Zentiva company with a. Chlorprothixene. International nonproprietary or generic name

Tablets - 1 tablet:

Active substance: chlorprothixene hydrochloride 50 mg;
Excipients: corn starch - 37.5 mg, lactose monohydrate - 135 mg, sucrose - 20 mg, calcium stearate - 3.75 mg, talc - 3.75 mg;
compound film shell: hypromellose 2910/5 - 3.6594 mg, macrogol 6000 - 0.1333 mg, macrogol 300 - 0.9166 mg, talc - 2.4194 mg, titanium dioxide - 0.3423 mg, iron dye yellow oxide - 0.029 mg.

10 tablets in a PVC/A1 blister. 3 blisters along with instructions in a cardboard box.

Description of the dosage form

Film-coated tablets from light brown to light yellow color, round, biconvex; fracture view - the core is white to almost white.

Pharmacokinetics

Metabolized in the liver. It is excreted primarily by the kidneys.

Pharmacodynamics

Antipsychotic drug (neuroleptic), thioxanthene derivative. It has antipsychotic, antidepressant, sedative, antiemetic effects, and has alpha-adrenergic blocking activity.

It is believed that the antipsychotic effect is associated with blockade of postsynaptic dopamine receptors in the brain. Antiemetic effect is associated with blockade of trigger zone chemoreceptors medulla oblongata. The sedative effect is due to an indirect weakening of the activity of the reticular system of the brain stem. Suppresses the release of most hormones of the hypothalamus and pituitary gland. However, as a result of blockade of the prolactin inhibitory factor, which inhibits the release of prolactin from the pituitary gland, the concentration of prolactin increases.

According to the chemical structure and pharmacological properties thioxanthenes are similar to piperazine phenothiazine derivatives.

Clinical pharmacology

Antipsychotic drug (neuroleptic).

Indications for use of Chlorprothixene zentiva

Psychoses, including schizophrenia and manic states, occurring with psychomotor agitation, agitation and anxiety;
Withdrawal syndrome in alcoholism and drug addiction;
Hyperactivity, irritability, agitation, confusion in elderly patients;
Behavioral disorders in children;
Depressive states, neuroses, psychosomatic disorders;
Insomnia;
Pain (in combination with analgesics);

Contraindications for the use of Chlorprothixene zentiva

Hypersensitivity to the components of the drug (including phenothiazines). Central nervous system (CNS) depression of any origin (including those caused by alcohol, barbiturates or opiates), coma, vascular collapse, pathological changes blood, oppression bone marrow, pheochromocytoma, hereditary diseases such as lactose or fructose intolerance, lactase deficiency or glucose-galactose malabsorption, sucrase/isomaltase deficiency (due to the presence of lactose and sucrose in the composition), childhood up to 6 years old.

Chlorprothixene zentiva Use during pregnancy and children

Contraindicated during pregnancy and children under 6 years of age.

Chlorprothixene zentiva Side effects

From the side of the central nervous system: possible psychomotor inhibition, mild extrapyramidal syndrome, increased fatigue, dizziness; in isolated cases, a paradoxical increase in anxiety is possible, especially in patients with mania or schizophrenia.

From the outside digestive system: Possible cholestatic jaundice.

From the side of the heart vascular systems s: possible tachycardia, ECG changes, orthostatic hypotension.

From the organ of vision: possible clouding of the cornea and lens with visual impairment.

From the hematopoietic system: possible agranulocytosis, leukocytosis, leukopenia, hemolytic anemia.

From the outside endocrine system: possible frequent hot flashes, amenorrhea, galactorrhea, gynecomastia, weakened potency and libido.

On the metabolic side: increased sweating, impaired carbohydrate metabolism, increased appetite with increased body weight are possible.

Dermatological reactions: photosensitivity, photodermatitis are possible.

Effects due to anticholinergic action: dry mouth, constipation, accommodation disturbances, dysuria.

Drug interactions

When used simultaneously with anesthetics, opioid analgesics, sedatives, sleeping pills, antipsychotics, with ethanol, ethanol-containing drugs enhance the inhibitory effect on the central nervous system.

When used simultaneously with antihypertensive drugs, the hypotensive effect is enhanced.

When used simultaneously with anticholinergic, antihistamine, antiparkinsonian drugs, the anticholinergic effect is enhanced.

When used simultaneously with drugs that cause extrapyramidal reactions, an increase in the frequency and severity of extrapyramidal reactions is possible; with levodopa - the antiparkinsonian effect of levodopa may be inhibited; with lithium carbonate - pronounced extrapyramidal symptoms and neurotoxic effects are possible.

When used simultaneously with epinephrine, it is possible to block the alpha-adrenergic effects of epinephrine and, as a result, develop severe arterial hypotension and tachycardia.

When used simultaneously with phenothiazines, metoclopramide, haloperidol, reserpine, the development of extrapyramidal disorders is possible; with quinidine - an increased inhibitory effect on the heart is possible.

If it is necessary to use chlorprothixene, the risks and benefits of treatment should be compared in patients with chronic alcoholism, diseases of cardio-vascular system(increased risk of developing transient arterial hypotension), Reye's syndrome, as well as with glaucoma or a predisposition to it, peptic ulcer stomach and duodenum, urinary retention, Parkinson's disease, epileptic seizures, hypersensitivity to other thioxanthenes or phenothiazines.

When using chlorprothixene, false-positive results of an immunological pregnancy test using urine, as well as false-positive results of a urine test for bilirubin, are possible.

During the treatment period, avoid drinking alcohol.

During the treatment period, you should refrain from engaging in potentially hazardous activities that require increased attention, fast psychomotor reactions.

This is a fairly strong antipsychotic and has a wide spectrum of action.

The thioxanthene derivative is very effective in helping to overcome both mild and severe disorders mental state, as well as a nervous breakdown and the consequences of drinking alcohol.

Pharmacological action of the drug

This is a drug that has antipsychotic, neuroleptic(inhibits the action of the central nervous system), anticonvulsant, antiemetic(antiemetic), tranquilizing(calming) effect.

It also tends to enhance the effect of analgesics (painkillers).

Has good thymoleptic influence(antidepressive effect, which is achieved through the activation of noradrenergic transmission): the speed of thinking increases, initiative increases, and the feeling of fatigue disappears in unusual conditions.

The antipsychotic effect of the drug is associated with its ability to block dopamine receptors, mesocortical and mesolimbic systems (eliminates delusions and hallucinations).

Chlorprothixene also has the property block adenomine and histamine receptors , which determines its adrenergic blocking and antihistamine effects.

The antiemetic property is explained by the ability to inhibit the trigger area of the vomiting center.

Suppresses the release of most pituitary and hypothalamic hormones.

What happens after taking the medicine

When taking the drug orally, the active components are absorbed quite quickly. Chlorprothixene begins to act within 20 minutes after consumption and is quickly absorbed in the intestines.

The maximum concentration in the blood is detected within 2-3 hours after taking the drug.

The half-life from the body is approximately 10-16 hours.

Chlorprothixene has the ability to penetrate the placenta and is excreted in breast milk in small quantities.

It is excreted from the body in feces and urine. Accordingly, metabolizing this drug organs - kidneys and intestines.

Counting on that daily dose 300 mg, the content of chlorprothixene metabolites is 29%, chlorprothixene sulfoxide – 41%.

Indications for use

The drug represents a group of fairly effective sedative neuroleptics and has an extensive group of indications:

Contraindications for use

Instructions for use of Chlorprothixene indicate that taking the drug is strictly prohibited:

state alcohol intoxication or intoxication;
when consuming or overdosing on drugs;
the action of the central nervous system is inhibited by any other factors;
increased level of sensitivity to the component(s) of the drug;
coma;
severe diseases of the hematopoietic organs;
bone marrow suppression;
children under 6 years old;
vascular collapse (sudden falls blood pressure);
pregnancy;
parkinsonism.

Before you decide to take an antipsychotic drug, you should definitely study it - the medicine has many side effects.

You can see what an MRI of the brain shows in our video and read about what is happening.

Use with caution

The instructions for use indicate that Chlorprothixene tablets also have relative contraindications (taking the drug is possible, but with great caution), which are as follows:

combination with other drugs and substances (for more details, see “Interaction with other drugs”);
epilepsy clinical stage or at the stage of complications;
diseases of the renal and hepatic parenchyma;
decompensated defect;
somatic exhaustion;
tachycardia;
elderly age;
diseases of the cardiovascular system (possibly a transient increase in blood pressure);
cerebral atherosclerosis at an advanced stage;
stomach ulcer;
lesions of the duodenum;
glaucoma or a predisposition to its occurrence;
breathing disorders caused by asthma, acute infectious diseases, pulmonary emphysema;
diabetes;
benign or malignant growth of the mucous membrane prostate gland, which has clinical manifestations(the drug may cause urinary retention).

In case of impaired renal and liver function

The drug should be used with caution, since structural and functional disorders of these organs may occur.

You should be especially careful if you have the following accompanying diseases:

pheochromocytoma (hormonally active tumor in the adrenal glands);
Reye's syndrome (taking the drug increases the risk of developing hepatotoxicity);
urinary retention.

Mode of application

General indications for the use of Chlorprothixene Zentiva, which are listed in instructions:

Accept orally by 25–50 milligrams 3–4 times a day. If necessary, it is possible to prescribe 60 grams per day (with subsequent reduction in dosage), intramuscularly – up to 25–50 milligrams 2–3 times a day.

Typically, the highest dose of the drug is prescribed before bedtime.

Dosage depending on the disease and concomitant condition

The dose size largely depends on patient's condition:

Psychosomatic disorders and severe depressive states: Chlorprothixene is used as an adjuvant drug (as part of complex therapy). Typically, 60 to 90 mg per day is prescribed (the dose is divided into several doses).
Psychoses, schizophrenia, manic states: first the drug is taken 50–200 mg per day, then daily norm increases to 250–300 mg. In advanced conditions of the disease, it is possible to increase the dosage to 1200 milligrams (the daily dose is divided into 3–4 doses, about 40% in the evening).
Maintenance therapy: 100–200 milligrams per day.
Neuroses: 10–15 mg at bedtime, less often – 30 mg at bedtime, in extreme cases – 45 mg at bedtime.
Withdrawal syndrome(“hangover” or post-drug state): the drug is taken 3 times a day, with a volume of 500 mg (divide into 3 equal portions). In this case, the course lasts 5-7 days. After completing the course, the dose of the drug is reduced to 15-45 milligrams per day (as maintenance therapy, to prevent breakdowns).
Irritability, hyperactivity, nervous agitation, confusion in elderly patients: therapy begins with a dosage of 15–90 mg per day, the dose is increased gradually until the appropriate effect is achieved.
Insomnia: take 15–30 milligrams of medication an hour before bedtime.
Behavioral disorders in children: the dosage is calculated using the formula 0.5-2 mg X child’s weight (kg). On average, it is prescribed: for neuroses 5–30 mg per day, for psychoses from 100 to 200 mg per day.
Pain(to enhance the effect of analgesics): take 15–300 mg of the drug per day along with painkillers.
Itchy skin(various origins): 15–100 milligrams per day, divided into 4 doses.
R abortion lawsuit, premature birth: 15 mg in portions (2-3 times a day), for 2-3 days. Then reduced doses of the drug are prescribed for 7–10 days.

Injective administration of the drug is prescribed if the patient refuses to take pills or at the beginning of the course (for maximum fast acting drug).

Composition and release forms of the drug

Pills: biconvex, coated with a thin film-shell, 15 mg (orange tablets), 50 mg (light brown tablets), available in blisters, 1 blister contains 10 tablets. There are 50 pieces in 1 package.

Compound: active substance– chlorprothixene hydrochloride.

Auxiliary components: lactose monohydrate, talc, corn starch, calcium stearate, sucrose.

Shell composition: macrogol 6000, 300, talc, aluminum varnish, hypromellose 2910-5.

Injection: ampoules of 1 ml of 2.5% solution, 2 ml of 5% solution. 1 package contains 10 or 100 ampoules.

Drops: for oral administration

Side effects

As an individual reaction of the body, the following are possible: symptoms:

Central nervous system: mild extrapyramidal syndrome, inhibition, feeling of fatigue, dizziness, drowsiness. In the first 6 hours after taking the drug, akatasia (an irresistible desire to move, inability to sit still) is possible. Isolated cases of tardive dystonia. It is extremely rare that anxiety levels may increase, especially in patients with schizophrenia.
Digestive system: increased urination, constipation, dry mouth. After long-term use of the drug, cholestatic jaundice may occur.
The cardiovascular system: flushing of the face, tachycardia (rapid heartbeat), orthostatic hypotension, changes in echocardiogram (QT interval).
Organs of vision: Sometimes patients experience blurred vision and an inability to focus quickly.
Hematopoietic system: possible leukocytosis, hemolytic anemia, agranulocytosis (4-10 weeks of treatment), benign leukopenia.
Endocrine system: possible amanorrhea, frequent hot flashes, galactorrhea, gynecomastia, weakened sexual desire and potency (with long-term use of the drug), diabetes mellitus.
Metabolism: Sometimes there is an increase in the amount of sweating, increased appetite, disturbances in carbohydrate metabolism, accompanied by weight gain (with long-term use of the drug).
Epidermis: Photodermatitis or photosensitivity are possible.
Vestibular apparatus: in some cases, there may be a lack of coordination of movements (shaking, slowness).

Drug overdose

Symptoms: respiratory failure, convulsions, severe drowsiness, increased body temperature, tachycardia, decreased blood pressure, shock, coma, uncontrolled movements, excessive excitability.

Treatment: You can perform gastric lavage, give laxatives or absorbent substances. Maintenance therapy should also be carried out in parallel, depending on the symptoms manifested.

The dialysis procedure will not be effective.

In case of cardiovascular symptoms, you should not give adrenaline (this may cause a drop in blood pressure).

Seizures can be relieved with diazepam.

Bioperiden will effectively help in case of motor neuropathic disorders.

You should not try to induce vomiting, as particles of vomit may enter the respiratory tract.

special instructions

Instructions for use with the drug Chlorprothixene Zentiva indicate that you should also remember the following: moments:

Taking Chlorprothixene may give false results in an immunobiological urine pregnancy test or a blood test for bilirubin levels.
During the course of treatment, it is advisable not to drink alcohol and avoid significant amounts of ultraviolet radiation.
During intensive treatment, you should refrain from activities that require high speed physical and mental reactions (this includes working at height, driving a vehicle, crane...).
In order to avoid “withdrawal” syndrome (levelling the results of treatment), the drug should be gradually removed from the body, gradually reducing the dosage.
The likelihood of blood pressure fluctuations is higher in adolescents than in adults.
If you have the diseases indicated in the list relative contraindications, you should carefully weigh the need for treatment with this drug and the possible risks.
Long-term use of the drug causes dependence and addiction.

Interaction with other drugs

The interaction of the drug with other drugs is quite good studied:

using Chlorprothixene in parallel with antipsychotics, hypnotics, anesthetics and sedatives, ethenol-containing drugs, they can enhance the effect of Chloroprothixene on the central nervous system;
combination with antihistamines and anticholinergic drugs can lead to a slowdown in the conduction of nerve impulses;
Chloroprothixene enhances the effect of antihypertensive drugs;
a combination of medication with adrenaline can provoke tachycardia and arterial hypotension;
Chloroprothixene reduces the effectiveness of levodopa;
combination of the drug with phenothiazines, haloperidol, reserpine, metoclopramide can cause movement disorders (due to neurological complications).

tab., cover film-coated, 15 mg: 30 pcs. Reg. No.: P N012015/01

Clinical and pharmacological group:

Antipsychotic drug (neuroleptic)

Release form, composition and packaging

Film-coated tablets orange, round, biconvex.

Excipients: corn starch, lactose monohydrate, sucrose, calcium stearate, talc.

Shell composition: hypromellose 2910/5, macrogol 6000, macrogol 300, talc, aluminum varnish based on sunset yellow dye.

10 pieces. - blisters (3) - cardboard packs.

Description of the active components of the drug " Chlorprothixene zentiva»

pharmachologic effect

The antipsychotic effect of chlorprothixene is associated with its blocking effect on dopamine receptors. The antiemetic and analgesic properties of the drug are also associated with the blockade of these receptors. Chlorprothixene is able to block 5-HT 2 receptors, α 1 - adrenergic receptors, as well as H 1 - histamine receptors, which determines its adrenergic blocking hypotensive and antihistamine properties.

Indications

Chlorprothixene Zentiva is a sedative antipsychotic with wide range indications, which include:

- psychoses, including schizophrenia and manic states, occurring with psychomotor agitation, agitation and anxiety;

— “hangover” withdrawal syndrome in alcoholism and drug addiction;

- hyperactivity, irritability, agitation, confusion in elderly patients;

— behavioral disorders in children;

— depressive states, neuroses, psychosomatic disorders;

- insomnia;

- pain (in combination with analgesics).

Dosage regimen

Psychoses, including schizophrenia and manic states.

Treatment begins with 50-100 mg/day, gradually increasing the dose until the optimal effect is achieved, usually up to 300 mg/day. In some cases, the dose may be increased to 1200 mg/day. The maintenance dose is usually 100-200 mg/day. The daily dose of Chlorprothixene Zentiva is usually divided into 2-3 doses, given the pronounced sedative effect of Chlorprothixene Zentiva, it is recommended to prescribe a smaller part of the daily dose in the daytime, and the larger part in the evening.

Hangover withdrawal syndrome in alcoholism and drug addiction.

The daily dose, divided into 2-3 doses, is 500 mg. The course of treatment usually lasts 7 days. After symptoms of withdrawal disappear, the dose is gradually reduced. A maintenance dose of 15-45 mg/day allows you to stabilize the condition and reduces the risk of developing another binge.

In elderly patients

In children

Depressive states, neuroses, psychosomatic disorders.

Chlorprothixene Zentiva can be used for depression, especially when combined with anxiety, tension, as an addition to antidepressant therapy or independently. Chlorprothixene Zentiva can be prescribed for neuroses and psychosomatic disorders accompanied by anxiety and depressive disorders up to 90 mg/day. The daily dose is usually divided into 2-3 doses. Since taking Chlorprothixene Zentiva does not cause addiction or drug addiction it can be used for a long time.

Insomnia. 15 - 30 mg in the evening 1 hour before bedtime.

Pain. The ability of Chlorprothixene Zentiva to potentiate the effect of analgesics can be used in the treatment of patients with pain. In these cases, Chlorprothixene Zentiva is prescribed together with analgesics in doses of 15 to 300 mg.

Side effect

Drowsiness, tachycardia, dry mouth, increased sweating, difficulty of accommodation. These side effects, usually occurring at the beginning of therapy, often disappear as it continues.

Orthostatic hypotension may occur, especially when using Chlorprothixene Zentiva in high dosages.

Dizziness, dysmenorrhea, skin rashes, constipation is rare. Extrapyramidal symptoms are especially rare.

Isolated cases of a decrease in the convulsive threshold, the occurrence of transient benign leukopenia and hemolytic anemia have been described.

With long-term use, especially in high doses, the following may be observed: cholestatic jaundice, galactorrhea, gynecomastia, decreased potency and/or libido, increased appetite, increased body weight.

Contraindications

- CNS depression of any origin (including those caused by alcohol, barbiturates or opiates);

- comatose states;

- vascular collapse;

— diseases of the hematopoietic organs;

- pheochromocytoma;

- hypersensitivity to the components of the drug.

Pregnancy and lactation

Chlorprothixene Zentiva should, if possible, not be prescribed to pregnant women and during breastfeeding.

Use for liver dysfunction

Chlorprothixene Zentiva should be administered with caution to patients with severe liver dysfunction.

Use for renal impairment

Chlorprothixene Zentiva should be prescribed with caution in cases of severe renal impairment.

Use in old age

In elderly patients in the presence of hyperactivity, irritability, agitation, confusion, 15-90 mg/day is prescribed. The daily dose is usually divided into 3 doses.

Application for children

In children for the correction of behavioral disorders Chlorprothixene Zentiva is prescribed at a rate of 0.5-2 mg/kg body weight.

special instructions

Chlorprothixene Zentiva should be prescribed with caution to patients suffering from epilepsy, parkinsonism, severe atherosclerosis cerebral vessels, with a tendency to collapse, with severe cardiovascular and respiratory failure, with severe dysfunction of the liver and kidneys, diabetes mellitus, prostate hypertrophy.

The use of Chlorprothixene Zentiva may lead to false positive result when conducting an immunobiological urine test for pregnancy, a false increase in the level of bilirubin in the blood, a change in the QT interval on the electrocardiogram.

Impact on the ability to drive vehicles and operate machinery

Taking Chlorprothixene Zentiva has a negative effect on activities that require a high speed of mental and physical reactions (for example, managing vehicles, machine maintenance, work at height, etc.).

Overdose

Symptoms Drowsiness, hypo- or hyperthermia, extrapyramidal symptoms, convulsions, shock, coma.

Treatment. Symptomatic and supportive. Gastric lavage should be performed as quickly as possible, and the use of a sorbent is recommended. Measures should be taken to maintain the functioning of the respiratory and cardiovascular systems. Adrenaline should not be used because this may lead to a subsequent decrease in blood pressure. Seizures can be treated with diazepam, and extrapyramidal disorders with biperiden.

Drug interactions

Conditions for dispensing from pharmacies

On prescription.

Storage conditions and periods

List B. Store at a temperature of 10-25°C, in a dry place out of reach of children. Shelf life - 3 years.

Drug interactions

The inhibitory effect of chlorprothixene on the central nervous system may be enhanced by simultaneous use of ethanol and ethanol-containing drugs, anesthetics, opioid analgesics, sedatives, hypnotics, and antipsychotics.

The anticholinergic effect of chlorprothixene is enhanced by the simultaneous use of anticholinergic, antihistamine and antiparkinsonian drugs.

The drug enhances the effect of antihypertensive drugs.

The simultaneous use of chlorprothixene and adrenaline can lead to arterial hypotension and tachycardia.

The use of chlorprothixene leads to a decrease in the threshold of convulsive activity, which requires additional adjustment of the dose of antiepileptic drugs in patients with epilepsy.

The ability of chlorprothixene to block dopamine receptors reduces the effectiveness of levodopa.

Extrapyramidal disorders may occur with the simultaneous use of phenothiazines, metoclopramide, haloperidol, and reserpine.

Antipsychotic drug (neuroleptic), thioxanthene derivative. It has antipsychotic, antidepressant, sedative, antiemetic effects, and has alpha-adrenergic blocking activity.

It is believed that the antipsychotic effect is associated with blockade of postsynaptic dopamine receptors in the brain. The antiemetic effect is associated with blockade of the chemoreceptor trigger zone of the medulla oblongata. The sedative effect is due to an indirect weakening of the activity of the reticular system of the brain stem. Suppresses the release of most hormones of the hypothalamus and pituitary gland. However, as a result of blockade of the prolactin inhibitory factor, which inhibits the release of prolactin from the pituitary gland, the concentration of prolactin increases.

The chemical structure and pharmacological properties of thioxanthenes are similar to piperazine derivatives of phenothiazine.

Pharmacokinetics

Metabolized in the liver. It is excreted primarily by the kidneys.

Release form

Orange film-coated tablets, round, biconvex; fracture view - the core is white to almost white.

Excipients: corn starch - 10 mg, lactose monohydrate - 92 mg, sucrose - 10 mg, calcium stearate - 1.5 mg, talc - 1.5 mg.

Film shell composition: hypromellose 2910/5 - 2.011 mg, macrogol 6000 - 0.069 mg, macrogol 300 - 0.49 mg, talc - 1.43 mg, aluminum varnish based on sunset yellow dye (E110) - 1 mg.

10 pieces. - blisters (3) - cardboard packs.
10 pieces. - blisters (5) - cardboard packs.

Dosage

Individual. For oral administration for adults, the daily dose varies from 10 mg to 600 mg, for children - from 5 mg to 200 mg. The frequency of administration and duration of treatment are determined by the indications.

Interaction

When used simultaneously with anesthetics, opioid analgesics, sedatives, hypnotics, antipsychotics, ethanol, ethanol-containing drugs, the inhibitory effect on the central nervous system is enhanced.

When used simultaneously with antihypertensive drugs, the hypotensive effect is enhanced.

When used simultaneously with anticholinergic, antihistamine, antiparkinsonian drugs, the anticholinergic effect is enhanced.

When used concomitantly with epinephrine, it is possible to block the alpha-adrenergic effects of epinephrine and, as a result, develop severe arterial hypotension and tachycardia.

Side effects

From the digestive system: cholestatic jaundice is possible.

From the cardiovascular system: possible tachycardia, ECG changes, orthostatic hypotension.

From the organ of vision: possible clouding of the cornea and lens with visual impairment.

From the hematopoietic system: possible agranulocytosis, leukocytosis, leukopenia, hemolytic anemia.

From the endocrine system: frequent hot flashes, amenorrhea, galactorrhea, gynecomastia, weakened potency and libido are possible.

On the metabolic side: increased sweating, impaired carbohydrate metabolism, increased appetite with increased body weight are possible.

Dermatological reactions: photosensitivity, photodermatitis are possible.

Effects due to anticholinergic action: dry mouth, constipation, accommodation disturbances, dysuria.

Indications

Psychoses and psychotic states, accompanied by anxiety, fear, psychomotor agitation, aggressiveness, incl. with depressive-paranoid, circular schizophrenia, with simple sluggish schizophrenia with psychopath-like and neurosis-like symptoms and with others mental illness; discirculatory encephalopathy, traumatic brain injury (as part of combination therapy), alcoholic delirium; sleep disorders with somatic diseases; the need for long-term therapy for states of excitation and anxiety, psychosomatic, neurotic and behavioral disorders in children; convulsive cough, spastic conditions in the gastrointestinal tract; premedication; dermatoses accompanied by persistent itching; allergic reactions.

Contraindications

CNS depression, incl. in case of intoxication with alcohol, barbiturates and other medicines, having a depressing effect on the central nervous system, pathological changes in the blood picture, myelodepression, pregnancy, lactation, hypersensitivity to chlorprothixene.

Features of application

Use during pregnancy and breastfeeding

Contraindicated for use during pregnancy and lactation.

Use for liver dysfunction

Should not be used in cases of severe liver dysfunction.

Use for renal impairment

Should not be used in cases of severe renal impairment.

Use in elderly patients

Should not be used in old age.

special instructions

It should not be used for epilepsy, a tendency to collapse, parkinsonism, heart defects in the stage of decompensation, tachycardia, cerebral atherosclerosis, severe liver and kidney dysfunction, hematopoietic disorders, cachexia, and in old age.

If it is necessary to use chlorprothixene, the risks and benefits of treatment should be compared in patients with chronic alcoholism, diseases of the cardiovascular system (increased risk of developing transient arterial hypotension), Reye's syndrome, as well as glaucoma or a predisposition to it, peptic ulcer of the stomach and duodenum, delayed urine, Parkinson's disease, epileptic seizures, hypersensitivity to other thioxanthenes or phenothiazines.

When using chlorprothixene, false-positive results of an immunological pregnancy test using urine, as well as false-positive results of a urine test for bilirubin, are possible.

During the treatment period, avoid drinking alcohol.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, you should refrain from engaging in potentially hazardous activities that require increased attention and rapid psychomotor reactions.