Ketanov: instructions for medical use. What helps Ketanov tablets? What are Ketorolac Ketan tablets from?

It is a drug with a pronounced analgesic effect. The drug is produced in such forms as tablets, capsules, gel and injection. Appointed during the complex drug treatment and for symptomatic therapy.

Indications for taking the drug

Ketanov is prescribed for the relief of pain of any origin and intensity. The drug is produced in the form of tablets, injections, suppositories, ointments and creams and anesthetizes even in cases where other drugs are ineffective. Ketanov copes well with:

1. Moderate to severe postoperative pain.
2. Pain that occurs against the background of gynecological diseases.
3. Feelings of discomfort resulting from orthopedic manipulations.
4. Urological pain.
5. Acute muscle pain resulting from injury.
6. Pain resulting from fractures and tissue ruptures, dislocations of strong sprains.
7. Unpleasant consequences of visiting the dental office.

Ketanov is an indispensable pain reliever prescribed for:

• Toothache, caries and pulpitis.
• Pericoronite.
• Renal colic.
• Postpartum pain.
• Otite.
• Onset of sciatica.
• Fibromyalgia.
• osteoarthritis spasms.
• Removal of symptoms of sciatica.
• Osteochondrosis.
• stock pathological processes in muscles and tissues.
• Fight against drug addiction.

In each case, the dosage of the drug is calculated individually. At the same time, a consultation with a doctor is absolutely necessary - an erroneous dose will not only not relieve pain, but will also have an undesirable effect. side effect on the body.

Rules for taking pills

The use of the drug Ketanov in the form of tablets is not recommended:

• Elderly people (over 65 years old).
• Patients weighing less than 50 kg.
• In the presence of pathologies of the liver and kidneys.

Dosage of the medicinal product in the form of a solution

Ketanov in the form of a solution is prescribed for intramuscular injections. First bout of pain relieved 10mg medicinal product. The next dosage rises to 30 mg - the second injection is given 5 hours after the first. The introduction of the drug should be made under the supervision of the attending physician.

The total dose of Ketanov per day should not exceed 90 mg. For elderly patients, it should be reduced to 60 mg.

Ketanov injections are given for two days - this period is quite enough to remove pain syndrome. Next, the patient is prescribed Ketanov tablets. The course of their admission is from 5 to 7 days - during this time the pain will completely disappear.

The first injection stops the pain syndrome in half an hour. The patient becomes lighter, completely pain disappear after two hours. Depending on the diagnosis of the patient and his well-being, the doctor may change the dosage of the drug. The main thing is that it should not be exceeded - in this case, the likelihood of side effects is high.

Contraindications

In some cases, the appointment of the drug Ketanov, as an anesthetic, is prohibited - patients have a lot of contraindications. Taking the medicine in such a situation will not only not bring the expected result, but can also seriously harm. Ketanov is contraindicated if the patient has:

• Allergies to any of the ingredients that make up the tablets and solutions.
• Open active ulcer.
• Stomach bleeding.
• Ulcerative diseases.
• Bronchial asthma.
• Angioedema.
• Rhinitis.
• Urticaria.
• Heart failure.
• Polyps in the nose.
• Bronchospasm.
• Hemorrhagic diathesis.
• Blood clotting disorders.

Also, Ketanov is not prescribed before surgery, in the postoperative period, in the process of manipulating blood vessels. It is strictly forbidden to take the drug to pregnant women and persons prone to the occurrence of Quincke's edema.

In any case, before taking Ketanov, you should consult your doctor. Better yet, pass full examination in order to detect hidden disorders in the body. Otherwise, the medicine will not only not help relieve the pain syndrome, but will also cause serious health problems.

Reception during pregnancy

The anesthetic drug Ketanov is not prescribed for pregnant women - its use is strictly prohibited at any time. The substances that make up the drug can cause irreparable harm to the health of not only the expectant mother, but also her child.

It is also not recommended to take the drug during lactation - having got into the baby's body with mother's milk, Ketanov can cause him an allergy. If the situation is serious and a nursing woman cannot do without taking the medicine, from breastfeeding She will have to give up the baby.

Interaction with other drugs

The joint use of the drug Ketanov with some drugs is categorically not recommended - the analgesic effect can be reduced, and the risk of complications is increased significantly. Ketanov should not be taken simultaneously with:

• Warfarin- it reduces the analgesic effect of the drug by 97%. And also with Digoxin, Heparit and other salicylates.
• Acetylsalicylic acid- Possible side effects.
• Probenecid- the effect of the drug Ketanov decreases.
• Cyclosporine- there are nephrotoxic side effects.
• Oxpentifilin- there is a risk of developing dangerous hemorrhages.
• Mifepristone- Ketanov completely destroys its healing characteristics.
• Lithium preparations.
• Anticoagulants- There is a risk of bleeding.

This list is far from complete - the attending physician must know what medications the patient is taking. Only then will he be able to make a correction in his appointments and calculate the correct dose of Ketanov - the treatment will be successful, and the risk of side effects will be minimized.

Overdose

If the dose of Ketanov is exceeded, side effects cannot be avoided. In such a situation, the patient complains of:

1. Slow reaction.
2. Severe headache.
3. Drowsiness and lethargy.
4. Nausea and vomiting.
5. Abdominal pain.
6. The occurrence of attacks of arterial hypertension.
7. development of renal failure.
8. The appearance of breathing problems.

With a significant overdose of the drug, gastric bleeding may open, convulsions will begin and the patient will fall into a coma.

Medicine knows cases when long-term use of high doses of the drug led to the death of the patient. Therefore, doctors strongly recommend that anyone taking Ketanov should report any side effects immediately.

In case of overdose, the patient is prescribed symptomatic therapy– he must induce vomiting and drink a certain number of pills activated carbon(at least 100 gr. for an adult). This must be done no later than 4 hours after taking the medicine. If necessary, as additional preventive measures, the doctor may prescribe osmotic preparations.

If the overdose is one-time, its main symptoms will be nausea and abdominal pain. It is necessary to stop taking the drug and discomfort will disappear.

In no case should you ignore the sudden discomfort, pain and other symptoms of an overdose - when taking large doses of Ketanov, the risk of dangerous complications increases many times over.

Side effects

Like any drug, Ketanov has a lot of side effects. The patient must be aware of them - doctors focus everyone's attention on this. How much and how to take the drug, only a specialist can say.

Patients who experience jumps blood pressure, taking Ketanov should be administered with great caution. However, with a well-chosen dosage, the drug will not cause unwanted side effects and the treatment will be effective.

Features of use

Compliance with the rules for taking Ketanov is one of the conditions for the success of treatment. It is not difficult to follow them, the main thing is to know them.

• To minimize the risk of possible complications the minimum dose of the drug is prescribed first. And its reception should be limited in time - a couple of days is enough to stop the pain. Prolonged use of the drug can lead to serious disruption of the organs and systems.
• It takes at least half an hour for the pain to go away after the injection. You need to be patient and wait. Do not rush and, in the hope of speeding up the process, take any other painkillers. Concentrating in the body, they interact, weaken each other's action and cause irreparable harm to health.
• It is highly undesirable to drink tablets for more than 5 days.
• Patients who have problems with the liver and kidneys should take the medicine only under the supervision of a doctor. The dose of the drug in such difficult situations is minimized, diuresis and the condition of the kidneys are under the constant supervision of a specialist.
• Taking Ketanov is strictly prohibited for women who have problems conceiving.
• Prescribing the drug to people suffering from Crohn's disease requires an individual approach.
• For patients with cardiovascular pathology, Ketanov is prescribed with great care; it is better for them to be in the hospital during treatment.

Storage conditions

Ketanov must be stored at a temperature of 25 ° C in a dark, protected from sun rays place. Children should never have access to the drug. The shelf life of the drug Ketanov is limited - no more than three years from the date of manufacture. It is strictly forbidden to take expired medicine!

Ketanov's instructiondescribes the drug as an analgesic that has an inhibitory effect on the production of prostaglandins. In addition, the drug has a slight anti-inflammatory effect.Ketanov's testimonywith pathologies of the musculoskeletal system and other ailments, they include severe pain. The medicine can be used internally or externally.

The tool is distinguished by the variability of dosage forms, therefore it can be prescribed for different stages pathologies of the musculoskeletal system.

Ketanov is provided to customers in several forms of release:

• Long-acting tablets;
• Capsules;
• Tablets in a special shell;
• Ampoules with a means for injection;
• Cream or ointment;
• Gel.

Ketanov tablets

Ketanov tabletsSold in packs of 10, 20 and 100 pieces. The active ingredient of the drug is ketorolac tromethamine. The tablet contains 10 milligrams of the drug. Auxiliary elements incomposition of Ketanov: microcrystalline cellulose, starch, silicon dioxide, magnesium stearate, talc

Ketanov ointment

Ketanov ointment and cream are considered similar means. The concentration of the active ingredient in the preparation is 5%. An ointment is rarely prescribed, more often the medication is used orally.

Ketanov in ampoules

Ketanov in ampoulesused to prepare a solution for injections. The color of the drug is transparent or slightly yellowish.Dosage of Ketanov: 30 milligrams of the active ingredient per 1 milliliter of the drug. One package contains 10 ampoules.

The active agent is ketorolac trometamol. Auxiliary components in the composition: sodium chloride, ethanol, purified water and others.

Pharmacological properties

The active component of the drug ketorolac refers to non-narcotic analgesics.

Ketanov's instructioncalls the remedy a non-steroidal drug with anti-inflammatory, analgesic and slight antipyretic effect.

The drug blunts the production of prostaglandins. The effect of the drug on opioid receptors was not revealed. Moreover, the advantage of the drug is that, in addition to the occurrence of side effects, it:

• Does not constrict pupils;
• Does not affect the dulling of respiratory functions;
• Does not cause disturbance nervous system;
• Does not lead to pathologies genitourinary system;
• Gently affects the work of the heart;
• Does not cause pressure drops.

Ketanov testimony

Ketanov's testimonyrefer to the elimination of severe pain that occurs for various reasons.

Both tablets and injections are prescribed for the same pathologies and symptoms. Dosage form depends on the preferences of the patient, the risk of side effects or individual intolerance to the auxiliary components incomposition of Ketanov.

You can stop the pain with the drug in such pathologies:

• Diseases of the oral cavity, for example, diseases of the teeth;
• Violations of the state of the musculoskeletal system;
• Particularly severe headaches;
• education malignant tumors;
• Colitis;
• Ear diseases;
• Discomfort after childbirth and during menstruation.

Separately, it is worth highlighting the use of funds for the treatment of pathologies of the back and joints. For example, Ketanov copes well with pain in osteochondrosis or osteoarthritis.

Ketanov for children

Ketans for children approved for use from 16 years of age. The reason is that the drug is too powerful for the fragile body of the child.

In some cases, and only with the permission of the doctor, the remedy is acceptable for use by babies over 2 years old. The duration of the course of therapy does not exceed one dose. Before deciding on treatment children with Ketanov it is worth trying to stop the pain by other means with a similar effect, but a weaker effect.

Side effects of the drug in babies include:

• partial loss of vision;
• hearing problems;
• Pathologies of the respiratory organs, for example, lung cancer;
• kidney failure;
• Psychological disorders.

Ketanov contraindications

Contraindications to Ketanovcan be divided into absolute and relative. In the first case, you will have to abandon the medicine and replace it with another remedy. Relative restrictions allow careful use of the medication.

Main contraindications to Ketanov include:

• Hypersensitivity to active substances and auxiliary components in the composition of the product;
• Aspirin asthma in the past or present.
• Pathology of the bronchi;
• Edema of the angioedema type;
• Insufficient amount of fluid in the body;
• Violations of blood exchange;
• Pathology of the gastrointestinal tract;
• Ulcers on the legs;
• problems with blood clotting;
• Kidney disease, excessive concentration of creatinine in the body;
• Risk of hemorrhagic stroke;
• Diathesis;
• Predisposition to bleeding;
• The period of gestation and lactation;
• Pain of a permanent nature;
• Childhood.

Ketanov and its side effects

Side effects of Ketanovaggravated by the simultaneous use of the drug and alcoholic beverages. Consequences include gastrointestinal ulcers and internal hemorrhages. Since alcohol numbs the senses, severe pain during the period of intoxication may go unnoticed, and urgently needed hospitalization will not occur.

Side effects of Ketanov include:

• Nausea and vomiting;
• Pathologies of the gastrointestinal tract (for example, diarrhea or constipation, bloating, flatulence);
• The development of hepatitis;
• Violation of the intestinal microflora;
• Pain in lumbar;
• Frequent urination with chronic pain and spotting;
• partial hearing loss;
• Respiratory disorders;
• arrhythmia;
• Hemorrhages inside;
• Thickening and redness of the skin;
• Allergic reactions (including rash, breathing problems, difficulty swallowing);
• Hyperthermia;
• Increased sweating.

In case of an overdose of Ketanov, the following symptoms may occur:

• Lethargy and fatigue;
• Headaches;
• Nausea;
• Bleeding in the gastrointestinal tract;
• kidney failure;
• Labored breathing;
• Seizures.

When overdose of Ketanovor the manifestation of side effects, the medication should be stopped immediately and consult a doctor urgently.

Ketanov price

Price for Ketanov depends on the form of release and the capacity of the package:

• Tablets, in a pack of 10 capsules - cost from 25 to 35 rubles;
• Tablets, 20 pieces per pack - 60-70 rubles;
• Tablets, in a pack of 100 servings - are sold for 250-275 rubles;
• Means for injections, in a package of 10 ampoules - the cost is about 110-140 rubles

Ketanov's analogs

Reviews about Ketanovclaim that the remedy is the most effective among similar medicines. Moreover, the drug starts to stop the pain faster.Analogue of Ketanovcalled a drug of non-narcotic type with anti-inflammatory effect.

Drugs with similar effects to this include:

• Dolac;
• Adolor;
• Ketolac;
• Ketorol;
• Voltaren;
• Diclovit;
• Toradol.

At the moment, Ketanov is considered the most powerful medicine. No drugs have yet been invented that have such a quick effect with a lower risk of developing negative consequences.

Ketanov or Ketorol - which is better?

Main differencesanalogue of Ketanovfrom the drug described in the article:

• Different composition. Ketanov contains titanium dioxide and hypromellose. Ketorol uses anhydrous silicon dioxide.
• visual inconsistency. Ketanov is marked with the inscription "KVT". The letter "S" is squeezed out on Keterol tablets;
• risk of consequences. The instruction describes more side effects in Ketanov.
• Assimilation. As the study showed, it is easier for the body to accept the main remedy, and not its analogue.

So the choiceKetanov or Ketoroldepends only on minor details of the pathologies of the joints and back.

Toradol or Ketanov - what to choose?

The active ingredient in Toradol is ketorolac tromisamine.

The drug is sold in the form of tablets (10 and 20 capsules each) and injections (5 ampoules with medicine in a package).

Like Ketanov, the drug is used once or twice in a row. His goal is to temporarily stop pain symptom strong and moderate

Side effects of Toradol coincide with those that appear with Ketanov. Stomatitis and loss of healthy skin color are also possible.

Ketanov or Dolak - which is cheaper?

Like Ketanov, Dolak has two forms of release - tablets and injections.

Capsules are sold in packs of 10 or 20. The drug for injection contains 30 milligrams of the active ingredient in one ampoule. Sold in packs of 10 containers.

Side effects are similar to those that occur with Ketone therapy, and may occur more frequently.

Dolac is also one of the strongest painkillers in this category.

Prices are about half as low as for Ketanov:

• 20 Dolac tablets will cost 30-40 rubles;
• 10 ampoules cost close to 70-80 rubles.

Ketanov reviews

Maria, 29 years old, artist: “I started having problems with my joints three years ago. The doctors say it's because of the injury. The pains are intermittent. The doctor warned immediately: Ketanov should not be taken long time. This alignment suited me perfectly - a single use of the medicine helps to get rid of pain for a long time. I always follow the instructions, because there were no side effects. ”

(dental, head) we resort to drugs that have an analgesic effect. Instructions for use of Ketanov positions it as an effective and effective drug designed to eliminate pain and inflammation.

Description of the drug and release form

Ketanov belongs to the group of NSAIDs - anti-inflammatory non-steroidal drugs that provide anti-inflammatory and analgesic effects. The active substance of the drug - ketorolac, refers to the derivatives of pyrrolysine-carboxylic acid. The drug is available in two dosage forms:

• Tablets - round, convex, coated with a white shell, engraved in the form of the abbreviation "KVT".
• Ampoules with solution for intramuscular injections.

The solution can be either completely transparent or have a pale yellowish tint.

Each tablet of the drug contains ketorolac tromethamine in an amount of 10 mg, and its content in the injection solution is 30 mg per 1 ml.

In addition to ketorolac tromethamine, the drug includes auxiliary and binding components that contribute to the greatest effectiveness of the main substance. This combination allows you to effectively stop inflammatory process and reduce pain.

Operating principle

The analgesic Ketanov has a pronounced and anti-inflammatory effect and exhibits a moderate antipyretic effect. The active ingredient of the drug (ketorolac) inhibits the activity of both types of COX enzymes, affects the formation of arachidonic acid in the body and inhibits the biosynthesis of prostaglandin (the main mediator of inflammation, pain and feverish conditions). The drug has a number of important advantages, namely:

• does not reduce the number and activity of platelets in the blood;
• does not depress respiratory function;
• does not suppress psychomotor activity;
• not addictive;
• does not have an anxiolytic effect.

That is, the drug is effective as an anti-inflammatory and analgesic for any intensity of pain. In this regard, it is superior to other drugs from the NSAID group, and its analgesic properties are comparable in strength to the use of Morphine.

The pain symptom completely stops 30-40 minutes after taking the medication, and the maximum peak of drug activity in the body occurs 2 hours after taking it.

When taken orally active substance it is rapidly absorbed from the gastrointestinal tract, but the presence of food in the stomach, especially fatty food, delays this process and the maximum concentration of ketorolac in the blood is observed 1 hour after taking the pill.

At intramuscular injection peak concentration active substance noted after 30 - 40 minutes. When prescribing the drug, it should be borne in mind that ketorolac penetrates into the tissues of the developing fetus during pregnancy and into the milk of a woman during breastfeeding.

The drug is excreted from the body naturally, by the liver and kidneys. The half-life of the drug averages from 5 to 6 hours, but this time interval increases in the elderly and in patients suffering from kidney pathologies.

The functionality and health of the liver do not affect the duration of the half-life of the drug, but in renal failure, this time increases to 12-14 hours.

What helps Ketanov?

Ketanov tablets for pain and inflammation are prescribed by doctors for the following pathological conditions:

• toothache of any nature;
• inflammatory processes in the gums, including fluxes;
• renal and hepatic colic;
• inflammation of the middle ear or otitis;
• osteoarthritis;
• manifestations of sciatica or gout;
• pain syndrome in oncological tumors;
• gynecological pains;
• sinusitis of any type.

Ketanov pain injections

They are used less often, with severe inflammation or pain. As a mandatory preventive and remedy, doctors prescribe these injections during the rehabilitation period after surgical interventions in such areas as:

• general, emergency and purulent surgery;
• dentistry;
• gynecology;
• otolaryngology;
• orthopedics;
• traumatology;
• urology.

Ketanov injections and tablets are additionally prescribed for household and sports injuries (sprains and bruises).

Contraindications

Like any drug from the NSAID group, the Ketanov medication has restrictions for taking, and they are quite serious. Treatment with this remedy is contraindicated in the following conditions:

• high individual sensitivity to ketorolac tromethamine or other components of the drug;
• the presence of the "aspirin triad", that is, with intolerance to aspirin;
• asthma, tendency to bronchospasm and angioedema;
• hypovolemia dehydration;
• erosions of the mucous membranes of the stomach or intestines;
• peptic ulcer of the stomach or 12 duodenal ulcer;
• tendency to peptic ulcers, bleeding disorders and hemophilia;
• hemorrhagic strokes;
• hemorrhagic diathesis;
• pregnancy and breastfeeding;
• under 16 years of age.

With extreme caution and only in the individual dosage indicated by the doctor, the drug is used for pathologies of the liver and kidneys, chronic heart failure, high blood pressure.

At the discretion of the attending physician remains the use and dosage of the drug for such pathologies as:

• cholecystitis;
• systemic lupus erythematosus;
• ulcerative lesions and bleeding from the gastrointestinal tract in history;
• polyps on the mucous membrane of the nasopharynx and nose;
• arterial hypertension;
• cholestasis;
• hepatitis of any type;
• sepsis;
• age over 65 years.

It is forbidden to take Ketanov simultaneously with other non-steroidal drugs, due to the very high risk"Overlay" effect and, accordingly, increase the risk of bleeding.

In addition, Ketanov should not be taken on the eve of surgical interventions, due to its effect on blood clotting.

Instructions for use

Ketanov tablets are recommended to be taken for pain attacks no more than 4 times a day in an amount, in a daily dose not exceeding 40 (4 tablets). A single dose of the drug is 10 mg. The duration of the use of the drug should not exceed 5 days, in order to avoid the accumulation of decay products of ketorolac in the tissues.

As for injections, the dosage of the drug is selected by the attending physician, based on the general condition of the patient, the intensity and nature of the pain, as well as taking into account concomitant diseases and possible contraindications.

As a rule, for sick people whose age has exceeded 65 years, the drug is administered in a volume of 10 to 30 mg every 4-6 hours, but at the same time, daily dose the drug entering the body should not exceed 90 mg.

For patients with impaired renal function, the volume of a single injection is reduced to 10-15 mg, and the total daily allowable amount of the drug is up to 60 mg.

The volume of the maximum allowable daily intake of Ketanov in 90 mg is also preserved for other patients, but medical practitioners allow it to be increased to 100 mg in case of urgent need and with good tolerability of the drug.

Adverse reactions

Among the side effects of the drug, the following manifestations are most often noted:

• development of diarrhea;
• face and lower limbs;
• restlessness, irritability and nervousness;
• discoordination of movements;
• bouts of dizziness;
• drowsiness, lethargy;
• allergic reactions all types;
• difficulty breathing, shortness of breath;
• nausea or heartburn.

The use of the drug can cause a number of undesirable side effects from various organs and systems of the body (digestive, cardiovascular, nervous, hematopoietic, respiratory).

Reception of Ketanov can provoke allergic reactions, including anaphylactic shock or angioedema. Such acute complications are rare, however, the likelihood of their occurrence should be taken into account when anxiety symptoms call for emergency medical attention immediately.

The consequences of an overdose of Ketanov are abdominal pain of a spasmodic type, vomiting or severe nausea, pain in the kidneys and disruption of their work, exacerbation or appearance of gastritis, ulcers.

As for the possibility of combining Ketanov with other drugs, it is highly undesirable. The combination of the drug with such drugs leads to an increase in the likelihood of erosions, ulcers, bleeding and a decrease in blood clotting:

• thrombolytics;
• anticoagulants;
• antiplatelet agents;
• glucocorticosteroids;
• preparations and dietary supplements with calcium;
• acetylsalicylic acid.

Ketanov enhances the action of insulin, which must be taken into account for patients with diabetes. In addition, the drug greatly reduces the effectiveness of diuretics and antihypertensive drugs.

Ketanov is completely incompatible with drugs containing lithium and tramadol, as well as with any alcohol-based medication. Reception of Ketanov cannot be combined with the use of alcohol, since such an interaction enhances the toxic effect of ethanol on the liver.

Analogues and price

If necessary, Ketanov can be replaced with other structural analogues containing the same active ingredient or other drugs with a similar therapeutic effect. Among them:

• Dicloberl Retard;

• Metindol;
• Rapten;
• Zerodol;
• Ketorol;
• Ketonal and Ketonal Duo;
• Ketalgin;
• Ketorolac;
• Ketolac.

Numerous reviews of patients using non-steroidal pain relievers suggest that the drug Ketonal has the greatest similarity with Ketanov, which acts faster, but the duration of its action is much shorter.

As for the cost, the anesthetic drug is quite affordable, and you can buy it at any pharmacy without a doctor's prescription. The price for Ketanov tablets is 54-65 rubles, for ampoules with a solution - 110-125 rubles.

Ketorol is one of the most effective painkillers from the NSAID group. It is available under various trade names, including Ketones. We will tell you how to use these injections correctly, providing instructions for use.

What are Ketan injections?

Ketanov- This is a drug for injection, which is prescribed as an anesthetic, less often - an antipyretic. It has a slight anti-inflammatory effect, so it can be used in inflammatory processes.

The drug is manufactured in India by Ranbaxy Laboratories Limited.

Composition and active substance

The active ingredient of the drug is ketorol. This is a drug of the group of non-steroidal anti-inflammatory drugs (NSAIDs), which has a pronounced analgesic effect, the strongest among related drugs. An additional substance is saline, or water for injection.

Release form

Ketanov ampoules are intended for intramuscular injections only.

The release form of the drug is a solution for intramuscular injection(in everyday life it is called injections).

It should be remembered that the agent can only be administered into the muscle, for subcutaneous and intravenous injections it is not applicable. The content of the active substance in the solution is 30 mg / ml.

Ketanov is also available in tablets. The content of the active substance in them is 10 mg.

pharmachologic effect

Ketorol interferes with the formation of one of the enzymes involved in the inflammatory response and blocks it. Thanks to this, three effects of the drug are achieved (listed in order of severity) - analgesic, antipyretic, anti-inflammatory.

The analgesic effect of Ketanov is much greater than its related drugs and is close to the most powerful of the known analgesics - morphine. Unlike him, ketorol is not addictive.

Indications for the use of injections

Ketanov is used for severe pain various origins, including cancer patients. Injections are given in a hospital or treatment room. They are appointed when required. high doses active substance, or the patient's condition does not allow him to drink tablets.

Most often, ketorol injections are used in surgical and intensive care units.

Instructions for use intramuscularly

Inject slowly to reduce pain!

The drug is administered in the ward or treatment room, intramuscularly deeply. During administration, severe pain occurs, to reduce which it is important to administer the drug slowly.

Dosage is selected individually, on average, adults are given 1 mg of Ketanov for pain, patients over 65 years of age - 0.5 ml, the same amount - for adults with impaired renal function. Children calculate the dose based on body weight.

special instructions

The drug can give side effects from the central nervous system - drowsiness, lethargy. Therefore, it is better to refuse work that requires attention and concentration. Also, the drug has a significant effect on blood clotting, but it stops a day after taking Ketanov.

If there is a need to administer the drug repeatedly, then it is administered every 5-6 hours for 4 days. In chronic pain in cancer patients, the duration of the drug is not limited.

Is it possible to drink an ampoule

If it is impossible to make an injection, the ampoule can be drunk.

The drug, according to the instructions for use, is not intended for oral administration. Nevertheless, if the patient drinks the solution for intravenous administration from the ampoule, the medicine will have its effect.

There will be no harm from such a procedure, but you should know that Ketanov tastes very bitter and can cause a gag reflex.

For inflammatory and oncological diseases mouth rinses and ingestion of a solution for injection of Ketans justify themselves.

Application during pregnancy

Ketanov is not recommended during pregnancy. Studies to establish its safety have not been conducted, so you should not risk the life and health of the baby. If there are vital indications, the question of the admissibility of using Ketorol is decided, possible methods treatment, the need to maintain or terminate the pregnancy.

During lactation

In childhood

Ketanov is not used in patients under 16 years of age. There are no data on the safety and efficacy of ketorol in children and adolescents.

Contraindications

Ketanov manufacturer Ranbaxy

The tool does not apply if:

• The patient was allergic to NSAIDs (aspirin asthma);
• The patient suffers from peptic ulcer duodenum or stomach in the acute stage;
• There are blood clotting disorders, including hemophilia;
• Hemorrhagic stroke, as well as any signs of a stroke before an MRI diagnosis;
• There are disorders of the liver and kidneys, drug-induced hepatitis, decreased glomerular filtration, hepatic and kidney failure;
• In obstetric practice;
• For chronic pain of unknown origin.

The last contraindication is due to the fact that the drug in this case does not cure, but masks the symptoms, and the disease develops in the meantime.

Side effects

The most common side effect of the drug is drowsiness and incoordination, and blurred vision is possible. After the injection, you should not engage in active physical labor.

Another common effect is the provocation of gastric and duodenal ulcers. This is due to the mechanism of action of the drug. There are also blood thinning effects that can be detrimental to patients with clotting disorders.

Interaction with other drugs

The tool can not be used together with other NSAIDs - this causes an increase in side effects, and does not enhance the main one. For the same reason, the combination of Ketanov and steroid hormones is fatal.

Diabetics should recalculate the dose of insulin, taking into account the hypoglycemic effect of Ketanov.

In patients with cancer or severe postoperative pain, Ketanov is combined with opioid analgesics to reduce the dose of the drug.

Information on the back of the package

Terms and conditions of storage

Shelf life - 3 years. A damaged ampoule is unusable. The medicine should be stored at room temperature, keep away from children and pets.

Price

The solution is in pharmacies from 120r sold strictly by prescription.

Other forms of release and prices

Also, the product is available in coated tablets, their cost starts from 60 rubles. Tablets are also dispensed by prescription.

Analogues and prices

Ketorol
Nurofen

Paracetamol
Tramadol

What analogues are stronger than Ketanov

The advantage of Ketanov over other NSAIDs is that he is significantly superior to his "relatives" in terms of analgesic effect.

The effectiveness of the drug approaches the same indicators for strong narcotic analgesics - promedol and morphine. Morphine is the only substance whose effect is clearly stronger than that of Ketanov.

P N 012170/01-310317

Trade name of the drug:

Ketanov ®

International non-proprietary name:

Ketorolac

Dosage form:

coated tablets film sheath

Composition:

One coated tablet contains:

Active substance: ketorolac trometamol -10.00 mg.

Excipients:

corn starch - 44.76 mg, microcrystalline cellulose - 122.41 mg, colloidal silicon dioxide - 1.83 mg, magnesium stearate - 1.00 mg.

Film sheath:

hypromellose - 2.91 mg, macrogol-400 - 0.68 mg, purified talc - 0.16 mg, titanium dioxide - 1.25 mg.

Description:

Round, biconvex, film-coated tablets, white or off-white, debossed with "KVT" on one side.

Pharmacotherapeutic group:

non-steroidal anti-inflammatory drug (NSAID).

The codeATX: M01AB15

Pharmachologic effect:

Pharmacodynamics

Ketorolac has a pronounced analgesic effect, also has an anti-inflammatory and moderate antipyretic effect.

The mechanism of action is associated with non-selective inhibition of the activity of the enzyme cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), mainly in peripheral tissues, resulting in inhibition of prostaglandin biosynthase - modulators of pain sensitivity, thermoregulation and inflammation. Ketorolac is a racemic mixture of the [-]S and [+]R enantiomers, with the analgesic effect due to the [-]S form.

The drug does not affect opioid receptors, does not depress breathing, does not cause drug dependence, does not have a sedative and anxiolytic effect. The strength of the analgesic effect is comparable to morphine, significantly superior to other non-steroidal anti-inflammatory drugs.

After oral administration, the onset of analgesic action is observed after 1 hour, respectively, the maximum effect is achieved after 1-2 hours.

Pharmacokinetics

After oral administration, ketorolac is well absorbed in the gastrointestinal tract - the maximum concentration (Cmax) in blood plasma (0.7-1.1 μg / ml) is reached 40 minutes after taking a dose of 10 mg on an empty stomach. rich in fat food reduces the maximum concentration of the drug in the blood and delays its achievement by 1 hour. 99% of the drug binds to plasma proteins, and with hypoalbuminemia, the amount of free substance in the blood increases. Bioavailability - 80-100%). Time to reach equilibrium concentration (Css) at oral administration- 24 hours when administered 4 times a day (above subtherapeutic) and after oral administration of 10 mg 0.39-0.79 μg / ml.

The volume of distribution is 0.15-0.33 l/kg. In patients with renal insufficiency, the volume of distribution of the drug can increase by 2 times, and the volume of distribution of its R-enantiomer by 20%.

Penetrates into breast milk: after the mother takes the first and second doses of ketorolac 10 mg, Cmax in milk is reached after 2 hours and is 7.3 ng / ml and 7.9 g / l, respectively.

More than 50% of the administered dose is metabolized in the liver with the formation of pharmacologically inactive metabolites. The main metabolites are glucuronides, which are excreted by the kidneys, and p-hydroxyketorolac. It is excreted by 91% by the kidneys, 6% - through the intestines.

Half-life (T1/2) in patients with normal renal function is 2.4-9 hours after oral administration of 10 mg. Т1/2 lengthens in the elderly and shortens in the young. Liver function does not affect T1 / 2 . In patients with impaired renal function with a plasma creatinine concentration of 19-50 mg / l (168-442 μmol / l)

T1 / 2 is 10.3-10.8 hours, with more severe renal failure - more than 13.6 hours.

The total clearance is when administered orally 10 mg - 0.025 l / kg / h; with renal failure with a plasma creatinine concentration of 19-50 mg / l when administered orally 10 mg-0.016 l / kg / h.

Not excreted by hemodialysis.

Indications:

Pain syndrome of moderate and severe intensity various genesis(including in the postoperative period, with oncological diseases, etc.)

Contraindications

• Hypersensitivity (including to other non-steroidal anti-inflammatory drugs);
• Complete or incomplete combination of bronchial asthma. recurrent polyposis of the nose and paranasal sinuses and intolerance acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including history);
• Erosive and ulcerative lesions gastrointestinal tract and duodenum, active gastrointestinal bleeding, inflammatory diseases intestines:
• Severe renal failure (creatinine clearance below 30 ml / min).
• Liver disease (exacerbation);
• Diseases thyroid gland;
• Confirmed hyperkalemia;
• Acute infarction myocardium;
• The period after coronary artery bypass grafting;
• Acute disorders of cerebral circulation (ischemic, hemorrhagic stroke);
• Diseases of the bone marrow and blood (leukopenia, including history, thrombocytopenia, hemophilia), myelosuppression;
• Severe myopathy, myasthenia gravis;
• Pregnancy, breastfeeding period, childhood(up to 16 years old);
• Simultaneous use with probenecid;
• Simultaneous use with pentoxifylline;
• Simultaneous use with acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (including cyclooxygenase-2 inhibitors);
• Simultaneous use with lithium salts;
• Simultaneous use with anticoagulants (including warfarin and heparin);

The drug is not used:

- for prophylactic pain relief before and during major surgery due to the high risk of bleeding.

For the treatment of chronic pain.

Carefully:

peptic ulcer stomach and duodenum, ulcerative colitis, Crohn's disease, history of liver disease, hepatic porphyria, chronic renal failure (creatinine clearance 30-60 ml / min), chronic heart failure, arterial hypertension, significant decrease in volume
circulating blood (including surgical intervention), elderly patients (including those receiving diuretics, debilitated patients and those with low body weight), bronchial asthma, simultaneous use of glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline), ischemic disease heart disease, cerebrovascular disease, dyslipidemia/hyperlipidemia, diabetes, peripheral arterial disease, smoking, infection Helicobacter pylori, long-term use of non-steroidal anti-inflammatory drugs, tuberculosis, severe osteoporosis, alcoholism, severe somatic diseases, hypotension, hypertension.

Use during pregnancy and during breastfeeding

Safety of use during pregnancy this drug not installed. Use during the third trimester of pregnancy drugs. disrupting the synthesis of prostaglandins, can cause premature closure of the ductus arteriosus and weaken the contractility of the uterus. Due to a violation of uterine contractions, labor slows down and the risk of uterine bleeding increases.

Ketorolac passes into breast milk. Both the mother and the child have an increased risk of bleeding.

The use of the drug Ketanov® is contraindicated during pregnancy and during breastfeeding.

Dosage and administration:

In the form of tablets, Ketanov® is used orally once or repeatedly, depending on the severity of the pain syndrome. A single dose - 10 mg, with repeated administration, it is recommended to take 10 mg up to 4 times a day, depending on the severity of pain; the maximum daily dose should not exceed 40 mg.

When taken orally, the duration of the course should not exceed 5 days.

Side effect

By frequency, side effects are divided according to WHO criteria into the following categories: very often (> 1:10), often (> 1: 100 and<1:10), нечасто (>1:1000 and<1:100). редко (>1:10000 and<1:1000), очень редко. включая отдельные случаи (<1:10000).

CNS disorders: often - headache, dizziness, drowsiness; rarely aseptic meningitis (fever, severe headache, neck stiffness), hyperactivity, mood changes, anxiety, hallucinations, depression, psychosis.

Cardiovascular disorders: infrequent increase in blood pressure; rarely - pulmonary edema, fainting.

Respiratory system disorders: rarely - bronchospasm, shortness of breath, rhinitis, laryngeal edema.

Digestive disorders systems: often (especially in elderly patients over 65 years of age with a history of erosive and ulcerative lesions of the gastrointestinal tract) gastralgia, diarrhea; infrequently - stomatitis, flatulence, constipation, vomiting, feeling of fullness in the stomach; rarely - nausea, erosive and ulcerative lesions of the gastrointestinal tract (including with perforation [sharp abdominal pain] and bleeding [vomiting like coffee grounds, melena] - conditions that can lead to death), cholestatic jaundice, hepatitis, hepatomegaly. acute pancreatitis.

Excretory system disorders: rarely - acute renal failure, back pain with or without hematuria and / or azotemia, hemolytic-uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination, increased or decreased daily diuresis, nephritis, edema of renal origin.

Sensory disturbances: rarely - hearing loss, tinnitus, visual impairment (including blurred vision).
Disorders from the hemostasis system: rarely - bleeding from a postoperative wound, epistaxis, rectal bleeding.

Hematopoietic disorders: rarely anemia, eosinophilia, leukopenia.

Skin disorders: infrequently - skin rash (including maculopapular rash), purpura; seldom- exfoliative dermatitis, urticaria, Stevens-Johnson syndrome, Lyell's syndrome.

Allergic reactions: rarely anaphylactic reactions, anaphylactoid reactions (skin hyperemia, rash, urticaria, pruritus, shortness of breath, shortness of breath, angioedema).

Other violations: often - edema (face, legs, weight gain); infrequently - increased sweating; rarely - swelling of the tongue, fever.

Overdose:

Symptoms: abdominal pain, nausea, vomiting, occurrence of peptic ulcers of the stomach or erosive gastritis, impaired renal function, metabolic acidosis.

Treatment : gastric lavage, the introduction of adsorbents (activated carbon) and symptomatic therapy (maintenance of vital functions in the body).

Not sufficiently excreted by dialysis.

Interaction with other drugs

Simultaneous use of ketorolac with acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including cyclooxygenase-2 inhibitors), calcium preparations, glucocorticosteroids, ethanol, corticotropin can lead to a significant increase in the risk of adverse reactions, including the formation of ulcers of the gastrointestinal tract and the development of gastrointestinal - intestinal bleeding. Simultaneous use with non-steroidal anti-inflammatory drugs is contraindicated.

Simultaneous use with paracetamol increases nephrotoxicity. with methotrexate - hepato- and nephrotoxicity.

The simultaneous use of ketorolac and methotrexate is possible only when using low doses of the latter (to control the concentration of methotrexate in the blood plasma) and diuretic drugs (the synthesis of prostaglandins in the kidneys decreases).

When combined with opioid analgesics, the doses of the latter can be significantly reduced.
Antacids do not affect the absorption of the drug.

Ketorolac enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose recalculation is required). Simultaneous use with sodium valproate causes a violation of platelet aggregation.

Increases plasma concentration of verapamil and nifedipine.

When used with other nephrotoxic drugs (including gold preparations), the risk of developing nephrotoxicity increases.

Drugs that block tubular secretion reduce the clearance of ketorolac and increase its concentration in blood plasma.

Simultaneous use with probenecid leads to an increase in plasma concentration and half-life of ketorolac. Simultaneous use with probenecid is contraindicated.

Simultaneous use of lithium salts and certain drugs that inhibit the synthesis of prostaglandins. leads to a violation of the excretion and an increase in the plasma concentration of lithium salts.
Simultaneous use with lithium salts is contraindicated.
With the simultaneous use of cyclosporine, tacrolimus with ketorolac (as with other NSAIDs), caution is recommended due to the increased risk of nephrotoxicity.

There have been reports of hematoma formation in HIV-infected patients with hemophilia treated concomitantly with zidovudine and ibuprofen.

Therefore, caution should be exercised when using NSAIDs and zidovudine concomitantly. Ketorolac does not affect the binding of digoxin to blood proteins.

According to animal studies, the simultaneous use of NSAIDs with quinolone antibiotics increases the risk of seizures.

Within 8-12 days after the use of mifepristone, it is not recommended to use NSAIDs. since it is possible to reduce the effect of mifepristone.

special instructions

Ketorolac inhibits platelet aggregation and increases blood clotting time. The effect on platelet aggregation stops after 24-48 hours.

Hypovolemia increases the risk of adverse reactions from the kidneys.
If necessary, it can be prescribed in combination with narcotic analgesics.

Ketanov® is not recommended for use as a means for premedication and maintenance anesthesia.
When using ketorolac, cases of fluid retention, arterial hypertension and edema have been reported. Care must be taken when prescribing to patients with heart failure, arterial hypertension.

Simultaneous use with other non-steroidal anti-inflammatory drugs can lead to such disorders as decompensation of heart failure, increased blood pressure. Patients with impaired blood coagulation are prescribed the drug only with constant monitoring of the number of platelets, which is especially important in the postoperative period, when careful monitoring of hemostasis is required.

According to clinical studies, the use of some non-steroidal anti-inflammatory drugs in high doses may lead to an increased risk of arterial thrombotic complications (eg, myocardial infarction, stroke). Despite the fact that such complications have not been reported with ketorolac, the existing data are insufficient to rule out the risk of such complications. The risk of developing adverse reactions increases with the lengthening of the treatment period and the increase in oral doses of more than 40 mg / day.

To reduce the risk of developing NSAID gastropathy, it is recommended to use antacids, misoprostol, as well as drugs that reduce gastric secretion (histamine H2 receptor blockers, proton pump inhibitors).

Influence of a medicinal product for medical use on the ability to drive vehicles, mechanisms

During the treatment period, side effects from the central nervous system (drowsiness, dizziness, headache) may develop, which reduces the speed of mental and motor reactions and therefore it is necessary to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed. reactions.

Release form:

Film-coated tablets, 10 mg.
10 tablets in an aluminum foil/PVC blister or OPA-A1-PVC/A1 blister. 1, 2, 3 or 10 blisters with instructions for use in a cardboard box.

Storage conditions

At a temperature not higher than 25°C. Keep out of the reach of children.

Best before date:

Do not use after the expiration date.

Leave conditions:

On prescription.

Registration ownercertificates

S.K. Therapy S.A., 400632, Fabrichi st.

124, Cluj-Napoca. Cluj County, Romania.

Manufacturer

C.K. Therapy C.A.. 400632, Fabrici str.
124, Cluj-Napoca, Cluj County, Romania.
S.C. Terapia S.A., 400632, 124 Fabricii
Street, CI uj-Napoca, Cluj County, Romania.

Sun Pharmaceutical Industries Ltd.,
Industrial Area No. 3, A. V. Road, Dewas -

455 001, India
Sun Pharmaceutical Industries Ltd., Industrial
Area No3, A. B. Road, Dewas - 455 001,
India

Claims of consumers should be directed to the representative office of Sun Pharmaceutical Industries Ltd. by the address:

129223, Moscow, Prospect Mira, 199, building 537/2.