Bromhexine tablets dosage for adults. "Bromhexine": analogues of the drug, their comparison and reviews. Types of medication, commercial names of analogues, release forms

Name: Bromhexine

Name: Bromhexin

Indications for use:
Acute and chronic inflammatory diseases trachea, bronchi, lungs; bronchiectasis (lung disease with the formation of cavities filled with sputum in the lung tissue), pneumoconiosis (the general name for an occupational respiratory disease); in the pre- and postoperative period, the product is used for bronchography.

Pharmachologic effect:
Increases the secretion of secretions by the bronchial glands and reduces the viscosity of sputum, which gives a pronounced expectorant effect and facilitates the release of sputum. The drug is low toxic. Does not have a significant effect on blood circulation.

Bromhexine method of administration and dosage:
Bromhexine is taken orally (regardless of food intake) in tablet form. Doses for adults - 0.016 g (16 mg = 2 tablets of 0.008 mg) 3-4 times every day; for children from 3 to 4 years old - 0.002 g (2 mg), from 5 to 14 years old - 0.004 g (4 mg) 3 times every day; The product is not prescribed to children under 3 years of age.
The effect of the product usually begins to appear 24-48 hours after the start of treatment. The course of treatment is from 4 days to 4 weeks.
When used by inhalation, the solution should be diluted 1:1 with distilled water and heated to body temperature to prevent coughing. In sick people bronchial asthma or asmatic bronchitis, before inhalation you should take a bronchodilator (a drug that dilates the lumen of the bronchi). Inhalation is carried out twice every day for adults 4 ml, children over 10 years old - 2 ml, children aged 6 to 10 years - 1 ml, children aged 2 to 10 years - 10 drops and children under 2 years old - 5 drops per inhalation. Parenteral (bypassing the digestive tract) administration of the product is recommended for treatment in severe cases, also in the postoperative period to prevent the accumulation of thick sputum in the bronchi. Administer 1 ampoule subcutaneously, intramuscularly or intravenously 2-3 times every day slowly over 2-3 minutes. The product is administered intravenously along with glucose or saline. The drug is incompatible with alkaline solutions.
If necessary, bromtexine is prescribed simultaneously with antibacterial, bronchodilator, cardiac and other drugs.

Bromhexine contraindications:
There are no absolute contraindications. Relative: high susceptibility to the product, peptic ulcer, recent stomach bleeding, first trimester of pregnancy.

Bromhexine side effects:
Rarely, with long-term use - nausea, vomiting, dyspeptic symptoms (digestive disorders), exacerbations peptic ulcer. Extremely uncommon - angioedema (allergic) Quincke's edema, increased levels of transaminases (enzymes) in the blood serum.

Release form:
Tablets: 0.008 g, 0.016 g. Dragees: 0.004 g, 0.008 g, 0.012 g. Syrup (1 ml - 0.0008 g). Medicine (1 ml -0.0008 g). Solution for oral (by mouth) use (1 ml - 0.002 g). Elixir (1 ml - 0.0008 g, or 0.00016 g) Solution for inhalation (1 ml -0.0002 g). Solution for parenteral use (1 ml - 0.002 g).

Synonyms:
Bromhexine chloride, Bisolvon, Mucovin, Solvin, Brexol, Brodisol, Bromobene, Bromxin, Bisolvon, Brombenzonium, Brokokin, Lizomucin, Mugocil, Fulpen A.

Storage conditions:
Regular.

Attention!
Before using the medication "Bromhexine" You should consult your doctor.
The instructions are provided for informational purposes only. Bromhexine».

Bromhexine is an expectorant that affects the viscosity of sputum and also promotes its rapid removal from respiratory tract. The active ingredient of the drug is bromhexine hydrochloride. Bromhexine belongs to pharmacological group mucolytics with expectorant action.

The drug is available in the following dosage forms:

• Bromhexine tablets: 1 tablet contains 4 or 8 mg of active ingredient. Packages of 10, 20, 25, 50 tablets are available in pharmacies;
• Bromhexine solution for oral administration: in 5 ml of the drug the concentration of the substance is 4 mg. Bottles are available in volumes of 60, 100, 150 ml, each of them comes with a measuring spoon;
• Bromhexine drops for oral administration: in 1 ml of the drug the content of bromhexine hydrochloride is 8 mg. The medicine also contains anise (0.25 mg) and fennel (0.74 mg) oils. Each bottle contains 20 ml of the drug;
• Bromhexine syrup: 5 ml of syrup contains 4 mg of active ingredient. The product is available in bottles of 60 and 100 ml, with a measuring spoon included.

Also this drug is part of combination cough medicines, such as:

• Joset syrup: per 5 ml there are 1.205 mg of salbutamol, 0.5 mg of menthol, 2 mg of bromhexine, 50 mg of guaifenesin;
• Ascoril expectorant in syrup form: 2 mg salbutamol, 4 mg bromhexine, 100 mg guaifenesin, 1 mg menthol;
• Ascoril expectorant in tablet form: 8 mg bromhexine, 100 mg guaifenesin, 2 mg salbutamol;
• Solvin tablets: 8 mg of bromhexine in 1 tablet and 4 mg in 5 ml of elixir;
• Bromhexine Berlin Hemi syrup 4 and 8 mg active substance for 5 ml, in a bottle – 60 ml;
• Bromhexine Berlin Hemi in the form of tablets of 4 and 8 mg in 1 piece, in foreign currency - 25 tablets.

Pharmacological action of Bromhexine

According to the instructions, Bromhexine reduces the viscosity of sputum by breaking complex bonds inside polysaccharide molecules. As a result, the sputum turns into a liquid state and is easily coughed out of the bronchi. Consequently, in this way the lungs and bronchi are cleansed.

In addition, Bromhexine activates the production of internal lubrication of the alveoli (surfactant) and improves the respiratory functions of the lungs.

Indications for use

According to the instructions, Bromhexine is prescribed for diseases of the lungs, bronchi and trachea, such as:

• acute or chronic bronchitis;
• bronchial asthma;
• obstructive diseases of the bronchi and lungs;
• inflammatory diseases of the upper respiratory tract: tuberculosis, tracheitis, laryngitis, tracheobronchitis, pharyngitis and others;
• pneumonia.

The drug effectively relieves the symptoms of wet (productive) cough.

Contraindications to the use of Bromhexine

A contraindication to the use of Bromhexine according to the instructions is individual sensitivity to its components.

During pregnancy, Bromhexine syrup and tablets can be taken only after consultation with a doctor, although the medicine does not have any compelling contraindications for this category of patients.

Side effects of Bromhexine

Bromhexine syrup, tablets and elixir may cause side effects such as:

• V digestive system: vomiting and nausea, painful sensations in the stomach, bleeding, in some cases exacerbation of peptic ulcer;
• V nervous system: headache, weakness, frequent dizziness;
• in the immune system: allergic reactions, in particular, rash, itching, swelling, urticaria and others.

Instructions for use of Bromhexine and dosage

Bromhexine is taken orally in tablet form. When treating with this drug, do not focus on food intake. The dosages of the tablets are as follows:

• for adult patients, 0.016 g per dose, which is equivalent to 2 tablets (1 tablet – 0.008 g) three to four times a day;
• for children aged 3 to 4 years – 2 mg per dose with the same frequency as for adults;
• for children aged 5-14 years – 4 mg of the drug three times a day.

The therapeutic effect of Bromhexine appears already 1-2 days after the start of treatment. On average, the course lasts from 4 days to a month.

When using the drug in the form of a solution for inhalation, it is necessary to dilute it with distilled water in equal proportions and heat it to body temperature. Patients with asthmatic bronchitis or bronchial asthma before the procedure need to take a bronchodilator - a drug that widens the lumen in the lungs. Inhalations are carried out 2 times a day for adults (4 ml) and children over 10 years old (2 ml). Younger age categories (6-10 years) are prescribed 1 ml and 5 drops (2-6 years).

In severe cases, parenteral administration of the drug may be prescribed. The same method is used to prevent the accumulation of thick sputum in the bronchi during the postoperative period. Bromhexine is administered subcutaneously in a dosage of 1 ampoule. Also, if necessary, intravenous and intramuscular administration is allowed. The procedure is carried out 2-3 times a day in slow mode for two to three minutes. When used intravenously, the drug is supplemented with saline or glucose. Do not use the product with alkaline solutions.

Sometimes Bromhexine is used with cardiac, bronchodilator and antibacterial drugs.

Dragee Bromhexine Hemi 8 is taken in a daily dosage of 3-4 jokes for adults and adolescents over 14 years of age. In severe cases, the dose of Bromhexine Berlin Chemie is doubled. Children aged 6 to 14 years are prescribed Bromhexine Hemi in the form of syrup in a dosage of 5-10 ml (or 1 tablet of 8 mg of active substance) three times a day.

special instructions

The drug should not be taken simultaneously with drugs that block the cough reflex, for example, Sinecode, Codex, Stoptussin, Terpincode. Otherwise, stagnation of sputum in the bronchi may occur, which entails the development of primary and secondary infectious processes. Increased inflammation and damage to the wall of the bronchial tree is also possible. When combining Bromhexine, it can be taken during the day, and antitussives can be taken before bed.

In this article you can find instructions for use medicinal product Bromhexine. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Bromhexine in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications were observed and side effects, perhaps not stated by the manufacturer in the annotation. Analogues of Bromhexine in the presence of existing structural analogues. Use for the treatment of cough, including dry cough with bronchitis and asthma in adults, children, as well as during pregnancy and lactation.

What kind of medicine is this

Bromhexine is a medicine wide application, produced in various forms, used as effective remedy in the treatment of diseases and lesions of the respiratory tract, characterized by a dry, irritating, wet cough with difficult to separate sputum. The substances contained in Bromhexine, due to their activity, have emollient, expectorant, mucolytic and even anti-inflammatory effects. Therefore this medicine is considered the best drug in the treatment of bronchitis, tracheitis, laryngitis.

Used as an additional remedy for acute pneumonia, tracheobronchitis.

Bromhexine helps to quickly reduce the viscosity of the resulting sputum, which gives a quick, effective expectorant effect, facilitating the separation of sputum from the lungs. The drug is not considered toxic to the body and does not affect blood circulation. Suitable for treating children, elderly people, pregnant women. Compatible with many medications, has few contraindications.

Drug group

International and generic name or INN - Bromhexine.

The name in Latin is Bromhexinum.

A group of drugs are mucolytic agents.

Trade names: Bromhexine, Bronchotil, Solvin, Bronchosan, Flegamine, Flecoxin, Bromhexine 8, Bromhexine 4 Berlin-Chemie.

Compound

The core of the drug is its main active component - bromhexine (bromhexine hydrochloride).

Auxiliary components: starch, gelatin, magnesium stearate, lactose monohydrate, silicon dioxide.

Depending on the form, the composition contains sucrose, calcium carbonate, magnesium, talc, glucose syrup, E-171, U-104.

Mechanism of action and properties

The pharmacology of the drug Bromhexine is determined by the following features: it has a good mucolytic and expectorant effect. Its effectiveness lies in depolymerization, rarefaction of mucoprotein, mucopolysaccharide fibers of sputum. An important characteristic is the ability to activate the synthesis of surfactant - an active substance formed in the cells of the alveoli of the lungs. The synthesis of this substance can be disrupted in all diseases of the bronchopulmonary system, which manifests itself in disruption of cell stability and weakening of their response to harmful factors.

The drug also has some antitussive effect. Thanks to the effects of Bromhexine, thick sputum becomes liquid, it is easier to cough up, as a result of which the cough becomes less.

Pharmacokinetics. After oral (oral) administration, the medicine is completely absorbed from the stomach and intestines and excreted in the urine. The active metabolite is ambroxol, a substance similar in action in the body to Bromhexine. The bioavailability of the drug is about 80%.

How long does it take for Bromhexine to start working? The drug is well absorbed and is characterized by increased adsorption capacity when using any of its forms: syrup, tablets or inhalation form. The effect appears one day after the start of the course of taking the medication. A pronounced therapeutic effect can be noticed after two days. The maximum concentration in the patient’s blood and the maximum effect are achieved an hour after consumption.

When and how is the drug removed? The half-life of the drug is 4-5 hours. Metabolism (breakdown) occurs in the liver. Excreted by the kidneys. The drug has no visible effect on the liver, but may accumulate if taken for a long enough time. Bromhexine penetrates well through the blood-brain and placental barriers of a pregnant woman, and is found in milk when breastfeeding. A small part of the drug is excreted unchanged in the urine without affecting the kidneys.

Indications

What is Bromhexine used for and what does it help with?

The drug is used in the event of acute, chronic diseases of various respiratory organs, which are manifested by a dry, lingering, irritating or wet cough with the formation of dense sputum. The benefit of Bromhexine also lies in its antitussive properties.

What does Bromhexine treat?

The drug is effective in treating diseases:

• Acute inflammatory diseases of the trachea, lungs, bronchi.
• Pharyngitis, laryngitis, tracheitis.
• Tracheobronchitis, obstructive, acute bronchitis.
• Bronchial asthma with the presence of viscous sputum, its difficult discharge.
• infectious diseases complicated by the appearance of tracheitis, bronchitis, alveolitis.
• Nasopharyngitis, laryngotracheitis.
• Chronic bronchitis (with visible respiratory failure or its absence).
• Cystic fibrosis, emphysema, pneumonia, tuberculosis, obstructive diseases.
• Congenital pathologies of the respiratory system.
• Bronchiectasis.

Why is the drug prescribed in the pre- and postoperative period?

Can be used to cleanse the bronchi in the preoperative period, to prevent the accumulation of thick sputum after surgery. Prescribed to accelerate the release of the active substance after the bronchography procedure.

Release forms

Bromhexine can be sold in several dosage forms:

• Tablets 8 or 16 milligrams.
• Dragees 4, 8.12 milligrams.
• Syrup, a mixture of 0.0008 g in 1 milliliter, is used for young children.
• Solution for oral administration(by mouth) 2 milligrams per milliliter.
• Elixir, inhalation solution, solution for parenteral use (injections).
• Solution for injection (Bromhexine Egis).

Which is better: tablets or capsules, injections or syrup?

The choice of dosage forms of the drug is made on the recommendation of a doctor, depending on the form, characteristics of the disease, degree of severity, age and condition of the patient, and other factors.

Instructions for use

How to take or inject Bromhexine?

Before use, be sure to study the annotation (instructions), and it is better to consult with your doctor.

The drug in tablets can be taken regardless of meal time.

The normal dosage for adults is 16 milligrams, 3-4 doses per day.

Dosage for children:

• For children 3 - 4 years old, the dose is 2 milligrams, 3 times a day.
• Children over 4 years old - 4 milligrams, 3 times a day.
• Before 3 years of age, the form is not prescribed.

The course of treatment varies from several days to weeks. For some diseases, in particular stomach ulcers, the drug is taken under strict medical supervision.

The inhalation solution of the drug is mixed with distilled water in equal parts and heated to body temperature. The inhalation procedure itself is performed no more than twice a day; adults - 4 milliliters, children over 10 years old - 2 milliliters, children over 6 years old - 1 millilitre, over 2 years old - 10 drops, under 2 years old - 5 drops.

Administration of the drug parenterally through injections is used in severe advanced cases, in postoperative rehabilitation period. You can administer 1 ampoule intramuscularly or subcutaneously several times a day. For intravenous use, glucose and saline solution are used.

In severe cases the maximum daily dose increases according to the recommendations of medical specialists.

Side effect

The drug is well tolerated. Minor allergic reactions are possible (rash, rhinitis, itching, urticaria). Stomach and intestinal disorders may occur, and slightly increased levels of certain enzymes in the blood may occur; with further use of the drug, their amount decreases.

With long-term use, nausea, digestive disorders, increased peptic ulcer disease, dizziness, and pain may occur. A rare phenomenon is allergic Quincke's edema.

Contraindications

There are no absolute contraindications to taking the drug. Its use is undesirable when hypersensitivity the body to it, with a stomach ulcer, intestinal ulcer, or the presence of internal bleeding. Medicine is not recommended for initial stage pregnancy, while breastfeeding. Bromhexine is used with caution in the treatment of childhood diseases, as well as diseases associated with liver and kidney failure.

Use in children

Bromhexine for children is most often used in the form of syrup. The drug can be in different flavors: apricot, pear, cherry.

Most forms can be given to children only from 2-3 years of age, strictly observing the above dosage standards.

The mixture has been used since birth. The dosage of the medicine is determined exclusively by the pediatrician.

Treatment is best carried out together with postural drainage and massage of the child chest, increasing the outflow of sputum.

Use during pregnancy and breastfeeding

Use of Bromhexine during pregnancy and lactation absolute contraindications they do not, but it must be agreed upon with doctors. During pregnancy, Bromhexine is used in cases where the benefit to the mother significantly outweighs the risk to the health of the fetus. Self-medication and determining the dosage “by eye” during pregnancy and breastfeeding are strictly prohibited. This has possible serious consequences. The safest period to use is the third semester.

Use in the elderly

For people of advanced retirement age, Bromhexine is used in the treatment of diseases and elimination of their symptoms as an expectorant. In pensioners, due to age-related impairment of the excretion of metabolic products due to diseases or decreased functioning of the liver and kidneys, it is recommended to increase the usual interval between the use of the drug. The use of the drug should be supervised.

Driving a car and other mechanisms

According to the instructions, “Some degree of caution is required when operating vehicles, during other dangerous activities that require attention and reactions.” Despite the precautions for long-term use of the drug, the reaction remains high level and drowsiness does not appear.

Do you need a prescription?

Drug in different forms available without a prescription.

Compatibility with other drugs

Bromhexine has good drug interactions with other drugs and is prescribed together with bronchodilators, antibacterial agents, other drugs. Incompatible with alkaline solutions.

It is not recommended to use together with drugs to block the cough reflex (Codelac, Stoptussin, Libexin), which are prescribed for dry cough. There is a danger of prolonged stagnation of sputum, which leads to the proliferation of harmful infectious agents, increased inflammation, damage to the bronchi.

Alcohol compatibility

Taking Bromhexine with alcohol is strictly prohibited. To avoid consequences, you must abstain from all alcohol during the period of treatment. If there is a periodic violation of compatibility, the drug may increase its side effects on the liver, and there will be a likelihood of developing an ulcer. Headache, tinnitus, and general lethargy appear. In an advanced state, a combination of alcohol and medical product leads to ulceration of the stomach lining and internal bleeding.

Analogues of the drug Bromhexine

Structural analogues of the active substance:

• Bromhexine 4 Berlin-Chemie;
• Bromhexine 4 mg for;
• Bromhexine 8;
• Bromhexine 8 Berlin-Chemie;
• Bromhexine 8 mg;
• Bromhexine Grindeks;
• Bromhexine MS;
• Bromhexine Nycomed;
• Bromhexine Acree;
• Bromhexine Ratiopharm;
• Bromhexine Rusfar;
• Bromhexine UBF;
• Bromhexine Ferein;
• Bromhexine Aegis;
• Bromhexine hydrochloride;
• Bronchotil;
• Vero-Bromhexine;
• Solvin;
• Phlegamine;
• Flexoxin.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Р N002461/01-2003

Trade name of the drug:

Bromhexine

International nonproprietary name:

bromhexine

Bromhexine dosage form:

pills

Bromhexine composition.One tablet contains:

active substance: bromhexine hydrochloride in terms of 100% substance - 4 mg or 8 mg;

Excipients: lactose monohydrate 60 mg or 120 mg, potato starch 4 mg or 8 mg, calcium stearate 1 mg or 2 mg, sodium carboxymethyl starch 1 mg or 2 mg, sucrose (sugar) 30 mg or 60 mg, respectively.

Description Bromhexine tablets.

Tablets from white to white with a creamy or yellowish tint, flat-cylindrical, with a bevel.

Pharmacotherapeutic group:

mucolytic expectorant.

Code ATX:

R05CB02.

pharmachologic effect

Pharmacodynamics.

Mucolytic (secretolytic) agent, has an expectorant and weak antitussive effect. Reduces the viscosity of sputum (depolymerizes mucoprotein and mucopolysaccharide fibers, increases the serous component of bronchial secretions); activates the ciliated epithelium, increases volume and improves sputum discharge. Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells during respiration. The effect appears within 2-5 days from the start of treatment.

Pharmacokinetics.

When taken orally, bromhexine is almost completely (99%) absorbed within 30 minutes. About 80% of bromhexine undergoes extensive metabolism due to the first-pass effect through the liver. In plasma, bromhexine binds to proteins and penetrates the blood-brain and placental barriers. In the liver, bromhexine undergoes demethylation and oxidation to form an active metabolite, ambroxol. The half-life is 15 hours due to slow reverse diffusion from tissues. Excreted by the kidneys. For chronic renal failure the excretion of bromhexine metabolites is impaired. With repeated use, bromhexine may accumulate.

Indications for use Bromhexine tablets

Diseases of the respiratory tract, accompanied by difficulty in the discharge of viscous sputum: tracheobronchitis, bronchitis of various etiologies (including complicated by bronchiectasis), bronchial asthma, pulmonary tuberculosis, pneumonia, cystic fibrosis. Sanitation of the bronchial tree in the preoperative period and during therapeutic and diagnostic intrabronchial manipulations, prevention of accumulation of thick viscous sputum in the bronchi after surgery.

Contraindications

Hypersensitivity, pregnancy (first trimester), lactation period, gastric ulcer (in the acute stage), children under 6 years of age, lactase deficiency, lactose intolerance, glucose-galactose malabsorption.

Carefully

History of gastric bleeding, renal and/or liver failure, bronchial diseases accompanied by excessive accumulation of secretions.

Bromhexine tablets: method of administration and dosage

Inside, regardless of food intake.

Adults and children over 14 years old- 8-16 mg 3-4 times a day.

Children 6-14 years old- 8 mg 3 times a day.

The course of treatment is from 4 to 28 days.

Side effect

Rarely, with long-term use of the drug, allergic reactions, dyspepsia, incl. nausea, vomiting; exacerbation of gastric and duodenal ulcers, dizziness, headache, increased activity of “liver” transaminases. In these cases, the drug should be discontinued.

Overdose

Symptoms: nausea, vomiting, diarrhea.

Treatment: artificial vomiting, gastric lavage (in the first 1-2 hours after administration).

Interaction with other drugs

Bromhexine is not prescribed simultaneously with drugs that suppress the cough center (including those containing codeine), as this complicates the evacuation of liquefied sputum.

Bromhexine promotes the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfonamide medicines into bronchial secretions in the first 4-5 days of antimicrobial therapy.

Bromhexine is not compatible with alkaline solutions.

special instructions

In children, treatment should be combined with postural drainage or vibration massage chest, facilitating the evacuation of secretions from the bronchi.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Release form

Tablets 4 mg and 8 mg. 10 tablets in a blister pack.

2 blister packs for tablets with a dosage of 8 mg or 5 blister packs for tablets with a dosage of 4 mg along with instructions for use in a cardboard pack.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25°C.

Keep out of the reach of children.

Best before date

5 years.

Do not use after the expiration date.

Conditions for dispensing from pharmacies

Over the counter.

Manufacturer. Claims are accepted at

public corporation
“Chemical and pharmaceutical plant “AKRIKHIN”,

I N S T R U C T I O N

By medical use drug

Bromhexine

Composition of the medicinal product.

Active substance: bromhexine;

1 tablet contains bromhexine hydrochloride 8 mg;

lactose, sugar, ruberosum, potato starch, calcium stearate.

Dosage form. Pills.

Pills Pink colour.

Pharmacotherapeutic group.

Mucolytic agents. ATC code R05C B02.

Pharmacological properties.

Bromhexine has a mucolytic (secretolytic) and expectorant effect. Determines where the polymerization of mucoprotein and mucopolysaccharide polymer molecules occurs (mucolytic effect). Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells during breathing, their protection from adverse factors, improves the rheological properties of bronchopulmonary secretions, promotes its flow through the epithelium and the removal of sputum from the respiratory tract.

When taken orally within 30 minutes, it is almost completely (99%) absorbed. Bioavailability is 80% due to the “first pass” effect through the liver. In plasma it binds to proteins. Penetrates through the blood-brain and placental barriers. In the liver it is subject to demethylation and oxidation. Some of the metabolites formed retain pharmacological activity. The half-life is 1 hour, but the final half-life reaches 15 hours due to slow reverse diffusion from tissues. Excreted by the kidneys. For severe liver failure the clearance of bromhexine is reduced, and in chronic renal failure the release of its metabolites is impaired. May accumulate with repeated use.

INDICATIONS

Spicy and chronic diseases bronchi and lungs, accompanied by impaired formation and circulation of sputum.

Contraindications.

Hypersensitivity to the components of the drug, pregnancy (especially in the first trimester), breastfeeding. Childhood up to 6 years old. Relative contraindications: gastric ulcer and duodenum, diseases respiratory system, the course of which is accompanied by the formation large quantity liquid sputum, impaired renal and liver function.

Necessary safety measures during use.

Use with caution in patients suffering from bronchial asthma. During treatment, it is necessary to take a sufficient amount of fluid, which increases the expectorant effect of bromhexine. The drug should be used with caution if the patient has a disorder of bronchial motility, accompanied by the formation of a large amount of bronchial secretion (primary ciliary dyskinesia).

For gastric ulcers, as well as for indications of gastric bleeding in the anamnesis, Bromhexine should be used under the supervision of a physician.

In case of impaired renal function and severe liver diseases, the drug should be used with great caution (extend the duration of the medication or reduce its dose).

In acute renal failure, the possibility of accumulation of bromhexine metabolites in the liver should be taken into account.

When any disorders of the skin or mucous membranes appear for the first time when using bromhexine hydrochloride, you should immediately stop using the drug (this may be the beginning of the development of severe complications such as Stevens-Johnson syndrome or Lyell's syndrome).

Use during pregnancy or breastfeeding.

The drug is not used during pregnancy. During treatment with the drug, breastfeeding should be stopped.

The ability to influence the reaction speed when driving a vehicle or when working with other mechanisms.

During treatment with the drug, you should refrain from driving and operating other mechanisms.

Children. The drug in this dosage form Do not use for children under 6 years of age. In children over 6 years of age, it is recommended to combine treatment with vibration massage of the chest, which facilitates the removal of secretions from the bronchi.

Directions for use and doses

The drug is taken orally after meals with plenty of liquid. Adults and adolescents over 14 years of age: 8-16 mg (1-2 tablets) 3 times a day. Children from 6 to 14 years old, as well as patients weighing less than 50 kg: 8 mg (1 tablet) 3 times a day. The duration of treatment is determined individually, according to the indications and dynamics of the disease, but it should not exceed 4-5 days without appropriate doctor’s advice. In the presence of impaired renal function or severe liver disease, the dose of the drug should be reduced accordingly.

Overdose.

Symptoms: dyspeptic disorders, nausea, vomiting, diarrhea. Dizziness, headache, ataxia, diplopia, metabolic acidosis, rapid breathing. Treatments. In case of significant overdose, monitoring should be carried out of cardio-vascular system and, if necessary, appoint symptomatic therapy. Behind high degree binding to plasma proteins, large volume of distribution and slow reverse distribution of bromhexine from tissues to the blood, accelerated elimination of the drug during hemodialysis or forced diuresis should not be expected.

Side effects.

From the digestive system: stomach pain, dyspeptic disorders, nausea, vomiting, diarrhea, exacerbation of gastric and duodenal ulcers, transient increase in the activity of aminotransferases in the blood serum.

From the central nervous system: headache (migraine type), dizziness, chills.

Skin: increased sweating.

From the respiratory system: increased cough, bronchospasm, breathing disorders.

From the outside immune system: urticaria, skin rashes, skin itching, angioneurotic edema, anaphylactic reactions, including anaphylactic shock, Stevens-Johnson syndrome and Lyell's syndrome.

Interaction with other drugs and other types of interactions.

Bromhexine can be prescribed in combination with bronchodilators, antibacterial drugs, and drugs used in cardiology.

Bromhexine is not used with drugs that irritate the gastric mucosa. It is also not used simultaneously with medications containing codeine, since this prevents the expectoration of thin mucus.

Bromhexine promotes the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfonamide drugs into bronchial secretions in the first 4-5 days of antimicrobial therapy.

Best before date. 3 years.

Storage conditions. Store in a dry place at a temperature not exceeding 25 ° C.

Package. 20 tablets in a blister.