diseases The drug should be continued for two more days after the symptoms disappear.

The use of Isoprinosine for papillomas, condylomas and other diseases caused by the human papillomavirus

For papillomas and genital warts Duration of treatment is 14-28 days. In addition, the dosage of the medicine in such cases is somewhat different. For patients over 12 years old, it is 2 tablets 3 times a day. For children 3-11 years old, the dosage is calculated according to the standard formula - 1 tablet per 10 kg of weight. A total of three courses are recommended with a break of a month.

When treating papillomas, tablets can be used as monotherapy; for condylomas, either as monotherapy, or in combination with the surgical removal of condylomas.

For cervical dysplasia caused by the papilloma virus, the drug is taken 2 tablets 3 times a day. A total of three courses are required with a break of 10-14 days.

Isoprinosine for children

Isoprinosine has long been successfully used to treat children. However, it is worth remembering that the dosage in such a case should be less than for the treatment of adults. To calculate the required dosage of Isoprinosine, multiply the child's weight in kilograms by 50 mg. In addition, it should be remembered that Isoprinosine tablets are only suitable for children over 3 years of age.

Other information

Since Isoprinosine causes an increase in the concentration of uric acid in the blood, during the course of treatment with Isoprinosine the concentration of uric acid in the blood and urine should be determined once every two weeks. It is also necessary to do this procedure after completion of treatment. This is especially true in cases where the patient additionally takes drugs that increase the concentration of uric acid in the blood. It should be taken into account that elderly patients are more likely to experience increased concentrations of uric acid in the blood and urine than young and middle-aged patients.

You should also monitor possible changes every month. leukocyte formula, liver enzymes, blood creatinine level.

The tablets cannot be taken during pregnancy and breastfeeding, since their safety during these periods has not been studied.

Cases of overdose of Isoprinosine have never been recorded.

Driving vehicles and working with complex mechanisms

There are no instructions in this regard in the instructions. On the one hand, Isoprinosine does not directly affect nervous system, however, on the other hand, side effects such as drowsiness and dizziness are possible when taking the drug. Therefore, during the course of treatment, persons driving vehicles and performing work that requires concentration should consult a doctor.

Indications

• herpes of all varieties, caused by Herpes simplex viruses types 1-4 and (genital and labial herpes) and Varicella zoster (shingles, chicken pox) ;
• infectious mononucleosis caused by the Epstein-Barr virus;
• papillomas (caused by the human papillomavirus, including laryngeal papillomas and vocal cords fibrous type, genital papillomas);
• condylomas;
• warts;
• flu;
• ARVI;
• severe measles;
• viral bronchitis;
• cytomegalovirus infection;
• acute and chronic hepatitis B and C;
• subacute sclerosing panencephalitis;
• viral molluscum contagiosum;
• other chronic diseases respiratory and urinary tract.

The drug is also used in the following cases:

• in immunodeficiency conditions,
• during the recovery period after suffering serious illnesses,
• in stressful situations to prevent infectious diseases.

But, of course, it is worth remembering that you cannot self-medicate with the drug; it should only be prescribed by a doctor.

Contraindications

As with other drugs, inosine pranobex has situations where it is not recommended. And if there is a need to take the drug, you should first make sure that there are no contraindications in your case.

Fortunately, the drug does not have many contraindications. First of all, this is pregnancy, since the drug has not been tested on pregnant women. In addition, the drug should not be given to children under 3 years of age, and among patients older than this age - to those whose weight is less than 15 kg.

Contraindications also include individual intolerance to the components of the drug and arrhythmias.

Isoprinosine promotes the appearance of uric acid in the blood and urine, which in turn can lead to the appearance of insoluble stones in the urine - urinary stones. That is why taking the drug is contraindicated for diseases of the urinary system - urolithiasis and chronic renal failure. The drug is also prohibited for gout, a metabolic disease in which there is a deposition of insoluble uric acid salts in the tissues of the joints.

The drug should be taken with caution in patients with liver failure. This is due to the fact that the components of the drug are metabolized in the liver.

For viral diseases, drugs are in demand that have activity against viruses, as well as the ability to stimulate immune system sick person so that she can quickly cope with the infection. One of them can be called Isoprinosine. Is such a medication allowed for the treatment of children, when is it used and in what dosage is it prescribed for a particular disease?

Release form

Isoprinosine is available in only one form, which is almost white tablets that have a slight amine odor. They are distinguished by their oblong convex shape and the presence of a mark on one side, along which the drug can be divided into halves. One blister includes 10 tablets, and one pack can contain from 2 to 5 blisters. Such dosage forms, as a suspension, powder, dragee, syrup, capsules or injections, Isoprinosine does not.

Compound

The active component of the drug is a substance called “inosine pranobex”, which is also called “inosiplex” or “isoprinosine”. This is a complex of several compounds, presented in one tablet at a dose of 500 mg.

In addition, the medicine includes wheat starch and magnesium stearate. The medicine also contains povidone and mannitol. These additional ingredients ensure the hardness of the tablet, but occasionally allergies may occur to them, so it is important to take these substances into account when choosing medications for children with allergies.

Operating principle

Isoprinosine has an immunostimulating effect, which consists of the following effects:

• Restoration of depressed lymphocyte function.
• Stimulation of the formation of monocytic cells.
• Activation of receptors on T-helper membranes.
• Prevention of decrease in lymphocyte activity during treatment with glucocorticoid hormones.
• Normalization of thymidine incorporation into lymphocytes.
• Activity stimulation natural killer cells, as well as T cells with cytotoxic effects.
• Supports the function of T cells such as helper and suppressor cells.
• Increased production of immunoglobulin G.
• Activation of the formation of interleukins (types 1 and 2), as well as gamma interferon.
• Blocking the synthesis of cytokines that increase inflammation.
• Strengthening the chemotaxis of macrophages and other white blood cells.

Thanks to this effect, the drug helps fight viral infections, affecting:

• The causative agent of measles.
• Polioviruses.
• Herpes viruses.
• Influenza pathogens.
• ECHO viruses.
• Cytomegaloviruses.
• Causative agents of T-lymphoma and some others.

In addition to enhancing the immune response, the drug affects RNA and enzymes in the cells of some pathogens, which blocks their replication. Inosine pranobex affects other viruses through increased production of alpha and gamma interferon, which has antiviral activity.

Indications

At what age can it be taken?

Pediatricians prescribe the medication from the age of three, but the annotation contains a warning not to give such tablets to children weighing less than 15 kg. If the child is already 3 years old, but his weight is lower, treatment with Isoprinosine is contraindicated. For those children over 3 years old who weigh more than 15-20 kg, the drug is approved.

Contraindications

The medicine is not given in the following cases:

• If the child has hypersensitivity to any of its ingredients.
• If the baby’s kidney function is severely impaired (chronic failure is diagnosed).
• If little patient arrhythmia was detected.
• For urolithiasis or gout.

Side effects

Some patients may experience negative symptoms due to Isoprinosine, such as:

• Skin itching.
• Feeling nauseous.
• Pain in the upper abdomen.
• Painful sensations in my head.
• Vomiting attack.
• Feeling weak.
• Dizziness.
• Joint pain.

After taking the tablets, a blood test may show an increase in urea levels, as well as increased activity liver enzymes. Sometimes the drug causes constipation or loose stool, insomnia or drowsiness, increased urine volume.

Instructions for use

The tablet should be given to the child after meals, offering to wash down the medication with clean water in a small volume. If a small patient cannot yet swallow the drug whole, the tablet can be crushed in a spoon to a powder state, and then given to the child in crushed form, mixed with a small amount of still water.

Dosage

To determine the required dose in childhood, it is important to know the weight of the small patient in kilograms. It is multiplied by 50 and the daily dose of isoprinosine is obtained in mg, which is then divided into 3 or 4 doses.

You can also focus on this ratio - half a tablet for every 5 kilograms of the child’s weight. For example, a child weighs 30 kilograms, which means he needs 50 * 30 = 1500 mg of active compound per day. This is 3 tablets of Isoprinosine, so this patient should be given one tablet three times a day.

If the child is over 12 years old infectious disease is difficult, then the doctor may prescribe a higher dosage of the drug per day at the rate of 100 mg active substance for every kilogram of weight. The resulting number of milligrams is divided into 4, 5 or 6 doses. For example, body weight is 40 kg. Multiplying 40*100, we get 4000 mg, that is, 8 Isoprinosine tablets per day. It turns out that such a child can be given the medicine 2 tablets four times a day or one and a half tablets 6 times a day.

How long to give?

• The duration of use for acute diseases, for example, in the treatment of mononucleosis, is usually 5-14 days. The tablets are given to the child until the symptoms of the disease disappear and for another two days.
• If Isoprinosine is treated chronic pathology with relapses, the drug is prescribed in courses lasting from 5 to 10 days, with an 8-day break between them.
• Treatment herpetic infection often carried out according to this scheme– tablets are given in a therapeutic dose for 5-10 days, and then, to prevent relapses, they are continued in an individually determined maintenance dosage for up to 30 days.
• If a child is diagnosed with human papillomavirus infection, Isoprinosine monotherapy is prescribed for a course lasting 2-4 weeks.
• In cases where the drug is prescribed for a long period, two weeks after starting treatment, it is important to do a blood test to find out the concentration of uric acid. Four weeks after the start of treatment, you need to evaluate your kidney and liver function indicators, and then repeat such tests every month.

Overdose

About cases when too high dose tablets harmed the health of a child or adult patient, the manufacturer does not mention. However, if the drug is accidentally taken in large quantities It is recommended to induce vomiting and consult a doctor.

Interaction with other drugs

• The effectiveness of Isoprinosine will decrease if immunosuppressive drugs are given simultaneously with this medicine.
• Co-administration with acyclovir, zidovudine or alpha-interferon drugs enhances the effect of treatment with such drugs.
• If Isoprinosine is prescribed together with diuretics or xanthine oxidase inhibitors, this will increase the risk of increasing the concentration of uric acid in the blood of a small patient.

Terms of sale

To buy a pack of Isoprinosine at a pharmacy, you first need to visit a doctor and get a prescription for this medicine. average price a package of 20 tablets costs 700 rubles, and for a package containing 50 tablets you need to pay about 1,400 rubles.

Storage Features

Isoprinosine should be kept at home in a place hidden from children, away from sunlight. The recommended storage temperature for the medication is below +25 degrees Celsius. The shelf life from the date of release of the drug is 5 years and must be marked on the package. If the marking is erased or the expiration date has expired, it is unacceptable to give the pills to the child.

Reviews

About the use of Isoprinosine in children there are very different reviews. In positive cases, mothers say that the medicine helped to recover faster from cytomegalovirus infection, herpes conjunctivitis, ARVI and other diseases. Parents note that general state the child quickly returned to normal after taking the pills, and unpleasant symptoms the infections soon disappeared.

However, there are also negative opinions that mention the ineffectiveness of the medicine for some children. Also, many mothers complain about the high cost of the drug, and the form of the medication is called very inconvenient, since many children find it difficult to swallow a hard tablet, and it is very difficult for it to crumble in a spoon. In addition, some reviews note a deterioration in health after a course of Isoprinosine. After treatment, such patients more often developed acute respiratory viral infections or liver problems.

The attitude of doctors towards Isoprinosine is also different. Some doctors often prescribe it for influenza, mononucleosis, measles or herpes, noting a good therapeutic effect in some patients.

Others, including Dr. Komarovsky, advocate evidence-based medicine and claim that the effect of Isoprinosine has not been sufficiently studied, so its use is ineffective.

Positive opinions about such a drug are found mainly from medical practitioners who prescribe the medicine to patients and monitor the patients’ condition. They emphasize that the tablets are effective, but not always, so situations where Isoprinosine does not help are not uncommon.

Dr. Komarovsky’s opinion on immunomodulatory drugs in the video below.

Analogs

A medicine from the company Gedeon Richter called Groprinosin can replace the drug. This medication also contains inosine pranobex in each tablet of 500 mg. It, like Isoprinosine, is allowed to be given to children over three years of age, provided that the child weighs more than 15 kilograms. Contraindications, recommended doses, possible side effects and indications for these drugs are the same. The price of these funds is also approximately the same.

Registration certificate: P N015167/01 - 110210

P N015167/01-110210

Trade name of the drug: Isoprinosine

International nonproprietary name:

Chemical name: Inosine (hypoxanthine riboside): para-acetylaminobenzoic acid (acidobene): M,M-dimethylamino-2-propanol (dimepranol) = 1:3:3 complex

Dosage form:

Compound:

Active substance: Inosine Pranobex (Isoprinosine) - 500 mg

Excipients: mannitol, wheat starch, povidone, magnesium stearate.

Description

Oblong, biconvex tablets, white or almost white, with a slight amine odor, scored on one side.

Pharmacotherapeutic group:

Code ATX : J05AX05

Pharmacological properties

Isoprinosine is a synthetic complex purine derivative with immunostimulating activity and nonspecific antiviral effect. Restores the functions of lymphocytes in conditions of immunosuppression, increases blastogenesis in the population of monocytic cells, stimulates the expression of membrane receptors on the surface of T-helper cells, prevents a decrease in the activity of lymphocyte cells under the influence of glucocorticosteroids, and normalizes the inclusion of thymidine in them. Isoprinosine has a stimulating effect on the activity of cytotoxic T-lymphocytes and natural killer cells, the functions of T-suppressors and T-helpers, increases the production of immunoglobulin (Ig) G, interferon-gamma, interleukins (IL)-1 and IL-2, reduces the formation of pro-inflammatory cytokines - IL-4 and IL-10, potentiates the chemotaxis of neutrophils, monocytes and macrophages. The drug exhibits antiviral activity in vivo against Herpes simplex viruses, cytomegalovirus and measles virus, human T-cell lymphoma virus type III, polioviruses, influenza A and B, ECHO virus (human enterocytopathogenic virus), encephalomyocarditis and equine encephalitis. The mechanism of the antiviral action of Isoprinosine is associated with the inhibition of viral RNA and the enzyme dihydropteroate synthetase, which is involved in the replication of some viruses, enhances the synthesis of lymphocyte mRNA suppressed by viruses, which is accompanied by suppression of the biosynthesis of viral RNA and the translation of viral proteins, increases the production of alpha and gamma interferons by lymphocytes with antiviral properties. When administered in combination, it enhances the effect of interferon-alpha, the antiviral agents acyclovir and zidovudine.

Pharmacokinetics

After oral administration, the drug is well absorbed from the gastrointestinal tract. The maximum concentration of ingredients in blood plasma is determined after 1-2 hours.

It is quickly metabolized and excreted through the kidneys. Metabolized similarly to endogenous purine nucleotides with the formation of uric acid. N-N-dimethylamino-2-propranolone is metabolized to N-oxide, and para-acetamidobenzoate to o-acyl glucuronide. No accumulation of the drug in the body was detected. The half-life is 3.5 hours for N-N-dimethylamino-2-propranolone and 50 minutes for para-acetamidobenzoate. Elimination of the drug and its metabolites from the body occurs within 24-48 hours.

Indications for use

Treatment of influenza and other acute respiratory viral infections;
- infections caused by the Herpes simplex virus types 1, 2, 3 and 4: genital and labial herpes, herpetic keratitis, herpes zoster, chicken pox, infectious mononucleosis caused by the Epstein-Barr virus;
- cytomegalovirus infection;
- severe measles;
- papillomavirus infection: papillomas of the larynx/vocal cords (fibrous type), papillomavirus infection of the genitals in men and women, warts;
- molluscum contagiosum.

Contraindications

Hypersensitivity to the components of the drug;
- gout;
- urolithiasis disease;
- arrhythmias;
- chronic renal failure;
- children under 3 years of age (body weight up to 15-20 kg).

Use of the drug during pregnancy and lactation

Directions for use and doses

The tablets are taken orally after meals with a small amount of water.

The recommended dose for adults and children over 3 years of age (body weight from 15-20 kg) is 50 mg/kg per day, divided into 3-4 doses. Adults - 6-8 tablets per day, children - 1/2 tablets per 5 kg/body weight per day. At severe forms for infectious diseases, the dose can be increased individually to 100 mg/kg body weight per day, divided into 4-6 doses. Maximum daily dose for adults 3-4 g/day, for children – 50 mg/kg/day.

Duration of treatment:

Acute diseases: The duration of treatment in adults and children is usually from 5 to 14 days. Treatment should be continued until clinical symptoms disappear and for another 2 days in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

For chronic recurrent diseases in adults and children, treatment must be continued in several courses of 5-10 days with a break of 8 days.

For maintenance therapy, the dose can be reduced to 500-1000 mg per day (1-2 tablets) for 30 days.

At herpetic infection adults and children are prescribed for 5-10 days until the symptoms of the disease disappear; during the asymptomatic period - 1 tablet 2 times a day for 30 days to reduce the number of relapses.

For papillomavirus infection for adults the drug is prescribed 2 tablets 3 times a day, for children - 1/2 . tablets for 5 kg/body weight per day in 3-4 doses for 14-28 days as monotherapy.

For recurrent genital warts for adults the drug is prescribed 2 tablets 3 times, for children - 1/2 tablets for 5 kg/body weight per day in 3-4 doses per day either as monotherapy or in combination with surgical treatment for 14-28 days, then with three repetitions of the specified course at intervals of 1 month. At cervical dysplasia, associated with the human papillomavirus, prescribe 2 tablets 3 times a day for 10 days, followed by 2-3 similar courses with an interval of 10-14 days.

Side effect

The incidence of side effects after using the drug is classified according to WHO recommendations.

Often:>=1%and<10%.

Sometimes: >=0.1% and<1%.

From the gastrointestinal tract: often - nausea, vomiting, epigastric pain, sometimes - diarrhea, constipation.

From the liver and biliary tract: often - a temporary increase in the activity of transaminases and alkaline phosphatase in the blood plasma, an increase in the concentration of urea in the blood plasma.

For the skin and subcutaneous fat: often - itching.

From the nervous system: often - headache, dizziness, weakness; sometimes drowsiness, insomnia.

From the urinary system: sometimes - polyuria.

From the musculoskeletal system and connective tissue: often - joint pain, exacerbation of gout.

Overdose.

Cases of drug overdose have not been described.

Interaction with other drugs

Immunosuppressants may reduce the effectiveness of the drug. Xanthine oxidase inhibitors and uricosurics (including diuretics) may contribute to the risk of increased serum uric acid levels in patients taking Isoprinosine.

special instructions

After 2 weeks of using Isoprinosine, the concentration of uric acid in the blood serum and urine should be monitored.

With long-term use, after 4 weeks of use, it is advisable to monitor liver and kidney functions every month (transaminase activity in blood plasma, creatinine, uric acid).

It is necessary to monitor the level of uric acid in the blood serum when prescribing isoprinosine in combination with drugs that increase uric acid levels or drugs that impair renal function.

Impact on management ability vehicles and others mechanisms

There are no special contraindications.

Release form

Tablets 500 mg. 10 tablets in a blister of PVC/PVDC and aluminum foil.
2, 3 or 5 blisters in a cardboard pack along with instructions for use.

Best before date
5 years.
Do not use after the expiration date indicated on the package.

Storage conditions

List B. Store at a temperature not exceeding +25 ° C in a dry place, protected from light. Keep out of the reach of children.

Vacation conditions

On prescription.

Manufacturer

Technical Pharmaceutical Society "Luzomedikamenta", Portugal
Packer
Pharmaceutical plant Teva Private Co. Ltd., Hungary
Address for receiving complaints
119049, Moscow, st. Shabolovka, d.Yu, bldg. 2, Business center "Concord"

The composition of 1 tablet of the drug Isoprinosine includes 500 mg (isoprinosine ) - active substance.

Additionally, the tablet contains:

• 10 mg – povidone;
• 67 mg – wheat starch;
• 67 mg – ;
• 6 mg – magnesium stearate.

Release form

The drug Isoprinosine is available in the form of biconvex, oblong tablets, white or similar in color, with a score line on one side.

One package contains 20, 30 or 50 tablets.

pharmachologic effect

Immunostimulating, antiviral.

Pharmacodynamics and pharmacokinetics

Isoprinosine is a complex derivative synthetic purine and exhibits an immunostimulating effect, and also has nonspecific antiviral effects.

The use of Isoprinosine leads to recovery lymphocyte function during immunosuppression , increases blastogenesis in a number of monocytic cells, activates the expression of membrane receptors located on the surface of T-helper cells, prevents a decrease in the activity of lymphocyte cells when exposed to glucocorticoids, and normalizes the interpolation of thymidine in them.

Isoprinosine has in vivo antiviral activity against viruses Herpes simplex (herpes) , measles virus , cytomegalovirus , influenza A and B, human T-cell lymphoma virus type III, human enterocytopathogenic virus, polioviruses, and equine encephalitis And encephalomyocarditis .

The antiviral effects of the drug are associated with inhibition of viral RNA and the enzyme dihydropteroate synthetase, which is involved in the synthesis of some viruses. The drug also stimulates the replication of lymphocyte mRNA, previously suppressed by viruses, which results in inhibition of the RNA biosynthesis of the virus itself and a decrease in the biosynthesis of viral proteins , increases production -alpha and -gamma , which exhibit antiviral effects.

After oral administration, it is well and fairly quickly absorbed from the gastrointestinal tract.

Cmax in blood plasma is observed after 1-2 hours.

It is rapidly metabolized to form uric acid and is excreted in the urine.

No accumulation of the drug in the body was detected.

The half-life for the two metabolites is 3.5 hours and 50 minutes.

Complete elimination of the drug Isoprinosine from the patient’s body occurs after 24-48 hours.

Indications for use of Isoprinosine tablets

• therapy virus and others ARVI;
• infectious diseases that were caused types 1, 2, 3, 4 and 5 (recently, information has appeared about the effectiveness in the treatment of herpes type 6, as well as types 7 and 8), labial herpes, And herpetic keratitis;
• , herpes zoster;
• , due to herpes virus type 4 ();
• measles (in case of severe disease);
• cytomegalovirus infection caused by herpes virus type 5;
• (HPV) , including papillomas of the vocal cords and larynx, fibrous type;
• the drug is also effective in HPV genitals in women and men and in therapy when getting rid of .

Contraindications

• arrhythmias;
• Contraindications to taking Isoprinosine include children under 3 years of age with a body weight of up to 20 kg, and hypersensitivity to the components of the drug.

Side effects

According to WHO recommendations, side effects of Isoprinosine are classified as “common” with a frequency of occurrence from 1% to 10% and “sometimes” with a frequency of occurrence from 0.1% to 1%. Also, the side effects of the drug are divided into groups according to their effect on various organs and systems of the human body.

Gastrointestinal organs:

• often - pain in the epigastric region, feeling of nausea, vomiting.
• Sometimes - or .

Liver and bile ducts:

• often - an increase in plasma activity alkaline phosphatase And transaminases as well as increasing the content urea .

Skin and subcutaneous fat:

• often - itching

Nervous system:

• often - headache , weakness , feeling dizzy.
• sometimes – sleep disturbances ( drowsiness or insomnia ).

Genitourinary system:

• Sometimes - polyuria.

Musculoskeletal system:

• often - exacerbation of gout , joint pain.

Instructions for use of Isoprinosine (Method and dosage)

As a rule, the daily dose of Isoprinosine for adult patients and patients over 3 years old weighing more than 20 kg is 50 mg/kg, in 3-4 doses per day.

Adult patients are prescribed 6-8 tablets per day, children - half a tablet for every 5 kg of weight per day.

If necessary, in severe cases of infectious diseases, the daily dose can be individually increased to 100 mg/kg body weight, in 4-6 doses.

For adult patients, the maximum dose of the drug per day is 3-4 grams.

Instructions for use by children define the maximum daily dose for this age category as 50 mg/kg.

When treating acute diseases, the course of treatment for all age categories continues for 5 to 14 days. After the symptoms of the disease disappear, the pills are continued for another 2 days. If necessary and under the supervision of a physician, the course of therapy can be increased.

For chronic pathologies with relapses, several courses of therapy are prescribed lasting 5-10 days, with an interval of 8 days between courses.

Maintenance therapy can take place with a reduced daily dose of up to 500 mg or 1000 mg (1-2 tablets). The course of treatment is carried out for 30 days.

Herpetic infection requires treatment for 5-10 days until symptoms disappear completely, and continues during the asymptomatic period for another 30 days, at a daily dose of 1000 mg divided into 2 doses (to reduce the risk of possible relapses).

At HPV The recommended daily dose for adult patients is 6 tablets (2 tablets 3 times a day), and half a tablet for every 5 kg of weight for pediatric patients, in 3-4 doses. Monotherapy continues for 14-28 days.

At genital warts with relapses the drug is prescribed in the same doses as for HPV . Treatment can be carried out either in monotherapy or in combination with surgical treatment for 14-28 days. In the future, a three-fold repetition of the course of therapy with breaks of 1 month is indicated.

At , due to exposure HPV , the daily dose is 6 tablets in 3 divided doses (2 tablets each). The course of therapy takes 10 days, followed by 2-3 similar courses, with a break of 10-14 days.

The cost of a course of therapy using Isoprinosine will require significant funds, so before carrying out treatment, take a closer look at how much the tablets of this drug cost, so as not to interrupt the therapy process in the future.

Overdose

Cases of overdose with Isoprinosine have not been described.

Interaction

Uricosuric drugs (including diuretics ), and xanthine oxidase inhibitors increase the risk of increased serum concentrations uric acid , during therapy with Isoprinosine.

Immunosuppressants reduce the effectiveness of Isoprinosine.

Terms of sale

On prescription.

Storage conditions

Store at a temperature not exceeding +25 °C.

Best before date

special instructions

After 2 weeks of therapy with Isoprinosine, it is necessary to conduct studies on the content uric acid in urine and blood serum.

When carrying out long-term treatment (more than 4 weeks), it is recommended to monitor kidney and liver functions every month (activity transaminases , level creatinine , content uric acid ).

It is necessary to monitor the level uric acid in the blood when using Isoprinosine in combination with drugs that increase its level, as well as with drugs that impair renal function.

Isoprinosine analogues

Due to the relative high cost of the drug, analogues are often looked for cheaper than the drug Isoprinosine.

It is worth noting that the price of Isoprinosine analogues can indeed be an order of magnitude lower, but most often they do not have such strongly pronounced immunostimulating and antiviral effects.

It is possible to note a more gentle dosing regimen of the drug Groprinosin , and therefore, it is more often prescribed for the treatment of children and elderly patients.

For children

Isoprinosine for children is prescribed exclusively in those doses prescribed for children in the instructions for use.

Prevention of viral diseases with Isoprinosine most often receives positive reviews for children over 3 years of age.

With alcohol

When carrying out the prevention and treatment of diseases of viral etiology, you should not combine Isoprinosine and alcohol.

Drinking alcohol, especially in large quantities, has a detrimental effect on the human immune system; therefore, the compatibility of drugs for alcohol with alcohol boost immunity , at best will lead to leveling of mutually exclusive effects.

During pregnancy and lactation

The safety of Isoprinosine during pregnancy and lactation has not been studied.