Nifuroxazide Richter instructions for use, price, composition, indications. Medicinal reference geotar Intestinal antibiotic nifuroxazide

Nifuroxazide: instructions for use and reviews

Latin name: Nifuroxazide

ATX code: A07AX03

Active substance: nifuroxazide

Manufacturer: Jurabek Laboratories Ltd. (Uzbekistan), Gedeon Richter (Romania), Warsaw Pharmaceutical Plant (Poland)

Updating the description and photo: 13.08.2019

The nature of stool is an important indicator of child health. With diarrhea, it is liquid, and from frequent trips to the toilet the child loses a lot of fluid. At the same time, digestibility is impaired nutrients in the intestines: food does not stay in it for long. The absorption of vitamins is also interfered with by the harmful microflora that caused. Antidiarrheals will help in treatment. For example, Nifuroxazide, which we will talk about now.

Nifuroxazide is primarily used as an intestinal antiseptic.

When is Nifuroxazide prescribed?

Nifuroxazide is indicated for children from 2 months with diarrhea, caused by various reasons:

• The predominance of gram-positive bacteria and some types of gram-negative bacteria in the intestines (Vibrio cholerae, Salmonella, Klebsiella, Shigella, Escherichia coli and Enterobacter).
• Diseases whose symptom is diarrhea: appendicitis, autoimmune chronic gastritis.
• Welcome.
• Food poisoning.

Attention! Don't panic if you notice it once loose stool in the child, and it never happened again. Treatment is only necessary in cases where there is repeated diarrhea throughout the day.

Additional alarming symptoms may be: nausea and vomiting, fever and feeling unwell, weakness.

If you have prolonged abdominal pain, consult a doctor.

Composition and effect of the drug

The active component of the intestinal antiseptic is called nifuroxazide. 5 ml of suspension contains 220 mg of this substance. Additionally, the composition includes:

• sucrose;
• sodium hydroxide;
• carboxypolymethylene;
• distilled water;
• methyl parahydroxybenzoate;
• citric acid monohydrate;
• banana essence (aroma);
• emulsion that inhibits foaming (Antifoam F).

A drug not absorbed into the blood and is concentrated only in the gastrointestinal tract. In small and medium doses, Nifuroxazide acts as an antibacterial medicine (it stops the proliferation of only harmful bacteria that are sensitive to the active substance). At high levels - as a bactericidal agent (completely kills intestinal microflora, including beneficial ones).

The medicine is excreted in the feces.

The duration of action is the first few hours after administration. It depends on the dose taken and the condition of the intestines. On average it is 6-12 hours. The drug is excreted within a few days along with feces.

Christina left a review:

Nifuroxazide - effective remedy from diarrhea. It quickly eliminates diarrhea, keeping the body's water balance normal. At the end of the course of treatment, the intestines are completely freed from pathogenic microorganisms. But, despite the fact that the drug is practically free of side effects, consult your pediatrician before using it.

Alisa Nikitina

Trade name:

Nifuroxazide Alkaloid

International nonproprietary or generic name:

nifuroxazide

Dosage form:

suspension for oral administration

Compound:

5 ml of suspension contains:

Active substance: nifuroxazide 200.00 mg.
Excipients: liquid sorbitol, glycerol, sodium citrate dihydrate, carbomer 940, masking flavor, sodium benzoate, sodium saccharinate, banana flavor, simethicone emulsion 30%, disodium edetate, polysorbate 80, purified water.

Description:

homogeneous yellow suspension with a characteristic banana odor.

Pharmacotherapeutic group:

antimicrobial agent - nitrofuran

ATX code:

Pharmacological properties

Pharmacodynamics
Nifuroxazide is an antimicrobial agent, a derivative of nitrofuran. Blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell. Destroys the microbial cell membrane, reduces the production of toxins by microorganisms.

Highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp, Shigella spp; Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp. Weakly sensitive to nifuroxazide: Citrobacter spp, Enterobacter cloacae and Proteus indologenes. Resistant to nifuroxazide: Klebsiella spp, Proteus mirabilis, Providencia spp., Pseudomonas spp.

Does not disturb the balance of intestinal microflora. In acute bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.

Pharmacokinetics
After oral administration nifuroxazide is practically not absorbed from digestive tract, and exerts its antibacterial effect exclusively in the intestinal lumen. Nifuroxazide is excreted by the intestines: 20% unchanged, and the remaining amount of nifuroxazide is chemically modified.

Indications for use

Acute bacterial diarrhea, occurring without deterioration in general condition, increase in body temperature, or intoxication.

Contraindications

Hypersensitivity to nifuroxazide, to nitrofuran derivatives and other components of the drug, pregnancy, fructose intolerance, childhood up to 3 years (if it is necessary to use nifuroxazide in children under 3 years of age, use medications nifuroxazide, not containing excipients sorbitol).

Carefully

Liver diseases, alcoholism, traumatic brain injury, brain diseases, breastfeeding period, childhood.

Use during pregnancy and breastfeeding

In animal studies, no teratogenic effect was detected. However, as a precaution, taking nifuroxazide during pregnancy is not recommended. During the lactation period, it is possible to continue breastfeeding in case of a short course of treatment with the drug. You should consult your doctor.

Directions for use and doses

For oral administration.

A measuring cup is used for dosing.

Shake the suspension well before use!

Children from 3 to 6 years old: 200 mg of nifuroxazide (5 ml of suspension) 3 times a day (interval between doses is 8 hours).

Children from 6 to 18 years old: 200 mg of nifuroxazide (5 ml of suspension) 3-4 times a day (interval between doses 6-8 hours).

Adults: 200 mg of nifuroxazide (5 ml of suspension) 4 times a day (interval between doses is 6 hours).

The duration of treatment is 5-7 days, but not more than 7 days. If there is no improvement within the first 3 days of taking it, you should consult a doctor. Use the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.

Side effect

Allergic reactions ( skin rash, urticaria, Quincke's edema, anaphylactic shock). If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Overdose symptoms are not known. Treatment is symptomatic.

Interaction with other drugs

Simultaneous use with drugs that cause the development of disulfiram-like reactions, drugs that inhibit the function of the central nervous system is not recommended. nervous system.
If you are taking other medications (including over-the-counter medications), consult your doctor before using Nifuroxazide Alkaloid.

special instructions

When treating diarrhea, rehydration therapy must be carried out simultaneously with nifuroxazide therapy.

When bacterial diarrhea with signs systemic damage(deterioration of general condition, increase in body temperature, symptoms of intoxication or infection) you should consult a doctor to decide on the use antibacterial drugs systemic action. If symptoms of hypersensitivity appear (shortness of breath, rash, itching), you should stop taking the drug.

Drinking alcohol during therapy with nifuroxazide is prohibited.

5 ml of suspension contains 1400 mg of sorbitol, which is about 0.076 bread units (XU). Daily dose sorbitol is 0.228 XE when taking 5 ml of suspension 3 times a day and 0.304 XE when taking 5 ml of suspension 4 times a day.

Impact on the ability to drive vehicles and machinery

The drug does not affect the ability to drive vehicles and machinery.

Release form

Oral suspension 200 mg/5 ml.
90 ml of suspension in a dark glass bottle, with a dosage insert, sealed with a screw cap with a first-opening control system.
The bottle, complete with a measuring cup and instructions for use, is placed in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25 °C.
Keep out of the reach of children!

Best before date

3 years.
Store an opened bottle for no more than 6 months.
Do not use after the expiration date.

Vacation conditions

Available without a prescription.

Manufacturer:

Registration Certificate Holder:

Alkaloid JSC, Republic of Macedonia.
Boulevard Aleksandar Makedonski 12, 1000 Skopje.

Organization receiving consumer complaints:

Representative office of JSC "ALKALOID" (Macedonia).
Russian Federation, 119048, Moscow, st. Usacheva, 33, building 2.

In treatment infectious pathologies Nifuroxazide suspension is used for infants - the instructions for children do not provide for any serious age restrictions. Children are heavier than adults when pathogenic microbes and viruses enter the digestive tract. The child has not yet fully developed the body’s resistance to pathogens intestinal infections, and permeability blood vessels higher than that of an adult. This causes the rapid spread of bacteria, viruses, protozoa and the occurrence of dyspeptic disorders - nausea, vomiting, diarrhea. Nifuroxazide acts more mildly than antibacterial drugs, but is no less effective.

Nifuroxazide suspension will help cure diarrhea in children older than 2 months

Features of the pharmacological drug

The main purpose of Nifuroxazide is to destroy pathogenic pathogens of intestinal infections that cause severe diarrhea in children. This negative symptom, along with vomiting, leads to dehydration of the body. Together with the liquid, mineral compounds necessary for the active functioning of all human life systems are removed from cells and tissues. This condition is extremely dangerous for young children, especially infants.

Warning: Loss of 10% of body fluid in a newborn can cause death.

Therefore, diarrhea must be treated very quickly, following all medical recommendations. After laboratory tests and if necessary instrumental studies The pediatrician usually recommends Nifuroxazide or its analogues. This preference is based on the advantages of suspensions or tablets over other means. What are the advantages of an antidiarrheal drug:

• taking Nifuroxazide does not upset the balance of the microflora of the gastrointestinal tract, since active substance not absorbed into the bloodstream;
• the use of the drug helps prevent the development of bacterial infection;
• the drug can be used in the treatment of newborns (with the exception of premature babies);
• Nifuroxazide does not penetrate biological barriers, therefore it is indicated for use during pregnancy and lactation;
• The drug is characterized by high clinical efficacy.

The drug, regardless of its release form, is absolutely safe and well tolerated by children and adults.

Composition and release form

Manufacturers produce an antidiarrheal drug in two dosage forms:

• in the form of biconvex smooth yellow tablets No. 24;
• in the form of a sweet suspension with banana flavor.

Primary packaging of Nifuroxazide is a foil blister or a dark glass bottle of 90 ml. The composition of the tablets and suspension includes auxiliary ingredients:

• lemon acid;
• talc;
• starch;
• silica;
• sucrose;
• gelatin;
• titanium dioxide.

These components are necessary not only for the formation of tablets. With the help of auxiliary compounds, Nifuroxazide is delivered as intended - into the intestinal lumen, avoiding negative impact acidic gastric juice. The secondary packaging of the medicinal product is cardboard box with attached annotation. The suspension comes with a convenient graduated measuring spoon.

Nifuroxazide tablets are used in the treatment of intestinal infections in children over 7 years of age

Indications for use

Colds in children are often treated with antibacterial drugs. And after recovery, the child may develop diarrhea. Reason unpleasant symptom Intestinal dysbiosis occurs after taking antimicrobial agents. In this case, pediatricians prescribe Nifuroxazide syrup, which quickly restores normal peristalsis. The drug is indicated for use in the following cases:

• diarrhea caused by the penetration of gram-positive bacteria into the human body - streptococci or staphylococci;
• diarrhea caused by gram-negative pathogens of intestinal infections - Shigella, E. coli, Salmonella;
• diarrhea accompanying diseases of the gastrointestinal tract;
• complex therapy of enterocolitis or chronic colitis.

Nifuroxazide tablets and suspension are used as a prophylactic against the development of intestinal infections and dysbacteriosis during surgical interventions on the abdominal organs.

pharmachologic effect

Nifuroxazide belongs to a group of drugs with antimicrobial activity wide range actions. The drug exhibits different properties when using high or low dosages. Pediatricians and gastroenterologists take this feature into account when prescribing Nifuroxazide. During therapy, the amount of active substance taken may vary depending on intermediate results laboratory research biological samples.

Recommendation: While taking Nifuroxazide suspension or tablets, you should drink plenty of fluids, including saline solutions with glucose or dextrose - Regidron, Gidrovit. This will enhance the therapeutic effect and prevent the development of dehydration in children and adults.

Pharmacodynamics

Nifuroxazide for children in medium and low doses has a bacteriostatic effect as a result of inhibition of dehydrogenase activity. There is a disruption in the biosynthesis of essential compounds in the bacterial cell. Blockage of the respiratory chain leads to loss of the ability to grow and reproduce. When consumed high dose the drug exhibits a bactericidal effect, destroying the bacterial cell membrane. Violation of its integrity causes the rapid death of the pathogenic microorganism.

Nifuroxazide is able to inhibit the production of compounds by gram-negative and gram-positive bacteria that trigger symptoms general intoxication- fever, weakness and fatigue. As a result of using the drug:

• epithelial cells cease to experience irritation;
• the release of fluid into the intestinal lumen is significantly reduced.

Pharmacodynamics

The undoubted advantages of Nifuroxazide include the absence of any effect on the beneficial microflora of the digestive tract. Despite antimicrobial properties drug, taking a suspension or tablets does not provoke the development of dysbacteriosis. The drug is not absorbed by its walls and is excreted from the body along with feces.

Instructions for use

How to take Nifuroxazide tablets is determined by the pediatrician, taking into account the results laboratory tests. The medicine in tablets cannot be chewed or crushed in any other way. The result of such neglect of the instructions in the annotation will be a decrease in the concentration of the active substance in the intestinal lumen and the absence of the proper therapeutic effect. The tablets must be taken with plenty of clean water.

Advice: You can take Nifuroxazide tablets for no more than one week. If a child does not experience any improvement in condition 2-3 days after the start of treatment, then you should inform your doctor about this.

Taking Nifuroxazide does not depend on the presence of food in the stomach, so you can use the medicine at a time convenient for children and their parents. Before using the suspension, the bottle must be shaken to mix its contents. A measuring spoon will help you dose the sweet syrup.

The Nifuroxazide suspension comes with a convenient measuring spoon.

Contraindications and side effects

Since Nifuroxazide is not absorbed by the walls of the gastrointestinal tract and is not metabolized in the body, the only limitation for its use is age:

• the suspension should not be taken by infants under 2 months and premature babies;
• tablets are approved for use by children over 6 years of age.

Since the syrup contains artificial sweeteners, its use is contraindicated for people with lactase deficiency or galactose intolerance. In this case, the pediatrician will replace the Nifuroxazide suspension with tablets or select pharmacological drug similar therapeutic effect.

It is extremely rare that during therapy with Nifuroxazide, disturbances in the functioning of the digestive system may occur:

• pain in the epigastric region;
• nausea;
• bouts of vomiting.

In adults, negative symptoms quickly disappear, so the drug cannot be discontinued. If these signs appear in a child of any age, then taking the suspension or tablets should be stopped immediately and consult a pediatrician. He will adjust the dosage or replace the medication.
People with individual sensitivity to Nifuroxazide may develop allergic reaction. Usually it occurs like urticaria - rashes and redness appear on the skin various localizations. This condition requires discontinuation of the drug. In the future, children and adults should not take Nifuroxazide and its analogues (Ersefuril,

Nifuroxazide is a bactericidal and antibacterial drug intended for the treatment of diarrhea in children. It is produced in tablet and liquid form. In the second case, the drug is called a suspension, solution, syrup. The thick yellow mass with the smell of banana is pleasant to the taste. The drug is not an antibiotic; it belongs to the nitrofuran group.

Nifuroxazide: indications and contraindications

Nifuroxazide is an antidiarrheal drug that eliminates diarrhea of ​​any type and nature:

• Acute/chronic diarrhea associated with the activation of streptococci and staphylococci, salmonella, klebsiella and other microorganisms.
• Diarrhea caused by long-term use of antibiotics.
• Diarrhea that opens with appendicitis, food poisoning or autoimmune gastritis.
• Toxic diarrhea in 2-month-old children and older children.

In addition, syrup is prescribed for intestinal dysbiosis, colitis and enterocolitis, as well as to prevent infection after surgical intervention into the intestinal tract.

Contraindications to taking the drug are covered in the instructions. Their number is:

1. age up to 2 months;
2. prematurity;
3. deficiency of enzymes that break down sucrose (restriction applies to children under 1 year of age);
4. allergy to Nifuroxazide (reactions include itching, rash on the body, shortness of breath).

For other categories of children, the suspension is measured in accordance with the leaflet. You can use it without fear of worsening your intestinal condition. Rarely, children experience nausea or vomiting after consuming Nifuroxazide.

How to give Nifuroxazide to children

Since Nifuroxazide suspension can separate, the instructions suggest shaking the bottle before treating children.

Parents can choose the optimal dosage based on age and severity of the disease. The printed instructions give the exact amount of the product that should be given to a sick child at a time.

• Baby aged 2 – 6 months. syrup is given in 2.5 or 5 ml 2 r. per day with an interval of 12 hours.
• From the 2nd half of life to 6 years, the dosage is increased. The instructions suggest giving children 5 ml of the solution every 8 hours.
• After 6 years, the suspension is given 4 rubles. per day, i.e. every 6 hours the child receives 5 ml of the drug.

Nifuroxazide is given to children either with food or between meals. This factor does not affect the absorption of the active substance.

But doctors recommend that children follow a diet that requires the exclusion of juices from the diet, raw vegetables and fruits, as well as fatty, spicy and any difficult-to-digest foods.
If you have an intestinal disorder, it is useful to drink mineral water, saline solutions, weakly brewed unsweetened tea.
The instructions recommend antidiarrheal therapy for 5 to 7 days.

Special instructions for treatment with Nifuroxazide

If after 3 days from the start of taking the drug, the mother understands that it did not help, and general state the child has deteriorated, the advisability of further therapy should be discussed with a specialist. The following symptoms require immediate medical attention:

1. vomit;
2. temperature increase;
3. excretion of mucous or bloody impurities with feces;
4. signs of dehydration - lethargy, small amounts of urine with frequent trips to the toilet, dry lips and tongue.

Nifuroxazide: equivalent drugs for diarrhea

The anti-diarrhea drug Nifuroxazide has several analogues. Drugs in different forms contain the same active ingredient – ​​nifuroxazide:

• Stopdiar tablets;
• Nifuroxazide Richter – tablets and solution;
• Ecofuril and Ersefuril in capsules;
• Lecor – capsules and suspension;
• Enterofuril - capsule and liquid form.