10 tablets of phenibut at a time. Phenibut - instructions for use. How to take Phenibut when you miss the next dose

Thank you

The site provides background information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Release forms and composition of Phenibut

The composition of Phenibut as an active ingredient includes gamma-amino-beta-phenylbutyric acid , which is briefly called aminophenylbutyric acid . The following substances are included in Phenibut tablets as auxiliary components:

• lactose (milk sugar);
• Potato starch;
• Polyvinylpyrrolidone low molecular weight;
• Stearic calcium.

Despite the fact that the drug is produced by different factories, the composition and ratio of auxiliary components are usually the same, since the same technology is used.

Dosage and manufacturers

Phenibut is produced by several pharmaceutical plants in the countries of the former USSR. Currently, pharmacies have Phenibut from the following manufacturers:

• Olainfarm (Latvia);
• Belmedpreparaty RUP (Belarus);
• LLC "Ozon" (Russia, Zhigulevsk, Samara region);
• OOO "Organika" (Russia, Novokuznetsk);
• OOO "Mir-Pharm" (Russia, Obninsk, Moscow region).

Phenibut - therapeutic effect (from which pills)

Some scientists prefer to classify Phenibut as a tranquilizer rather than a nootropic, as they consider the anxiolytic effects to be more important and necessary for therapy. various disorders accompanied by anxiety. However, this approach seems to be one-sided, since the drug combines the properties of both a nootropic and a tranquilizer. The most rational classification position is the assignment of Phenibut to the group of nootropics with weak tranquilizer properties, effective in the presence of neurosis-like conditions in a person, characterized by the simultaneous presence of sensation internal stress with tearfulness, mood lability, faintheartedness, and excessive emotional reaction to irritants.

It is the unique spectrum of therapeutic activity of Phenibut, which combines the activating effects of a nootropic and anti-anxiety tranquilizer, that makes it possible to use the drug in conditions when a person needs to get rid of anxiety, but at the same time work highly efficiently and productively with the tension of intellectual abilities. In other words, if a person's work is associated with constant severe stress, but at the same time requires excellent mental performance and results, then Phenibut is the drug of choice, which simultaneously relieves anxiety and anxiety and increases the intellectual-mnestic function of the brain.

Phenibut has the following direct therapeutic effects:

• Reducing internal tension;
• Relief of anxiety;
• Relief of anxiety;
• Relief of fear;
• Normalization of sleep by eliminating fears and anxiety;
• Improves cerebral circulation (blood flow rate increases, microcirculation in the tissues of the brain and eyes increases and vascular resistance decreases);
• Improves the functional activity of the brain, due to which a person finds solutions to various problems faster and easier;
• Reduces the severity of speech and movement disorders;
• Reduces the manifestations of asthenia, increasing interest and motivation for various activities;
• Stops manifestations of vegetative-vascular dystonia (such as headache, feeling of heaviness in the head, irritability, emotional instability and difficulty falling asleep);
• Increases mental performance;
• Improves memory, attention, as well as accuracy and speed of reactions;
• Reducing the depressing effect of alcoholic beverages on the central nervous system;
• It has a weak anticonvulsant effect;
• Lengthening and enhancing effects sleeping pills, drugs and antipsychotics.

When Phenibut is used in elderly people over 65 years of age, it does not cause lethargy and a relaxing aftereffect, on the contrary, it stimulates a person to be active.

Phenibut - indications for use

• Asthenic condition (lethargy, apathy, feeling of exhaustion, etc.);
• Anxious-neurotic states;
• Constant incessant anxiety for various reasons;
• Feeling of fear;
• Feeling anxious;
• Insomnia, nocturnal restlessness and nightmares in the elderly;
• Neurosis obsessive states;
• Psychopathy;
• With strong excitement before a surgical operation or any other invasive diagnostic intervention;
• Meniere's disease and other pathologies of the vestibular apparatus caused by trauma, vascular and other disorders;
• Otogenic labyrinthitis;
• Dizziness due to disruption of the vestibular apparatus;
• Prevention of motion sickness;
• stuttering in children;
• Tiki various genesis in children;
• Enuresis (urinary incontinence) in children;
• Alcohol withdrawal syndrome (in combination with other drugs);
• Predelirious state in alcoholism;
• To enhance the effect of antiparkinsonian drugs.

Phenibut - instructions for use

General provisions

You can start taking Phenibut immediately at the full therapeutic dosage. You do not need to first take the drug in the minimum dosage and gradually increase it to the required therapeutic.

However, it is better to stop the course of therapy gradually, and not abruptly. Although scientists and many doctors say that Phenibut does not have a withdrawal syndrome, nevertheless, when the drug is abruptly stopped, a person may experience discomfort about which he started taking pills. This phenomenon is caused by the addiction of the human body to Phenibut, which supplies the brain with the necessary metabolites, and it does not begin to produce these substances on its own in the required amount.

Relatively speaking, Phenibut supplies the necessary substances to the brain from the outside, but the nerve cells themselves do not produce them. And if in such a situation you abruptly stop taking the drug, then the brain cells will not be able to quickly adapt to the changed circumstances and begin to independently produce the necessary substances. Therefore, the brain cells need to be given a little time so that they gradually get used to the new state, when the intake essential substances first decreases, and then stops altogether. With a slow decrease in the dosage of Phenibut, the brain cells get used to stopping the supply of metabolic substances from the outside and learn to produce them on their own. Therefore, when the drug is completely canceled, the person does not begin to suffer from painful symptoms, due to the addiction of the body and the impossibility of its instant restructuring to a different mode of functioning.

To prevent this condition, it is recommended to stop taking Phenibut gradually, slowly, reducing the dosage over 1 to 2 weeks and, in the end, completely canceling the drug. It is recommended to reduce the dosage by half or a quarter of a tablet every 3 days.

With prolonged use of Phenibut, it is necessary to take a general blood test once a week in order to identify possible eosinophilia. Also, once a week it is necessary to take a blood test for the activity of AST and ALT.

In the presence of organ diseases gastrointestinal tract it is necessary to use Phenibut with caution, since the drug has an irritating effect on the mucous membranes. If after taking Phenibut a person feels discomfort and burning in the stomach, then the dosage of the drug should be reduced.

When using Phenibut with other psychotropic drugs, it is necessary to reduce the dosage of both drugs taken.

When motion sickness Phenibut should be taken 20 - 30 minutes before the trip, because only in this case it will be effective. If a person has symptoms of motion sickness (vomiting, dizziness, and others), then taking Phenibut is useless, since in this case it is ineffective.

Dosages, rules and duration of use

Usually, adults with various conditions are prescribed Phenibut 250-500 mg (1-2 tablets) three times a day. If necessary, the dosage is increased to 750 mg (3 tablets) three times a day. For children under 8 years of age, Phenibut is prescribed 20–150 mg 3 times a day, and for children aged 8–14 years, 250 mg 3 times a day. Maximum allowable dosage Phenibut, which can be taken at one time, is 750 mg (3 tablets) for adults, 500 mg (2 tablets) for the elderly over 65, 300 mg for children 8-14 years old, and 150 mg for children under 8 years of age.

Since the dosage of Phenibut for children is low, it is recommended that they be given the drug not in the form of ready-made tablets, but in the form of powders that are prepared in the prescription departments of pharmacies. In these powders, the dosage of the drug necessary for the child is maintained and the risk of overdose is minimized. To buy such a powder, you need a prescription from a doctor for Phenibut, which should indicate the recommended dosage of the drug.

The duration of Phenibut therapy for various conditions ranges from 2-3 to 4-6 weeks. Courses of therapy can be repeated, observing intervals between them, equal in duration to the course of treatment. The dosage of the drug depends on the disease.

To prevent motion sickness, Phenibut should be taken one hour before the trip once at a dose of 250-500 mg (1-2 tablets). If the manifestations of motion sickness have already developed, then it is not necessary to take Phenibut, since in this case the drug is useless.

With dyscirculatory encephalopathy, Phenibut should be taken 250 mg once a day for 1 to 2 months. After 5-6 months, the course of therapy can be repeated.

For the prevention of migraine, Phenibut is taken 150 mg once a day, and for the relief of an attack, 100-150 mg once.

In asthenic conditions and neuroses, it is recommended to take the drug 250 mg 1-2 times a day for 1-1.5 months.

With anxiety, insomnia, nightmares and fussy anxiety in the elderly, it is necessary to take Phenibut 250 mg 2 times a day for 1.5 - 3 months.

To improve and restore mental performance, as well as with high loads it is recommended to take Phenibut 250 mg once a day for 1-1.5 months. If the period of intensive work ended earlier, then the course of taking Phenibut is reduced.

With alcohol withdrawal Phenibut is recommended to take 250-500 mg 3 times a day, and an additional 750 mg before going to bed. Thus, the drug should be taken for 3-5 days, after which the fourth dose should be removed at a dosage of 750 mg at bedtime and left at 250-500 mg three times a day.

In Meniere's disease and otogenic labyrinthitis in the first week, Phenibut should be taken 750 mg 3-4 times a day, in the second week - 250-500 mg 3 times a day, and in the third week - 250 mg 1 time per day. day. If the disease occurs in mild form, then Phenibut is taken 250 mg 2 times a day during the first week, and then in the second week 250 mg 1 time per day.

In case of violations of the vestibular apparatus, accompanied by dizziness and caused by vascular or traumatic causes, Phenibut should be taken 250 mg 3 times a day for 12 days.

Influence on the ability to control mechanisms

Overdose

• severe drowsiness;
• Vomit;
• Fatty degeneration of the liver (when taking more than 7000 mg per day);
• Pressure reduction ;
• Violation of the kidneys;
• Eosinophilia (an increase in the number of eosinophils in the blood).

Compatibility with other drugs

Phenibut should not be combined with alcoholic beverages. Care should be taken when combining Phenibut with drugs that have toxic effect on the liver and blood system. To determine whether the drug has a similar effect, you must read the instructions for use, where indicated. Phenibut is compatible with other drugs and can be used simultaneously.

Phenibut for children and babies

Infants are not recommended to give Phenibut, because this drug can have a multidirectional effect on the child, which is impossible to predict in advance. Therefore, psychiatrists advise to refrain from using Phenibut for at least two years. If the child is hyperactive, whiny, mobile and suffers from other functional disorders behavior, then other drugs should be used, the effects of which are more predictable and understandable for both the doctor and the baby's parents.

The above-described recommended use of Phenibut for children in practice is currently practically not observed due to the peculiarities of diagnosis, perception and differentiation of the states of the norm and pathology of the behavior of babies. In the countries of the former USSR, there is a practice of overdiagnosis of various neurological, mental and behavioral disorders in children, especially younger age. This means that in polyclinics, children are diagnosed with a disease that they do not have, and they begin treatment with potent drugs, including Phenibut. And if, with a really existing disease, Phenibut is effective and indicated, then in the case of overdiagnosis, the drug will not bring the child anything but possible side effects, a sense of inferiority and a possible aggravation of psychological disorders.

Most often, Phenibut is prescribed for hyperactivity, constant tantrums and neurosis, and the diagnosis is made on the basis of a simple examination of the child and from the words of the mother. That is, there is an exclusively subjective perception of the child's behavior, which is assessed from the position of the mother's and the doctor's ideas as "correct" or "wrong". And if the child's behavior is assessed as incorrect, then a clinical diagnosis is made and treatment with Phenibut or another nootropic drug, for example, Phenotropil, begins. Meanwhile, such a diagnosis by a neurologist or a psychiatrist is unacceptable, since this is a profanation of medical science. Any neurological or psychiatric diagnosis is made only on the basis of objective test results, examination, examination and conversation with the child, as well as observation of him in various situations. If during all these examinations the doctor reveals really existing violations, then only in this case he can make an appropriate diagnosis.

If tests and conversations were not carried out, then the child cannot be diagnosed only from the words of the mother, who thinks that he does not cry like that, screams a lot, throws tantrums, etc. After all, there are no objective data for the presence of the disease, but there are only observations of the mother, which diverge from the ideas that have developed in her head about how the child should behave and respond to various stimuli. When, on the basis of such complaints of the mother, the doctor makes a clinical diagnosis of the child, then it is precisely overdiagnosis that takes place. Remember that even mental disorders are strictly classified and for their detection there are special tests and methods that exclude the subjectivity of the doctor's perception, and not just the mother's observation of the behavior of her child. Therefore, Phenibut should not be used for children. early age if there are no violations confirmed by surveys.

In most cases, children do not have severe disorders that are a clinical diagnosis. Usually the child suffers from a disorder of behavior or mental reactions, which are corrected by the correct behavior of the parent. In such situations, it is enough to use tinctures of valerian or motherwort to calm the child. However, in order to normalize the behavior of the child, parents will have to work by changing their behavior and habits, as well as carefully controlling their actions.

Returning to Phenibut, we can say that the drug is often prescribed to treat non-existent pathologies identified during "overdiagnosis". However, such use of the drug cannot be considered correct and justified, therefore, all recommendations remain on the conscience of a particular doctor and the child's parents.

Phenibut and alcohol

The fact is that Phenibut in combination with alcohol can cause rapid and severe intoxication or, on the contrary, help not to get drunk and maintain clarity of mind, and not suffer from a hangover in the morning. Basically, people try to take Phenibut with alcohol in order to prevent hangovers and severe intoxication. However, what effect Phenibut will have in each specific case is unknown and impossible to predict.

In addition, with the combined use of Phenibut and alcohol, a very quick addiction to the drug occurs, as a result of which it becomes very difficult to cancel its intake. Therefore, drinking alcoholic beverages while taking Phenibut is still not worth it, although if you do this, then there is no risk of death.

Side effects

• Drowsiness;
• Nausea;
• Headache (only at the first appointments);
• Increased irritability;
• Excitation;
• Anxiety;
• Dizziness;
• Allergic reactions (rash and itching of the skin).

Contraindications for use

• Individual sensitivity or intolerance to the components of the drug;
• Pregnancy and the period of breastfeeding;

Phenibut: therapeutic effect, indications and contraindications - video

Phenibut - analogues

Synonyms of Phenibut are the following drugs:
1. Anvifen capsules;
2. Noofen capsules.

Phenibut's analogues are the following drugs:

• Adaptol tablets;
• Afobazol tablets;
• Divaza tablets;
• mebicar tablets;
• Mebix tablets;
• Neurofasol concentrate;
• Selank nasal drops;
• Stresam capsules;
• Tenoten and Tenoten children's pills for resorption;
• Tranquezipam tablets and solution for injection;
• Fezaneuf tablets;
• Fezipam tablets;
• Fenzit tablets;
• Phenazepam tablets and solution for injection;
• Phenorelaxan tablets and solution for injection;
• Elzepam tablets and solution for injections.

INN: γ-amino-β-phenylbutyric acid hydrochloride (Gamma-amino-beta-phenylbutyrate hydrochloridum).

One Phenibut tablet contains 0.25 g phenibut as active substance. Also, the composition of the drug includes a number of auxiliary components:

• microcrystalline cellulose (Cellulosum microcrystallicum);
• colloidal silicon dioxide (Colloidal anhydrous Silica);
• sodium starch glycolate;
• calcium stearate (Calcium stearate).

Release form

The drug is available in the form of flat-cylindrical tablets, the color of which can vary from white to slightly yellowish. Each tablet has a risk and a chamfer.

pharmachologic effect

The drug belongs to the group psychostimulating And nootropic medicines.

Pharmacological action provided by Phenibut:

• nootropic ;
• anxiolytic .

Pharmacodynamics and pharmacokinetics

What is Phenibut?

Wikipedia states that Phenibut is a phenyl derivative in its structure gamma-aminobutyric acid - a substance that performs the function of an inhibitory mediator of the central nervous system in the human body. Phenibut can also be considered as a derivative phenethylamine .

The substance is a white powder with a crystalline structure and a sour taste. The powder is highly soluble in water and alcohols. Hydrogen index (pH) aqueous solution phenibut is in the range from 2.3 to 2.7.

Pharmacodynamics

Acting like nootropic , Phenibut renders positive influence on the higher integrative activity of the human brain. It stimulates mental activity, cognitive functions, memory function, and also helps to increase the resistance of the brain to the effects of various damaging factors, including extreme stress and oxygen starvation.

Phenibut reduces the severity of the effects serious illnesses associated with traumatic brain injury , damage spinal cord, intoxication of the brain, etc..

In patients with severe traumatic brain injury , while taking the drug, the amount mitochondria in the area of ​​perifocal changes and improves the dynamics of energy processes occurring in the brain, processes of tissue respiration, utilization glucose brain and blood supply.

In addition, the drug helps to strengthen cortico-subcortical connections , that is, in other words, connections between the cerebral cortex and its subcortical regions.

The pharmacological activity of Phenibut is expressed in the ability to:

• to have a corrective effect on higher cortical functions disturbed due to local lesions of the brain;
• improve critical capabilities and improve judgment;
• improve cortical activity control subcortical zones ;
• to influence the processes associated with the function of memory (memorization and recollection, the ability to learn);
• increase the level of wakefulness, influence the state of oppressed or clouded consciousness, increasing its clarity;
• increase the level of the body's overall resistance to the effects of stress factors;
• render anti-asthenic action , which is expressed in a decrease in weakness, elimination of symptoms mental And physical asthenia , reducing lethargy, etc.;
• stimulate mental activity (the drug reduces the severity of mental retardation, increases volitional activity, stimulates motor and speech activity, etc.);
• render antidepressant action ;
• render sedative And tranquilizing action reducing irritability and emotional excitability.

The stimulating effect of Phenibut is not accompanied by an increase in speech or motor excitation, depletion of the functional reserves of the body, addiction to the drug and the development of dependence on it.

Like other nootropics, the tool is characterized low toxicity , good compatibility with drugs of other pharmacotherapeutic groups, as well as the absence of serious side effects and complications.

The therapeutic effect of taking Phenibut develops gradually over, as a rule, several weeks. For this reason, the drug is recommended to take long courses.

Anxiolytic action the drug is realized by reducing the excitability of the subcortical structures of the brain (including the structures limbic complex , and ), which are responsible for emotions, inhibition of their interaction with the cerebral cortex, as well as suppression spinal reflex activity (in particular, it depresses polysynaptic spinal reflexes ).

By directly acting on γ-aminobutyric acid receptors, Phenibut facilitates GABA-mediated transmission of nerve impulses to the CNS. The active substance of the drug has the ability to improve the functional state of the brain by normalizing the metabolic processes occurring in it and improving cerebral circulation.

At the same time, the patient shows an improvement in performance hemodynamics (in particular, the volumetric and linear velocity of blood flow increases), the indicators of vascular resistance decrease, the microcirculation (including in the tissues of the eye) and create conditions that prevent spontaneous and induced aggregation (which in turn reduces the likelihood of formation blood clots in people suffering from circulatory disorders in the brain).

In addition, Phenibut has antioxidant And anticonvulsant action .

In the treatment of elderly patients with the drug, the latter do not have depression of the central nervous system function, a decrease in muscle tone and an increase in general lethargy.

The drug reduces the inhibitory effect ethyl alcohol on the CNS.

Pharmacokinetics

Once in the body, Phenibut is well absorbed and then just as well distributed in its various tissues. The substance easily passes through the BBB, which is a physiological barrier between the system blood vessels and CNS.

Approximately 0.1% of the administered dose of the drug enters the brain tissue. Moreover, this figure is higher for young and old people.

Phenibut is characterized by the ability to be evenly distributed in the liver and kidneys. Biotransformation of the substance by 80-95% is carried out in the liver tissues. The resulting products have no pharmacological activity.

Cumulation of the substance in the body is not observed. The process of removing Phenibut from the body begins after about three hours. Moreover, the concentration of the substance in the brain tissues does not decrease. It can be detected in the brain for another six hours.

About 5% of Phenibut is excreted from the body kidneys V pure form, partially the substance is excreted along with the bile.

Indications for the use of Phenibut

Indications for the use of Phenibut are:

• decrease in intellectual activity;
• decreased emotional activity;
• memory disorders;
• symptoms asthenic syndrome ;
• anxiety disorders ;
• fears, including nightmares ;
• increased anxiety, restlessness;
• decreased concentration;
• alcohol dependence, as well as psychopathological and somato-vegetative disorders arising as a result of alcohol withdrawal (in combination with other therapeutic measures);
• Meniere's syndrome ;
• caused by vestibular dysfunction caused by diseases vascular system, injury or infectious disease;
• prevention of motion sickness caused by motion sickness (kinetosis) ;
• in the cervical and / or thoracic spine and in women (the drug is prescribed in combination with other therapeutic measures);
• stuttering , hyperactivity and tics in children.

Phenibut tablets in combination with others detoxification agents also used to treat alcohol withdrawal with delirium (delirious syndrome - illusory-hallucinatory stupefaction, which is accompanied by disorientation in time, place and in some cases in one's own personality) and alcoholic predilirious state .

An indication for the drug Phenibut is also the prevention of stressful conditions, which are often observed in patients before surgical operations and painful diagnostic studies.

Contraindications

The abstract lists the following contraindications to the appointment of Phenibut:

• individual hypersensitivity to phenibut or any of the excipients that make up the drug;
• pregnancy ;
• lactation ;
• age up to eight years;

With caution, Phenibut is prescribed to patients with pathologies digestive system And erosive and ulcerative lesions of the gastrointestinal tract . This category of patients is shown in reduced doses of the drug, since the latter is characterized by the ability to irritate the mucous membranes.

Side effects

As a rule, side effects after taking Phenibut occur only on initial stages therapy. Most often, patients experience increased drowsiness, seizures occur nausea , headache , there are jumps in indicators.

In certain groups of patients, Phenibut provokes the following side effects:

• increased irritability;
• increased levels of anxiety;
• increased arousal;
• dizziness;
• individual allergic reactions.

Instructions for use Phenibut (Method of administration and dosage)

Instructions for the use of Phenibut tablets indicate that the drug is intended for oral administration in courses, the duration of which varies from one to one and a half months.

The maximum allowable single dose of a drug for an adult patient under 60 years of age is a dose equal to 0.75 g of phenibut. Older people are not recommended to take more than 0.5 g of phenibut at a time.

Phenibut tablets: instructions for use and dosage for various diseases

Patients suffering from dizziness due to inflammation inner ear and people diagnosed with Meniere's syndrome Phenibut is prescribed according to the following scheme: during periods of exacerbations of the disease, the drug is taken 0.75 g three times a day for five to seven days; with a decrease in the severity of symptoms vestibular dysfunction the dose is reduced to 0.25-0.5 g three times a day (in this dosage, the drug is taken for five to seven days); further treatment is continued for another five days, taking 0.25 g of phenibut once a day.

If the disease is relatively mild, Phenibut is recommended to be taken in a daily dose of 0.5 g for five to seven days. The dose is divided into two doses. Further, the treatment is continued for another one to three weeks, taking 0.25 g of the drug once a day.

For the treatment of dizziness caused by trauma or vascular diseases , the drug is prescribed in a daily dose of 0.75 g of phenibut. It is recommended to divide it into three doses. The duration of the therapeutic course is usually up to two weeks.

For treatment osteochondrosis cervical and/or thoracic spine and relieve symptoms climacteric syndrome in women, Phenibut is prescribed in combination with other therapeutic measures.

During the first two weeks, the drug should be taken one tablet three times a day (daily dose of the drug is 0.75 g). Further, the number of doses is reduced to two, the dose remains the same - one tablet for each dose (the daily dose of the drug is 0.5 g).

In case of moderate pain syndrome at vertebral pathology or climacteric syndrome Phenibut is prescribed to be taken in combination with other drugs, one tablet twice a day (0.5 g per day). The recommended duration of treatment is four weeks.

Like its analogues, Phenibut is used prophylactically to prevent the so-called travel sickness or, in other words, motion sickness syndrome arising during an airplane flight or sea voyage.

For prevention motion sickness syndrome at seasickness Phenibut is taken as a single dose about an hour before the planned trip or if the first symptoms appear kinetosis . The optimal dose is 0.25-0.5 g (or one or two tablets). The effect of the drug is dose-dependent.

However, when severe symptoms of motion sickness appear (for example, severe vomiting ) even a dose of 0.75-1 g is ineffective.

For the prevention of motion sickness air sickness Phenibut is recommended to be taken according to the above scheme. That is, 1-2 tablets about an hour before the planned trip.

Instructions for use Phenibut for children

The drug is not intended for the treatment of children under eight years of age.

For children aged eight to fourteen years, the daily dose of Phenibut is 0.75 g, that is, three tablets of 0.25 g per day. It should be divided into three doses.

In cases where it is necessary, it is allowed to take the drug in the highest single dose, which is 0.3 g.

How to take Phenibut when you miss the next dose?

If the patient missed the next dose of the drug one or more times, the course of treatment is continued in accordance with the previously prescribed dosing regimen.

Overdose

An overdose of the drug is accompanied by the following symptoms:

• decline blood pressure ;
• nausea ;
• vomiting ;
• development kidney failure .

Treatment involves gastric lavage, induction of vomiting and the appointment of symptomatic therapy. The drug has no specific antidote.

Since Phenibut is a low-toxic compound, only its long-term use in doses significantly exceeding the therapeutic ones (from 7 to 14 g per day) can provoke the development hepatotoxic effects .

In particular, the patient has increased over physiological norm quantity eosinophils in the peripheral blood, and may also develop steatosis (fatty infiltration) of the liver — chronic illness due to accumulation in liver tissue a large number triglycerides and characterized by fatty degeneration of organ cells.

Interaction

For the purpose of mutual potentiation pharmacological effects combination of Phenibut with others is allowed psychotropic drugs . In this case, the dose of Phenibut and the drugs combined with it should be reduced.

The drug is characterized by the ability to enhance and increase the duration of action sleeping pills , narcotic analgesics , neuroleptic And anticonvulsant drugs .

The possibility of lengthening and enhancing the therapeutic effect of taking antiepileptic drugs makes Phenibut a first-line drug if it is necessary to prescribe nootropic therapy to patients who are sick.

Enhances the toxic effects and effects of alcohol. In addition, there is evidence that under its influence the action is also enhanced. antiparkinsonian drugs .

Terms of sale

The drug is released without a prescription.

Storage conditions

Phenibut should be stored out of the reach of children, in a dry, dark place at a temperature not exceeding 25 ° C.

Best before date

The drug retains its pharmacological properties for 36 months from the date of manufacture. After this period, it cannot be used. Оlainfarm ”.

Synonyms issued under a different name are Noobut ​​IC . When choosing which is better - Noofen or Phenibut, Phenibut or Noobut ​​- you should remember that all these drugs contain the same amount phenibut as the active substance and are interchangeable.

Phenibut for children

Phenibut and alcohol

However, this is not evidence of its compatibility with alcohol. The use of the drug for therapeutic purposes in alcohol addiction justified and gives positive effect only in cases where the patient is undergoing treatment in a hospital setting or is under constant medical supervision.

Despite the fact that the instruction does not directly prohibit taking alcohol during treatment with Phenibut, doctors have a negative attitude towards such a combination.

First, alcohol in doses exceeding the minimum has a depressing effect on the central nervous system. Phenibut, on the one hand, acts as tranquilizer , on the other hand, has a pronounced sedative effect , which is especially pronounced in the first days of the course of treatment.

That is, while taking the drug with alcoholic beverages, the effect of the latter on the body is greatly enhanced. Intoxication comes on more quickly and in a stronger form compared to the typical.

As a result, the symptoms in this case are expressed more powerfully, and addiction to the drug develops faster than usual. Reviews indicate that it is rather difficult to refuse such a potent combination, and often one cannot do without qualified help.

Secondly, the combination of alcoholic beverages with Phenibut during therapy not related to the treatment of alcoholism revealed a similarity of mechanisms. metabolism almost all funds from the group tranquilizers And nootropics And ethanol .

This leads to mutual competition of the active substance of the drug and alcohol in all metabolic processes occurring in the body, which in turn provokes a change in the action of Phenibut and the appearance of undesirable side effects.

Thus, the combination of Phenibut and alcohol is a rather unpredictable combination, the consequences of which can be of the most serious nature.

Prescribing the drug during pregnancy

Phenibut is contraindicated in pregnancy and women who are breastfeeding. The exception is when the expected benefit to the mother outweighs the potential risks to the child.

Asthenic and anxiety-neurotic states. - stuttering, tics and enuresis in children. - insomnia and night anxiety in the elderly. - Meniere's disease, dizziness associated with dysfunctions vestibular analyzer different genesis; prevention of motion sickness in kinetosis. - as part of complex therapy in the treatment of alcohol withdrawal syndrome, for the relief of psychopathological and somatovegetative disorders.

Pharmacotherapeutic group

Nootropic agent.

Pharmacological property

Nootropic agent, facilitates GABA-mediated transmission of nerve impulses in the central nervous system (direct effect on GABA-ergic receptors). Tranquilizing action is combined with an activating effect. It also has antiplatelet, antioxidant and some anticonvulsant effects. It improves the functional state of the brain by normalizing its metabolism and affecting cerebral blood flow (increases volumetric and linear velocity, reduces vascular resistance, improves microcirculation, and has an antiplatelet effect). Lengthens the latent period and shortens the duration and severity of nystagmus. Does not affect cholinergic and adrenergic receptors. Reduces vasovegetative symptoms (incl. headache, feeling of heaviness in the head, sleep disturbances, irritability, emotional lability). When taking a course, it increases physical and mental performance (attention, memory, speed and accuracy of sensory-motor reactions). Reduces the manifestations of asthenia (improves well-being, increases interest and initiative (activity motivation)) without sedation or arousal. Helps reduce feelings of anxiety, tension and anxiety, normalizes sleep. In the elderly, it does not cause depression of the central nervous system, the muscle-relaxing aftereffect is most often absent. Reduces the inhibitory effect of ethanol on the central nervous system.

Contraindications

hypersensitivity, pregnancy, breast-feeding, childhood up to 3 years. With caution in erosive and ulcerative lesions of the gastrointestinal tract, liver failure.

Application

Inside after eating 2-3-week courses. Adults and children over 14 years old: 250-500 mg 3 times a day (maximum daily dose 2500 mg). Children from 3 to 8 years old: 50-100 mg 3 times a day; from 8 to 14 years - 250 mg 3 times a day. Single maximum dose in adults and children from 14 years old is 750 mg, in people over 60 years old - 500 mg, in children under 8 years old - 150 mg, from 8 to 14 years old - 250 mg. Alcohol withdrawal syndrome: 250-500 mg 3 times a day and at night 750 mg, with a gradual decrease daily dose to normal for adults. Treatment of dizziness with dysfunctions of the vestibular apparatus and Meniere's disease: 250 mg 3 times a day for 14 days. Motion sickness prevention: 250-500 mg once 1 hour before the expected start of motion or when the first symptoms of motion sickness appear. The anti-swaying effect of phenibut increases with increasing dose of the drug. With the onset of pronounced manifestations of motion sickness (vomiting, etc.), the appointment of phenibut is ineffective even at doses of 750-1000 mg.

Side effects

Drowsiness, nausea. Increased irritability, agitation, anxiety, dizziness, headache (at the first dose), allergic reactions.

Country of origin

Product group

Psychostimulants and nootropics

Release forms

• 10 - cellular contour packs (1) - packs of cardboard. 10 - cellular contour packs (2) - packs of cardboard. 10 - cellular contour packs (3) - packs of cardboard. 10 - cellular contour packs (1) - packs of cardboard. 10 - cellular contour packs (2) - packs of cardboard. 10 - cellular contour packs (3) - packs of cardboard. 10 - cell packs to 10 pcs. - cellular contour packings (2) - packs of cardboard. 50 tabs per pack Tablets of 250 mg - 20 pcs per pack. pack of 20 tablets pack of 20 tablets

Description of the dosage form

• Round flat-cylindrical tablets of white or white with a slightly yellowish tint, with a bevel and a risk mark. Tablets Tablets of white or white with a slightly yellowish tint color flat-cylindrical shape. Tablets white or white with a slightly yellowish tint, flat-cylindrical, with a chamfer and a risk

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• 1 tab. gamma-amino-beta-phenylbutyric acid hydrochloride 250 mg Excipients: lactose monohydrate 180 mg, potato starch 56 mg, povidone 9 mg, calcium stearate monohydrate 5 mg. Aminophenylbutyric acid hydrochloride 0.25; Auxiliary in-va: lactose, potato starch, calcium stearate, gelatin phenibut 250 mg; Other Ingredients: lactose, potato starch, phenibut calcium stearate 250mg; Auxiliary substances: lactose, potato starch, calcium stearate, phenibut 250 mg; Other Ingredients: lactose, potato starch, calcium stearate

Phenibut indications for use

• Asthenic and anxiety-neurotic states, anxiety, fear, obsessive-compulsive disorder, psychopathy. Stuttering and tics in children, enuresis. Urinary retention due to myelodysplasia. Insomnia and nightmares in the elderly. Prevention of anxiety conditions that occur before surgical interventions and painful diagnostic studies (premedication). Meniere's disease, dizziness associated with dysfunctions of the vestibular analyzer of various origins (including with otogenic labyrinthitis, vascular and traumatic disorders); prevention of motion sickness in kinetosis. Primary open-angle glaucoma (as part of combination therapy). As adjuvant therapy in the treatment of alcoholism (for the relief of psychopathological and somatovegetative disorders in withdrawal syndrome). Treatment of predelirious and delirious conditions in alcoholism (in combination with conventional detoxification agents)

Phenibut contraindications

• Hypersensitivity to phenibut. Use during pregnancy and lactation Use with caution during pregnancy, during lactation. Application for violations of liver function Use with caution in liver failure.

Phenibut dosage

• 0.25 g 250 mg 250 mg

Phenibut side effects

• like others medicines, aminobutyric acid may cause side effects that may not occur in all patients. Aminobutyric acid is generally well tolerated. Classification adverse reactions by frequency of development: very frequent (> 10%); frequent > 1 but 0.1 but 0.01 but 0.1%); very rare (

drug interaction

Overdose

Storage conditions

• keep away from children
• store in a place protected from light