Glycerin suppositories side effects. Medicinal reference book geotar. Indications for use of suppositories

MINISTRY OF HEALTH OF THE RF
Pharmacologically approved
state committee
Ministry of Health of Russia
February 19, 1999

INSTRUCTIONS FOR USE OF CANDLES WITH GLYCERIN

(information for consumers)

International generic name - Glycerol.
Registration number 72/911/10
The drug contains glycerin:
from 1.12 to 1.36 g - in candles weighing from 1.53 to 1.69 g
from 1.91 to 2.33 g - in candles weighing from 2.61 to 2.89 g
Description
Candles are transparent or translucent, almost colorless or with a yellowish-brown tint, with a smearable surface, hygroscopic, torpedo-shaped.
Cloudiness of the candles, slight softening of the surface layer and sweating of the contour packaging are allowed.

Pharmacological properties

Suppositories with glycerin are a laxative drug. Due to the irritating effect on the rectal mucosa, they stimulate the act of defecation, causing bowel movement.

Indications for use

Suppositories with glycerin are used as a laxative for constipation of various etiologies: functional (habitual), psychogenic, senile, for constipation in sedentary patients and constipation associated with a decrease in the sensitivity of the receptor apparatus of the rectum.

Contraindications

Sharp cracks anus, hemorrhoids in the acute stage, inflammation of the rectal mucosa, rectal tumors.

Directions for use and doses

The suppository is released from the contour packaging, having previously cut it with scissors, and is inserted deep into the anus. Use one suppository per day, preferably 15-20 minutes after breakfast.

Side effect

With prolonged use in some patients, suppositories can cause discomfort in the rectum with the subsequent possible occurrence of catarrhal proctitis. In these cases, it is recommended to introduce warm oil (in the amount of one tablespoon) into the anus as an enema and temporarily stop using the drug.
Release form
Suppositories with glycerin weighing from 1.53 to 1.69 g and from 2.61 to 2.89 g, 5 pieces in contour packaging.
Storage conditions
In a cool, dry place.
Shelf life 2 years.
After the expiration date, the drug should not be used.
Keep the drug out of the reach of children!
Conditions for dispensing from pharmacies
Dispensed without a doctor's prescription.

Manufacturer:
Open Joint Stock Company "Nizhpharm", Nizhny Novgorod.

Rectal glycerin suppositories (suppositories) is a local laxative, an effective and safe means of aiding bowel movements. Glycerin suppositories prescribed for all types of constipation, as well as to facilitate bowel movements in patients after perineal surgery.

When inserted into the rectum, the suppository dissolves under the influence of body temperature. Glycerol – active substance drug, envelops the intestinal walls, softens dense feces, facilitates their promotion. Reduces tension during defecation. The drug acts on the rectal mucosa and activates peristalsis.

Instructions for use

The optimal time to administer a laxative is 15 minutes after a meal.

1. Wash your hands and, if possible, wear a rubber glove or fingertip.
2. Remove the candle from its packaging. For easier administration, it can be slightly moistened with cool water. Cream and oil are prohibited.
3. Lie on your left side, bend your knees and bring them slightly towards your stomach, relax.
4. Carefully insert the suppository with the pointed end into the anus.
5. To prevent the candle from slipping out, squeeze your buttocks together and lie down for 5-10 minutes.

The drug completely dissolves after half an hour, but sometimes the desire to empty the intestines arises earlier. The less often you use rectal suppositories, the faster they begin to act.

Advantages and disadvantages of glycerin suppositories

Contraindications

Side effects

Patients usually tolerate glycerin suppositories well. Undesirable effects are rare:

• local allergic reactions;
• burning and itching upon insertion;
• catarrhal proctitis;
• with prolonged use, dystrophy of the intestinal mucosa develops, and the natural mechanism of defecation is disrupted.

FAQ

When do glycerin suppositories begin to work?

The time for the onset of action of the drug depends on the individual sensitivity of rectal receptors. In some patients, the first urge to defecate occurs within 5-10 minutes after the administration of the suppository. It takes at least half an hour for the candle to completely dissolve.

How long does it work on adults?

During bowel movements, the drug is excreted in the feces, so after defecation, the effect of glycerin ceases.

Are glycerin suppositories addictive?

With prolonged and uncontrolled use of rectal suppositories, the sensitivity of rectal receptors decreases. The physiological regulation of bowel movements is weakened.

How often can you use glycerin suppositories?

The recommended dose is 1 suppository once a day. The duration of use of the drug in each specific case is determined by the doctor. When used independently, stop treatment immediately after bowel movements are restored.

Whycandles cannot help?

Glycerol facilitates the removal of dense feces that have filled the rectal ampulla. The medicine will not help with obstruction in other parts of the intestine. The most common reasons no effect: spastic colitis, irritable bowel syndrome.

Can glycerin suppositories be used for pregnant women?

The drug is approved for use during pregnancy. It is non-toxic and safe for the body of a woman and the unborn child. However, irritation of the rectum sometimes increases the tone of the uterus. Before using rectal suppositories, consult your obstetrician-gynecologist. If there is a threat of miscarriage, the doctor will recommend another laxative drug.

Alternative drugs

Suppositories with glycerin are an aid for difficult bowel movements. The main methods of preventing and treating constipation: diet correction, optimal drinking regimen, lifestyle changes.

A.06.A.X.01 Glycerol

Problems with bowel movements may develop in at different ages under the influence of negative factors environment. Stress and nervous tension, harmful products nutrition, potent medications, lack of fluid in the body leads to the development of constipation. The problem can be solved with safe and effective medications. Suppositories with glycerin are especially popular for treating constipation.

Glycerin suppositories can be used almost from the first days of life due to the minimal number of contraindications and side effects.Glycerin is safe for the human body, because it is not absorbed into circulatory system and quickly removes stagnant feces from the large intestine.

Glycerin, entering the intestines, begins to accumulate liquid and mucus, which, in turn, dilute the hardened decomposition products. Ultimately, feces gradually begin to be excreted naturally along with glycerin.

Do glycerin suppositories help with constipation?

Glycerin is highly effective in treating constipation. In addition, suppositories are allowed from the first days of life, because they have practically no contraindications. However, there are cases when glycerin will not help cope with constipation.

Problems with defecation come in different forms. Rectal suppositories with glycerin will not help in cases where constipation was caused by mechanical obstacles, for example, a tumor or intestinal spasm. Glycerin only helps when stool gets stuck in the colon.

Advantages and disadvantages

Glycerin suppositories have the following features and advantages:

• First of all, glycerin is not absorbed in the body, is not absorbed into the circulatory system and does not cause allergic reactions, therefore it is considered safe for health.
• Glycerin has a gentle effect on the intestinal mucosa without irritating it. Can be used even if you have anal fissures.
• Glycerin accumulates mucus in the large intestine, which liquefies hardened stool, gently removing it naturally.
• Can be used from the first days of life, because glycerin suppositories do not cause allergic reactions and do not affect the functioning of important organs.

Suppositories with glycerin also have their disadvantages, namely:

• Suitable for relieving mild constipation, when stool gets stuck in the large intestine.
• There may be a burning sensation in rare cases.
• Allergic reactions to glycerin almost never occur, but there are exceptions to the rule.

Indications

• For problems with bowel movements.
• At complete absence normal stool during two days.
• For constipation of an age-related, functional and psychogenic nature.
• During pregnancy and breastfeeding when there are problems with normal bowel movements.
• For the prevention of constipation in patients for whom physical activity is contraindicated.

Compound

The pharmacy offers glycerin suppositories for both adults and children. In addition to glycerin, the drug also contains sodium carbonate decahydrate, polyethylene oxide and stearic acid. One package contains 10 candles, ready to use.

Contraindications and side effects

• Pain and discomfort in various parts of the abdomen.
• Possible allergic reaction to one of the components of the drug.
• Neoplasms in the rectum.
• Internal bleeding of unknown origin.
• Inflammatory diseases of the rectum.
• Pointed hemorrhoids.
• Diarrhea.

A glycerin suppository, instructions for use of which are included in the package, may cause adverse reactions.

In case of overdose, the following negative effects are possible:

• Allergic reactions in the form of itching and burning in the anus.
• With long-term use, weakness of the rectal muscles may occur.

How long does it take for a glycerin suppository to work?

Glycerin suppositories are characterized by high level efficiency. Positive result occurs within 20-30 minutes after inserting the suppository into the rectal opening. That is why you need to be near the toilet in order to have time to empty your bowels in a timely manner.

Directions for use and doses

How to take suppositories with glycerin? detailed instructions from the manufacturer is included in the packaging of the drug.

• Suppositories should only be administered rectally a few minutes after eating. It is best to do this after breakfast in order to quickly restore the normal bowel movement process.
• Adults are prescribed one suppository per day.
• Babies of the first year of life are prescribed half a baby suppository (1.24 g).
• Children from 3 to 7 years old can take one children's candle per day.
• Pregnant women are allowed glycerin suppositories for adults, but only after consulting a doctor.
• The positive effect occurs within a few minutes after using glycerin suppositories.

How to put a glycerin suppository

In order to get the maximum benefit from treatment, you must adhere to the following regimen for using glycerin suppositories:

• First of all, you need to thoroughly wash your hands, because through them pathogenic bacteria can enter the human body when inserting suppositories. It's also a good idea to cool your hands. ice water to prevent the candle from melting. Glycerin melts very quickly, so suppositories must be handled with cold hands.
• Using a sharp object, such as scissors, carefully remove the protective film from the candle.
• For children of the first year of life, only half the dose is recommended. To do this, the candle needs to be cut in half.
• Only take the candle with clean hands so as not to introduce infection into the digestive system.
• For easy insertion, it is recommended to lubricate the tip of the candle with Vaseline.
• Next, you need to lie on your side and bend one leg at the knee.
• Lift the upper buttock to expose the rectal area.
• After this, you need to insert the candle into the anus as carefully as possible to a length of 2 to 5 cm for adults. For infants, the suppository can be inserted to a length of no more than 2.5 cm.
• Squeeze your buttocks and hold in this position for several minutes until the glycerin in the colon is completely dissolved.
• The positive effect should occur 20 minutes after administration of the suppository.

During pregnancy

Glycerin is not absorbed into the circulatory system, does not affect the functioning of the digestive system and other organs, and is therefore considered safe for the human body. That is why glycerin suppositories are prescribed to both adults and children, including pregnant women. In this case, you should definitely consult a doctor, because contraindications are possible, for example, pointed hemorrhoids, internal bleeding or allergic reactions to one of the components of the product.

In addition, glycerin can irritate not only the walls of the large intestine, but also the uterus, causing its contractions. However, there was not a single recorded case of this kind.

Glycerin suppositories for constipation

As you know, constipation can be of various types. Glycerin suppositories are effective only when mild form when stool gets stuck directly in the colon. Constipation that was caused by intestinal diseases cannot be eliminated with the help of glycerin suppositories.

Suppositories with glycerin are suitable only for mild constipation, caused, for example, by junk food or lack of fluid in the body.

Glycerin suppositories for children

How often can glycerin suppositories be given to children and adults? Glycerin-based preparations are suitable for one-time use only. Do not overuse this remedy to avoid side effects.

With prolonged use, an allergic reaction may develop and the activity of the rectal muscular system may decrease. Ultimately, digestive system gets used to constant stimulation and cannot cope with the rapid removal of decay products naturally on its own.

Glycerin suppositories are prescribed to children from the first year of life. Children are allowed to take half a suppository rectally once a day. Children from 3 to 7 years old can take one candle per day.

Before using any drug for constipation, you should definitely consult a doctor who will make the most accurate diagnosis.

Interaction with other drugs

No adverse symptoms were identified during simultaneous use with other drugs. It's not worth the risk though. It is better to take a break between taking various medications.

Overdose

Glycerin suppositories for constipation practically do not cause side effects, even with an overdose. However, there are cases when, with prolonged use, an allergic reaction to glycerin develops. The allergy manifests itself in the form of itching and burning in the anus. That is why you must strictly follow all recommended doses.

Precautionary measures

Only after consulting a doctor can you use glycerin for constipation, strictly adhering to the following recommendations:

• Suppositories with glycerin can be used only once to eliminate mild constipation.
• In case of overdose, allergic reactions may occur in the form of itching and burning in the anus.
• During pregnancy, you should definitely consult a gynecologist.
• Long-term use will weaken the muscles of the large intestine.
• Children of the first year of life can take only half a glycerin suppository.
• If any negative symptoms appear, you should definitely stop treatment.

Storage conditions

It is best to choose a dry and cool place where the air temperature does not exceed 25 degrees Celsius. Glycerin suppositories can be stored for two years in undamaged packaging.

Analogues

You can buy the following at the pharmacy: similar drugs, which contain glycerin: Norgalax, Dexeril, Normacol, Glycelax, RectActiv.

Compound:

1 suppository contains:

Active substance: glycerin (glycerol) – 2.11 g;

Excipients: macrogol 400, stearic acid 95, sodium carbonate decahydrate (sodium carbonate 10-water).

Description

Suppositories are torpedo-shaped, transparent or translucent, almost colorless or with a yellowish-brownish tint, with a smearable surface, hygroscopic. A funnel-shaped depression with a small amount of air bubbles is allowed.

Pharmacotherapeutic group

Other laxatives. CodeATX: А06АХ01

Pharmacological properties

Pharmacodynamics

A laxative, it softens and lubricates hardened feces, facilitates their passage through the colon, and has an irritating effect on the intestinal mucosa, reflexively stimulating intestinal motility.

Pharmacokinetics

There are no data on the pharmacokinetics of glycerol when administered rectally.

Indications for use

Symptomatic treatment of constipation of various etiologies.

Directions for use and doses

Rectally.

Adults and children over 7 years old - 1 suppository (2.11 g) 1 time per day.

The duration of use should not exceed 7 days. The duration of treatment is determined by the doctor individually for each patient, taking into account the characteristics of the disease, tolerability of the drug and the achieved therapeutic effect.

Side effect

Allergic reactions; local reactions at the site of administration of the suppository (discomfort, itching, burning); spasmodic pain in the intestines. With long-term use - weakening of the physiological process of defecation.

In patients with dehydration, after using glycerin in the form of suppositories, severe dehydration may develop, leading to cardiovascular failure and pulmonary edema. Cases of the development of non-ketotic hyperosmolar hyperglycemic coma, which can be fatal, have been described.

In case of adverse reactions, including those not specified in this instruction, you should stopuse of the medicine and consult a doctor.

Contraindications

Hypersensitivity to the components of the drug; intestinal obstruction, irritable bowel syndrome, appendicitis, gastrointestinal bleeding, diarrhea, inflammatory diseases of the rectum (proctitis, paraproctitis), hemorrhoids (acute phase), anal fissures, hemorrhagic rectocolitis, rectal tumors, undiagnosed abdominal pain, childhood up to 7 years.

Carefully

Kidney failure.

Overdose

A symptom of an overdose is frequent loose stools. In case of overdose, the drug should be discontinued.

Precautionary measures

Use with caution in patients with renal failure.

Do not lubricate suppositories with mineral liquid or solid oils.

When used, the remnants of the suppository are excreted from the intestines with feces.

Before and after using suppositories, you should wash your hands thoroughly.

If symptoms persist or worsen while using the drug, you should consult a doctor.

Use in children

The use of the drug Glycerin, rectal suppositories 2.11 g, is contraindicated in children under 7 years of age.

Use in children over 7 years of age is possible only after consulting a doctor and excluding diseases that could affect the delay in bowel movement.

The use of the drug in children must be carried out under the supervision of a physician.

Use during pregnancy or breastfeeding

Use during pregnancy and breastfeeding is possible only after consulting a doctor if the benefit to the mother outweighs the possible risk to the fetus/child. Prescribing the drug to women during the first trimester of pregnancy is not recommended.

Impact on the ability to drive vehicles and operate machinery

No information available.

Interaction with other drugs

Clinically meaningful interactions glycerol with other drugs have not been identified.

With simultaneous use of other rectally administered medicines, the laxative effect of the drug should be taken into account. If it is necessary to use other rectal medications, an interval between their use of at least 1 hour should be observed.

Release form

Rectal suppositories 2.11 g. 5 suppositories are placed in a contour cell packaging made of a two-layer aluminum-polyethylene film. Two blister packs along with instructions for use medicinal product placed in a cardboard pack.

Storage conditions

Store at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Duration: yearness

2 years. Do not use the drug after the expiration date.

Conditions for dispensing from pharmacies