"Nifuroxazide" for a child: instructions for use. Instructions for the use of nifuroxazide for intestinal infections Nifuroxazide 100 mg instructions for use tablets

One tablet contains

active substance- nifuroxazide, calculated as 100% substance 200 mg

Excipients: microcrystalline cellulose, povidone, lactose monohydrate, calcium stearate,

shellOpadry II Yellow 33G22623: hypromellose, lactose monohydrate, titanium dioxide (E171), polyethylene glycol 3000 (macrogol), triacetin, quinoline yellow (E104), sunset yellow FCF (E110), iron oxide yellow (E172), indigo carmine (E132).

Description

Tablets, coated film-coated yellow color, oval in shape, with a biconvex surface, with a line on one side of the tablet and the inscription “KMP” on the other side. A bright yellow core is visible on the fault

Pharmacotherapeutic group

Antidiarrheal drugs. Intestinal antimicrobial and anti-inflammatory drugs. Other intestinal antimicrobials. Nifuroxazide

ATX code A07A X03

Pharmacological properties"type="checkbox">

Pharmacological properties

Pharmacodynamics. Nifuroxazide is an antimicrobial drug of the 5-nitrofuran group and belongs to the intestinal antiseptics. Blocks the activity of dehydrogenases, inhibits processes cellular respiration, the tricarboxylic acid cycle, and also disrupts protein synthesis in the microbial cell. Reduces the production of toxins by microorganisms. At moderate therapeutic doses it exhibits bacteriostatic activity, and at higher doses it has a bactericidal effect.

The drug is active against gram-positive microorganisms of the family Staphylococcus and gram-negative microorganisms of the family Enterobacteriaceae (Escherichia, Citrobacter, Enterobacter, Klebsiella, Salmonella, Shigella, Yersinia), and Vibrio cholerae. Inactive against bacteria of the genus Pseudomonas and kind Proteus(view Proteus inconstans), as well as strains of subgroup A of the species Providentia alcalifaciens.

Pharmacokinetics. After oral administration, Nifuroxazide is not absorbed from digestive tract, providing a high concentration of the active substance in the intestines. The concentrations of traces of the drug in the blood plasma are determined; a small amount is detected in urine unchanged. Excreted in feces. The rate of elimination depends on the dose of the drug taken and the motility of the digestive tract.

Indications for use

Infectious diarrhea in adults, chronic colitis, enterocolitis - as an adjuvant in complex treatment intestinal dysbiosis.

Side effects

Brief abdominal pain, nausea, increased diarrhea

Rash, itching.

If hypersensitivity reactions develop, discontinuation of the drug is required.

Contraindications

Hypersensitivity to 5-nitrofuran derivatives and/or other components of the drug

Children and teenagers up to 18 years of age

Hereditary fructose intolerance, Lapp-lactase enzyme deficiency, glucose-galactose malabsorption

Drug interactions"type="checkbox">

Drug interactions

While taking Nifuroxazide, you should not use other oral medications, which is due to the strong adsorption properties of the drug. Nifuroxazide is not recommended for use with drugs with a high alcohol content.

Interaction of Nifuroxazide with others medicines has not been studied at this time.

special instructions"type="checkbox">

special instructions

The drug is not prescribed as monotherapy for the treatment of intestinal infections complicated by septicemia. If there are symptoms of dehydration in combination with the use of Nifuroxazide, rehydration should be carried out. The volume of fluid administered and the method of administration (per os, intravenously) must correspond to the severity of diarrhea, age and clinical condition of the patient (for adults - about 2 liters of fluid per day).

The drug contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.

During treatment, you should not eat spicy and hard-to-digest foods, raw fruits, vegetables and juices.

When using Nifuroxazide, the consumption of alcoholic beverages is contraindicated due to the risk of developing a disulfiram-like reaction, manifested by exacerbation of diarrhea, vomiting, epigastric pain, a feeling of heat in the face and upper body, hyperemia, tinnitus, difficulty breathing, tachycardia.

Use during pregnancy or breastfeeding.

The use of the drug during pregnancy is possible if the expected positive effect for the mother exceeds the potential risk to the fetus.

The drug is not excreted in breast milk, so it can be used during breastfeeding.

Use in pediatrics

Nifuroxazide is not prescribed to children and adolescents under 18 years of age.

Features of the effect of the drug on the ability to drive vehicle or potentially dangerous mechanisms

Nifuroxazide does not affect the reaction rate when driving vehicles or working with mechanisms that require increased attention and rapid mental and motor reactions.

Due to the characteristics of a growing child's body, children are more susceptible to various intestinal infections, since they do not yet have a developed protective system. For therapy, Nifuroxazide is used - a drug that fights the cause of the disease - various pathogenic microorganisms.

The drug is available in two forms: tablets and syrup. The latter form is best suited for the treatment of intestinal infections in children, even the youngest. Nifuroxazide can only be used as prescribed by a pediatrician.

Nifuroxazide syrup has a pleasant taste

Any child suffering from acute or chronic form caused by certain infectious agents, you can help cope with the disease with the help of Nifuroxazide.

This antidiarrheal drug, which is based on a nitrofuran derivative, fights various gastrointestinal bacteria, including:

• shigella
• enterobacter
• salmonella

These bacteria are both gram-positive and gram-negative. Classification is used to distinguish bacteria depending on the structure of their shell. Gram-negative bacteria have stronger protection and immune system it is more difficult for a child to deal with them.

It should be noted that despite its antibacterial activity, the product does not have a negative effect on the state of normal bacterial flora. Indications for the use of the drug are the following factors:

• caused by an infectious disease
• infectious chronic colitis and
• prevention of possible infectious diseases Gastrointestinal tract after surgical interventions
• complex therapy of intestinal dysbiosis

Nifuroxazide is used to treat various infectious diseases caused by both gram-positive and gram-negative pathogens.

Action of Nifuroxazide

Nifuroxazide syrup - in the treatment of intestinal infections

The product is active against most types of pathogenic microorganisms that cause infectious diseases. The activity of Nifuroxazide even affects strains of infections that are resistant to other antimicrobial drugs.

It is assumed that the action of the drug is based on inhibition of the activity of dehydrogenases, as well as on disruption of protein synthesis in infectious agents. Depending on the dose used, the drug has different effects on pathogenic bacteria.

When used in medium doses, the product has a bacteriostatic effect, as a result of which the growth and reproduction of microorganisms slows down. Higher doses of the product destroy pathogenic bacteria.

Therapeutic doses of Nifuroxazide remain in balance normal microflora intestines, and also do not allow pathogenic microorganisms to develop resistance to other antibacterial agents, which allows the drug to be used in combination with system means to combat generalized infections.

The drug is taken orally, with virtually no absorption of its components by the body. A particularly high concentration of the active substance is observed. Such features of the pharmacokinetics of the drug allow Nifuroxazide to exhibit an exclusively enteral antibacterial effect, not have toxic effects and be excreted from the body along with feces.

The drug is considered safe for children and exhibits side effects only in rare cases. The result of a side effect of the drug may be diarrhea. If any of these signs appear, you should consult a doctor.

Nifuroxazide, depending on the dose, has a bacteriostatic or bactericidal effect. The drug is considered safe, but if any side effects occur, you should inform your doctor.

Instructions for use of Nifuroxazide

You cannot take Nifuroxazide syrup without a doctor's prescription!

Nifuroxazide is also available in tablet form. The liquid form of the drug is a suspension, which is also mistakenly called syrup. Before giving the suspension to a child, the container with the product should be thoroughly shaken, since the drug becomes heterogeneous after some time. Depending on the age of the child, the drug is prescribed in different doses and with different frequency of administration:

• babies from two months to six months should be given the drug twice a day, in an amount of 110 to 220 milligrams (about half and a whole teaspoon, respectively)
• Children from six months to six years old should be given the drug three times a day in the amount of 220 milligrams per dose

The drug can be given at any convenient time: regardless of the time of administration, the drug acts the same. Therapy lasts for five to seven days. If the child feels better long before the end of the course, the doctor should be informed about this. If your baby begins to suffer from the following symptoms, you should contact a specialist as soon as possible:

• changes in baby's stool
• symptoms of dehydration
• sudden increase in temperature

When using the drug, especially if we are talking about a very young child, many parents may experience certain difficulties. In order to simplify this process somewhat, there are useful recommendations:

1. When giving the baby the remedy, you should make sure that the child is in a sitting or semi-lying position, in which his body is at an angle of forty-five degrees to the plane of the surface on which he is sitting. Thus, the likelihood that the baby will choke on the suspension taken is significantly reduced.
2. the spoon with the product must be placed closer to the corner of the lips, and not in the middle of the oral cavity. If the spoon is placed directly in the center, then the likelihood that the child will push out the spoon with the drug or choke on it increases.
3. You should not lie to your child that the medicine he is taking is some kind of treat. If the baby does not like the taste of the drug, then in the future he will trust the adults who deceived him less and it will become even more difficult to give him the medicine. When communicating with your baby, you should show calm and perseverance, and then everything will definitely work out.

Nifuroxazide suspension is used only as prescribed by the attending physician. The dosage and frequency of taking the drug depend on the age of the child.

Nifuroxazide - antibacterial agent, produced in the form of a suspension and. The suspension is excellent for children from two months who suffer from infectious diseases. The drug can only be prescribed by a doctor. If any side effects Taking the drug should be discontinued, and any signs that appear should be reported to the doctor as soon as possible.

Telegram

Read along with this article:

• 
  Enterofuril: suspension for children suffering from infectious…

In treatment infectious pathologies Nifuroxazide suspension is used for infants - the instructions for children do not provide for any serious age restrictions. Children are heavier than adults when pathogenic microbes and viruses enter the digestive tract. The child has not yet fully developed the body’s resistance to pathogens of intestinal infections, but the permeability blood vessels higher than that of an adult. This causes the rapid spread of bacteria, viruses, protozoa and the occurrence of dyspeptic disorders - nausea, vomiting, diarrhea. Nifuroxazide acts more mildly antibacterial drugs, but is no less effective.

Nifuroxazide suspension will help cure diarrhea in children older than 2 months

Features of the pharmacological drug

The main purpose of Nifuroxazide is to destroy pathogenic pathogens of intestinal infections that cause severe diarrhea in children. This negative symptom, along with vomiting, leads to dehydration of the body. Together with the liquid, mineral compounds necessary for the active functioning of all human life systems are removed from cells and tissues. This condition is extremely dangerous for young children, especially infants.

Warning: Loss of 10% of body fluid in a newborn can cause death.

Therefore, diarrhea must be treated very quickly, following all medical recommendations. After laboratory tests and if necessary instrumental studies The pediatrician usually recommends Nifuroxazide or its analogues. This preference is based on the advantages of suspensions or tablets over other means. What are the advantages of an antidiarrheal drug:

• taking Nifuroxazide does not upset the balance of microflora gastrointestinal tract, because active substance not absorbed into the bloodstream;
• the use of the drug helps prevent the development of bacterial infection;
• the drug can be used in the treatment of newborns (with the exception of premature babies);
• Nifuroxazide does not penetrate biological barriers, therefore it is indicated for use during pregnancy and lactation;
• The drug is characterized by high clinical efficacy.

The drug, regardless of its release form, is absolutely safe and well tolerated by children and adults.

Composition and release form

Manufacturers produce an antidiarrheal drug in two dosage forms:

• in the form of biconvex smooth yellow tablets No. 24;
• in the form of a sweet suspension with banana flavor.

Primary packaging of Nifuroxazide is a foil blister or a dark glass bottle of 90 ml. The composition of the tablets and suspension includes auxiliary ingredients:

• lemon acid;
• talc;
• starch;
• silica;
• sucrose;
• gelatin;
• titanium dioxide.

These components are necessary not only for the formation of tablets. With the help of auxiliary compounds, Nifuroxazide is delivered as intended - into the intestinal lumen, avoiding negative impact acidic gastric juice. The secondary packaging of the medicinal product is cardboard box with attached annotation. The suspension comes with a convenient graduated measuring spoon.

Nifuroxazide tablets are used in the treatment of intestinal infections in children over 7 years of age

Indications for use

Colds in children are often treated with antibacterial drugs. And after recovery, the child may develop diarrhea. Reason unpleasant symptom Intestinal dysbiosis occurs after taking antimicrobial agents. In this case, pediatricians prescribe Nifuroxazide syrup, which quickly restores normal peristalsis. The drug is indicated for use in the following cases:

• diarrhea caused by the penetration of gram-positive bacteria into the human body - streptococci or staphylococci;
• diarrhea caused by gram-negative pathogens of intestinal infections - Shigella, E. coli, Salmonella;
• diarrhea accompanying diseases of the gastrointestinal tract;
• complex therapy of enterocolitis or chronic colitis.

Nifuroxazide tablets and suspension are used as a prophylactic against the development of intestinal infections and dysbacteriosis during surgical interventions on the abdominal organs.

pharmachologic effect

Nifuroxazide belongs to a group of drugs with antimicrobial activity wide range actions. The drug exhibits different properties when using high or low dosages. Pediatricians and gastroenterologists take this feature into account when prescribing Nifuroxazide. During therapy, the amount of active substance taken may vary depending on intermediate results laboratory research biological samples.

Recommendation: While taking Nifuroxazide suspension or tablets, you should drink plenty of fluids, including saline solutions with glucose or dextrose - Regidron, Gidrovit. This will enhance the therapeutic effect and prevent the development of dehydration in children and adults.

Pharmacodynamics

Nifuroxazide for children in medium and low doses has a bacteriostatic effect as a result of inhibition of dehydrogenase activity. There is a disruption in the biosynthesis of essential compounds in the bacterial cell. Blockage of the respiratory chain leads to loss of the ability to grow and reproduce. When consumed high dose the drug exhibits a bactericidal effect, destroying the bacterial cell membrane. Violation of its integrity causes the rapid death of the pathogenic microorganism.

Nifuroxazide is able to inhibit the production of compounds by gram-negative and gram-positive bacteria that trigger symptoms general intoxication- fever, weakness and fatigue. As a result of using the drug:

• epithelial cells cease to experience irritation;
• the release of fluid into the intestinal lumen is significantly reduced.

Pharmacodynamics

The undoubted advantages of Nifuroxazide include the absence of any effect on the beneficial microflora of the digestive tract. Despite antimicrobial properties drug, taking a suspension or tablets does not provoke the development of dysbacteriosis. The drug is not absorbed by its walls and is excreted from the body along with feces.

Instructions for use

How to take Nifuroxazide tablets is determined by the pediatrician, taking into account the results laboratory tests. The medicine in tablets cannot be chewed or crushed in any other way. The result of such neglect of the instructions in the annotation will be a decrease in the concentration of the active substance in the intestinal lumen and the absence of the proper therapeutic effect. The tablets must be taken with plenty of clean water.

Advice: You can take Nifuroxazide tablets for no more than one week. If a child does not experience any improvement in condition 2-3 days after the start of treatment, then you should inform your doctor about this.

Taking Nifuroxazide does not depend on the presence of food in the stomach, so you can use the medicine at a time convenient for children and their parents. Before using the suspension, the bottle must be shaken to mix its contents. A measuring spoon will help you dose the sweet syrup.

The Nifuroxazide suspension comes with a convenient measuring spoon.

Contraindications and side effects

Since Nifuroxazide is not absorbed by the walls of the gastrointestinal tract and is not metabolized in the body, the only limitation for its use is age:

• the suspension should not be taken by infants under 2 months and premature babies;
• tablets are approved for use by children over 6 years of age.

Since the syrup contains artificial sweeteners, its use is contraindicated for people with lactase deficiency or galactose intolerance. In this case, the pediatrician will replace the Nifuroxazide suspension with tablets or select pharmacological drug similar therapeutic effect.

It is extremely rare that during therapy with Nifuroxazide, disturbances in the functioning of the digestive system may occur:

• pain in the epigastric region;
• nausea;
• bouts of vomiting.

In adults, negative symptoms quickly disappear, so the drug cannot be discontinued. If these signs appear in a child of any age, then taking the suspension or tablets should be stopped immediately and consult a pediatrician. He will adjust the dosage or replace the medication.
People who are individually sensitive to Nifuroxazide may develop an allergic reaction. Usually it occurs like urticaria - rashes and redness appear on the skin various localizations. This condition requires discontinuation of the drug. In the future, children and adults should not take Nifuroxazide and its analogues (Ersefuril,

IN pediatric practice Nifuroxazide is widely used and is one of the best pharmaceutical drugs for treating eating disorders. A distinctive advantage is that the drug does not provoke the development of dysbacteriosis. In addition, it is important to note that the drug is available for children in the form of a suspension with a pleasant taste.

In addition to the suspension, there are also Nifuroxazide tablets and capsules. These forms of the drug are used in the treatment of adults and older children. While the oral suspension yellowish color with banana flavor is approved for use in children from six months of age.
The main active ingredient is Nifuroxazide.
In addition, the composition includes additional components:

• Carboxypolymethylene;
• Sucrose;
• Sodium hydroxide;
• Citric acid monohydrate;
• Antifoam mixture (Antifoam F);
• Methyl parahydroxybenzoate;
• Banana flavor (banana essence);
• Purified water.

The suspension is available in quantities of 90 ml in dark glass bottles with a double dosing spoon (2.5 and 5 ml) in the set. The drug is packaged in factory-made cardboard boxes.

Clinical and pharmacological group

Antidiarrheal drug. Has an antimicrobial effect.
Food antiseptic, 5-nitrofuran derivative. Effective against most pathogens of intestinal infections (including mutant strains resistant to other antimicrobial agents): gram-positive (Staphylococcus spp.) and gram-negative (Escherichia spp., Citrobacter spp., Enterobacter, Klebsiella spp., Salmonella spp., Shigella spp., Proteus spp., Yersinia spp.) and Vibrio cholerae.
Not effective against microbes of the family Pseudomonas spp., Proteus spp. (Proteus inconstans), as well as strains of subgroup A of the Providentia alcalifaciens variety.
The drug "Nifuroxazide" suppresses the activity of dehydrogenases and disrupts protein synthesis in pathogenic microbes. In average therapeutic doses it has bacteriostatic activity, and in increased doses it functions bactericidal. The effect appears from the first hours of treatment. In therapeutic doses does not change the balance of the symbiotic bacterial flora of the intestine; does not transform pathogenic microbes into resistant to treatment and does not cross-resistance of microbes to other antimicrobial drugs, which allows, if necessary, for generalized infections, to supplement therapy with systemic drugs with Nifuroxazide.
At food infections viral origin eliminates the possibility of developing bacterial superinfection.

The suspension is almost insoluble in water, does not enter the blood and is not distributed by current throughout the body. Due to these qualities, the drug is long time is retained in the stomach and intestinal tract, which makes it possible to more effectively destroy pathogenic bacteria. This drug is excreted from the intestinal tract through feces.

It is worth noting that Nifuroxazide is often attributed to antibiotics. This statement is definitely incorrect. The product does not contain any components related to medical drugs antibiotic series, because it does not disrupt the microflora of the intestinal tract, but rather promotes its restoration. As a result, harmful bacteria are completely destroyed, and the mucous membrane remains in in perfect order. The suspension has the property of destroying not only bacteria, but also fights Trichomonas, fungi of the Candida family and Giardia.

Pharmacokinetics

After oral administration, the drug is not absorbed from the gastrointestinal tract, forming the highest concentration of the main substance in the intestinal tract. Thanks to these pharmacokinetic properties, the drug has an enteral antiseptic effect, does not have systemic bactericidal activity, does not cause general toxic effects, and is excreted from the body in feces.

Nifuroxazide does not affect the clinical and biochemical characteristics of a blood test.

Indications for use of "Nifuroxazide"

Acute and chronic diarrhea caused by intestinal gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Haemophilus influenzae), as well as gram-negative bacteria (Salmonella spp., Shigella spp., Klebsiella spp., Escherichia coli, Proteus spp., Enterobacter spp. ).

• Diarrhea in children caused by unspecified digestive infections;
• Intestinal dysbiosis;
• Prevention of infections during surgical operations on the intestinal tract;
• Chronic colitis and enterocolitis.

Contraindications

• Prematurity;
• Less than two months old;
• Allergy to the main or excipients of the drug.

Directions for use and dosage of the suspension for children

The drug "Nifuroxazide" in the form of a suspension is taken orally, without drinking water or other liquids, regardless of meals. Before use, the bottle must be shaken until a homogeneous mixture is obtained.

• Children aged 2-6 months are given 2.5 ml or 5 ml twice a day (i.e. once every 12 hours). The dosage is prescribed by the doctor in each case individually, depending on the severity of the disease.
• Children aged 6 months to 6 years need a large dose of the drug: 5 ml of Nifuroxazide suspension three times a day (every 8 hours).
• Children over 6 years of age are prescribed adult dosage: 5 ml of Nifuroxazide suspension four times a day (every 6 hours).

Special instructions

In children younger age(from 2 months to a year) before starting therapy with Nifuroxazide, it is necessary to exclude a congenital disease associated with the lack of enzymes that process sucrose.

You need to know that treatment of children with a suspension should not last longer than 7 days. If, after the specified period, diarrhea has not been eliminated, you must contact your pediatrician again to review the treatment strategy or prescription. additional examination child. Treatment may require more serious medications or antibiotics.

The composition of the medicine in the form of a suspension includes lactose. As a result, it is better for patients who are sensitive to this substance to replace Nifuroxazide with another lactose-free drug.

You should not use other oral medications together with Nifuoxazide, because there is a possibility of reducing their pharmacological action against the background of the sorption effect of “Nifuroxazide”.

At the same time as taking Nifuroxazide, solutions for oral dehydration are prescribed. This is necessary to reduce the risk of dehydration.

Use of Nifuroxazide during pregnancy

Scientific studies related to the effect of the drug on pregnant women and the fetus have not been conducted. IN medical practice There have been no cases of negative effects of the drug on fetal development. Therefore, the use of Nifuroxazide by pregnant women is allowed, but strictly as prescribed by a doctor who evaluates the ratio of the likely benefits of using the drug to the likely risk of the drug affecting the fetus.

Overdose and side effects

The medicinal product has low bioavailability, which means drug poisoning is excluded. The instructions for use of the Nifuoxazide suspension for children indicate that in case of an overdose of the drug, it is recommended to rinse the stomach and consult a specialist.

Conditions of storage and release from pharmacies, expiration date

"Nifuroxazide" is allowed for sale only with a doctor's prescription. Stored in a dark, cool place, out of reach of children, for 2 years at a temperature of 14 to 26 degrees.

Capsules 100 mg:

Hard gelatin capsules No. 1 are cylindrical in shape with hemispherical ends of yellow color.

Capsules 200 mg:

Hard gelatin capsules No. 0 are cylindrical in shape with hemispherical ends of yellow color.

Compound

Each capsule contains:

active substance: nifuroxazide – 100 mg or 200 mg;

Excipients: sucrose, magnesium stearate, modified corn starch (Starch 1500).

Composition of the gelatin capsule shell:

Gelatin, titanium dioxide E171, quinoline yellow E104, azorubine E122, crimson
4R E124, purified water.

Release form

Capsules 100 mg, 200 mg.

Pharmacotherapeutic group

Antidiarrheal, anti-inflammatory, antimicrobial agents for the treatment of intestinal infections.

ATX code

Indications for use

Treatment acute diarrhea bacterial origin caused by sensitive strains of Staphylococcus spp., Salmonella spp., Escherichia coli in the absence of signs of invasion (for example, deterioration general condition, fever, toxic infection, etc.) in addition to rehydration therapy.

The dose and method of rehydration (orally or intravenously) is determined depending on the severity of diarrhea, age, condition of the patient, and the presence of concomitant diseases.

Directions for use and dosage

Nifuroxazide-LF is taken orally, regardless of food intake, at regular intervals.

Adults – 800 mg (4 capsules of 200 mg or 8 capsules of 100 mg) per day, divided into 4 doses.

Children over 6 years old - 600-800 mg (3-4 capsules of 200 mg or 6-8 capsules of 100 mg) per day, divided into 3-4 doses.

To treat acute diarrhea, the drug must be taken for 3 days. If after this the symptoms of the disease do not disappear, you should consult a doctor.

The duration of taking nifuroxazide should not exceed 7 days.

Side effect

From the hematopoietic and lymphatic system:

One case of granulocytopenia has been described.

From the gastrointestinal tract:

In cases of individual hypersensitivity to nifuroxazide, abdominal pain, nausea and exacerbation of diarrhea may occur. If such symptoms of minor intensity occur, there is no need to use special therapy or discontinue the use of nifuroxazide. If the above symptoms develop to significant intensity, you should stop taking the medication. In the future, the patient should not take nitrofuran derivatives.

From the skin and subcutaneous tissue:

Allergic reactions may develop ( skin rash, urticaria, Quincke's edema, anaphylactic reactions).

If hypersensitivity reactions occur, such as shortness of breath, swelling of the face, tongue, lips, skin rash, itching, you should immediately stop using the drug.

In case of adverse reactions, including those not specified in this instruction, you should stop using the drug and consult a doctor.

Contraindications

• allergic reactions to 5-nitrofuran derivatives;
• increased sensitivity to any of the components of the drug;
• fructose intolerance, glucose-galactose malabsorption syndrome or sucrase and isomaltase deficiency (due to the presence of sucrose in the drug).
• childhood up to 6 years old.

Overdose

Overdose symptoms are not known. If the dose is exceeded, gastric lavage and symptomatic treatment are recommended.

Use during pregnancy and lactation

Use of nifuroxazide during pregnancy:

There are no clinical data regarding the use of nifuroxazide during pregnancy. Animal studies show no direct or indirect effect on pregnancy, embryonic or fetal development, labor or child development after birth.

Nifuroxazide should preferably not be used in pregnant women. Before prescribing the drug, the attending physician should carefully weigh the expected benefits and risks of its use.

Use of nifuroxazide during breastfeeding:

Due to the lack of sufficient clinical data, caution should be exercised when prescribing nifuroxazide to breastfeeding women.

Precautionary measures

During treatment with nifuroxazide, the consumption of alcoholic beverages is contraindicated, because alcohol increases the body's sensitivity to the drug and can provoke a disulfiram-like reaction, which is expressed by exacerbation of diarrhea, vomiting, abdominal pain, skin flushing, a feeling of heat in the face and upper body, noise in the head, difficulty breathing, tachycardia, and a feeling of fear.

The drug is not prescribed as monotherapy for the treatment of intestinal infections accompanied by septicemia.

If symptoms of dehydration appear during treatment with the drug, it is necessary, depending on the clinical condition patient, carry out rehydration therapy (adults - about 2 liters of fluid per day).

If hypersensitivity reactions occur, such as shortness of breath, skin rash, itching, you should stop using the drug.

Nifuroxazide should be used with a strict diet, excluding juices, raw vegetables and fruits, spicy and indigestible foods.

If diarrhea continues after 3 days of treatment, it is necessary to conduct an in-depth diagnosis, the purpose of which is to determine the cause of the symptoms, and consider starting antibiotic therapy.

In case of severe invasive diarrhea, antibiotic therapy is necessary, since nifuroxazide is not absorbed from the gastrointestinal tract.

The ability to influence reaction speed when driving a vehicle or while working with other mechanisms

The drug does not affect the ability to drive a car or operate other mechanisms.

Interaction with other drugs

Drinking alcohol during treatment with nifuroxazide may cause disulfiram-like reactions. While taking nifuroxazide, the simultaneous use of other oral medications should be avoided due to the strong adsorption properties of the drug.

Storage conditions and shelf life

Store in a place protected from moisture and light at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life – 2 years.

Do not use after the expiration date stated on the package.

Package

10 capsules per blister pack made of polyvinyl chloride film and aluminum foil.

Three blister packs along with instructions for use are placed in a cardboard pack.