Riboxin recipe in Latin solution. Riboxin solution for injection: instructions for use. Treatment of heart diseases

The medication restores blood circulation in the coronary vessels and increases the energy balance of the heart muscle. Thanks to these properties, the drug is used not only to improve the functionality of the heart and digestive organs, but also to increase endurance and physical fitness.

Description of the dosage form

The main component of the drug is inosine. In appearance, it is a white or yellowish powder with a neutral odor and bitter taste.

Riboxin solution is administered intramuscularly and intravenously

Riboxin injections contain the following substances:

The injection solution (2%) is injected into a vein or muscle. The colorless liquid is packaged in ampoules of 5 and 10 ml.

Properties of the drug

Riboxin is an anabolic drug that has antihypoxic and antiarrhythmic effects. Inosine is a chemical precursor of adenosine triphosphate; it is involved in glucose metabolism and stimulates metabolic processes against the background of hypoxia.

The solution has an antihypoxic and antiarrhythmic effect

The components of the solution for injection stimulate the metabolism of pyruvic acid, as a result, it is normalized cellular respiration even with ATP deficiency. After administration of the drug, its components act on enzymes that participate in metabolic processes. They activate xanthine dehydrogenase, which converts hypoxanthine into uric acid. The solution exhibits a therapeutic effect faster than Riboxin tablets.

Inosine inhibits the process of platelet adhesion, as a result, the likelihood of thrombus (blood clot) formation in the lumen of the vessel decreases. This is a kind of prevention of thrombosis and thromboembolism (blockage blood vessel thrombus). Under the influence of the drug, the processes of regeneration of myocardial tissue and the internal membranes of the digestive organs are launched.

After intravenous administration, the drug enters the tissues that need ATP. Residues of the drug are excreted in urine, feces, bile.

Pros and cons of the drug

The advantages of Riboxin include the effect of inosine on metabolic processes in the heart muscle. The drug increases the energy balance of heart muscle cells, accelerates the formation of nucleoside phosphates (phosphorus esters of nucleosides), as a result, the regeneration of heart tissue is accelerated. The drug normalizes the contractile activity of the heart muscle and the complete course of diastole (relaxation of the myocardium between contractions).

The disadvantages of Riboxin include its ability to change the natural sequence of the metabolic cycle. This means that inosine, coming from outside, corrects metabolic processes. Doctors try not to interfere with human physiology, since medicinal properties drugs can provoke dangerous complications. But if there is a pathological process in the body that causes destructive changes in the myocardium, then it is simply necessary to change the metabolism. Without intervention, the likelihood of death increases.

Riboxin is prescribed for ischemia, arrhythmia, porphyria, cirrhosis, etc.

Purpose of Riboxin

According to the instructions for using Riboxin in ampoules, the medication has the following indications:

• Cardiac ischemia (complex therapy). The drug is used regardless of the stage of the disease, as well as during recovery after a heart attack.
• Primary myocardial damage of unknown etiology. Then Riboxin is used for a long time.
• For arrhythmia, the drug helps normalize the heart rhythm. The best effect can be achieved during the treatment of a disease that arose as a result of an overdose of medications.
• Congenital porphyria.
• Cirrhosis, steatosis (replacement of liver cells with fatty tissue), hepatitis, etc. For these diseases, Riboxin is used in the composition complex therapy.
• Open-angle glaucoma (complex therapy).
• Radiation therapy is also an indication for use. The medicine makes the procedure easier to perceive and reduces the severity of adverse reactions.
• Prolonged intense physical activity, which negatively affects general state.
• Pregnant women are prescribed the drug exclusively by the attending physician, who then monitors the patient’s condition.

These are the main indications for the use of the drug.

A prescription is not required to purchase Riboxin.

Precautionary measures

The instructions for using injections state that the medication is prohibited from being taken in the following cases:

• Intolerance to inosine and other components of the drug.
• Gouty arthritis.
• Increased concentration uric acid in blood.
• During pregnancy and breastfeeding.
• Patients younger than 12 months.

Riboxin in the form of a solution is contraindicated in case of gout, pregnancy, breastfeeding, hypersensitivity to components

In case of functional renal failure, the drug is used when the possible benefit outweighs the potential risk. The decision to prescribe medication is made solely by the attending physician.

During the period of therapy, you need to regularly take blood tests. This is necessary in order to control the concentration of uric acid.

The medicine is not prescribed to patients in the younger age category due to the lack of information about its safety. The reaction of a child's body to the drug is unpredictable, so it is not worth the risk.

Riboxin does not cause drowsiness, for this reason it is used before activities related to concentration.

Typically, patients tolerate the effect of the solution well, but sometimes it still provokes negative reactions:

• decreased blood pressure;
• increased concentration of urea and its salts;
• cardiopalmus;
• rash on the skin that itches;
• skin redness;
• nettle fever;
• general weakening of the body;
• with long-term therapy, gout worsens.

Drug interactions

Riboxin interacts with other medications in different ways:

• β-adrenergic receptor blockers. Riboxin can be combined with drugs from this group.
• Cardiac glycosides. This combination prevents arrhythmia and makes it more pronounced inotropic effect. Riboxin enhances the effect of heparin on long time. Nitroglycerin, Nifedipine, Furosemide, Spironolactone can be combined with Riboxin.
• Alkaloids. This is a clear example of incompatibility, when substances react, the alkaloid base is separated, resulting in the formation of insoluble compounds.
• Tannin. When combined, a precipitate forms.
• Acids, alcohols, heavy metal salts. Complete incompatibility.
• Pyridoxine (vitamin B6). Should not be used together, as both compounds are deactivated.

Any combination of Riboxin with other drugs is created by the attending physician

Solution dosage

Riboxin in ampoules is administered intramuscularly and intravenously. Quick jet injections are administered in a minimum dosage - 10 ml of solution (2%) once. Then, if the patient tolerated the medicine well, the dose is increased to 20 ml 1 or 2 times a day. The therapeutic course lasts from 10 to 15 days. The dose of medication is increased only if the patient tolerates Riboxin well.

For acute heart rhythm disorders, 10 to 20 ml of solution is administered once.

To protect kidneys affected by ischemia, the medicine is administered using a syringe in a dosage of 60 ml 10-15 minutes before the doctor clamps the renal artery. Then it is necessary to administer another 40 ml of the medicine immediately after the resumption of blood circulation.

Parenteral administration is a method of administering a solution using a dropper. Before administering the solution, it must be mixed with glucose (5%) or 250 ml of sodium chloride. The rate of administration of the medicine by the drip method is from 40 to 60 drops per minute.

Riboxin during pregnancy and lactation

According to the instructions for use, Riboxin is prohibited from use during gestation and breastfeeding. However, despite this, doctors prescribe the drug to expectant and new mothers. Many women are afraid to take medicine so as not to harm the child. But according to doctors, therapeutic doses of the drug will only bring benefits.

The drug improves metabolism and energy supply to tissues, that is, the body of the woman and fetus is more actively saturated with useful substances during their deficiency. This is one of the main advantages of Riboxin.

During pregnancy, a woman often suffers from oxygen deficiency. This is very dangerous condition, since during pregnancy the respiratory organs of the expectant mother must provide oxygen not only to her body, but also to the body of the fetus. Often the lungs and bronchial tree are not able to saturate two organisms with oxygen. Riboxin has an antihypoxic effect; the drug minimizes the effects of oxygen starvation and saturates the body with the necessary gas.

Riboxin injections are taken during pregnancy and breastfeeding only under the supervision of a doctor.

The drug restores normal contractile activity of the heart muscle. The medication regulates the metabolism of myocardial muscle cells and stimulates trophic processes. That is why Riboxin is used to prevent arrhythmia, tachycardia and other disorders of myocardial functionality.

Riboxin for animals

The pharmaceutical origin of Riboxin is non-specific, for this reason it is used in veterinary medicine. The drug is often prescribed to treat heart disease in cats and dogs. In this case, the medication has the following indications:

• Functional heart failure.
• Myocarditis.
• Endocarditis.
• Myocardosis (to improve the metabolic abilities of the heart).
• Heart defects.

These are the most common heart problems in older animals.

The solution is administered intramuscularly, as this is the most rational method of administration for animals. Daily dosage medications - from 100 to 200 mg/10 kg of total weight three times. The therapeutic course lasts no longer than 4 weeks. If necessary, the veterinarian will prescribe a second course in order to more thoroughly adjust the metabolism or eliminate severe degenerative changes.

Patients about Riboxin

Many patients and doctors speak well of the effect of the liquid dosage form of Riboxin. The drug is usually well tolerated by patients and has wide range actions. The medication has a beneficial effect on the heart muscle, stomach, and intestines.

“My grandmother, who suffered 2 heart attacks, used Riboxin as prescribed by a cardiologist. I was prescribed medication after mitral valve prolapse was discovered. I administer the solution in the dosage indicated by the doctor in courses. I carry out treatment twice a year. I am satisfied with the effect of the drug. Riboxin improves not only the functionality of the heart, but also the liver. I recommend the drug to everyone to whom a doctor prescribed it. Use the medicine, as the consequences of the disease can be very dangerous. I didn’t find any side effects during treatment.”

“About 4 months ago, interruptions in the functioning of the heart appeared, which manifested themselves rapid heartbeat, tremors in the chest, followed by a pause. In addition, there was shortness of breath, weakness, dizziness, my vision was getting dark, and several times I felt like I was about to lose consciousness. These symptoms scared me very much, so I went to the hospital. After examination, the cardiologist diagnosed extrasystolic arrhythmia and prescribed Riborxin. First, I administered the solution intravenously, 5 ml once for 2 days. Then the portion of the medicine was increased to 10 ml once a day for 10 days. After using the solution, I was prescribed tablets, which I used for 3 months. I felt an improvement after just a week of using Riboxin. Now the heart is working normally. By the way, there were no side effects during the therapeutic course.”

“I was prescribed Riboxin during pregnancy, as I had hypoxia and my heart was not working properly. The doctor prescribed injections, which were administered to me for 10 days. After treatment, my condition improved significantly. The child was born healthy, and my allergies did not manifest themselves during treatment. So I recommend it to expectant mothers if the doctor recommends such treatment.”

Based on all of the above, Riboxin solution is effective drug, which exhibits antihypoxic and antiarrhythmic effects. The drug has a beneficial effect on the functionality of the myocardium, as well as digestive tract. To avoid side effects the medicine is used only for medical reasons, and the patient must strictly follow all the doctor’s recommendations regarding its use.

Riboxin in ampoules

Manufacturer: Arterium (Arterium) Ukraine

ATS code: C01EB14

Release form: Liquid dosage forms. Injection.

General characteristics. Compound:

1 ml of solution contains inosine 20 mg;

Excipients: hexamethylenetetramine, 1 M sodium hydroxide solution, water for injection.

Pharmacological properties:

Pharmacodynamics. Riboxin is an anabolic drug that has antihypoxic and antiarrhythmic effects. It is a precursor of ATP, is directly involved in glucose metabolism and promotes metabolism activation under hypoxic conditions and in the absence of ATP. The drug activates the metabolism of pyruvic acid to ensure the normal process of tissue respiration and promotes the activation of xanthine dehydrogenase. Riboxin has a positive effect on metabolism in the myocardium, in particular, it increases the energy balance of cells, stimulates the synthesis of nucleotides, and increases the activity of a number of Krebs cycle enzymes. The drug normalizes the contractile activity of the myocardium and promotes complete relaxation of the myocardium in diastole due to the ability to bind calcium ions that penetrated the cells during their excitation, and activates tissue regeneration (especially the myocardium and the mucous membrane of the digestive canal).

Pharmacokinetics. When administered intravenously, Riboxin is quickly distributed in tissues, metabolized in the liver, where it is completely utilized in the biochemical reactions of the body. Excreted mainly in urine.

Basic physicochemical characteristics: transparent colorless liquid.

Incompatibility. The drug should not be mixed with other medicines in one syringe or in one infusion system. Use only recommended solvents.

Indications for use:

Complex treatment of coronary heart disease (condition after myocardial infarction, angina pectoris), heart rhythm disturbances, intoxication with cardiac glycosides, treatment of cardiomyopathies of various origins, myocardial dystrophies (against the background of severe physical activity, infectious and endocrine origin), myocarditis; liver diseases (hepatitis, liver cirrhosis, fatty liver); prevention of leukopenia during irradiation. To improve visual function in open-angle glaucoma with normalized intraocular pressure.

Directions for use and dosage:

Apply intravenously by drip or stream. First, 200 mg (10 ml of a 2% solution) is administered once a day, then, if well tolerated, up to 400 mg (20 ml of a 2% solution) 1-2 times a day. The course of treatment is determined individually (on average per day).

When administered drip into a vein, a 2% solution of the drug is diluted in a 5% glucose solution or 0.9% sodium chloride solution (up to 250 ml). The drug is administered drip-wise slowly, at a drop rate of 1 minute. In case of acute cardiac arrhythmias, a single dose of jet injection (10-20 ml of 2% solution) is possible.

Adverse reactions. Patients with hypersensitivity to the drug may experience allergic reactions(itching, skin hyperemia, rash, urticaria). From the heart side vascular system possible: arterial hypotension, tachycardia. Various manifestations are possible local reactions, general weakness.

In rare cases, during treatment, an increase in the level of uric acid in the blood may occur, and with prolonged treatment, an exacerbation of gout may occur.

Features of application:

At renal failure the use of the drug is possible only when, in the opinion of the doctor, the expected positive effect exceeds the possible risk of use.

During treatment, the level of uric acid in the blood should be regularly monitored.

The ability to influence reaction speed when driving vehicles or operating other mechanisms. No data.

Side effects:

If adverse reactions occur, the drug should be discontinued.

Interaction with other drugs:

With simultaneous use of Riboxin with beta blockers, the effect of Riboxin does not decrease. In combination with cardiac glycosides, the drug can prevent the occurrence of arrhythmias and enhance the inotropic effect. Riboxin can enhance the effects of heparin, increasing the duration of its action. Possible simultaneous use with nitroglycerin, nifedipine, furosemide, spironolactone. Incompatible with alkaloids in the same container: upon interaction, the alkaloid base is separated and insoluble compounds are formed. Forms sediment with tannin. Incompatible with acids and alcohols, salts of heavy metals. Incompatible with vitamin B6 (pyridoxine hydrochloride) due to deactivation of both compounds.

Contraindications:

Increased individual sensitivity to the drug. Gout, hyperuricemia. A limitation to the use of Riboxin is renal failure.

Use during pregnancy or breastfeeding. Studies of the effectiveness and safety of use for this group of patients have not been conducted.

Children: Should not be used in children due to lack of safety data.

Overdose:

Individual intolerance to the drug in the form of itching, skin hyperemia is possible (the drug is discontinued and desensitizing therapy is carried out).

Storage conditions:

Shelf life: 3 years. In a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Vacation conditions:

Package:

5 ml or 10 ml per ampoule; 10 ampoules per box. 5 ml or 10 ml per ampoule; 5 ampoules in a blister; 2 blisters per pack.

Riboxin

Description current as of 10/28/2014

• Latin name: Riboxin
• ATX code: C01EV
• Active ingredient: Inosine
• Manufacturer: Binnopharm ZAO (Russia); Asfarma (Russia); Ozon LLC (Russia); Irbit Chemical Pharmaceutical Plant (Russia); Borisov Medical Preparations Plant (Republic of Belarus).

Compound

1 tablet of the pharmaceutical drug contains:

• Riboxin – 0.2 g;
• Calcium stearate;
• Potato starch;
• Powdered sugar;
• Opadry II Yellow coating mixture - Indigo carmine (E 132), Lactose monohydrate, Titanium dioxide (E 171), Macrogol (polyethylene glycol 3000), Quinoline yellow (E 104), Iron oxide (E 172).

Composition of solution for injection:

Release form

• 2% solution for injection in ampoules of 10 ml (total content of the main active substance– 200 mg). Cardboard box holds 10 ampoules.
• TabletsRiboxin yellow color, covered with a shell with a biconvex surface. In the cross section, two layers are clearly visible. The drug is packaged in contour cellular blisters made of aluminum foil or PVC, 10 tablets each. A pack contains 1, 2, 3, or 5 plates.
• Riboxin Lect - capsules containing Inosine - 0.2 g. 20, 30 or 50 pieces are placed in a cardboard package.

pharmachologic effect

What is Riboxin?

Riboxin is an anabolic drug that has nonspecific antihypoxic and antiarrhythmic effects. The main active component of the drug is Inosine (Inosine - INN or international generic name pharmaceutical products) is a chemical precursor of adenosine triphosphate (ATP), which is directly involved in the metabolism of glucose and promotes the activation of metabolic processes in conditions of oxygen deficiency (“oxygen starvation”).

Mechanism of action of the drug

Biologically active substances, which are part of the drug, activate the metabolism of pyruvic acid (PVA), which ensures the normalization of tissue respiration even in the absence of the required amount of ATP. The active components also affect the enzymatic component of metabolic processes - when they enter the human body, they stimulate the activity of xanthine dehydrogenase, which in turn catalyzes oxidative reactions followed by the formation of uric acid from hypoxanthine.

The benefits and harms of Riboxin

The positive effects of the pharmaceutical drug include the effect of the main components of Riboxin on metabolism in the myocardium (heart muscle). Thus, the therapeutic properties of the drug are manifested in an increase in the energy balance of cardiomyocytes, accelerated formation of nucleotides, which is manifested in enhanced processes of physiological regeneration of cardiac tissue. That is, the medicine helps to normalize the contractile activity of the myocardium and a more complete course of diastole, when the heart completely relaxes due to the ability to bind with chemical chains of calcium ions that penetrate into the intracellular space during systole.

The negative effects of Riboxin include a change in the physiological sequence of the metabolic cycle. That is, the active components of a pharmaceutical drug, coming from outside, make adjustments to metabolic processes. As a rule, qualified specialists try, if possible, not to interfere in this area of ​​​​biochemistry of the human body, since therapeutic effects can cause very adverse consequences for the patient. However, in the presence of a pathological process that destructively affects the heart muscle (the vital “pump” of the circulatory system), a change in metabolism is necessary, because non-intervention will lead to a much worse outcome.

Wikipedia about Riboxin

The free encyclopedia of knowledge on the Internet also reveals some aspects pharmacological action medicine. In particular, all the cardiac effects of the biologically active components that make up Riboxin are described. In addition, on the page about this medicine there is information about the effect on the cellular component of the blood coagulation system - Inosine reduces platelet aggregation, thereby reducing the risk of developing thrombosis and thromboembolism. The regenerative therapeutic properties of the pharmaceutical drug extend not only to the heart muscle, but also to the mucous membrane of the gastrointestinal tract.

Separately, it should be noted that Inosine pranobex is a type of drug that has immunostimulating activity and a nonspecific antiviral effect. The drug suppresses harmful pathogens such as viruses herpes simplex, CMV (cytomegalovirus), measles and T-cell lymphoma virus type 3, human enterocytopathogenic virus and many others. The mechanism of this action lies in the inhibition of ribonucleic acid and inhibition of the biological catalyst dihydropteroate synthetase, which manifests itself in the suppression of viral replication and increased production lymphocytes interferons that destroy pathological organisms.

Pharmacodynamics and pharmacokinetics

When taken orally, Riboxin is well and almost completely absorbed into the body. gastrointestinal tract. When administered intravenously, the pharmaceutical drug is quickly distributed into tissues that need ATP. Regardless of the route of administration, unused active ingredients are metabolized in the liver, where the final stages of metabolic biochemical reactions take place. A small amount of Riboxin is excreted in urine, feces and bile.

Indications for use of Riboxin

Indications for use of Riboxin tablets:

• Complex treatment of coronary heart disease (angina pectoris, coronary insufficiency, condition after myocardial infarction);
• Intoxication with cardiac glycoside drugs;
• Cardiomyopathies of various origins;
• Myocarditis;
• Rheumatic, congenital and acquired heart defects;
• Cardiac arrhythmia;
• Myocardial dystrophy of infectious or endocrine origin (especially against the background of heavy physical exertion);
• Coronary atherosclerosis;
• Nonspecific liver diseases (hepatitis, fatty degeneration of the parenchymal organ, cirrhosis);
• Drug and alcohol liver damage;
• Urocoproporphyria;
• Prevention of a decrease in the number of leukocytes during irradiation;
• Peptic ulcer of the stomach and duodenum;
• Open-angle glaucoma with normalized intraocular pressure.

Specific indications for the use of injections:

• Urgent pathological conditions of cardiac arrhythmia;
• Surgeries on an isolated kidney (as a means of pharmacological protection in case of temporary absence of blood circulation);
• Arrhythmias of unknown etiology in medicine;
• Acute radiation exposure to prevent the development of changes in the blood formula.

Contraindications

• Hereditary or acquired intolerance to the constituent components of a pharmaceutical drug;
• Individual hypersensitivity to the active ingredients of the drug;
• Gout;
• Kidney failure;
• Hyperuricemia (increased amount of uric acid salts in the blood).

Side effects

As a rule, the medicine is well tolerated, only in isolated cases the following side effects are observed:

Instructions for use of Riboxin (Method and dosage)

Riboxin tablets, instructions for use

Tablets are used orally, before meals. The dosage, as a rule, is set individually in view of the characteristics of the metabolism of the active components and indications for conservative therapy. However, there are certain general schemes treatment with this pharmaceutical drug, according to which daily dose for adults and children over 12 years of age is 0.6-2.4 g per day. Sanitation begins with small dosages (about 0.6-0.8 g - 1 tablet 3-4 times a day), and then, if the medicine is well tolerated and has a beneficial effect on the body, the dose is gradually increased over 2-3 days .

The maximum amount of the drug taken is 2.4 g per day - 4 tablets 3 times per day. This dosage is achieved after 2 months of the course. conservative treatment, the entire duration of which, as a rule, lasts from 1 to 3 months and is regulated taking into account individual indications for therapeutic intervention.

Separately, it should be noted how to take tablets for urocoproporphy, since the pathophysiology of this disease associated with an increase in uric acid salts in biological fluids and secretions. Riboxin, in turn, accelerates the metabolism of urates, activating the enzymatic oxidation of hypoxanthine. Therefore, in order to avoid deposits and the formation of stones, the dosage of the drug is 0.8 g per day - 1 tablet 4 times a day and must be strictly observed during conservative treatment.

Riboxin injections, instructions for use

Slow drip parenteral administration or rapid jet injections are used, depending on individual indications and the urgency of the pathological condition. If the attending physician chooses injections, then first apply a minimum dosage of 200 mg of Riboxin (10 ml of 2% injection solution) once a day. In case of acute cardiac arrhythmias, a single dose of Inosine (10-20 ml of 2% solution) intravenously can be used.

The dosage of jet administration is increased only if the drug is well tolerated. The maximum amount of the drug can be 400 mg of Riboxin (two ampoules of a 2% solution) 1 or 2 times a day. The duration of the course is selected individually (according to the general protocol - days).

If you use Riboxin intravenously (intravenously), then before its administration, a 2% solution of the drug must be diluted in 5% glucose or a hypotonic sodium chloride solution (concentration - 0.9%) to obtain 250 ml of medicinal liquid. The rate of administration is drops per minute.

Instructions during pregnancy

Riboxin is used intravenously for pregnant women, because in this way its effects are revealed more fully. The dosage and duration of the course of conservative therapy is selected strictly individually in each individual case, based on the results of various clinical studies and the opinion of qualified specialists.

How to use Riboxin Lect?

The dosage and duration of treatment with this variation of the pharmaceutical drug do not differ from the generally accepted protocols for therapeutic care with Riboxin. However, the Lect form of the drug is not used as an emergency correction of dysfunction of the heart muscle or other organs, since its effects develop somewhat more slowly.

Overdose

The medical pharmacological literature does not describe cases of overdose with this pharmaceutical drug.

Interaction

The combined use of a drug with cardiac glycosides enhances the inotropic effect of the latter and prevents the development of such an adverse effect drug treatment, as the occurrence of arrhythmia, for which Riboxin is sometimes prescribed together with this group of pharmaceuticals.

Simultaneous use of Riboxin with anticoagulants such as heparin increases the duration of their therapeutic action.

The drug is completely incompatible with acids and alcohols, pyridoxine hydrochloride or vitamin B6, since both are deactivated chemical compounds, salts of heavy metals, plant alkaloids. The latter, when interacting with Riboxin, form insoluble and non-removable compounds due to the detachment of the alkaloid base.

Terms of sale

The drug belongs to list B, therefore it can be purchased only upon presentation of a certified receptor form. Certain old-fashioned pharmacy stalls may even require a prescription in Latin.

Storage conditions

The medicine should be stored in its original packaging at temperature conditions not higher than 25 degrees Celsius in a dry place, out of reach of children younger age place. Also, the drug should be protected from exposure to direct sunlight.

Best before date

special instructions

Riboxin in bodybuilding

The pharmaceutical drug is classified as a metabolic agent and biochemical stimulant, so the drug can be used to gain weight, improve physical performance and increase strength. Riboxin was actively used in sports back in the 70s. The following types of nutrition for bodybuilders are known, which are actively sold to this day:

• Premium Inosine;
• Ultimate nutrition;
• Inosine mega-pro;
• Inosine life extension;
• Cell-tech hardcore.

How to take Riboxin for bodybuilding?

In sports nutrition, a tablet form of the drug is used, which is administered orally before meals. The dosage ranges from 1.5 to 2.5 g per day. As for therapeutic purposes, the number of tablets taken should be gradually increased from a starting dosage of 0.6-0.8 g 3-4 times a day to 2.5 g. Riboxin for athletes should be used for 4 weeks to 1.5 -3 months.

To enhance the effect of the drug on the myocardium and reduce the period of mid-mountain and climatic adaptation, Potassium orotate and Riboxin can be used together. In this case, the dosage of the potassium salt of orotic acid is 0.25-0.5 g 2-3 times a day before meals (course duration is days), and Riboxin is used according to the above scheme.

Riboxin in veterinary practice

The drug is non-specific in its pharmaceutical nature, therefore it can also be used in veterinary therapeutic practice. Often the drug is used for dogs to eliminate heart failure, treat myocarditis and endocarditis, improve the metabolic abilities of the muscular organ with myocardosis and heart defects, which are very common senile problems in animals.

How should animals take Riboxin?

As a rule, the drug is administered intramuscularly, because this is the most rational route of administration in veterinary practice. The dosage is 0.1-0.2 g of the drug per 10 kg of animal weight 3 times a day. The course of conservative treatment lasts about a month. Repeated prescriptions of Riboxin are possible for a more thorough correction of metabolism or elimination of deep degenerative changes.

Riboxin's analogues

Riboxin analogues constitute a small pharmaceutical group with an identical main active ingredient - Inosie-F, Inosine, Riboxin bufus, Ribonosine. As a rule, the price of these medicines is even lower, which is why Riboxin tablets can be replaced with these analogues for greater savings.

With alcohol

Riboxin IV (intravenously) should not be combined with drinking alcohol, as this can lead to side effects from the list above or the emergence of new adverse effects of conservative therapy with a pharmaceutical drug.

Riboxin during pregnancy (and lactation)

The pharmaceutical drug is actively prescribed during the most critical periods for a woman, which, as a rule, plunges expectant mothers into slight bewilderment. Even after reading the instructions, many questions remain, the main one of which, of course, is what Riboxin is for during pregnancy. The drug improves energy supply and tissue metabolism, that is, it provides the woman and fetus with a more active supply of beneficial nutrients. nutrients during the period when they suffer from deficiency conditions. This is one of the main aspects of using Riboxin.

Also, the active ingredients help reduce harm from the so-called “oxygen starvation”, which is a common complication during pregnancy. Arises pathological condition, because respiratory system women supplies vital gas to two organisms. But such a powerful need for oxygen runs counter to the capabilities of the lungs and bronchial tree. Therefore, the antihypoxic effect of Riboxin comes in handy, and this is the second, but no less important aspect of using the drug during pregnancy.

Among the therapeutic properties of a pharmaceutical drug, a significant part consists of effects on cardiac activity. Riboxin normalizes myocardial contractile activity, regulates the metabolic needs of cardiomyocytes, and helps enhance trophic processes. Thus, the drug plays the role of preventive sanitation, since it is not uncommon for pregnant women to develop such pathological processes, such as arrhythmias, tachycardias and other rhythm disturbances of the heart muscle.

How to take Riboxin for pregnant women?

The dosage and duration of use of a pharmaceutical drug during pregnancy is always selected individually based on the indicators of diagnostic tests, data ultrasound examination and other physiological parameters. As a rule, Riboxin is administered intravenously during pregnancy, but in medical literature and on thematic forums for pregnant women, cases of prescribing the tablet form of the drug are described.

Instructions

By medical use medicine

Riboxin

Tradename

Riboxin

International nonproprietary name

Dosage form

Solution for intravenous administration 20 mg/ml, 10 ml

Compound

1 ml of the drug contains:

active substance: Riboxin (inosine) - 20 mg;

Excipients: hexamethylenetetramine (methenamine), sodium hydroxide solution, water for injection.

Description

Transparent colorless or slightly colored liquid.

Pharmacotherapeutic group

Drugs for the treatment of heart diseases.

Other cardiotonic drugs.

ATX code:C01 E.B.

Pharmacological properties

Pharmacokinetics

Metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. A small amount is excreted through the kidneys.

Pharmacodynamics

Has antihypoxic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, and prevents the consequences of intraoperative renal ischemia. It is directly involved in glucose metabolism and promotes the activation of metabolism under hypoxic conditions and in the absence of ATP.

Activates the metabolism of pyruvic acid, which is necessary to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of some Krebs cycle enzymes. Penetrating into cells, it has positive action on metabolic processes in the myocardium - increases the strength of heart contractions and promotes more complete relaxation of the myocardium in diastole, resulting in an increase in stroke volume. The mechanism of antiarrhythmic action is not completely clear.

Reduces platelet aggregation, activates tissue regeneration (especially the myocardium and the mucous membrane of the gastrointestinal tract).

Indications for use

In complex treatment:

Previous myocardial infarction,

Coronary heart disease,

Heart rhythm disturbances caused by the use of cardiac glycosides, as well as against the background of myocardial dystrophy after infectious diseases;

Liver diseases (hepatitis, cirrhosis, fatty degeneration), urocoproporphyria. Surgeries on an isolated kidney (as a means of pharmacological protection when turning off blood circulation).

Directions for use and doses

The drug is administered intravenously in a slow stream or drip (40-60 drops per minute). Treatment begins with the administration of 200 mg (10 ml of a 20 mg/ml solution) 1 time per day, then, if well tolerated, the dose is increased to 400 mg (20 ml of a 20 mg/ml solution) 1-2 times a day. Duration of treatment is 10-15 days.

Injection of the drug is possible for acute cardiac arrhythmias in a single dose of 200-400 mg (10-20 ml of a 20 mg/ml solution).

For pharmacological protection of kidneys subjected to ischemia, Riboxin is administered intravenously as a bolus in a single dose of 1.2 g (60 ml of a 20 mg/ml solution) 5-15 minutes before clamping the renal artery, and then another 0.8 g (40 ml of a 20 mg/ml solution) mg/ml) immediately after restoration of blood circulation.

When administered drip into a vein, a 20 mg/ml solution of the drug is diluted in a 5% dextrose (glucose) solution or isotonic sodium chloride solution (up to 250 ml).

Side effects

Allergic reactions:

Itchy skin

Skin hyperemia (the drug should be discontinued).

Increased concentration of uric acid in the blood

Tachycardia.

Contraindications:

Hypersensitivity to the drug

Gout

Hyperuricemia

Pregnancy

Lactation period

Age up to 18 years (efficacy and safety have not been established).

Carefully

Kidney failure.

Drug interactions

Immunosuppressants reduce the effectiveness of Riboxin.

When used together with cardiac glycosides, the drug can prevent the occurrence of arrhythmias and enhance the positive inotropic effect.

special instructions

Riboxin is not used for emergency correction of cardiac dysfunction. If itching and hyperemia of the skin occurs, treatment should be discontinued.

During long-term treatment, it is advisable to monitor the concentration of uric acid in the blood and urine.

Pregnancy and lactation

Use during pregnancy is contraindicated. If it is necessary to use the drug during lactation, breastfeeding should be stopped during treatment.

Features of the effect of the drug on the ability to drive vehicle or potentially dangerous mechanisms

Considering the side effects of the drug, during the treatment period you should refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Overdose

Currently, no cases of overdose have been reported.

"Riboxin" is medical drug from the category of drugs that affect metabolic reactions in human body by increasing workable cellular energy. Acts on metabolic, antiarrhythmic, antihypoxic and coronary dilation processes. The medication is highly active against cardiac structures, therefore it is often prescribed in cardiology for the treatment of various heart pathologies. You can find out more information about Riboxin injections from the instructions for use.

The main ingredient of Riboxin is inosine - 20 mg per milliliter. The ampoule also contains excipients and water.

Release form

The medicine is produced in the form of a solution for intravenous injections. A 2% solution of "Riboxin" for injection is produced in ampoules of 10 ml. Riboxin ampoules include 20 mg of inosine per milliliter. The solution is injected into a vein. The drug is not used intramuscularly.

Dosing

"Riboxin" is infused intravenously through a dropper or by the jet method. The initial daily dose is 200 mg once daily. The dose is then adjusted to 400 mg once or twice daily. The duration of therapy is determined by the attending physician, usually two weeks.

For acute cardiac pathologies, sudden arrhythmias, acute failure cardiac muscle, one-time use of the drug by jet method is possible, 200 - 400 milligrams.

The effect of "Riboxin" on the body

“Riboxin” is the formation of purine, a nucleoside that includes hypoxanthine associated with a residual amount of ribofuranose. Precedes ATP - adenosine triphosphate. The main active component of the drug, inosine, triggers metabolic processes in the body in a state of oxygen deficiency and is directly involved in the biological reaction of glucose formation. "Riboxin" is a medicine that controls the biochemical reactions of converting useful substances into energy.

The drug exhibits particular activity against myocardial cells and liver. Produces antihypoxic and antiarrhythmic effects. Replenishes the deficiency of cellular tissue oxygen. Increases the energy and power of the myocardium, accelerates the movement of blood through the coronary vessels, intensifies cardiac work, and participates in the process of diastolic relaxation of the heart muscle. As a result, the volume of blood pushed out by the heart increases, and a normal heart rhythm is established. Thanks to Riboxin, the heart recovers after myocardial infarction. The medication triggers the metabolism of pyruvic acid, which normalizes respiration in tissues even with ATP deficiency.

"Riboxin" intensifies heart saturation oxygenated blood, normalizes the movement of blood through the kidneys after surgical interventions. Stimulates the action of xanthine dehydrogenase, which catalyzes oxidative reactions, and forms uric acid with the participation of hypoxanthine. Reduces the formation of blood clots. Prevents the occurrence of heart failure syndrome.

Accelerates the process of cell regeneration inside the stomach after erosions and ulcers, and also improves the condition of the liver in any pathology.

Pharmakinetics

"Riboxin" is completely absorbed by the stomach. The liver metabolizes it with the production of glucuronic acid and its further oxidation reaction. A small part is excreted through the kidneys.

What is the drug used for?

1. According to the instructions for use, Riboxin injections are used mainly for cardiovascular pathologies: metabolic disorders in the structures of the heart muscle, ischemia, cardiac defects of any etiology, conditions after myocardial infarction, arrhythmias (especially with glycoside lesions), myocarditis, after intense physical stress, infections or due to endocrine disorders. For ischemia, the medicine begins to be used at any period of the disease, regardless of the stage.
2. In case of fatty liver transformation, which also occurs due to taking medications or alcohol. For toxic damage to hepatocytes, hepatitis, cirrhosis.
3. As a preventive measure against a decrease in the level of leukocytes in the blood when exposed to radioactive substances.
4. During kidney operations as a means of medicinal protection in the process of stopping blood circulation.
5. With uroporphyria, there is a failure of metabolic biological reactions.
6. For glaucoma in combination with basic treatment.
7. The drug is indicated during sessions radiation therapy, which helps improve procedures and eliminate side effects.
8. Prescribed for severe physical stress as a means of increasing the body's endurance. Used by athletes during intense training.
9. For male infertility.
10. In cosmetology.

Contraindications

• hypersensitivity to inosine;
• gout;
• hyperuricemia;
• age up to 3 years;
• fructose intolerance and glucose malabsorption syndrome or sucrose deficiency;
• renal failure;
• diabetes;
• complex kidney diseases.

Side effects

Allergic responses: itchy skin rash, redness of the skin, angioedema. The occurrence of an allergy requires discontinuation of the medication.

Increased uric acid density and relapse of gout with long-term use (occurs infrequently). It is necessary to stop therapy with Riboxin and prescribe appropriate treatment to relieve inflammation in the joints.

Pregnancy and lactation period

No studies have been conducted to confirm the safety of the drug for pregnant and lactating women. Therefore, it is forbidden to use Riboxin during pregnancy. Although some doctors note the positive effect of the medication on metabolic reactions in the woman and fetus and prescribe it. In this case, the decision must be made by the doctor, taking into account the potential risks to the child. It is recommended to stop breastfeeding during medication injections.

What to pay attention to

During therapy with Riboxin, you need to keep the amount of uric acid in the urine and blood under control.

In patients undergoing chemotherapy, the drug is prescribed with caution under strict medical supervision, since it can sharply worsen the general condition of such patients.

The drug is safe for drivers when driving vehicles and devices that require particularly strong concentration.

Overdose situations

"Riboxin" is used strictly according to medical prescriptions. In situations where the dosage is exceeded, allergic symptoms, itching of the skin, increased heart rate, and cardiac heaviness may appear. Typically, such manifestations are not scary and disappear after a decrease in inosine in the blood. Medical studies do not contain information describing cases of drug overdose.

Compatibility with other drugs

The effectiveness of Riboxin decreases when used together with immunosuppressants - drugs that suppress the immune system.

The drug combines well with cardiac metabolites, their joint use prevents the development of arrhythmic reactions and enhances the inotropic effect.

The medication increases the anabolism of steroid and non-steroidal drugs when used together.

The drug reduces the bronchodilator effect of theophylline and the psychoactivating effect of caffeine.

In injections, the medicine does not combine with alkaloids; their combination leads to the formation of insoluble substances.

Vitamin B6, when taken together with inosine, deactivates both substances.

The injection solution should not be combined with any medications in the same syringe, as such use may cause undesirable results.

Pros and cons of the drug

A positive consequence of the use of the drug is the optimization of metabolism in the myocardium. Medicinal characteristics inosine are expressed in increasing the energy of the muscle cells of the heart, accelerating the production of nucleotides, which is expressed in the activation of regenerative formations in the tissue structures of the heart.

A negative effect of Riboxin is considered to be a change in the physiological order of metabolic processes. Many researchers have a negative attitude towards any interference in the metabolic processes of the body, especially through substances coming from outside. However, the ratio of possible benefits and harm should be taken into account. In the presence of various pathologies and disruptions in the activity of the heart muscle, the benefit of the medication is higher than the potential harm.

Riboxin and sports

"Riboxin" is known not only to doctors, but also to athletes as an energy supplement for bodybuilders. It is especially often used by bodybuilders who build muscle. The drug does not harm the body; it is used by supporters of non-steroidal and anti-doping sports.

Riboxin is a component of the protein biosynthesis reaction that helps build muscle. Thanks to the drug, the athlete’s performance, endurance and strength increase and training becomes easier.

Thank you

The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

The drug has an antiarrhythmic effect (normalizes heart rhythm), normalizes coronary circulation, and also helps to increase the energy balance of the myocardium. Riboxin is involved in glucose metabolism and stimulates metabolic processes in the absence of ATP and in the presence of hypoxia.

The use of Riboxin leads to a decrease in platelet aggregation (an indicator that determines blood clotting) and promotes active tissue regeneration, which is especially pronounced for the tissues of the gastrointestinal mucosa and myocardium.

IN pure form the substance is a white or slightly yellowish powder, odorless and with a bitter taste. Riboxin is insoluble in water and poorly soluble in alcohol.

Indications for use

8. In cases of excessive physical activity, which can negatively affect the human body as a whole.

In each case, the dosage of Riboxin and the duration of the course of taking the drug are determined individually.

Contraindications for use and adverse reactions

The main contraindication to the use of Riboxin is the presence hypersensitivity body to this medicine or the components included in its composition.

Riboxin is contraindicated for patients with gout, as well as for those who have a metabolic disorder of uric acid and purine bases.

Modern research shows that the benefits of long-term treatment with this drug are questionable, and it is better to refuse long courses. However, reviews of Riboxin and the opinions of doctors with experience are so far unanimous: long courses are effective.

Like any other medicine, Riboxin should be used according to the instructions, as prescribed by a doctor and not exceed acceptable standards. In case of overdose, it may appear skin itching, redness of the skin and rashes, heaviness in the chest, increased heartbeat and others discomfort. In the vast majority of cases, such symptoms are not dangerous and disappear quite quickly with a decrease in the concentration of the active substance in the blood.

Directions for use and dosage

In the first days of treatment, the drug is taken 1 tablet 3-4 times a day (0.6-0.8 g). If there are no negative reactions from the body, then the daily dose is increased, up to 2.4 grams per day (on the 2nd or 3rd day from the start of treatment).

The duration of treatment is determined by the doctor and can range from 4 weeks to 3 months.

Patients diagnosed with urocoproporphyria take Riboxin in the amount of 0.8 g per day for 4-12 weeks.

For urocoproporphyria, the daily dose is 0.8 g (200 mg 4 times a day). The drug is taken daily for 1-3 months.

In addition to tablet form, you can also buy Riboxin in pharmacies in the form of a 2% solution for injection.

The Riboxin solution is administered intravenously. It can be administered either drip-wise (40-60 drops per minute) or as a stream. In the case of the jet method, the solution should be introduced slowly.

On the first day of taking the drug, the solution should be administered to the patient only 1 time in an amount of 10 ml (which corresponds to 200 mg of the substance). If after the first administration no negative side reactions are detected within 24 hours and the patient’s body tolerates the medicine well, then the dose can be increased to 20 ml of solution 1-2 times a day.

To perform drip administration, the required dose of the drug should be dissolved in a solution of glucose or sodium chloride 5% (in a volume of up to 250 ml).

Course duration is 10 – 15 days.

Riboxin during pregnancy

Riboxin is an antihypoxant, antioxidant, and good remedy improving metabolic processes in tissues, which is especially important during the period of bearing a child.

The drug is prescribed to prevent heart disease and support cardiac activity during periods of increased stress. Riboxin is often administered directly during childbirth, since the load on the heart at such a moment is especially high.

Doctors often prescribe the medicine if a pregnant woman has gastritis and liver disease in order to treat existing problems. The drug helps normalize gastric secretion and reduce unpleasant symptoms.

A doctor may prescribe Riboxin during pregnancy if fetal hypoxia is detected. By normalizing metabolic processes in tissues, the medicine reduces the degree of oxygen starvation of the fetus.

If the drug is well tolerated, expectant mothers take 1 tablet orally 3-4 times a day for 1 month. Despite the harmlessness of the medicine, as in any other case, Riboxin should be prescribed by a doctor strictly on an individual basis.

Riboxin in bodybuilding

Riboxin is a precursor of ATP, i.e. source of energy for body cells. The drug acts as an activator of reductive and oxidative processes, which improves metabolism and energy supply to tissues, as well as improves their oxygen saturation.

Riboxin has complex impact on the body and as a result of its use:

• the body's metabolism and energy processes improve;
• the risk of hypoxia of tissues and organs is significantly reduced;
• tissue regeneration is enhanced at the cellular level;
• blood flow and tissue respiration improves;
• the work of the heart muscle is improved and maintained, and the risk of myocardial ischemia is reduced.

Thanks to proper use of the drug, the bodybuilder becomes more resilient and strong. Such an athlete finds it easier to perform heavy physical activity.

An athlete should start taking Riboxin with small doses in order to check the reaction of his body to this medicine. In the first days, you should take (before meals) no more than 3-4 tablets per day (1 tablet at a time). If no negative side effects are felt within three days, then the number of tablets can be gradually increased up to 14 tablets per day. In this case, the maximum duration of the course should be no more than three months, after which a 1-2 month break should be taken so that the body can rest from the medicine.

Interaction with other drugs

When used simultaneously with heparin, an increase in the effectiveness of the latter is observed, as well as an increase in the duration of its effect.

If Riboxin must be used as an injection, then it should be remembered that it is incompatible in the same volume with alkaloids and, when mixed, leads to the formation of insoluble compounds.

Riboxin injections and tablets can be safely taken together with medications such as furosemide, nitroglycerin, spironolactone, nifedipine.

Riboxin is incompatible with vitamin B6. When used simultaneously, both compounds are deactivated.

Riboxin solution for injection is not recommended to be mixed with other medicines(except for the specified solvents) in one infusion system or syringe, since mixing may lead to undesirable chemical interaction components with each other.

1 ml of solution contains

active substance: inosine - 20 mg;

excipients: hexamethylenetetramine, water for injection.

Description

Transparent colorless liquid.

Pharmacotherapeutic group

Other cardiotonic drugs. Code ATX C01EV.

Pharmacological properties

Pharmacokinetics

When administered, Riboxin is quickly distributed in tissues. Metabolized in the liver, where it is completely utilized in the biochemical reactions of the body. A small amount is excreted mainly in the urine.

Pharmacodynamics

Riboxin is an anabolic drug that has antihypoxic and antiarrhythmic effects.

It is a precursor of ATP, is directly involved in glucose metabolism and promotes metabolism activation under hypoxic conditions and in the absence of ATP. The drug activates the metabolism of pyruvic acid to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Riboxin has a positive effect on metabolism in the myocardium, in particular, it increases the energy balance of cells, stimulates the synthesis of nucleotides, and enhances the activity of a number of Krebs cycle enzymes. The drug normalizes the contractile activity of the myocardium and promotes more complete relaxation of the myocardium in diastole due to the ability to bind calcium ions that have penetrated into the cells when they are excited, and activates tissue regeneration (especially the myocardium and the mucous membrane of the digestive canal).

Indications for use

Ischemic disease hearts, incl. myocardial infarction, angina pectoris, coronary insufficiency (as part of complex therapy)

Heart rhythm disturbances

Intoxication with cardiac glycoside drugs

Treatment of cardiomyopathies of various origins, myocardial dystrophies (due to heavy physical exertion, infectious and endocrine origins), myocarditis

Liver diseases (hepatitis, liver cirrhosis, fatty liver)

Directions for use and doses

Adults are prescribed intravenously by drip or stream. First, 200 mg (10 ml of a 2% solution) is administered once a day, then, if well tolerated, up to 400 mg (20 ml of a 2% solution) 1-2 times a day. The course of treatment is determined individually (on average 10-15 days). When administered drip into a vein, a 2% solution of the drug is diluted in a 5% glucose solution or 0.9% sodium chloride solution (up to 250 ml). The drug is administered drip-wise slowly, 40-60 drops per minute. In case of acute cardiac arrhythmias, jet injection in a single dose of 200 - 400 mg (10-20 ml of 2% solution) is possible.

Side effects

From the outside immune system, skin and subcutaneous tissue: allergic/anaphylactic reactions, including rash, itching, skin flushing, urticaria, anaphylactic shock.

From the outside of cardio-vascular system: tachycardia, arterial hypotension, which may be accompanied by headache, dizziness, nausea, vomiting, sweating.

From the side of metabolism, metabolism: hyperuricemia, exacerbation of gout (with long-term use of high doses).

General disorders: general weakness, changes at the injection site (including hyperemia, itching).

Contraindications

– Hypersensitivity to inosine or other components of the drug

– hyperuricemia

– kidney failure

– gout

Pregnancy and lactation

Children and teenagers up to 18 years of age.

Drug interactions

When using the drug simultaneously with other drugs, it is possible:

with heparin: enhancing the effects of heparin, increasing the duration of its action;

with cardiac glycosides: preventing the occurrence of arrhythmias, enhancing the positive inotropic effect.

With simultaneous use of the drug with β-blockers, the effect of Riboxin does not decrease.

Possible simultaneous use with nitroglycerin, nifedipine, furosemide, spironolactone.

Incompatible in the same container with alkaloids, acids, alcohols, salts of heavy metals, tannin, vitamin B6 (pyridoxine hydrochloride).

special instructions

If itching and hyperemia of the skin occurs, treatment with the drug should be discontinued.

During treatment, it is necessary to monitor the level of urea concentration in the blood and urine. The limitation for the use of the drug is renal failure. In case of renal failure, prescribing the drug is advisable only when, in the opinion of the doctor, the expected effect exceeds the possible risk of use.

Use during pregnancy or breastfeeding.

No studies have been conducted on the effectiveness and safety of use in this group of patients, so it should not be used during pregnancy or breastfeeding.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

The drug does not have a negative effect on the ability to drive a car or operate complex machinery.

The drug should not be used in children due to the lack of safety data.