Naphthyzine poisoning in children. Overdose of vasoconstrictor drops in a child: symptoms and treatment. Poisoning with nasal drops in children What to do with an overdose of vasoconstrictor drops

Can a child be poisoned by Naphthyzin? Yes maybe. Even the simplest and safest-looking nasal drops can lead to serious consequences and harm the child’s health. Poisoning in children medicines not at all uncommon. Poisoning with vasoconstrictor drugs occurs especially often, due to the selection and use of medications by parents independently without a doctor’s prescription, also due to an incorrectly calculated dose of the drug and its incorrect storage.

During colds, runny nose, allergies, teething, there is a need to give drops to children. Parents use Naphthyzin because the drug has a quick effect, removes swelling of the nasal mucosa, and clears the respiratory passages.

Behind last years the number of Naphthyzin poisonings has increased. Mothers are increasingly going to the hospital with similar poisonings in their children.

Naphthyzin, like other drugs, has side effects not only with long-term use, but also with short-term use. Sometimes symptoms of poisoning occur even with a single use.

The main reasons why there is an increase in drug poisoning:

Naphthyzin is produced in plastic bottles up to 20 ml. Due to such packaging, it is possible to make a mistake and take the wrong dosage, because during one press on the bottle the dose can increase up to ten times;
Parents often make a mistake and buy a 0.1% solution of the drug, but they should use a 0.05% solution;
Failure to follow the instructions for using the medicine. Let’s say the instructions indicate that naphthyzine can be used for children older than one year, but in practice it turns out that parents have been using it since the baby’s birth.
Price for the drug. The cost of the drug is very insignificant, compared to other drops, the price is very meager, about 10 rubles, which is why the medicine is popular, but the price may increase in the future, then you will have to fight for the health and life of the child.

Symptoms

Poisoning with drugs for the common cold is quite common in children. However, in order to accurately determine whether it is poisoning or not, you should monitor the baby’s well-being. Main symptoms of poisoning:

General weakness of the body;
Bad mood;
Dizziness and headache;
Painful sensations in the abdomen;
Nausea, possibly vomiting;
Reduced body temperature;
Slow heart rate;
Decreased pressure;
Lack of appetite;
Drowsiness;
Slight constriction of the pupils;
Pallor of the skin;
The skin is damp and cold.

If symptoms of poisoning are detected in a child, you should urgently call ambulance , which will provide professional assistance and eliminate the symptoms of overdose. Carrying out treatment at home is unsafe for the child’s health.

Treatment

Treatment of poisoning consists of eliminating symptoms. If symptoms of naphthyzine poisoning are detected in children, the first thing to do is stop taking the medicine and call a doctor. The doctor should tell how the drug was taken and in what dosage.

It happens that the baby took the medicine himself; such cases occur if the medicines are in full view of the children's eyes. Therefore it is advisable to put everything medical supplies out of the reach of children.

First aid

While you are waiting for an ambulance, the main thing is not to panic and not to pass on your panic state to your child. First of all, you should monitor the child’s condition, provide him with a comfortable position, move him to the bed and calm him down.

Actions:

Ensure that the child remains conscious;
Provide your child with plenty of fluids. Cooled boiled water with a volume of up to a liter or more is suitable for this;
In case of poisoning, it is forbidden to give milk to children, as this promotes rapid absorption of the medicine into the blood;
Check your breathing and monitor your heart rate;
Wrap the baby in a blanket or blanket to keep him warm;
Monitor your pulse.

Naphthyzine poisoning is increasingly occurring, the main reasons being incorrect administration or use of medications that have expired. It is necessary to monitor the expiration date and throw away all drugs that are already spoiled and buy new ones. Otherwise, much larger sums will be required for treatment than for new drops.

Degrees of overdose

The presence of various symptoms. Naphthyzine overdose has three degrees of severity.

In the first degree of overdose, there is no need to hospitalize the patient and call an ambulance. Symptoms disappear after stopping the medication. This degree is called mild.
With moderate severity, there is no need to hospitalize the child either. Parents can independently help the baby, stop taking the medication and monitor the patient’s condition. If the symptoms go away, then there is no need to call a doctor.
The most dangerous degree is severe. In this case, you need to immediately call an ambulance and put the child in the hands of specialists. In this case, hospitalization is mandatory.

Treatment of poisoning should first begin with eliminating the symptoms and stopping the drug.

Can Naphthyzin be used for children?

Naphthyzin is effective drug, which constricts blood vessels in a short time, belongs to the group of selective adrenergic agonists.

Parents often ask whether children are allowed to use the drug? It is allowed, provided that the correct concentration of the solution is selected and the dosage is observed. The drug for children is produced in the form of a 0.05% solution, a 0.1% solution is contraindicated for children; this dose causes poisoning in children.

Instructions

The drug should not be used by children under one year of age. After a year, naphthyzine is prescribed by a doctor, subject to strict adherence to the dosage. The dose of the drug for children is 1-2 drops of 0.05 naphthyzine solution in each nasal passage, this dosage promotes the release respiratory tract and makes breathing easier.

Naphthyzin causes the body to become addicted to the drug and the medicine stops working. Increasing the dose does not increase the effect of the drug, but, on the contrary, increases the risk of naphthyzine poisoning (in children this process occurs much faster than in adults, since the body is still quite weak and cannot fight poisoning).

Due to rapid addiction, children can use the medicine no more than once every 7 hours. The effect of the drug begins within thirty minutes.

Since a plastic bottle causes errors in the dosage of the drug and leads to an overdose and subsequently to poisoning, the use of a pipette to maintain the exact dose is considered effective. This way you can see how much of the drug you have taken.

In order not to cause addiction in the child, you should alternate the use of naphthyzine with other similar medications, for example.

Every year, as soon as the ARVI season begins, messages appear on the Internet: small children end up in the hospital in serious condition simply because they were treated for... a runny nose! No, he was not placed with his legs in a basin with hot water. Didn't rub it with mustard. Not subjected to other Chinese torture. They just dropped naphthyzine into the nose. Or even a product that you bought at the pharmacy for yourself, without even thinking that its concentration could be dangerous for the baby. After all, this is a common runny nose, people don’t die from it.

Photo GettyImages

“The mother of one-year-old Vanyushka is forced to work because she is raising her son alone. The baby stays with his grandmother while his mother is at work. And then Vanyusha fell ill. The grandmother was given clear instructions, and the mother went to work. But my grandmother thought that the snot needed to be treated more actively, and my mother, as luck would have it, did not leave any drops. Grandmother dropped naphthyzine 0.1%. Yes, more so that you can heal well. The grandmother noticed that the baby went to bed very early nap. Sick, she thought. During the day I woke her up several times to again treat her with naphthyzine. And when the mother returned home late in the evening and could not wake up the child who had been sleeping all day, then she called an ambulance,” the doctor Vanyusha saw described one such case.

The boy was in extremely serious condition. First degree coma, heart beating four times slower than it should. That time everything worked out, the baby was saved. But the danger has not gone away.

“Other drops for runny nose are not candy either, but naphthyzin is just rat poison. Stop putting it on the children already!” – calls the pediatrician Sergey Butriy.

According to the doctor, often the problem is that people buy cheap analogues instead of the products recommended by the doctor. Is the active ingredient the same? So there is no difference!

“The Mazda CX5 is the same as a Lada-five, don’t overpay! The Lada also has a steering wheel and pedals, and it drives! Its level of safety, speed, comfort and functionality are absolutely comparable to its imported counterpart, and anyone who says otherwise has simply sold out to car dealerships and is receiving kickbacks from them!” - the doctor makes an analogy.

As Sergei Butriy explained, it’s not just a matter of active substance, but also in its purity, dosage accuracy, delivery method, side effects. Moreover, pharmacies often advise customers to buy a cheap generic (copy) instead of the expensive original. Is Nazivin expensive? Take naphthyzine!

“In fact, naphthyzine nasal drops are an absolutely hellish drug, outdated and toxic,” says the doctor. And that's why.

1. Naphthyzin causes a rebound symptom - it relieves nasal swelling well, but after the end of the effect (after 2-3 hours) the nose swells even more, this leads to too frequent instillation and medicinal rhinitis or even poisoning.

2. Causes medicinal (atrophic) rhinitis within 1-2 weeks of constant use.

3. Naphthyzin easily causes poisoning when instilled into the nose. In addition, a child can easily drink it - this is how the product is packaged. The severity of poisoning depends on the dose. Some will get away with a little drowsiness, but in other cases the baby may die.

Photo GettyImages

“The situation is aggravated by the fact that parents do not understand how dangerous naphthyzine poisoning is. They will hide grandma’s blood pressure pills, they will even hide my mother’s harmless hormonal contraceptives, but they will leave naphthyzin in plain sight - it’s just droplets in the nose,” Sergei Butriy is indignant.

The doctor advises, in principle, to be wary of vasoconstrictor drops for children. In some countries, it is generally prohibited to give them to children under two to five years of age. If you can't afford expensive medicines that the doctor prescribes, do not hesitate to ask him to prescribe cheaper analogues. But under no circumstances listen to the pharmacist at the pharmacy! In addition, one family member must give medications to the child. So that it doesn’t happen that mom drips, dad drips, and grandma doesn’t stand aside either.

“If you injected a child by mistake adult dosage naphthyzine, or when pressing on a plastic dropper, the tip fell off and a lot of the drug poured into the child’s nose, or if the child drank even a small amount of vasoconstrictor drops, immediately call an ambulance, this is very dangerous,” the doctor warns.

Symptoms of naphthysine poisoning:

Inappropriate sleepiness

Bradycardia (slow pulse),

Pallor,

Cold sweat,

Child's lethargy.

26.04.2009, 13:27

The topic may be banal, but...

4. Clinical picture poisoning is completely opposite to that described in the reference literature:
- hypothermia, lethargy, decreased blood pressure, bradycardia, pale skin occurs - in real life,
- instead of indications of possible tachycardia, increased blood pressure, agitation - according to the letter of the theory.

I ask my colleagues to express their opinions.

27.04.2009, 08:54

Can I ask a few clarifying questions?
1. Is the number of cases increasing according to your observations, or are you guided by some statistics?
2. Toxic reactions when following recommended doses? Or when exceeded?
3. If possible, list the drugs, it’s unlikely that there are so many of them

27.04.2009, 09:06

Hypothermia, lethargy, decreased blood pressure, bradycardia, pale skin occur - in real life,

Actually, such a clinic has always been described and observed everywhere... :confused:

1. The number of cases is increasing.
Naturally, because mothers love to treat their children. A completely natural process.
2. Toxic reactions occur when used according to indications, i.e. when instilled into the nose.
Mom dripped, dad dripped, grandma dripped, grandfather came up, thought and also dripped.
3. The “black” list of drugs consists mainly of domestic names.
What's cheaper is more often. :)

In general, to be honest, I don’t see anything special in the situation. Vasoconstrictor poisoning in children is common.

27.04.2009, 09:13

Could you clarify, preferably with reference to descriptions of clinical cases, indicating that it was an overdose of “vasoconstrictor” drugs that led to the symptoms you describe. The fact is that Phenylephrine ([Only registered and activated users can see links]), as well as Tramazoline ([Only registered and activated users can see links]), Oxymetazoline ([Only registered and activated users can see links]) used in the Russian Federation. ), Xylometazoline ([Only registered and activated users can see links]) and Naphazoline ([Only registered and activated users can see links]) act by the mechanism of direct stimulation of adrenergic receptors, and the pattern of their overdose corresponds to that described in the “letter of the theory” ([ Links can only be seen by registered and activated users]). In the available data, it was not possible to find a description of cases of overdose of sympathomimetics with the clinic you provided.

[Only registered and activated users can see links] anel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
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In addition, the “indications” for the use of vasoconstrictor nasal drops in children have already been discussed several times, rather with negative conclusions. And then, in addition to nasal drops, sympathomimetics are included in “compotes for colds” (there was such a Koldakt, these same cough-cold medications :))

27.04.2009, 10:20

27.04.2009, 12:26

Poisoning with vasoconstrictors, primarily naphthyzine, is the most common childhood poisoning, at least in St. Petersburg, which is associated with the use of this drug in the treatment of OSLT, both by inhalation through a nebulizer and by jet pouring into the nose (See methodological recommendations of the Department of Emergency Medicine) .

Clinic - bradycardia, lethargy, drowsiness, hypothermia (about 35), miosis.

The clinic is logical if we remember that naphazoline is not a beta adrenergic agonist, but an alpha-1 one, and in case of overdose it exhibits a central alpha-2 adrenomimetic effect, similar to the action of clonidine.

27.04.2009, 13:15

Clinic - bradycardia, lethargy, drowsiness, hypothermia (about 35), miosis.
The most common reason for calling is “constantly sleeping, pale.”

That is, the clinic of naphthyzine poisoning is almost equal to the clinic of clonidine poisoning. Why this is not reflected in Russian literature is a mystery.

Absolutely right! Clinical manifestations similar to those in case of clonidine poisoning. But nowhere in the annotations to the drugs are there such instructions.

27.04.2009, 13:27

Statistics of the city children's intensive care unit with a capacity of 12 beds, for 670 thousand urban population. Dynamics over 5 years: 71, 85, 107, 133, 152 cases. Drugs: naphthyzin, naphazoline, otrivin.

27.04.2009, 14:14

Let me subtly hint: “Clonidine and related imidazoline poisoning”, “Imidazoline derivatives, such as tetrahydrozoline, naphazoline, oyxmetazoline, and xylometazoline, are found in commercial topical eye and nose decongestants. Brimonidine and apraclonidine are prescribed for the treatment of glaucoma. Tizanidine is a muscle relaxant used for the treatment of spasticity. Ingestion or systemic absorption of small amounts of these can produce toxicity syndromes agents strikingly similar to that produced by clonidine ":ah:

Such cases: "The classic toxic syndrome, or "toxidrome," associated with clonidine consists of central nervous system depression, bradycardia, hypotension, respiratory depression, and small pupil size." There is nothing to argue:bo:

27.04.2009, 14:57

Convinced. Source [Only registered and activated users can see the links] (And in ApTuDate, just an indication that “this could happen”, without links, and not “drops in the nose”: D, and what’s interesting, even in the instructions for the drugs in the same source - nothing similar, except low temperature for xylomethazine)
Case report

Naphazoline intoxication in a child-a clinical and forensic toxicological case

F. MusshoffCorresponding Author Contact Information, E-mail The Corresponding Author, a, A. Gerschlauerb and B. Madeaa

A Institute of Legal Medicine, Rheinische Friedrich-Wilhelms-University, Stiftsplatz 12, 53111, Bonn, Germany

B St. Marien-Hospital, Robert-Koch-Street 1, 53115, Bonn, Germany

The imidazoline derivative naphazoline, an α2-adrenergic agonist, is used as non-prescription eye and nasal preparation because of its vasoconstrictive and decongestive properties. Especially in children, overdose and/or systemic side effects due to absorption can quickly cause severe central nervous system depression and cardiovascular adverse effects. In a 7-year-old boy was diagnosed with a naphazoline intoxication by toxicological analysis. The case was also of forensic interest, because the naphazoline mixture was prepared in a pharmacy in a concentration 80 times above the adequate dosage for children. In general, physicians, pharmacists and the public should be educated about the toxicity of over-the-counter preparations.

2.Case report
A 7-year-old boy was inconspicuous until the evening. Suddenly he began to vomit repeatedly, rolled his eyes, and has been unconscious for 2 min. After that he had a headache. Before this attack he was treated once with Vomex A Supp (40 mg) and nose drops. At hospitalization in reduced general condition the patient was described as somnolent with paleness of the skin and rolling eyes. Reaction only was found in case of strong pain stimulus. Additionally eupnea, a reddened throat, bradycardia, diminished bowel sounds, reduced tone of the musculature, and miosis were diagnosed. In the hospital initially a CCT was made to exclude an intracranial bleeding. Laboratory parameters as well as blood gas analysis showed no abnormalities, so that the boy was hospitalized into the intensive care unit and treated with infusion therapy. A persistence of bradycardia near 50 bpm for the first 6 h was observed with a blood pressure initially at 145/95 mm Hg. The patient was still somnolent. Awakening and adequate reactions were only found after 6 h of time with retrograde amnesia for the events of the preceeding hours. After quick normalization of the vital parameters a transfer to the regular ward was possible. Under close-meshed monitoring there were no pathological parameters observed.
4. Discussion
The chemical–toxicological analysis furnished the proof for the presence of naphazoline in the given nose drops as well as in the vomitted gastric content and in the urine sample of the boy. Pharmacologic actions of such imidazoline derivatives are peripheral and central α2-adrenergic receptor stimulation.
But it’s not clear where the central alpha 2 stimulation comes from: bn: Or does it still penetrate the BBB? (Crocodiles fly, only low, low (c))

27.04.2009, 16:28

So it penetrates.
[Only registered and activated users can see links] ([Only registered and activated users can see links])
Here he is, my dear. With a green cap.
Parents think it's a spray. No matter how it is. This is a real fountain.
Toxicologists at our children's hospital No. 5 always rejoice at the sight of this green cap.

I don't understand one thing. How, with so many poisonings, with such persistence, do departments continue to recommend inhalations and jet infusions into the nose with this muck for laryngeal stenosis?

Nazivin is a popular nasal remedy with anti-edematous and vasoconstrictor effects. It is successfully used to restore breathing in patients of any age, even in children from the first days of life. However, in order to avoid undesirable consequences from taking it, it is important to strictly follow the instructions accompanying the drug, accurately calculate the dosage and consult with your doctor.

What is Nazivin and its use

Nazivin – pharmacological drug based on oxymetazoline. Available in the form of drops (in bottles with a pipette cap, dosage 0.01%, 0.025% and 0.05%), and in the form of a spray 0.05% (10 ml bottle).

In various dosages it is used to treat a runny nose, reduce swelling of the mucous membrane and relieve nasal congestion during respiratory diseases, allergic and vasomotor rhinitis, sinusitis, otitis.

Contraindications and side effects

Main contraindications for use:

hypersensitivity to oxymetazoline, as well as to any excipient in the composition;
atrophic runny nose;
acute atherosclerosis;
severe diabetes mellitus;
closed glaucoma;
pregnancy and lactation (however, use is possible as prescribed by a doctor if the benefit to the mother is higher than the risk to the fetus).

Drops 0.025% should not be used to treat children under 1 year of age; Nazivin 0.05% is prohibited for children under 6 years of age.

Side effects:

Often – dryness and burning sensation of the nasal mucosa.
Less often – increased heart rate and pulse, increased blood pressure.
Rarely - increased fatigue, headache, fatigue, insomnia.

With constant use, the effectiveness of the drug decreases; long-term use can lead to addiction. In the presence of hypersensitivity, and if the recommended doses are too high, patients may experience allergic reactions.

Causes and symptoms of poisoning

Intoxication may occur due to exceeding the recommended dosage, accidental ingestion of the drug, or failure to follow the instructions for use.

The likelihood of being poisoned by Nazivin is much higher in a child than in an adult. Children are curious and want to taste everything, so you should not leave drops or any other medicines freely available to them.

Acute poisoning

This condition is more common in young children, whose bodies are not strong and may react painfully to even a small dose of medication. Any drops should be used in infants with extreme caution. In older children and adults acute poisoning is caused by a significant excess of the dose or atypical use of the drug - orally or as eye drops.

Main symptoms:

a sharp and significant increase in body temperature;
feeling of nausea, instantly turning into vomiting;
severe constriction of the pupils;
organ dysfunction respiratory system: the patient is suffocating, shortness of breath appears, breathing problems;
from the central nervous system - strong excitement, sharply replaced by apathy;
heart rhythm disturbance;
arterial hypertension or, conversely, a sharp decline pressure;
bluish tint of the skin;
delusions and hallucinations.

Chronic poisoning

With long-term (more than 7 days) use of the drug in large doses, signs of chronic overdose appear. These include:

nasal congestion;
sleep disorder;
periodic headache;
nosebleeds;
depression;
high blood pressure.

If one of the symptoms or a combination of them occurs, you should urgently seek help. medical care. Self-medication is unacceptable and can lead to serious consequences. Abrupt withdrawal of the drug without consulting a doctor can worsen the situation.

What happens if a child drinks Nazivin?

Ingestion of the solution, especially by a child, can lead to tragic consequences. The following symptoms are observed:

slow heartbeat;
decrease in temperature;
depression of the central nervous system;
arterial hypotension;
in the most severe cases - respiratory and cardiac arrest, coma.

It is urgent to call an ambulance: doctors will perform gastric lavage using a tube and prescribe further treatment depending on the symptoms.

Perform gastric lavage at home using large quantity water is not advisable: liquid helps accelerate the absorption of the drug into the blood and leads to a worsening of the condition.

What to do in case of overdose: first aid and treatment

If the drug was taken nasally, you must:

Help the patient take a horizontal position.
Ensure maximum flow of fresh air into the room.

If poisoning occurs as a result of ingestion, you should:

Drink 1.5-2 liters of water or a weak solution of potassium permanganate at once, then induce vomiting.
Take a laxative, ideally a saline solution.
Use an adsorbent ( Activated carbon, Enterosgel or the like).

There is no universal antidote for Nazivin overdose.

Possible consequences

Consequences of poisoning with this drug:

Lungs – insomnia, slight restlessness, slight dizziness.
Moderate severity – surges in blood pressure, malfunctions gastrointestinal tract and CNS.
Severe – persistent increase in blood pressure, disruption of the respiratory system, allergic pulmonary edema, coma.

The consequences can be especially serious for children, people with weakened immune systems and elderly patients. To avoid worsening the condition, at the first signs of intoxication you should immediately consult a doctor.

Prevention measures

To avoid drug overdose, you must adhere to the following rules:

Follow the dosage that should ideally be prescribed by a doctor for an adult or child. During the examination, he will adequately assess the patient’s health condition and prescribe a method and time of admission. At self-treatment it is important not to exceed the dose recommended by the instructions. The opinion that the more the drug enters the body, the sooner it will become easier, is erroneous.
Do not leave the drug unattended and store it out of the reach of children.
Do not allow drops to get into your eyes.
When purchasing a medicine, check that the expiration date has not expired.

The human body is individual, and sometimes intolerance to any component of the drug may become known only when taking it for the first time. Allergies, including those due to a weakened immune system, can manifest themselves in the form of a rash or Quincke's edema. Therefore, you should be prepared for the manifestation allergic reactions and always keep antihistamines at home to relieve the first symptoms.

The drug Nazivin is a solution of oxymetazoline of varying concentrations, which depends on the age category for which it is intended (children, adults). Belongs to the group of α-adrenergic agonists, vasoconstrictors, and is an anticongestant. It is used exclusively locally in otolaryngological practice.

Source: takeda.com.ru

Having a vasoconstrictor effect, Nazivin reduces swelling of the mucous membrane of the upper respiratory tract. The mechanism of anti-edematous action is associated with selective stimulation of α 1 -adrenergic receptors of the mucous membrane. Activation of the receptors leads to spasm of the vessels of the nasal mucosa and, as a result, a weakening of its blood supply. This eliminates inflammatory edema and reduces mucus production and helps restore breathing.

Nazivin is available in the form of drops containing 0.05% 0.025% or 0.01% oxymethozoline, and in the form of a spray of 0.025% and 0.05%. For children under one year of age, the drug is prescribed only in the form of drops, since when applied to the mucous membrane, the spray can cause involuntary spasm of the laryngeal muscles.

Effect after use medicine develops within 10–15 minutes and persists for 6–8 hours.

The main indications for prescribing the drug are:

non-purulent inflammation of the middle ear, including of unknown etiology;
recovery drainage function with inflammation of the auditory tube (eustachitis);
acute nasopharyngitis;
acute inflammation paranasal sinuses nose (frontal sinusitis, sinusitis, ethmoiditis, sphenoiditis), including unspecified etiology;
vasomotor rhinitis;
allergic rhinitis;
elimination of swelling before diagnostic manipulations in the nasal passages.

The results of clinical tests have proven that Nazivin in therapeutic doses does not have a systemic effect, acting exclusively on the mucous membrane of the upper respiratory tract.

newborns (up to 4 weeks of age) – 1 drop of 0.01% solution in each nostril 2-3 times a day;
children from 1 month to 1 year – 1-2 drops of a 0.01% solution in each nostril 2-3 times a day;
children aged 1 to 6 years – 1-2 drops (or spray doses) of a 0.025% solution in each nostril 2-3 times a day;
adults and children over 6 years old - 1-2 drops (or spray doses) of a 0.05% solution in each nostril 2-3 times a day.

In rare cases, the dosage regimen may be changed at the discretion of the attending physician.

Symptoms of acute overdose occur when the recommended doses are significantly exceeded or when the drug is used atypically (orally, as eye drops), chronic - when it is used for a long time (more than 7 days) even in therapeutic doses.

Signs of overdose

Despite the fact that in therapeutic doses Nazivin does not have a systemic effect, with extreme overdose, ingestion or use of Nazivin as eye drops, an acute overdose is possible, characterized by symptoms of involvement of the central nervous and cardiovascular systems:

constriction of the pupils;
nausea, vomiting;
cyanosis of the skin and mucous membranes;
fever, sometimes low body temperature;
increased heart rate, in severe cases – bradycardia less than 45-50 beats/min;
heart rhythm disturbances;
arterial hypertension or, conversely, a sharp drop in blood pressure (blood pressure);
shortness of breath, suffocation;
state of depressed consciousness;
delusions, hallucinations;
drowsiness, apathy.

Long-term systematic use high doses The drug is manifested by the following symptoms (chronic overdose):

sleep disorders (insomnia, nightmares);
depressive states;
dyspeptic disorders (decreased or lack of appetite, nausea, stool disorders);
persistent increase in blood pressure and increased heart rate;
attacks of headache;
nosebleeds;
constant nasal congestion.

Long-term use of Nazivin leads to atrophy of the nasal mucosa, thinning blood vessels and their increased fragility. In addition, it is possible to develop recurrent swelling of the mucous membranes of the nasal cavity (medicinal rhinitis) and tachyphylaxis. Tachyphylaxis (escape syndrome) in this case is manifested by a decrease in the effectiveness of Nazivin when used uncontrolled, up to the complete disappearance of the therapeutic effect.