Does Riboxin need to be diluted with saline? Riboxin for injection - instructions for use. Film-coated tablets and film-coated tablets

Riboxin is a medical drug that helps improve metabolism in the body. Available in the form of a solution for injection and for oral administration in tablets and capsules. Let's look at the instructions for using the injection form.

Composition and release form

Riboxin in 5 ml ampoules contains a ready-made solution for injection. The active ingredient is inosine. Each milliliter of the drug contains 20 mg of inosine, a whole ampoule contains 100 mg of the substance.
Rice – Riboxin injection solution
Manufacturers are different.

Properties

• improves the body's absorption of oxygen and glucose;
• significantly increases the resistance of organs, cells and tissues to hypoxia (lack of oxygen);
• leads to normalization of heart rhythm resulting from various diseases;
• increases the supply of energy necessary for the life of cells and tissues;
• activates the process of restoration of damaged tissues.

After intravenous injection Riboxin is distributed in all tissues of the body. Transformation occurs in the liver with the formation of glucuronic acid followed by its oxidation.

Indications

• cardiac ischemia;
• pain in the center chest(angina pectoris);
• arrhythmia – disturbance of heart rhythm;
• heart failure;
• heart defects;
• damage to the arteries, in which their lumen narrows and blood supply decreases;
• poisoning of the body with cardiac glycosides;
• therapy for primary damage to the heart muscle of various origins;
• failure of metabolic processes in the myocardium resulting from various circumstances (physical stress, illnesses caused by infections and bacteria);
• inflammation of the heart muscle (myocardium);
• inflammation of the liver, fatty degeneration of its tissues;
• preventing a decrease in white blood cell counts resulting from irradiation.

Contraindications

• increased sensitivity and allergic reactions on medicine;
• the urea content in the blood is higher than normal (according to laboratory tests);
• disruption of the normal functioning of the kidneys and liver;
• children under 3 years old;
• the period of gestation and breastfeeding;
• a disease of joints and tissues caused by metabolic disorders in the body - gout.

Dosages

Intravenous stream or drip (rate 40-60 drops per minute). The dose per injection is 200 mg once a day. Further, 400 mg 1-2 times a day in the absence of symptoms described in the section “ Side effects" The duration of treatment and dose are determined by the doctor individually.

Overdose

Not described in the instructions for use.

Side effects

• allergic manifestations;
• itching on the skin, redness;
• increase in content uric acid in the blood - exacerbation of gout.

If these symptoms appear, you should stop treatment with the drug.

special instructions

During therapy, it is necessary to monitor the amount of urea in the blood and urine.
The medicine is prescribed with extreme caution for kidney diseases.

Speed ​​and reaction

During the period of therapy using the drug Riboxin, there is no prohibition on driving independently and working with complex mechanisms.

Drug interactions

Not listed in the instructions.

With alcohol

No data.

Conditions for dispensing from pharmacies

On prescription.

Analogs

• Inozie-F;
• Inosine.

Sources

1. Riboxin https://www.vidal.ru/drugs/riboxin__15782

Pharmacist. Work experience of more than 10 years in chain pharmacies and 5 years as a medical representative in the companies HiPP, KRKA, Sanofi. She was involved in the promotion of targeted drugs among doctors and pharmacies in Kazan. Since 2016, I have been continuing distance learning using the NMIFO system. I actively attend medical conferences, symposiums, lectures by leading experts, I like to gain new knowledge and share it with people, supplemented with information from scientific publications of the Consilium medicum. Diploma

1 tablet of the pharmaceutical product contains:

• Riboxin – 0.2 g;
• Calcium stearate;
• Potato starch;
• Powdered sugar;
• Opadry II Yellow coating mixture - Indigo carmine (E 132), Lactose monohydrate, Titanium dioxide (E 171), Macrogol (polyethylene glycol 3000), Quinoline yellow (E 104), Iron oxide (E 172).

Composition of solution for injection:

• – 20 mg/ml.

Release form

• 2-% injection in ampoules of 10 ml (total content of the main active ingredient – ​​200 mg). Cardboard box holds 10 ampoules.
• Pills Riboxin yellow color, covered with a shell with a biconvex surface. In the cross section, two layers are clearly visible. The drug is packaged in contour cellular blisters made of aluminum foil or PVC, 10 tablets each. A pack contains 1, 2, 3, or 5 plates.
• Riboxin Lect - capsules with Inosine content - 0.2 g. 20, 30 or 50 pieces are placed in a cardboard package.

pharmachologic effect

What is Riboxin?

Riboxin is a drug anabolic character that has a nonspecific antihypoxic And antiarrhythmic action. The main active ingredient of the drug is Inosine (Inosine - INN or international generic name pharmaceutical products) – chemical precursor adenosine triphosphate (ATP), which is directly involved in glucose and promotes the activation of metabolic processes under conditions of oxygen deficiency (“”).

Mechanism of action of the drug

The biologically active substances included in the drug activate the metabolism of pyruvic acid (PVA), which ensures normalization of tissue respiration even in the absence of the required amount of ATP. The active components also affect the enzymatic component of metabolic processes - when they enter the human body, they stimulate xanthine dehydrogenase activity , which in turn catalyzes oxidative reactions followed by the formation of uric acid from hypoxanthine.

The benefits and harms of Riboxin

Positive The effects of the pharmaceutical drug include the effect of the main components of Riboxin on metabolism in the myocardium (heart muscle). Thus, the therapeutic properties of the drug are manifested in increasing the energy balance of cardiomyocytes , accelerated formation of nucleotides, which manifests itself in enhanced processes of physiological regeneration cardiac tissue. That is, the medicine helps to normalize the contractile activity of the myocardium and a more complete course of diastole, when the heart completely relaxes due to the ability to bind with chemical chains of calcium ions that penetrate into the intracellular space during systole.

TO negative the influences of Riboxin can be attributed to change in the physiological sequence of the metabolic cycle . That is, the active components of a pharmaceutical drug, coming from outside, make adjustments to metabolic processes. As a rule, qualified specialists try, if possible, not to interfere in this area of ​​​​biochemistry human body, since the therapeutic effects can cause very adverse consequences for the patient. However, in the presence of a pathological process that destructively affects the heart muscle (the vital “pump” of the circulatory system), a change in metabolism is necessary, because non-intervention will lead to a much worse outcome.

Wikipedia about Riboxin

The free encyclopedia of knowledge on the Internet also reveals some aspects of the pharmacological action of the drug. In particular, all the cardiac effects of the biologically active components that make up Riboxin are described. In addition, on the page about this medicine there is information about the effect on the cellular component of the blood coagulation system - Inosine reduces aggregation , which reduces the risk of developing and thromboembolism . The regenerative therapeutic properties of the pharmaceutical drug extend not only to the heart muscle, but also to the mucous membrane of the gastrointestinal tract.

Separately, it should be noted Inosine pranobec c – a type of drug that has immunostimulating activity and nonspecific antiviral action. The drug suppresses such harmful pathogens as simplex virus, CMV (cytomegalovirus), type 3 T-cell lymphoma virus, human enterocytopathogenic virus and many others. The mechanism of this action lies in inhibition of ribonucleic acid and inhibition of the biological catalyst dihydropteroate synthetase, which manifests itself in the suppression of viral replication and increased production lymphocytes interferons that destroy pathological organisms.

Pharmacodynamics and pharmacokinetics

When taken orally, Riboxin is good and almost completely absorbed V gastrointestinal tract. When administered intravenously, the pharmaceutical drug quickly distributed in tissues that need ATP. Regardless of route of administration, unused active ingredients metabolized in the liver, where the final stages of metabolic biochemical reactions take place. A small amount of Riboxin is excreted in urine, feces and bile.

Indications for use of Riboxin

Indications for use of Riboxin tablets:

• Complex treatment coronary disease hearts ( , coronary insufficiency, state after );
• Intoxication with cardiac glycoside drugs;
• Cardiomyopathies of various origins;
• Myocarditis ;
• Rheumatic, congenital and acquired heart defects;
• Cardiac arrhythmia;
• infectious or endocrine origin (especially against the background of severe physical activity);
• Coronary ;
• Nonspecific liver diseases ( hepatitis , fatty degeneration of a parenchymal organ, );
• Drug and alcohol liver damage;
• Urocoproporphyria ;
• Prevention of reduction in quantity during irradiation;
• And duodenum ;
• Open angle with normalized intraocular pressure.

Specific indications for the use of injections:

• Urgent pathological conditions of cardiac arrhythmias;
• Operations on an isolated kidney (as a means of pharmacological protection in case of temporary lack of blood circulation);
• unknown etiology in medicine;
• Acute radiation exposure to prevent the development of changes in the blood formula.

Contraindications

• Hereditary or acquired intolerance constituent components of a pharmaceutical product;
• Individual increased sensitivity To active ingredients medicine;
• Kidney failure ;
• Hyperuricemia (increased amount of uric acid salts in the blood).

Side effects

As a rule, the medicine is well tolerated, only in isolated cases the following side effects are observed:

• Arterial hypotension ;
• Increased levels of uric acid and its salts in the blood;
• General weakness;
• Exacerbation of gout ;
• allergic origin;
• Redness of the skin.

Instructions for use of Riboxin (Method and dosage)

Riboxin tablets, instructions for use

Tablets are used orally inside, before meals. The dosage, as a rule, is set individually in view of the characteristics of the metabolism of the active components and indications for conservative therapy. However, there are certain are commontreatment regimens this pharmaceutical preparation, according to which daily dose for adults and children over 12 years of age is 0.6-2.4 g per day. Rehabilitation begins with small dosages (about 0.6-0.8 g - 1 tablet 3-4 times a day), and then, if the medicine is well tolerated and has a beneficial effect on the body, the dose is gradually increased over 2-3 days.

Maximum amount The drug taken is 2.4 g per day - 4 tablets 3 times per day. This dosage is achieved after 2 months of the course. conservative treatment, the entire duration of which, as a rule, lasts from 1 to 3 months and is regulated taking into account individual indications for therapeutic intervention.

Separately, it should be noted how to take pills with urocoproporphy , since pathophysiology of this disease associated with an increase in uric acid salts in biological fluids and secretions. Riboxin, in turn, accelerates the metabolism of urates, activating the enzymatic oxidation of hypoxanthine. Therefore, in order to avoid deposits and the formation of stones, the dosage of the drug is 0.8 g per day - 1 tablet 4 times a day and must be strictly observed during conservative treatment.

Riboxin injections, instructions for use

Slow parenteral drip administration is used or rapid jet injections , depending on individual indications and the urgency of the pathological condition. If the attending physician chooses injections, then first apply a minimum dosage of 200 mg of Riboxin (10 ml of 2% injection solution) once a day. For acute disorders rhythm of cardiac activity, a single injection of 200-400 mg of Inosine (10-20 ml of 2% solution) intravenously can be used.

The dosage of jet administration is increased only if the drug is well tolerated. Maximum amount the drug can be 400 mg of Riboxin (two ampoules of a 2% solution) 1 or 2 times a day. The duration of the course is selected individually (according to the general protocol - 10-15 days).

If you use Riboxin IV (intravenously) drip , then before its administration, a 2% solution of the drug must be diluted in 5% glucose or hypotonic sodium chloride solution (concentration - 0.9%) to obtain 250 ml of medicinal liquid. The rate of administration is 40-60 drops per minute.

Instructions for

Riboxin is used intravenously for pregnant women, because in this way its effects are revealed more fully. The dosage and duration of the course of conservative therapy is selected strictly individually in each individual case, based on the results of various clinical studies and the opinion of qualified specialists.

How to use Riboxin Lect?

The dosage and duration of treatment with this variation of the pharmaceutical drug do not differ from the generally accepted protocols for therapeutic care with Riboxin. However, the Lect form of the drug is not used as an emergency correction of dysfunction of the heart muscle or other organs, since its effects develop somewhat more slowly.

Overdose

The medical pharmacological literature does not describe cases of overdose with this pharmaceutical drug.

Interaction

Combined use of a drug with cardiac glycosides enhances the inotropic effect of the latter and prevents the development of such an adverse effect drug treatment, as the occurrence of arrhythmia, for which Riboxin is sometimes prescribed together with this group of pharmaceuticals.

Simultaneous use with Riboxin with such anticoagulants , How , increases the duration of their therapeutic action.

The drug is completely incompatible with acids and alcohols , or , since both are deactivated chemical compounds, salts of heavy metals , vegetable alkaloids . The latter, when interacting with Riboxin, form insoluble and non-removable compounds due to the detachment of the alkaloid base.

Terms of sale

The drug belongs to list B, therefore it can be purchased only upon presentation of a certified receptor form. Certain old-fashioned pharmacy stalls may even require a prescription in Latin.

Storage conditions

The medicine should be stored in its original packaging at temperature conditions not higher than 25 degrees Celsius in a dry place, out of reach of children younger age place. Also, the drug should be protected from exposure to direct sunlight.

Best before date

special instructions

Riboxin in bodybuilding

A pharmaceutical drug is classified as metabolic agent and a stimulator of biochemical processes, so the medicine can be used for weight gain , improving physical performance and increasing strength indicators . Riboxin was actively used in sports back in the 70s. The following types of nutrition for bodybuilders are known, which are actively sold to this day:

• Premium Inosine;
• Ultimate nutrition;
• Inosine mega-pro;
• Inosine life extension;
• Cell-tech hardcore.

How to take Riboxin for bodybuilding?

IN sports nutrition used tableted a form of medication that is administered orally before meals. Dosage ranges from 1.5 to 2.5 g per day. As for therapeutic purposes, the number of tablets taken should be gradually increased from a starting dosage of 0.6-0.8 g 3-4 times a day to 2.5 g. Riboxin for athletes should be used for 4 weeks to 1.5 -3 months.

To enhance the effect of the drug on the myocardium and reduce the period of mid-mountain and climatic adaptation, they can be used together and Riboxin. In this case, the dosage of the potassium salt of orotic acid is 0.25-0.5 g 2-3 times a day before meals (course duration is 15-30 days), and Riboxin is used according to the above scheme.

Riboxin in veterinary practice

The drug is non-specific in its pharmaceutical nature, therefore it can also be used in veterinary therapeutic practice. Often the drug is used for dogs for the purpose of liquidation heart failure , treatment myocarditis and, improving the metabolic abilities of the muscular organ with myocardosis And heart defects , which are very common aging problems in animals.

How should animals take Riboxin?

Typically, the drug is administered intramuscularly , because this is the most rational route of administration in veterinary practice. The dosage is 0.1-0.2 g of the drug per 10 kg of animal weight 3 times a day. The course of conservative treatment lasts about a month. Repeated prescriptions of Riboxin are possible for a more thorough correction of metabolism or elimination of deep degenerative changes.

Riboxin's analogues

Riboxin analogues constitute a small pharmaceutical group with an identical main active ingredient - Inosie-F, Inosine, Riboxin bufus, Ribonosine . As a rule, the price of these medicines is even lower, which is why Riboxin tablets can be replaced with these analogues for greater savings.

With alcohol

Riboxin IV (intravenously) should not be combined with drinking alcohol, as this is fraught with side effects from the list above or the emergence of new adverse consequences of conservative therapy with a pharmaceutical drug.

Riboxin during pregnancy (and lactation)

The pharmaceutical drug is actively prescribed during the most critical periods for a woman, which, as a rule, plunges expectant mothers into slight bewilderment. Even after reading the instructions, many questions remain, the main one of which, of course, is what Riboxin is for during pregnancy. Medicine improves energy supply and tissue metabolism , that is, it provides the woman and fetus with a more active supply of beneficial nutrients during the period when they suffer from deficiency states. This is one of the main aspects of using Riboxin.

Also, the active ingredients help reduce harm from the so-called “ oxygen starvation ", which is a common complication during pregnancy. Arises pathological condition, because respiratory system women supplies vital gas to two organisms. But such a powerful need for oxygen runs counter to the capabilities of the lungs and bronchial tree. Because antihypoxic effect Riboxin comes in handy, and this is the second, but no less important aspect of using the drug during pregnancy.

Among the therapeutic properties of a pharmaceutical drug, a significant part consists of effects on cardiac activity . Riboxin normalizes myocardial contractile activity, regulates the metabolic needs of cardiomyocytes, and helps enhance trophic processes. Thus, the drug plays the role preventive sanitation , since it is not uncommon for pregnant women to develop such pathological processes, as well as other disturbances in the rhythm of the heart muscle.

How to take Riboxin for pregnant women?

The dosage and duration of use of a pharmaceutical drug during pregnancy is always selected individually based on indicators diagnostic tests, ultrasound data and other physiological parameters. As a rule, Riboxin is administered intravenously during pregnancy, but in medical literature and on thematic forums for pregnant women, cases of prescribing the tablet form of the drug are described.

Reviews about Riboxin

Reviews about Riboxin characterize the drug from a positive point of view in their overwhelming majority. The drug has an extremely small list of possible side effects, which seems even more insignificant if we consider the entire range of indications for the use of Riboxin. The active components make it possible to effectively fight and stop the pathological effects of most common nosological entities affecting the vital circulatory system and its “main pump”.

However, the therapeutic effects of the drug are not limited to effects on the myocardium. The active components promote active regeneration of the mucous membrane in destructive diseases of the gastrointestinal tract, and how often in modern world you will meet a person without at least light form gastritis. The positive effects also extend to the blood system, metabolic processes in the kidneys and other organs and systems.

Compound

1 ml contains the active substance: inosine (riboxin) - 20.0 mg.

Pharmacotherapeutic group

Metabolic agent.

ATX code

pharmachologic effect

Inosine is a derivative (nucleoside) of purine and is a precursor of adenosine triphosphate (ATP). Belongs to the group of drugs that stimulate metabolic processes. Has antihypoxic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, and prevents the consequences of intraoperative renal ischemia. It is directly involved in glucose metabolism and promotes the activation of metabolism under hypoxic conditions and in the absence of ATP. Activates the metabolism of pyruvic acid, which is necessary to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of some Krebs cycle enzymes. Penetrating into cells, it has positive action on metabolic processes in the myocardium - increases the strength of heart contractions and promotes more complete relaxation of the myocardium in diastole, resulting in an increase in stroke volume. The mechanism of antiarrhythmic action is not completely clear. Reduces platelet aggregation, activates tissue regeneration (especially the myocardium and the mucous membrane of the gastrointestinal tract).

Contraindications

Increased sensitivity to the drug. Gout, hyperuricemia, pregnancy, breastfeeding, age under 18 years (efficacy and safety have not been established).

Directions for use and doses

The drug is administered intravenously slowly, in a stream or drip (40-60 drops per minute). Treatment begins with the administration of 200 mg (10 ml of a 20 mg/ml solution) 1 time per day, then, if well tolerated, the dose is increased to 400 mg (20 ml of a 20 mg/ml solution) 1-2 times a day. Duration of treatment is 10-15 days. Jet administration of the drug is possible for acute cardiac arrhythmias in a single dose of 200-400 mg (10-20 ml 20 mg/ml). For pharmacological protection of kidneys subjected to ischemia, Riboxin is administered intravenously as a bolus, in a single dose of 1200 mg (60 ml of a 20 mg/ml solution) 5-15 minutes before clamping the renal artery, and then another 800 mg (40 ml of a 20 mg/ml solution ) immediately after restoration of blood circulation. For intravenous drip administration, a solution of 20 mg/ml is diluted in a 5% dextrose (glucose) solution or 0.9% sodium chloride solution (up to 250 ml).

Release form

Solution for intravenous administration 20 mg/ml. 5 or 10 ml in ampoules of colorless neutral glass type I with a colored break ring, a colored dot and a notch or without a break ring, a colored dot and a notch. The ampoules may additionally be coated with one, two or three color rings and/or a two-dimensional bar code, and/or alphanumeric coding, or without additional color rings, a two-dimensional bar code, or alphanumeric coding. 5 ampoules per blister pack made of polyvinyl chloride film and lacquered aluminum foil or polymer film or without foil and without film. Or 5 ampoules are placed in a pre-made form (tray) made of cardboard with cells for laying ampoules. One or two contour blister packs or cardboard trays, together with instructions for use and a scarifier or ampoule knife, or without a scarifier and ampoule knife, are placed in a cardboard package (pack).

Country of origin

Product group

A drug that normalizes myocardial metabolism and reduces tissue hypoxia

Release forms

• 10 - contour cell packaging (5) - cardboard packs. 10 ampoules of 10 ml per box, 10 ml - ampoules (10) - cardboard packs, 10 ml - ampoules (10) - cardboard packs. 10 ml - ampoules (10) - cardboard packs. 10 ml - ampoules (10) - cardboard packs. 10 ml - ampoules (5) - cardboard packs. 10 ml - ampoules (10) - cardboard packs. 10 ml - ampoules (5) - cardboard packs. 10 ml - ampoules (10) - contour plastic packaging (1) - cardboard packs 10 pcs. - contour cell packaging (5) - 5 ml cardboard packs - ampoules (10) - cardboard packs. 5 ml - ampoules (5) - contour plastic packaging (2) - cardboard packs. 50 - dark glass jars (1) - cardboard packs. 10 - contour cell packaging (5) - cardboard packs of 50 tablets per pack Solution for intravenous administration 20 mg/ml - 10 ml per ampoules - 10 pcs per pack. Solution for intravenous administration 20 mg/ml - ampoules of 10 ml - 10 pcs per pack. Solution for intravenous administration 20 mg/ml, 10 ml in ampoules made of low-density polyethylene or polypropylene - 10 pcs. in pack Solution for intravenous administration 20 mg/ml, 5 ml in ampoules made of low-density polyethylene or polypropylene - 10 pcs. in pack pack of 10 ampoules of 5 ml

Description of the dosage form

• Transparent colorless or slightly colored liquid. Round, biconvex tablets, coated film-coated, from light yellow to yellow - orange color. On a cross section, two layers are visible: the inner one is white, the outer one is light yellow to yellow-orange. Transparent colorless or slightly yellowish liquid. clear, colorless or slightly colored liquid. Transparent or almost transparent, colorless or slightly colored liquid. Transparent or almost transparent, colorless or slightly colored liquid. transparent, colorless or slightly colored liquid Solution for intravenous administration, injection solution Round, biconvex, film-coated tablets, yellow in color. The cross-section shows two layers of yellow-coated tablets, round with a biconvex surface. Film-coated tablets. Film-coated tablets.

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• 1 ml 1 amp. inosine 20 mg 200 mg 1 amp. inosine 200 mg 1 tablet contains Active substance: riboxin (inosine) - 200 mg Excipients: core - potato starch, methylcellulose, sugar, polyvinylpyrrolidone (povidone), Tween - 80 (polysorbate), stearic acid, sodium carboxymethyl starch (Primogel); shell – methylcellulose, hyprolose (hydroxypropylcellulose), titanium dioxide, Tween – 80 (polysorbate), silicone emulsion, tropeolin O. 1 ml of solution contains 20 mg of riboxin (inosine) as active substance; Excipients: hexamethylenetetramine (methenamine), sodium hydroxide solution 1 M, water for injection. 1 ml of solution contains: active substance: riboxin (inosine) - 20 mg, excipients: sodium hydroxide - 4.8 mg, diluted hydrochloric acid - to pH 8.5 to 9.5, sodium chloride - 8.5 mg, water for injection - q.s. up to 1 ml 1 ml contains inosine (riboxin) 20 mg excipients: hexamethylenetetramine, 1M sodium hydroxide solution, water for injection. 1 tab. inosine 200 mg 1 tablet contains the active substance riboxin (inosine) - 200 mg; excipients: potato starch, water-soluble methylcellulose, sucrose (refined sugar), stearic acid; the shell contains: water-soluble methylcellulose, polysorbate 80 (Tween-80), titanium dioxide (titanium dioxide), tropeolin O, beeswax. 1 film-coated tablet contains riboxin 0.2 g; , Auxiliary ingredients: sucrose, potato starch, povidone K-30, stearic acid. inosine 20g, Auxiliary ingredients: hexamethylenetetramine, sodium hydroxide solution, water Inosine - 100 mg in 5 ml of solution; excipients – hexamethylenetetramine, sodium hydroxide, water for injection. riboxin /inosine/ 20MG; Auxiliary ingredients: methenamine, sodium solution hydroxide, water riboxin /inosine/; hexamethylenetetramine; sodium chloride; water d/in Riboxin 0.2g; Auxiliary ingredients: potato starch, methylcellulose, sugar, stearic acid

Riboxin indications for use

• IHD, myocardial dystrophy, condition after myocardial infarction, congenital and acquired heart defects, heart rhythm disturbances, especially with glycoside intoxication, myocarditis, dystrophic changes myocardium after heavy physical exertion and suffering infectious diseases or due to endocrine disorders; hepatitis, liver cirrhosis, fatty liver, incl. caused by alcohol or medicines; prevention of leukopenia during radiation exposure; operations on an isolated kidney (as a means of pharmacological protection in case of temporary absence of blood circulation in the operated organ).

Riboxin contraindications

• Hypersensitivity to the drug, gout, hyperuricemia, renal failure, pregnancy, lactation period, childhood up to 1 year

Riboxin dosage

• 20 mg/ml 200 mg

Riboxin side effects

• Possible allergic reactions such as urticaria, skin itching, skin hyperemia (drug discontinuation required). Rarely, when treated with Riboxin, the concentration of uric acid in the blood increases and exacerbation of gout (with long-term use).

Drug interactions

Overdose

Storage conditions

• store in a dry place
• keep away from children
• store in a place protected from light

A drug that normalizes myocardial metabolism and reduces tissue hypoxia

Active substance

Release form, composition and packaging

Film-coated tablets light yellow to yellow-orange, round, biconvex, slightly rough; on a cross section, two layers are visible: the core is white or white with a slightly yellowish tint and the shell is light yellow to yellow-orange.

Excipients: potato starch 54.1 mg, methylcellulose 3.2 mg, sucrose 10 mg, stearic acid 2.7 mg.

Shell composition: opadry II yellow (polyvinyl alcohol, titanium dioxide, talc, macrogol 3350 (polyethylene glycol 3350), iron (III) oxide, aluminum varnish based on quinoline yellow) - 8 mg.

10 pieces. - contour cell packaging (5) - cardboard packs.
25 pcs. - contour cell packaging (2) - cardboard packs.

pharmachologic effect

Inosine belongs to the group of drugs that regulate metabolic processes. The drug is a precursor for the synthesis of purine nucleotides: adenosine triphosphate and guanosine triphosphate.

It has antihypoxic, metabolic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, and prevents the consequences of intraoperative renal ischemia. Takes direct part in metabolism and promotes activation of metabolism under conditions of hypoxia and in the absence of adenosine triphosphate.

Activates the metabolism of pyruvic acid to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of some Krebs cycle enzymes. Penetrating into cells, it increases energy level, has a positive effect on metabolic processes in the myocardium, increases the strength of heart contractions and promotes more complete relaxation of the myocardium in diastole, resulting in an increase in stroke volume of blood.

Reduces platelet aggregation, activates tissue regeneration (especially the myocardium and the mucous membrane of the gastrointestinal tract.

Pharmacokinetics

Well absorbed in the gastrointestinal tract. Metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. A small amount is excreted by the kidneys.

Indications

Prescribed to adults in complex therapy of coronary heart disease, after suffered a heart attack myocardium, cardiac arrhythmias caused by the use of cardiac glycosides.

Prescribed for hepatitis, cirrhosis caused by alcohol or drugs, and urocoproporphyria.

Contraindications

Hypersensitivity to the drug, gout, hyperuricemia. Fructose intolerance and glucose/galactose malabsorption syndrome or sucrase/isomaltase deficiency.

Carefully:, diabetes.

Dosage

Prescribed for adults orally, before meals.

The daily dose when taken orally is 0.6-2.4 g. In the first days of treatment, the daily dose is 0.6-0.8 g (200 mg 3-4 times a day). If well tolerated, the dose is increased (on days 2-3) to 1.2 g (0.4 g 3 times a day), if necessary - to 2.4 g per day.

Course duration is from 4 weeks to 1.5-3 months.

For urocoproporphyria, the daily dose is 0.8 g (200 mg 4 times a day). The drug is taken daily for 1-3 months.

Side effects

Allergic reactions are possible in the form of urticaria, skin itching, skin hyperemia (discontinuation of the drug is required). Rarely, during treatment with the drug, the concentration of uric acid in the blood increases and exacerbation of gout (with long-term use).

Drug interactions

(azathioprine, antilympholine, cyclosporine, thymodepressin, etc.) when used simultaneously reduce the effectiveness of Riboxin.