How long to take Xarelto. When is it better to take Xarelto in the morning or evening? What can you eat while taking Xarelto?

Xarelto is a direct acting anticoagulant. selective inhibitor factor Xa.

Release form and composition

The dosage form of Xarelto is coated tablets. film-coated: round, biconvex, on one side the Bayer logo in the form of a cross is applied by extrusion, on the other there is a triangle with the dosage designation (“2.5”, “10”, “15” or “20”), on the cross-section the core is white:

2.5 mg: 10 pcs. blisters, 10 blisters in a cardboard pack; 14 pcs. in blisters, in a cardboard pack of 1, 2, 4, 7, 12 or 14 blisters;
10 mg: 5 pcs. in blisters, in a cardboard box 1 blister; 10 pcs. in blisters, in a cardboard pack 1, 3 or 10 blisters;
15 mg: 10 pcs. blisters, 10 blisters in a cardboard pack; 14 pcs. in blisters, in a cardboard pack 1, 2 or 3 blisters;
20 mg: 10 pcs. blisters, 10 blisters in a cardboard pack; 14 pcs. in blisters, in a cardboard pack 1 or 2 blisters.

The active ingredient of the drug is rivaroxaban (micronized). Its content in tablets depending on the color of the shell:

Light yellow – 2.5 mg;
Pink – 10 mg;
Pink-brown – 15 mg;
Red-brown – 20 mg.

Auxiliary components: sodium lauryl sulfate, croscarmellose sodium, microcrystalline cellulose, magnesium stearate, lactose monohydrate, hypromellose 5cP.

Shell composition: hypromellose 15cP, macrogol 3350, titanium dioxide and dye (in tablets 2.5 mg - yellow iron oxide, in the rest - red iron oxide).

Indications for use

For 2.5 mg tablets (in combination with acetylsalicylic acid (ASA) or ASA and thienopyridines - ticlopidine or clopidogrel):

Prevention of mortality due to cardiovascular complications and myocardial infarction in patients after acute coronary syndrome (ACS), accompanied by an increase in cardiac-specific biomarkers.

For 10 mg tablets:

Prevention venous thromboembolism(VTE) in patients undergoing major orthopedic surgery lower limbs.

For 15 and 20 mg tablets:

Treatment of deep vein thrombosis (DVT) and thromboembolism pulmonary artery(PE), prevention of their relapses;
Prevention of systemic thromboembolism and stroke in patients with non-valvular atrial fibrillation.

Contraindications

All dosage forms Xarelto is contraindicated in the following cases:

Clinically significant active bleeding (eg, gastrointestinal or intracranial);
Heavy renal failure(with creatinine clearance (CC) less than 15 ml/minute);
Liver diseases accompanied by coagulopathy, which increases the risk of developing clinically significant bleeding, incl. functional liver disorders class B and C in accordance with the Child-Pugh classification, liver cirrhosis;
Glucose-galactose malabsorption, congenital lactase deficiency or lactose intolerance;
The need for therapy with other anticoagulants, such as heparin derivatives (including fondaparinux), oral anticoagulants (including apixaban, warfarin, dabigatran), low molecular weight heparins(including dalteparin and enoxaparin) and unfractionated heparin, except in cases of transfer of the patient from/to rivaroxaban or the use of unfractionated heparin in doses necessary to ensure the functioning of the central arterial or venous catheter;
Age up to 18 years;
Pregnancy;
Lactation;
Hypersensitivity to the components of the drug.

Additional contraindications depending on the dose of Xarelto:

2.5 mg tablets: treatment of ACS with antiplatelet agents in patients who have had a stroke or transient ischemic attack;
Tablets 15 and 20 mg: conditions or damage associated high risk major bleeding, such as recent head injury or spinal cord, recent or existing gastrointestinal ulcer, diagnosed or suspected esophageal varices, intracranial hemorrhage, malignant tumor with a high risk of bleeding, eye, spinal or brain surgery, vascular aneurysms or vascular pathologies of the brain/spinal cord, arteriovenous malformations.

Xarelto is used with extreme caution in the following cases:

Increased risk of bleeding: vascular retinopathy, exacerbation or recent acute peptic ulcer stomach and duodenum, history of bronchiectasis or pulmonary hemorrhage, uncontrolled severe arterial hypertension, congenital or acquired tendency to bleeding, pathology of the blood vessels of the brain or spinal cord, recent intracranial or intracerebral hemorrhage, recent surgery on the eyes, spinal cord or brain;
Moderate renal failure (creatinine clearance 30-49 ml/minute) in patients receiving drugs that increase the concentration of rivaroxaban in the blood plasma;
Severe renal failure (creatinine clearance from 15 to 29 ml/minute);
Concomitant use of drugs that affect hemostasis (for example, antiplatelet agents or other antithrombotic agents, nonsteroidal anti-inflammatory drugs);
Concomitant use of systemic azole antifungals (for example, ketoconazole) or human immunodeficiency virus protease inhibitors.

Directions for use and dosage

Xarelto 2.5 mg is taken 1 tablet 2 times a day, regardless of meals.

The drug is prescribed as soon as possible after stabilization of the patient's condition with OSK (including the revascularization procedure), no earlier than 24 hours after hospitalization, after the end of parenteral administration of anticoagulants.

Patients are also prescribed acetylsalicylic acid (ASA) at a daily dose of 75-100 mg or ASA at 75-100 mg/day in combination with clopidogrel at a dose of 75 mg/day or ticlopidine at a standard daily dose.

The duration of therapy is 12 months, for some patients it can be extended to 24 months. The risk ratio of ischemic events and bleeding should be regularly assessed throughout the treatment period.

If you miss the next dose, you should not double the dose; you must take the next dose at the scheduled time.

Xarelto 10 mg is taken 1 tablet 1 time per day, regardless of meals. Provided hemostasis has been achieved, the first tablet should be taken 6-10 hours after surgical intervention.

Duration of treatment:

After major surgery knee joint- 2 weeks;
After major hip surgery – 5 weeks.

If you miss the next dose, you must take the pill immediately and continue treatment the next day as before.

Xarelto 15 and 20 mg is taken with food.

For the prevention of systemic thromboembolism and stroke in patients with non-valvular atrial fibrillation, the drug is prescribed 20 mg once a day, in case of renal failure - 15-20 mg once a day.

When treating DVT and PE and preventing their relapses, 15 mg 2 times a day is prescribed during the first 3 weeks, then the dose is increased to 20 mg 1 time a day.

Maximum permissible daily doses: during treatment - 30 mg (during the first 3 weeks), with further prevention– 20 mg.

The duration of treatment in each case is determined individually, after a careful assessment of the balance between the benefits of therapy and the possible risks of bleeding. The minimum course is 3 months and is based on an assessment of reversible factors, such as trauma, previous surgery, and a period of immobilization. The doctor may decide to extend the duration of treatment in the event of the development of idiopathic pulmonary embolism or deep venous thromboembolism or after identifying persistent risk factors.

If the next dose is missed by a patient taking Xarelto at a dose of 15 mg 2 times a day, it is necessary to take the missed dose as quickly as possible in order to achieve daily dose 30 mg, i.e. both tablets can be taken at one time. The next day you need to continue regular use in accordance with the recommended regimen.

If the next dose is missed by a patient taking Xarelto at a dose of 20 mg 1 time per day, he should take the drug immediately, and the next day continue regular use in accordance with the prescribed regimen.

For all patients who have difficulty swallowing whole tablets, they can be crushed or mixed with water/ liquid nutrition(for example, applesauce) immediately before use.

If necessary, a crushed tablet with a small amount of water can be administered through a gastric tube (the position of which must be agreed with the doctor), after which a little water should be introduced to wash off the remaining drug from the walls of the tube. After taking Xarelto at a dose of 15 or 20 mg, you should immediately receive enteral nutrition.

Side effects

Hematopoietic system: often – anemia, infrequently – thrombocythemia (including increased platelet count)*;
The cardiovascular system: often – hematoma, arterial hypotension; infrequently - tachycardia;
Digestive system: often – pain in the area gastrointestinal tract, dyspepsia, gastrointestinal bleeding(including rectal), nausea, bleeding gums, diarrhea, vomiting*, constipation*; uncommon – dry mouth;
Nervous system: often – dizziness and headache; infrequently – short-term fainting, intracerebral and intracranial hemorrhage;
Organ of vision: often – hemorrhage in the eye (including in the conjunctiva);
Liver: infrequently – functional impairment liver; rarely - jaundice;
Genitourinary system: renal failure (including increased concentrations of creatinine and urea)*, bleeding from the urogenital tract (including menorrhagia and hematuria**);
The immune system: infrequently - allergic dermatitis, allergic reactions;
Respiratory system: often – hemoptysis, nosebleeds;
Musculoskeletal system: often – pain in the limbs*; infrequently - hemarthrosis; rarely - hemorrhage into the muscles;
Skin and subcutaneous tissues: often - skin and subcutaneous hemorrhages, rash, ecchymosis, itching; uncommon – generalized itching, urticaria;
From the body as a whole: deterioration general well-being(including weakness and asthenia), peripheral edema, fever*; infrequently – malaise and anxiety; rarely – local swelling*;
Laboratory indicators: often - increased transaminase levels; uncommon – increased activity of alkaline phosphatase, lipase, amylase, gamma-glutamyltransferase and lactate dehydrogenase*, increased bilirubin concentration; rarely - an increase in the concentration of conjugated bilirubin (including with a concomitant increase in alanine aminotransferase activity);
Other: often - excessive hematoma due to a bruise, hemorrhages after procedures (including bleeding from a wound and postoperative anemia); uncommon – discharge from the wound*; rarely – vascular pseudoaneurysm***.

* – these side effects were recorded after major orthopedic surgeries.

** - these adverse reactions were recorded during the treatment of VTE as very common in women under 55 years of age.

*** – these events were recorded as infrequent during the prevention of myocardial infarction and sudden death in patients after acute coronary syndrome (after percutaneous interventions).

special instructions

When performing spinal/epidural anesthesia or lumbar puncture in patients taking platelet aggregation inhibitors to prevent thromboembolic complications, there is a risk of developing a spinal or epidural hematoma, which can lead to long-term paralysis. This risk subsequently increases with concomitant therapy with drugs that affect hemostasis and with the use of a permanent epidural catheter. Traumatic spinal or epidural puncture may also increase the risk. For timely diagnosis of symptoms of neurological disorders (for example, bladder or bowel dysfunction, numbness or weakness of the legs), patients should be under constant medical supervision. The epidural catheter should be removed no earlier than 18 hours after the last dose of Xarelto. The drug is prescribed no earlier than 6 hours after removing the catheter. In case of a traumatic puncture, the use of rivaroxaban should be postponed for 24 hours.

If necessary invasive procedure or surgery, Xarelto should be discontinued at least 24 hours in advance. If the procedure/surgery cannot be postponed, the increased risk of bleeding should be weighed against the need for urgent intervention. After the procedure, you can resume taking the drug only if there is adequate hemostasis and the presence of clinical indicators.

Patients at risk of developing gastric and/or duodenal ulcers can be prescribed appropriate preventive therapy.

Xarelto is not recommended for use as an alternative to unfractionated heparin in unstable PE, or when thrombolysis or thrombectomy is required, since the efficacy and safety of rivaroxaban in these clinical situations has not been established.

Fainting and dizziness may occur when taking Xarelto. Patients who experience these reactions should refrain from administering vehicles and performing potentially hazardous activities.

Drug interactions

With the simultaneous use of strong inhibitors of the CYP3A4 isoenzyme and P-glycoprotein, a decrease in hepatic and renal clearance and an increase in systemic exposure are observed, so they must be used with caution.

Ketoconazole enhances the pharmacodynamic effect of Xarelto, while rifampicin reduces it.

The simultaneous use of the drug with dronedarone should be avoided, because Clinical data on this combination are limited.

Ritonavir increases the maximum concentration of rivaroxaban by 1.6 times, which is accompanied by a significant increase in its pharmacodynamic effect, and therefore this combination is not recommended.

With simultaneous use of rivaroxaban with enoxaparin sodium (in a single dose of 40 mg), a summative effect was noted regarding the activity of anti-Xa factor.

Any other anticoagulants should be used with extreme caution, because high risk of bleeding.

When taking Xarelto at a dose of 15 mg in combination with clopidogrel (at a loading dose of 300 mg followed by a maintenance dose of 75 mg), no pharmacokinetic interaction was observed, but in a subgroup of patients it was detected significant increase bleeding time, which did not correlate with the content of P-selectin or GPIIb/IIIa receptor and the degree of platelet aggregation.

In some cases, with simultaneous administration of naproxen at a dose of 500 mg, a pronounced pharmacodynamic response is possible.

Platelet aggregation inhibitors and non-steroidal anti-inflammatory drugs (incl. acetylsalicylic acid) increase the risk of bleeding.

When transferring a patient from warfarin to rivaroxaban and vice versa, the prothrombin time increases.

If possible, it is recommended to avoid transferring patients from phenindione to rivaroxaban and vice versa, because Experience with this application is very limited. If such a need is justified, then the pharmacodynamic effect of the drugs (prothrombin time, MHO) should be monitored daily immediately before taking the next dose of Xarelto.

Terms and conditions of storage

Store at temperatures up to 30 ºС out of the reach of children.

Shelf life – 3 years.

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The drug seems to be working)

Grade: 5

At 5 weeks of pregnancy, my fetus froze. During hospitalization, I complained to the doctor about pain in my leg and after an ultrasound scan I was diagnosed with non-occlusive deep vein thrombosis. After completing the gynecological questions, I was admitted to the department vascular surgery and there I met Xarelto. In the hospital I took 15 mg twice a day. And when I came out, I was embarrassed when I saw the price of the drug, but health is more valuable than any money! In general, the result is as follows: After a month of taking 15 mg twice a day, the dynamics are wonderful. Ultrasound showed that 1 of the three affected veins had cleared and was completely patent. Now I’ve been taking 20 mg once a day for a month and, to be honest, I’ve started to feel my leg again, which worries me very much. Throbbing pain appears from time to time. I plan to go for an ultrasound scan in a couple of weeks, but I think everything is fine. In general side effects no (to avoid stomach problems I take omeprazole), I also take Phlebodia 600 at the same time and always wear class 2 compression stockings. Thanks to the scientists for such a wonderful drug! I don’t want to switch to analogues, because I don’t want to risk my health and treatment time for the sake of dubious savings of a couple of thousand rubles.

no better yet)

Grade: 4

I have been taking it for more than a year as a stroke prevention (I had one 3 years ago). There are no negative impressions, it is easy to take, there was no recurrent stroke. BUT...in the blood test, anemia began to be consistently recorded, which was not there before and the cause of which cannot be determined:-(
It’s a pity that the effectiveness cannot be monitored objectively; INR is not used)

Thins the blood

Grade: 4

As I understand it, this is the most modern drug that prevents the formation of blood clots. It works great! I had blood clots all over my leg, and now there is only one left. There is a positive forecast that he too will disappear.
I liked that there were no side effects or allergies to the medicine. The main thing is not to exceed the dose - the medicine is serious and you should always consult a doctor. I drink it at the same time in the morning and feel great. INR control is not needed, the drug acts gently and constantly. Somehow I missed an appointment, felt weak and dizzy. As I understand it, most likely I will have to drink it for life. The drug is expensive, but the price is justified.

No new blood clots

Grade: 4

Previously, I took another drug, but after two operations, the doctor prescribed Xarelto.
Unfortunately, it is prescribed for an indefinite period (but the instructions, by the way, indicate that it is recommended to take it for no more than one year; if there is no effect, you should stop taking it). I've been taking it for about six months at the moment. At the recommended dose of 20 mg per day, I take a little more than a tablet (the pack contains a dosage of 20 mg). The result is about 25 mg of medication per day. Since I have difficulty swallowing, I crush the medicine into food (they can also be taken this way, the doctor said there is no difference).
Due to the increased dosage, the first 3 weeks there was dry mouth. Over time, everything passed. To this day, the blood clot is not resolving, but at least it is not growing any further. There are also no new blood clots (they appeared before, but now there have been none for six months). The drug seems to have an effect. But for its price the effect is still not good enough, but there are no analogues

If kidney failure

Grade: 5

In addition, I am at risk of stroke and suffer from kidney failure. According to the instructions, I take 15 mg once a day. And with this dosage, the drug, it seems to me, works. I have been taking it for 5-6 months, no stroke has occurred.

Helps with DVT

Grade: 5

I had deep vein thrombosis. There was swelling in the lower leg, and the temperature even increased. They prescribed Xarelto and bought it, although the drug is not cheap. I took 15 mg twice a day before meals for the first 2-3 weeks, and then switched to 20 mg once a day.
I have been undergoing treatment for about 3 months. The pain and heaviness gradually go away. Vascular ultrasound shows improvement.

How to prevent

Grade: 5

Blood clots have resolved

Grade: 5

I have a lot of thrombotic masses on my legs. The doctor prescribed Xarelto. The summary for it is very detailed; the side effects included bleeding. I doubted whether it was worth taking the drug, since it had such possible unwanted reactions. Still, I decided, which I don’t regret at all now.
Before starting the course, it is necessary to examine the stomach (FGDS) to find out if there are any ulcers inside. And only if everything is clean, then taking the drug is allowed.

The dosage regimen is interesting, with increasing dosage. I took 10 mg for 20 days, and 20 mg for 40 days. Surprisingly, there were no side effects. Additionally, I drank herbal infusions and omeprazole to protect my stomach.
After a course of Xarelto, I did a venous doppler. The blood clots have resolved, the patency is excellent! Moreover, very quickly - in just 2 months. Xarelto is my salvation. Even if it is expensive, even if it is not sold everywhere, it gives a wonderful result.
We are all individual, our bodies react differently to new medications, so it is advisable to consult with doctors very carefully and not neglect additional research. Then the result will be excellent!

Improves blood quality

Grade: 5

My mother took Xarelto. The doctors prescribed Warfarin, but the dosage and the effect itself are very strong, so they decided not to risk it. Although the drug is cheaper than Xarelto.

Tablets cost about 3,000 rubles for 28 pieces of 20 mg each (you can rarely find them cheaper). Now we’ve decided to buy in large batches at once, so at least we can save some money.
Mom has been taking it for six months, and all blood tests are more or less good. If previously a bruise appeared at the slightest pressure on the skin, now we don’t have such problems. The tablets have no side effects.
In our case, the drug must be taken for life. Both due to age and health status.
Excellent product, easy to use. And most importantly, it works as it should, the results are visible both externally and by analysis. We don’t regret switching to Xarelto, so far the medicine has been nothing but good.

Highly effective anticoagulant

Grade: 5

About a year ago I was diagnosed with a condition that requires me to take anticoagulants regularly. At first Warfain was prescribed. I started taking it, but on the third day bleeding began with an exorbitant increase in INR. Warfain was immediately discontinued and Xarelto was prescribed, but they warned me that the drug was “slightly” more expensive and that I should not worry. In fact, this “slightly” turned out to be 20 times more expensive. The amounts are simply shocking. As the doctor said, there are simply no analogues with a similar composition. The drug is young and we can’t expect analogues in the next couple of years. If you buy a large package of 100 tablets, you can save a couple of thousand every three to four months. At least some savings. Over the year, the cost of the drug has increased by about 90 rubles, which seems a little, since the state controls the prices for the list of necessary drugs, and Xarelto is one of them, prices should not fluctuate depending on the exchange rate. That's a plus.

The main drawback is the duration of the course of treatment, since I drank one month out of three. There is no point in writing about the results. But the thrombus has become softer and the boundaries seem to have begun to blur, its diameter has decreased, but there is still pain. Still take it for 2 months, and then we can talk about whether it works or not. But the positive dynamics give us hope.
For the first month I took 15 mg per day, now I increase the dosage to 20. Now the intake has become much more convenient - a whole tablet. Previously, you had to divide it in half, and then “saw off” another quarter from the half, so that the total would be three quarters. This is not entirely convenient, it’s a pity that the manufacturer did not think about producing tablets in a dosage of 15 mg for ease of use in the first month.
I don’t deviate from the instructions. The list of side effects and contraindications is small, I unpleasant symptoms I didn’t experience any symptoms of nausea or weakness, my blood pressure was also normal.

Questions and answers

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Xarelto and any alcohol are not compatible. What happens if you break the drinking ban? Each of us sometimes requires anticoagulants for prevention or even treatment. One of the most effective drugs This focus is Xarelto. It is aimed at treating thromboembolism and is used as a prophylactic agent to prevent stroke and heart attack. Usually, one of the most common questions among patients is “is it possible to mix the drug and alcohol?” Undoubtedly, this is a common situation when at the end of the working day you want to relax with a glass of wine, but irreversible consequences can occur if compatibility is not taken into account. Therefore, in this article we will look at what the drug is, what indications and contraindications it has, what its interaction with alcohol is, and consider several reviews about the drug itself.

Essence of Xarelto

It is a high quality selective direct inhibitor targeting:

Stroke prevention;
Prevention of heart attack;
Prevention of thrombosis and embolism;
It is a prophylactic for atrial fibrillation.

The drug is produced in the form of coated tablets of 2.5, 10, 15, 20 mg. , 10 mg, 15 mg and 20 mg. Well-known doctors recommend a 10 gram dosage, but once every 24 hours.

Basically, the appointment is made after surgery on the legs. Treatment is prescribed based on the complexity of the operation performed and the dynamics of recovery. A 35-day course is prescribed for extensive surgery in the hip joint, 14 days - if the operation was performed on the knee joint.

In a situation where the patient forgot to take the drug, doubling the dose the next day cannot be done. If he does not remember whether he took the medicine, it is better to skip the dose rather than repeat it. Reviews from many patients confirm this fact.

Main contraindications for use:

If there is an individual intolerance to one of the components of the drug or hypersensitivity.
The possibility of intracranial and other bleeding was recorded.
If a person is already using anticoagulants, compatibility with them is negative.
During pregnancy and breastfeeding, a woman is prohibited from using Xarelto.
For liver pathologies that are combined with poor blood clotting.
Until reaching adulthood, taking the drug is prohibited.
In the presence of mild degree renal failure.
If a person does not tolerate lactose and galactose.

It is important to monitor the patient’s condition while using the drug in the presence of the following pathologies:

There may be a risk of bleeding.
In the presence of moderate to severe renal failure, since there is a risk of bleeding.
It is also not recommended for use in the treatment of fungal diseases.
In combination with drugs that affect hemostasis.
Persons who are predisposed to ulcers in the stomach or duodenum should be under close medical supervision.

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Main side effects

Like any other drug, Xarelto has its possible consequences:

Anemia (anemia);
Increased output platelets in bone marrow human (thrombocythemia);
Heavy bleeding from an open wound;
Cardiopalmus;
A sharp decline blood pressure;
Hemorrhages leading to the formation of bruises and hematomas;
Possible bleeding in the stomach (hemorrhages);
Bleeding gums;
Blood from the nose and genitals;
Vomiting;
Painful vomiting, possibly with blood cells;
Pain on palpation of the abdominal area;
Swelling and discomfort in abdominal cavity;
Painful digestion;
Dryness of mucous membranes, especially the oral cavity;
Weakness throughout the body increased fatigue;
Fever, headaches and dizziness;
Allergic reactions, possible urticaria, itching or various rashes;
Kidney failure;
Increased performance fermentation in analyses.

An extensive list and reviews from many patients indicate that Xarelto tablets are a chemical that can cause a lot of inconvenience to a person. The strongest effect is on the liver, because it will need to process the incoming toxin in the form of a medicine.

There have been cases of overdose, but then the listed side effects were not observed. In this case, there is no universal method of normalizing the condition or so-called antidote. You can use a unique cleaning agent - activated carbon.

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Alcohol compatibility

This is the most common question among patients who are prescribed a course this drug. In general, no drug can be combined with alcohol, but some have this option, and then the most serious consequence can only be neutralization of the effect of the tablets.

Xarelto is not classified as a drug compatible with ethanol. Their interaction cannot be called fatal, but taking two substances together is not recommended. Alcohol can drown out all the actions of the anticoagulant and the effect of the impact; this aspect can affect the person’s recovery process, and possibly aggravate his illness.

Alcohol affects the rhythm of the heart muscle, absolutely negatively, and the situation that occurs when mixed with the drug can lead to a heart attack, which the drug is aimed at preventing. We can say that these two substances are aimed at completely opposite actions.

Reviews from many researchers indicate that alcohol causes sudden surges in blood pressure as blood vessels dilate. As soon as ethanol leaves the blood, it immediately rises. This unstable situation will negatively affect the effect of Xarelto, and its side effects include the presence of low blood pressure.

If a person has a pathology associated with cardiac dysfunction, then in fact he is prohibited from taking the drug, even in the smallest quantities. The interaction of a drug, alcohol and a weakened body can lead to a heart attack or stroke, and Xarelto is aimed at treating these diseases. Even if a person is not affected by this disease, then heart failure is only guaranteed.

No drug will have excellent compatibility with alcohol; you should not combine them. It doesn’t even matter what drink was consumed: whiskey, vodka or ordinary medicinal tincture. If it contains at least one percent ethanol, you should stop taking it.

Describe the entire list possible consequences it is impossible, they depend on the individual susceptibility of the human body. In addition, it is important to consider what it is made from. alcoholic drink. It is possible that the drug will react negatively not to the ethanol, but for some additional ingredient. Therefore, it is impossible to predict how the body will behave.

As already mentioned, compatibility is not fatal, but this does not give the patient the opportunity to drink continuously. An acceptable dose (but not recommended) is 1 glass of dry red wine. It will speed up blood circulation without aggravating the person’s situation.

When treating any disease, it is important to stop drinking any alcoholic beverages, since they provoke the development of a particular disease.

It is important to remember the effects of both drugs and alcohol on the liver. By taking a certain drug, no matter for what purpose, you will cause some minor damage to the liver. When drinking alcohol, hepatocytes die and form connective tissue, if abused, the organ may simply fail. It turns out that as soon as the tablet entered the body, the liver began to work on breaking it down, then ethanol enters, which also requires digestion. The organ begins to work to the limit of its capabilities, thereby causing various negative consequences for the person.

They have been living with paroxysmal atrial fibrillation for 7 years, which is accompanied by frequent attacks. At first I took aspirin, but three years ago I was prescribed Xarelto 20 mg. I noticed that the attacks became much weaker, it became a little easier. But I noticed a lot of side effects:

The drug removes calcium, which is necessary at my age, so now I live with osteoporosis and a vertebral fracture.
I have not been able to cure herragic cystitis for several years now.
The mouth is constantly dry, sometimes there is blood
Bruises and bruises appear.

Almost everyone advises switching to Warfarin, but even it has the same side effects, although the price is lower. By the way, another significant disadvantage of the drug is the prohibitive price for a person who lives on one pension.

Valentina. My husband is 33 years old, former athlete.

As a result of a fracture of the knee joint, thrombosis of a vein arose in the leg, almost from the toes of the right foot to the groin area (soon it reached the abdominal cavity. Due to the deep conviction that “everything will go away on its own,” he suffered for a week from discomfort. I forced him to go to the clinic, where the only answer was “this case is hopeless, you can rely on Claresto’s action.” We took a month's course, 10 ml twice a day, the test showed that there was a positive trend. Of course, the drug has merit, but we still resorted to help alternative medicine. I gave my husband Iodinol to drink and made compresses from oak leaves. You cannot give up even in the most hopeless situations!

Marina 59 years old

I've been taking Xarelto for about 11 months. My diagnosis: thrombosis of the veins of the legs, I underwent two surgical interventions. They prescribed me Xarelto for life, sometimes I check for hemostasis. Although they said that you will need treatment for the rest of your life, I read that you can only drink it for a year. Doubts crept in, but apart from the high price, I didn’t notice any shortcomings.

Vladislav 58 years old

I was admitted with a diagnosis of pulmonary edema and was diagnosed with arrhythmia. I was prescribed a course of Xarelto. I did not experience a heart attack or stroke, and also did not notice any side effects. The only thing that is a little confusing is the price of the drug.

Valeria is 64 years old

A fracture of the femoral neck was diagnosed and there were numerous burns. There were complications in the form of thrombosis, and then I was prescribed Xarelto. I drank it for about 60 days, the swelling subsided greatly, the doctor said that improvement was expected, because... there is a positive trend. The only thing is that it is rare to find dosages of 10 ml, and besides, the price is high.

alcoholism.com

Xarelto

Xarelto is a direct-acting anticoagulant, a selective factor Xa inhibitor.

Release form and composition

The dosage form of Xarelto is film-coated tablets: round, biconvex, on one side the Bayer logo in the form of a cross is applied by extrusion, on the other there is a triangle with the dosage designation (“2.5”, “10”, “15” or “20” ), in cross section the kernel is white:

2.5 mg: 10 pcs. blisters, 10 blisters in a cardboard pack; 14 pcs. in blisters, in a cardboard pack of 1, 2, 4, 7, 12 or 14 blisters;
10 mg: 5 pcs. in blisters, in a cardboard box 1 blister; 10 pcs. in blisters, in a cardboard pack 1, 3 or 10 blisters;
15 mg: 10 pcs. blisters, 10 blisters in a cardboard pack; 14 pcs. in blisters, in a cardboard pack 1, 2 or 3 blisters;
20 mg: 10 pcs. blisters, 10 blisters in a cardboard pack; 14 pcs. in blisters, in a cardboard pack 1 or 2 blisters.

The active ingredient of the drug is rivaroxaban (micronized). Its content in tablets depending on the color of the shell:

Light yellow – 2.5 mg;
Pink – 10 mg;
Pink-brown – 15 mg;
Red-brown – 20 mg.

Auxiliary components: sodium lauryl sulfate, croscarmellose sodium, microcrystalline cellulose, magnesium stearate, lactose monohydrate, hypromellose 5cP.

Shell composition: hypromellose 15cP, macrogol 3350, titanium dioxide and dye (in tablets 2.5 mg - yellow iron oxide, in the rest - red iron oxide).

Indications for use

For 2.5 mg tablets (in combination with acetylsalicylic acid (ASA) or ASA and thienopyridines - ticlopidine or clopidogrel):

Prevention of mortality due to cardiovascular complications and myocardial infarction in patients after acute coronary syndrome (ACS), accompanied by an increase in cardiac-specific biomarkers.

For 10 mg tablets:

Prevention of venous thromboembolism (VTE) in patients undergoing major orthopedic surgery of the lower extremities.

For 15 and 20 mg tablets:

Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), prevention of their relapses;
Prevention of systemic thromboembolism and stroke in patients with non-valvular atrial fibrillation.

Contraindications

All dosage forms of Xarelto are contraindicated in the following cases:

Clinically significant active bleeding (eg, gastrointestinal or intracranial);
Severe renal failure (with creatinine clearance (CC) less than 15 ml/minute);
Liver diseases accompanied by coagulopathy, which increases the risk of developing clinically significant bleeding, incl. functional liver disorders class B and C in accordance with the Child-Pugh classification, liver cirrhosis;
Glucose-galactose malabsorption, congenital lactase deficiency or lactose intolerance;
The need for therapy with other anticoagulants, such as heparin derivatives (including fondaparinux), oral anticoagulants (including apixaban, warfarin, dabigatran), low molecular weight heparins (including dalteparin and enoxaparin) and unfractionated heparin, with the exception of cases of transfer of the patient from/to rivaroxaban or use of unfractionated heparin in doses necessary to ensure the functioning of the central arterial or venous catheter;
Age up to 18 years;
Pregnancy;
Lactation;
Hypersensitivity to the components of the drug.

Additional contraindications depending on the dose of Xarelto:

2.5 mg tablets: treatment of ACS with antiplatelet agents in patients who have suffered a stroke or transient ischemic attack;
15 and 20 mg tablets: conditions or injuries associated with a high risk of major bleeding, such as recent brain or spinal cord injury, recent or existing gastrointestinal ulcer, diagnosed or suspected esophageal varices, intracranial hemorrhage, high-risk malignancy bleeding, surgery on the eyes, spinal cord or brain, vascular aneurysms or vascular pathologies of the brain/spinal cord, arteriovenous malformations.

Xarelto is used with extreme caution in the following cases:

Increased risk of bleeding: vascular retinopathy, exacerbation or recent acute peptic ulcer of the stomach and duodenum, bronchiectasis or history of pulmonary hemorrhage, uncontrolled severe arterial hypertension, congenital or acquired tendency to bleeding, vascular pathologies of the brain or spinal cord, recent intracranial or intracerebral hemorrhage, recent surgery on the eyes, spinal cord or brain;
Moderate renal failure (creatinine clearance 30-49 ml/minute) in patients receiving drugs that increase the concentration of rivaroxaban in the blood plasma;
Severe renal failure (creatinine clearance from 15 to 29 ml/minute);
Concomitant use of drugs that affect hemostasis (for example, antiplatelet agents or other antithrombotic agents, nonsteroidal anti-inflammatory drugs);
Concomitant use of systemic azole antifungals (for example, ketoconazole) or human immunodeficiency virus protease inhibitors.

Directions for use and dosage

Xarelto 2.5 mg is taken 1 tablet 2 times a day, regardless of meals.

The duration of therapy is 12 months, for some patients it can be extended to 24 months. The risk ratio of ischemic events and bleeding should be regularly assessed throughout the treatment period.

If you miss the next dose, you should not double the dose; you must take the next dose at the scheduled time.

Xarelto 10 mg is taken 1 tablet 1 time per day, regardless of meals. Provided hemostasis has been achieved, the first tablet should be taken 6-10 hours after surgery.

Duration of treatment:

After major knee surgery – 2 weeks;
After major surgery hip joint- 5 weeks.

If you miss the next dose, you must take the pill immediately and continue treatment the next day as before.

Xarelto 15 and 20 mg is taken with food.

For the prevention of systemic thromboembolism and stroke in patients with non-valvular atrial fibrillation, the drug is prescribed 20 mg once a day, in case of renal failure - 15-20 mg once a day.

When treating DVT and PE and preventing their relapses, 15 mg 2 times a day is prescribed during the first 3 weeks, then the dose is increased to 20 mg 1 time a day.

Maximum permissible daily doses: during treatment - 30 mg (during the first 3 weeks), for further prevention - 20 mg.

If the next dose is missed by a patient taking Xarelto at a dose of 15 mg 2 times a day, it is necessary to take the missed dose as quickly as possible in order to achieve the daily dose of 30 mg, i.e. both tablets can be taken at one time. The next day you need to continue regular use in accordance with the recommended regimen.

For any patients who have difficulty swallowing whole tablets, they can be crushed or mixed with water/liquid food (eg, applesauce) immediately before administration.

Side effects

Hematopoietic system: often – anemia, infrequently – thrombocythemia (including increased platelet count)*;
Cardiovascular system: often – hematoma, arterial hypotension; infrequently - tachycardia;
Digestive system: often – pain in the gastrointestinal tract, dyspepsia, gastrointestinal bleeding (including rectal), nausea, bleeding gums, diarrhea, vomiting*, constipation*; uncommon – dry mouth;
Nervous system: often – dizziness and headache; infrequently – short-term fainting, intracerebral and intracranial hemorrhage;
Organ of vision: often – hemorrhage in the eye (including in the conjunctiva);
Liver: uncommon – functional liver disorder; rarely - jaundice;
Genitourinary system: renal failure (including increased concentrations of creatinine and urea)*, bleeding from the urogenital tract (including menorrhagia and hematuria**);
Immune system: uncommon – allergic dermatitis, allergic reactions;
Respiratory system: often – hemoptysis, nosebleeds;
Musculoskeletal system: often – pain in the limbs*; infrequently - hemarthrosis; rarely - hemorrhage into the muscles;
Skin and subcutaneous tissues: often - skin and subcutaneous hemorrhages, rash, ecchymosis, itching; uncommon – generalized itching, urticaria;
From the body as a whole: deterioration in general health (including weakness and asthenia), peripheral edema, fever*; infrequently – malaise and anxiety; rarely – local swelling*;
Laboratory indicators: often - increased transaminase levels; uncommon – increased activity of alkaline phosphatase, lipase, amylase, gamma-glutamyltransferase and lactate dehydrogenase*, increased bilirubin concentration; rarely - an increase in the concentration of conjugated bilirubin (including with a concomitant increase in alanine aminotransferase activity);
Other: often - excessive hematoma due to a bruise, hemorrhages after procedures (including bleeding from a wound and postoperative anemia); uncommon – discharge from the wound*; rarely – vascular pseudoaneurysm***.

* – these side effects were recorded after major orthopedic surgeries.

** - these adverse reactions were recorded during the treatment of VTE as very common in women under 55 years of age.

*** – these events were recorded as infrequent in the prevention of myocardial infarction and sudden death in patients after acute coronary syndrome (after percutaneous interventions).

special instructions

If an invasive procedure or surgery is necessary, Xarelto should be discontinued at least 24 hours in advance. If the procedure/surgery cannot be postponed, the increased risk of bleeding should be weighed against the need for urgent intervention. After the procedure, you can resume taking the drug only if there is adequate hemostasis and the presence of clinical indicators.

Patients at risk of developing gastric and/or duodenal ulcers can be prescribed appropriate preventive therapy.

Fainting and dizziness may occur when taking Xarelto. Patients who experience these reactions should refrain from driving or performing potentially hazardous activities.

Drug interactions

Ketoconazole enhances the pharmacodynamic effect of Xarelto, while rifampicin reduces it.

The simultaneous use of the drug with dronedarone should be avoided, because Clinical data on this combination are limited.

With simultaneous use of rivaroxaban with enoxaparin sodium (in a single dose of 40 mg), a summative effect was noted regarding the activity of anti-Xa factor.

Any other anticoagulants should be used with extreme caution, because high risk of bleeding.

When Xarelto 15 mg was taken in combination with clopidogrel (at a loading dose of 300 mg followed by a maintenance dose of 75 mg), no pharmacokinetic interaction was observed, but in a subgroup of patients a significant increase in bleeding time was detected, which was not correlated with P-selectin or GPIIb/IIIa receptor and the degree of platelet aggregation.

In some cases, with simultaneous administration of naproxen at a dose of 500 mg, a pronounced pharmacodynamic response is possible.

Platelet aggregation inhibitors and non-steroidal anti-inflammatory drugs (including acetylsalicylic acid) increase the risk of bleeding.

When transferring a patient from warfarin to rivaroxaban and vice versa, the prothrombin time increases.

Terms and conditions of storage

Store at temperatures up to 30 ºС out of the reach of children.

Shelf life – 3 years.

spravka03.net

Xarelto - instructions for use, analogues, reviews

Xarelto is a direct acting anticoagulant. Available in the form of film-coated tablets containing 10, 15 and 20 milligrams of the active substance. The active substance is micronized rivaroxaban.

Pharmacological action and pharmacodynamics

According to the instructions, Xarelto inhibits factor Xa and also has an anticoagulant effect.

The mechanism of action of Xarelto according to the instructions is direct inhibition of factor Xa. Rivaroxaban is highly selective and has high bioavailability (80-100 percent) when administered orally. Activation through the extrinsic and intrinsic coagulation pathways of factor X to form factor Xa plays the most important role in the coagulation cascade.

Pharmacokinetics

Rivaroxaban is rapidly absorbed - the maximum concentration in the blood is reached within two to four hours after taking the tablet. Once ingested, most rivaroxaban (92 to 95 percent) is bound to plasma proteins, the main binding component being serum albumin.

When administered orally, approximately two-thirds of a dose of rivaroxaban is metabolized and subsequently excreted in equal parts in feces and urine. The remaining third is excreted unchanged by direct renal excretion, primarily due to active renal secretion.

Indications for use of Xarelto

According to the instructions, Xarelto in the form of 10-milligram tablets is indicated for the prevention of venous thromboembolism in people who have undergone major orthopedic surgery on the lower extremities.

Xarelto tablets of 15 and 20 milligrams are indicated for the prevention of systemic thromboembolism and stroke in people with non-valvular atrial fibrillation, as well as for the treatment of pulmonary embolism and deep vein thrombosis, for the prevention of recurrent PE and DVT.

Contraindications to the use of Xarelto

According to the instructions, Xarelto is contraindicated in:

Hypersensitivity to the active substance (rivaroxaban) or any other substances contained in the tablets;
Intracranial, gastrointestinal or other bleeding;
Concomitant treatment with any other anticoagulants;
Conditions in which there is a high risk of major bleeding;
Pregnancy and lactation period;
Liver diseases in which coagulopathy is observed;
Under the age of eighteen;
Severe renal failure;
Hereditary galactose or lactose intolerance.

Xarelto is a direct-acting anticoagulant.

This group of drugs helps suppress blood clotting activity and prevents thrombosis due to reduced fibrin formation.

They affect the biosynthesis of certain elements of the body, allowing changes in blood viscosity, which leads to inhibition of clotting processes. The anticoagulant Xarelto can be used for both therapeutic and prophylactic purposes.

Clinical and pharmacological group

Direct acting anticoagulant.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

Prices

How much does Xarelto cost? average price in pharmacies it is at the level of 1,500 rubles.

Release form and composition

Xarelto is available in the form of tablets coated with a special soluble film coating with a pink-brown or red-brown coating. They are round and have biconvex sides with engraving. At their fracture, a homogeneous white mass is visible, which is surrounded by a colored soluble shell.

The drug tablet contains: micronized rivaroxaban in an amount of 10, 15 or 20 mg, and auxiliary components: microcrystalline cellulose, croscarmellose sodium, hypromellose 5cP, lactose monohydrate, magnesium stearate and sodium lauryl sulfate.
The film coating of the tablet shell consists of: red iron oxide dye, hypromellose 15cP, titanium dioxide and macrogol 3350.

Packages from 5 to 100 pieces are offered for sale.

Pharmacological effect

The active substance of this drug, rivaroxaban, is characterized by rapid action, a predictable dose-dependent response and high bioavailability. In this case, monitoring of coagulation parameters is not required, and there is virtually no risk of incompatibility with other foods or medications.

Xarelto is used as a preventative against stroke in patients suffering from atrial fibrillation, while showing good efficiency and portability. This anticoagulant can be taken once a day, following a fixed dose.

Rivaroxaban has a high absolute bioavailability of 80–100%. The main component is quickly absorbed with the onset of maximum concentration after 2-4 hours. Once in the body, there is a significant connection of the main part of rivaroxaban with blood plasma proteins, namely plasma albumin. The drug is excreted primarily in the form of metabolites.

Indications for use

A prophylactic agent for venous thromboembolism in people who have undergone significant surgical interventions on the lower extremities. For orthopedic interventions, the use of 10 mg tablets is recommended.

Xarelto 15 and 20 mg is used as a prophylactic agent for non-valvular atrial fibrillation. In this case, the drug helps prevent systemic thromboembolism and stroke.

The drug is used to treat deep vein thrombosis and pulmonary embolism and as a prophylactic agent to prevent recurrences of pulmonary embolism and deep venous thromboembolism.

Contraindications

General contraindications for Xarelto tablets:

Children and adolescents up to 18 years of age;
Pregnancy;
Breastfeeding period;
Hypersensitivity to the components of the drug;
Liver diseases occurring with coagulopathy, causing a clinically significant risk of bleeding;
Severe renal failure (creatinine clearance less than 15 ml/min);
Clinically significant active bleeding (for example, intracranial and gastrointestinal);
Congenital lactase deficiency, glucose-galactose malabsorption, lactose intolerance;
Concomitant treatment with any other anticoagulants, for example, oral anticoagulants (dabigatran, warfarin, apixaban), low molecular weight heparins (dalteparin, enoxaparin), unfractionated heparin (UFH), heparin derivatives (fondaparinux); The exception is when a patient is transferred from or to Xarelto therapy, or when low-dose UFH is prescribed to maintain patency of a central venous or arterial catheter.

Contraindications to the use of tablets, depending on the amount they contain active substance:

“2.5”: treatment of acute coronary syndrome with antiplatelet agents in patients who have suffered a transient ischemic attack or stroke;
"10", "15" and "20": injury or condition in which there is an increased risk of major bleeding (eg, aneurysms or vascular pathology of the spinal cord or brain, eye, brain or spinal cord surgery, arteriovenous malformations, recent brain injury or spinal cord, intracranial hemorrhage, suspected or diagnosed varicose veins of the esophagus, the presence malignant tumors with a high risk of bleeding, recent or existing gastrointestinal ulcer);
“10”: cases where surgical intervention for a femur fracture is indicated.

Conditions/diseases for which Xarelto tablets are prescribed with caution:

Simultaneous use with drugs that affect hemostasis;
Severe renal failure (creatinine clearance 15-29 ml/min), due to the possibility of increasing the concentration of rivaroxaban in the blood plasma;
Systemic therapy antifungal drugs azole group or human immunodeficiency virus protease inhibitors, with the exception of fluconazole;
Moderate renal failure (creatinine clearance 30-49 ml/min), in which patients receive medicines, increasing the concentration of rivaroxaban in the blood plasma;
Increased risk of bleeding: including bronchiectasis or history of pulmonary hemorrhage, congenital or acquired bleeding tendency, peptic ulcer and duodenum in the acute phase, recent acute peptic ulcer of the stomach and duodenum, vascular retinopathy, uncontrolled severe arterial hypertension, pathology of the spinal cord or brain vessels, recent intracerebral or intracranial hemorrhage, after recent surgery on the eyes, brain or spinal cord).

Use during pregnancy and lactation

Studies related to the safety and effectiveness of Xarelto during pregnancy were conducted in animals. As a result, the toxic effects of rivaroxaban on the body of the expectant mother and child were revealed. The medicine is contraindicated during pregnancy due to high risk penetration of the active substance through the placenta and the possibility of bleeding. For women of childbearing age, the medication is allowed only when using contraception.

Results of studies on the possibility of taking Xarelto with breastfeeding conducted on animals have shown that active substance excreted in milk. Experiments have proven that during feeding, toxic substances can enter the child’s body. It is allowed to start taking Xarelto only after the end of the lactation period.

Dosage and method of administration

The instructions for use indicate: Xarelto tablets of 10 milligrams are taken regardless of meals, 15 and 20 milligrams are taken with meals.

After major operations on the knee joint, the duration of treatment is two weeks, after major operations on the hip joint – five weeks. The initial dose is taken six to ten hours after surgery if hemostasis is achieved. The therapeutic dose is one tablet per day.

If you miss a dose, take the Xarelto tablet immediately and continue taking the drug regularly the next day as directed. To compensate for a missed dose, doubling the dose taken is prohibited.

Side effects

During the course of drug therapy in patients with hypersensitivity The following side effects were observed with Rivaroxaban:

Hematuria;
Hemoptysis, frequent nosebleeds;
Peripheral edema;
Fever;
General weakness, malaise;
Possible hemorrhages in the eyeball;
Impaired liver function, development of jaundice;
Increased level of liver transminase activity;
Increased bilirubin concentration;
Allergic skin reactions - itching, urticaria, rashes, hemorrhages under the skin;
From the hematopoietic system – development iron deficiency anemia, thrombocytopenia;
Headaches, fainting, dizziness, hemorrhages in the brain;
From the heart and blood vessels - decreased blood pressure, formation of bruises and hematomas under the skin, in rare cases, tachycardia;
From the authorities digestive tract– dyspepsia, flatulence, nausea, dry mouth, bleeding gums, exacerbation chronic diseases digestive canal, the risk of developing gastrointestinal bleeding.

Overdose

In case of an overdose of the drug, no bleeding or other adverse reactions were recorded. With excessive doses (50 mg and above), limited absorption of the drug is possible, leading to the formation of a concentration plateau without a further increase in the average concentration of rivaroxaban in plasma.

If bleeding occurs, it is necessary to postpone the next dose of the drug or cancel treatment for 5–13 hours. Treatment is selected individually, depending on the severity and location of the bleeding. If bleeding cannot be eliminated, specific reverse-acting procoagulant drugs (prothrombin complex concentrate, activated prothrombin complex concentrate, or recombinant factor VIIa) can be used.

special instructions

During the use of the drug, it is important to regularly monitor blood coagulation parameters.

In general, Xarelto does not affect driving ability. In extremely rare cases, undesirable reactions are observed in the form of impaired attention and general malaise, which requires caution.

In elderly patients, the likelihood of bleeding increases while using Xarelto. Therefore, careful dose selection is required.

Before execution surgical operations It is important to discontinue the use of the drug at least one day before their start.

Drug interactions

You should refrain from joint application rivaroxaban and dronedarone, since there are no clinical data on this combination.

It has been established that Clarithromycin, Erythromycin and Fluconazole may lead to variable changes in rivaroxaban concentrations, but this is considered to be within the order of normal variability and is not clinically significant.

The simultaneous use of Xarelto with the strongest inhibitors of the CYP3A4 and P-gp isoenzymes can cause a decrease in renal and hepatic clearance, which leads to a significant increase in systemic exposure and pharmacodynamic action of the drug.

Taking Xarelto and rifampicin, which is a strong inducer of CYP3A4 and P-gp, leads to a decrease in the pharmacodynamic effects of the drug. Therefore, treatment with this drug with other strong inducers should be carried out with caution.

Result: positive feedback

20 +

Slow, but safe

Advantages: Effective, safe

Disadvantages: Price, slow action, difficult to find

Before that I used Warfarex (this is also an anticoagulant, but indirect action) - the drug is certainly very effective, but not safe and extremely inconvenient. It must be taken under constant monitoring, with tests every 2 weeks and strictly according to the schedule, otherwise it leads to blood clotting disorders and, consequently, to hemorrhages in various organs. That's why I chose to switch to Xarelto, which does not have such disadvantages. It does not change the composition of the blood dramatically, so this remedy can even be used for a long time drink without fear. I took it for three whole months, and there were no hemorrhages, and in general, no side effects. If we compare Xarelto with Warfarex in this vein, the second one unconditionally loses - Warfarex at one time caused me not only numerous hemorrhages, but also serious problems with the liver and stomach, namely toxic poisoning and gastritis. In terms of effect, Xarelto is slightly behind Warfarex - due to the fact that it acts more slowly. If Warfarex eliminated two-thirds of the blood clot in less than two months, but Xarelto dealt with the remaining third in all three months. But I managed it once, and without causing harm to the body, twice, so, despite its high cost, I recommend it to you.

Result: negative feedback

It's better to buy Warfarin

Advantages: None

Disadvantages: Super expensive, weak effect, strong side effects

At the beginning of this year, I was diagnosed with a blood clot, and from that moment my ordeal began. The first drug that was prescribed to me was Xarelto - the doctor assured that the drug was the newest, most effective and harmless. In fact, everything turned out just the opposite. In 3 months, the only thing that was achieved was a reduction in blood clots by 12%. Considering the amount of money spent and the duration of treatment, this is simply a ridiculous result. Meanwhile, this “newest” drug has a huge number of side effects - it caused me abdominal pain, very strong attacks of nausea and vomiting, weakness, problems with urine output ( bladder overcrowded, but I can’t go to the toilet) and at the end of treatment it led to hemorrhage in the eye. After such a sad outcome, another doctor prescribed me Warfarin, a drug that costs tens of times less than Xarelto. In 3.5 months he managed to rid me of a blood clot, and as for side effects, except for rare dizziness, I didn’t notice anything. The conclusion is simple - new and super-expensive is not always better than proven and cheap.

Result: positive feedback

There are some disadvantages, but they are minor

Advantages: Needs to be taken only once a day, effective for prevention, did not cause anything other than mild nausea

Disadvantages: I wouldn’t call it affordable, expensive, can lead to ulcers or gastritis if taken before meals

The advantages of Xarelto are the following: it is easy to use, you only need to take one tablet a day, for people like me who forget to take medications 3-4 times a day, this is it. The drug is really effective - I take it in courses for prevention (I have diabetes, therefore, increased clotting), and after two months of treatment I managed to bring the level of platelets in my blood to normal. If the dose is set correctly and the duration of treatment does not exceed 2-3 months, problems with blood clotting do not occur - at first I was afraid that I would start bleeding from any wound, but this did not happen. Another advantage of Xarelto is that it is quite well tolerated - at least in my case, nothing was found other than mild nausea. The drug also has disadvantages, but they are not critical. The first thing that catches your eye is the high price. But given the effectiveness of the drug, it seems to me that it is forgivable. Secondly, Xarelto corrodes the walls of the stomach, so if you drink it before meals, gastritis or even an ulcer is guaranteed. There is a simple way out - take the drug only after a heavy snack, and also use drugs like Omez. The third and final disadvantage is due to the fact that Xarelto is the newest drug, finding it in pharmacies is almost impossible. Here I advise you to turn to online pharmacies, as the product has no other disadvantages.

Result: negative feedback

Advantages:

Flaws:

The best there is so far. Thromboembolism of both branches and small arteries, the doctors said we’ll do everything and called the relatives, come. Then 4 days of resuscitation in two hands with heparin every 4 hours, blood from a vein. Heparin in the stomach, other drugs in the backside. Oxygen in the nose day and night. Perindopril 4 mg daily and Xarelto 20 mg were pumped out. At first they said 6 months and then for life. in Krasnodar xarelto 20 mg 8100 rub. I drink very often. If you drink, the doctors have categorically forbidden you to take warfarin. and Xarelto is saving me so far. Wait, in 1818 the Germans will run out of license for Xarelto and everyone except the lazy will produce it, even us. The price will drop greatly.

Nina Zavalnyuk Reply

Very good drug. I had a blood clot under my knee, the doctor said only Xarelto would save me. I DRINKED IT FOR ALMOST A YEAR, IT’S EXPENSIVE, BUT I WANT TO LIVE. A YEAR AFTER THERE IS NOTHING LEFT FROM THE THROMBUS. 2 years passed, I went to Crimea, drove for 10 hours, and problems began with veins in the same leg. The doctor said again, take Xarelto for life, because thick blood. I WILL TAKE XARELTO AGAIN.

Result: negative feedback

Only made the problem worse

Advantages: No

Disadvantages: Crazy price, no benefit, could only be found in an online pharmacy

I took this remedy for about three months and was not delighted. Firstly, it’s expensive - a package that lasted me for two weeks cost about 2,720 rubles. During these three months, I lost a lot of money, as you can imagine. And it would be okay, it was not in vain, but this drug is not worth the money at all. This is the second thing - Xarelto is ineffective. By the time I was discharged from the hospital, having been treated and fed with pills, I still had a specific “bloody” cough, and I was breathing with difficulty, plus my lungs hurt quite noticeably. He couldn’t cope with these symptoms even after 3 whole months - the signs of thromboembolism and not only did not disappear, they did not even weaken! I’ll tell you even more - it was becoming harder and harder for me to breathe, I was constantly dizzy and at night I woke up from attacks of suffocation. I had to go to the hospital again, and after examinations they found out that my thrombosis had only worsened - the benefits that hospital treatment brought were practically destroyed as a result of Xarelto’s inaction. The money was wasted, there was no benefit from the drug, the time that I could have spent on treatment was more effective medicine, missed - after this I certainly won’t recommend it to anyone.

Result: positive feedback

Got rid of a blood clot

Benefits: Effectively eliminates blood clots

Disadvantages: High price, necessary long treatment, causes bleeding, difficult to find on sale

Four years on birth control pills They brought me to thrombosis - my right leg began to swell, go numb and turn blue. The doctor performed a duplex ultrasound, said that before the operation we should try to get by with medications and prescribed Xarelto for six months. To be honest, few people can afford such treatment; I spent about 18,200 rubles in six months. To save money, I always took a large package of 100 tablets - small packages are even more expensive. I didn’t expect a quick effect, however, after about two months of treatment, my seizures stopped, and the pain almost halved. If we judge the effectiveness in general, Xarelto really works, and works well. I underwent a control ultrasound twice – at the end of the third and sixth months of treatment. The fact that the blood clot had shrunk was noticeable already during the first examination, and the second revealed that the blood clot had been completely eliminated, so the remedy coped with its task 100 percent. It just has one big drawback - Xarelto causes bleeding. I had to remove one tooth during treatment, and after the procedure the doctor was able to stop the bleeding only with an injection - it did not clot on its own. And my periods turned into real torture - they became very long and heavy, which is why I started to get anemia. Therefore, I will give you two pieces of advice - don’t even think about doing any surgery while taking Xarelto, and also be sure to take iron supplements in a parallel course to avoid anemia.