Heparin-Acrigel is an affordable remedy against varicose veins. Heparin-Acrigel - an affordable remedy against varicose veins Composition and form of release

Heparin Acrigel is a drug that is part of the conservative treatment of diseases caused by varicose veins veins The medication belongs to the group, due to which it accelerates the blood clotting process. It is intended for external use because it can effectively eliminate swelling, local inflammatory process and improve tissue microcirculation. What are the indications for use? How to use the product correctly to achieve a quick effect?

Components of the drug

Heparin Acrigel 1000 is a gel-based drug. Active substance The product contains sodium heparin at a concentration of 1000 IU. Thanks to the active component, they are revealed medicinal properties gel, which consists in reducing the activity of thrombin, which promotes platelet aggregation.

The drug is produced in aluminum tubes containing a transparent gel with a specific odor

In addition to the main substance, the gel includes auxiliary components:

• Methyl parahydroxybenzoate (inhibits the growth and development of pathogenic microflora).
• Carbomer (cosmetic powder used to thin the consistency).
• Trometamol (thanks to diuretic effect, eliminates swelling of intracellular tissue).
• Ethanol(has antiseptic properties).
• Lavender oil (helps improve tissue microcirculation, and also has bactericidal, antiseptic, antispasmodic properties).
• Nerol oil (eliminates swelling, spasm and soreness).
• Distilled water.

The absorption of the active components of the product is slow, so its regular use does not lead to an overdose.

Pharmacological effects

When used externally, the gel penetrates the skin, where the active substances begin to act within a few hours. Due to the local action of the drug, it directly affects the area pathological process, eliminating symptoms resulting from the formation of blood clots in a blood vessel. Heparin activates metabolic processes in tissues, which improves microcirculation of the affected area.

Penetrating through the skin, Heparin enhances the process of clot destruction

The drug has the following pharmacological effects:

• Antithrombic. Reduces the incidence of vascular thrombosis and promotes the resorption of already formed blood clots.
• Antiexudative. Removes excess tissue fluid, eliminating swelling.
• Anti-inflammatory. Helps reduce inflammation in the affected area.

Regular use of the drug can reduce the risk of progression of varicose veins, which allows long time do not resort to surgical intervention.

Mechanism of action

The mechanism of action of the drug is based on the antiplatelet and anticoagulant properties of the active substance. After application to the skin, the combined composition of the drug is gradually absorbed into the bloodstream, where it activates the anti-clotting protein. After activation of this mechanism, the transformation of prothrombin into thrombin is disrupted, thrombin activity decreases and the degree of platelet aggregation decreases.

Neroli oil has a tonic and anti-sclerotic effect on blood vessels

Heparin has the property of inhibiting the formation of fibrin in the blood, which inhibits local tissue immunity and serves as the basis for the formation of clots. It also promotes the resorption of formed blood clots by accelerating blood circulation in small vessels and stimulating metabolic processes in tissues.

In what cases is it used?

The drug is used for prophylactic and therapeutic purposes in pathological conditions, accompanied by the formation of a blood clot in the lumen of peripheral and coronary vessels.

The gel can be used during exacerbation of hemorrhoidal disease in the acute stage

Experts prescribe the gel for the following diseases:

• thrombophlebitis of superficial vessels;
• local infiltrates;
• swelling of soft tissues;
• joint and tendon damage;
• injury connective tissue and joint;
• trophic ulcer of the leg;
• post-infectious hematomas;
• superficial mastitis;
• lymphedema.

Instructions for use Heparin Acrigel 1000 contains recommendations for correct use liniment intended exclusively for external application.

The product is recommended to be applied to clean and dried skin directly to the affected area.

To achieve maximum therapeutic effect, you should adhere to the following recommendations:

• The amount of gel is calculated so that an equal amount of product is applied to a skin area with a diameter of 3-5 cm.
• The product is applied in a thin layer, rubbed in with soft circular movements.
• The drug is taken daily 1 to 3 times a day.

The duration of the therapeutic course depends on regeneration skin and the rate of thrombus resorption. As a rule, the duration of treatment is determined by the attending physician based on diagnostic data. On average, it ranges from several days to 1 week or until the inflammatory process is completely eliminated.

The use of the gel is contraindicated in the presence of open wound surfaces, hemorrhages, purulent processes and impaired blood clotting.

Features of use for hemorrhoids

The effectiveness of the gel has been proven in the treatment of hemorrhoids. The drug is used in both acute and chronic forms of the pathological process. Regular application of Acrigel 1000 during exacerbation of hemorrhoids serves as a prevention of thrombosis hemorrhoids, reduces inflammation, pain, and also eliminates swelling of the soft tissues of the rectal opening. The treatment regimen is selected individually for each patient, taking into account the severity and stage of the pathology.

The gel is used for the treatment of external and internal forms of hemorrhoidal disease

Method of use of the drug for external hemorrhoidal formations:

• Before applying the product, it is necessary to carry out hygienic procedures in the anal area, without using aggressive detergents.
• A small amount of gel is applied to a bandage or cotton pad.
• The compress is placed on the inflamed area.

For internal hemorrhoids, the following method of applying liniment is used:

• The rectum should be cleaned by first administering a microenema, and then carry out hygienic procedures.
• Make a rectal swab in the form of an oblong cone from a sterile piece of gauze.
• Soak the tampon with ointment and insert it into the rectal canal in a circular motion to a depth of 2-3 cm.

When inserting a medicated tampon into the anal canal, patients should be careful, as there is a risk of injury to the cavernous formations and the development of bleeding. In the acute phase of the disease, rubbing liniment is prohibited, as this can cause rupture of the vascular wall.

The therapeutic course is about two weeks, and the number of applications varies from 2 to 3 times a day.

The ointment should be taken with caution by patients who suffer from arterial hypertension, diabetes, and bronchial asthma. Dose adjustment is carried out for tuberculosis in the active phase, liver failure, during radiation therapy.

During therapy, it is recommended to monitor blood clotting parameters

Precautions must be taken in elderly patients, especially women. During pregnancy, the drug is prescribed if beneficial features exceed possible harm, however, in accordance with strict indications.

What can be replaced

Analogs medicine, drugs with similar indications for use, pharmacological effect, as well as the mechanism of action. However, the concentration of the active substance may differ slightly, which affects the cost of the product. As a rule, more expensive substitutes contain additional components that enhance the effect of the active substance. It is necessary to replace liniment only after consultation with a specialist.

Review of the most popular analogues of the drug:

• Lyoton 1000. The active substance is sodium heparin, which prevents blood clotting and resolves formed blood clots. The drug is used for disorders venous outflow, thrombophlebitis.
• Heparin ointment. The active ingredient is heparin, which destroys clots and prevents the formation of new ones. The content of benzyl nicotinate causes dilation of the vascular wall, which improves the absorption of heparin.
• Venolife. The combined composition of the drug contains two active components: sodium heparin and dexpanthenol. There is an improvement in tissue metabolism, restoration of damaged tissue, and increased absorption of heparin.

Hepatothrombin is an effective substitute that can have analgesic and antiseptic effects

Heparin Acrigel 1000 is used for diseases caused by thrombosis blood vessels, and to eliminate associated symptoms. Regular use of the gel allows you to achieve remission of varicose veins, as well as prevent its progression. However, the product must be used as prescribed by a specialist, with regular monitoring of the blood coagulation system.

Instructions for use medicinal product

Trombless ®

Trombless

Heparin-Akrikhin 1000

gel for external use

Heparin-Akrikhin 1000 -1000 IU (0.00833 g with sodium heparin activity 120 IU/mg);

ethanol (ethyl alcohol), methyl parahydroxybenzoate (nipagin, methylparaben), propyl parahydroxybenzoate (nipazole, propylparaben), diethanolamine (2,2-iminodiethanol), carbomer (carbopol), water (purified water) - up to 1 g.

The gel is colorless or with a slight yellowish tint, transparent, with a specific odor.

Direct acting anticoagulant for local application

Direct anticoagulant, has anti-inflammatory, antiproliferative, anti-edematous and analgesic effects. Reduces platelet aggregation, binds to antithrombin III, preventing the transition of prothrombin to thrombin. Inhibits thrombin activity. Reduces the activity of hyaluronidase, increases the fibrinolytic properties of blood. Trombless

improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and blood clots, ultimately restoring the patency of veins, clinically this is accompanied by a pronounced analgesic and anti-inflammatory effect.

A small amount of heparin is absorbed from the skin surface into the systemic circulation. The maximum concentration of heparin in the blood is observed 8 hours after application. Heparin is primarily eliminated through the kidneys, with a half-life of 12 hours.

Thrombophlebitis of superficial veins; localized infiltrates and swelling of soft tissues; subcutaneous hematomas (including hematomas after phlebectomy), injuries and bruises of joints, tendons, and muscle tissue.

Contraindications

Hypersensitivity to the components of the drug; ulcerative-necrotic, purulent processes on the skin; traumatic violation of the integrity of the skin; increased tendency to bleeding, thrombocytopenia.

The drug can be used during pregnancy and lactation if the potential benefit to the mother outweighs the risk to the fetus and child.

Externally. A column of gel 3-10 cm long is applied with light rubbing movements to the skin over the affected area 1-3 times a day. The gel is used daily, on average from 3 to 7 days. The duration of treatment is determined by the doctor.

Side effects

With long-term use of the drug, it is possible local reactions in the form of skin hyperemia, allergic reactions.

Overdose

Due to low systemic absorption, overdose is unlikely.

Combined use of the gel with indirect anticoagulants may cause prolongation of prothrombin time.

The gel is not prescribed topically at the same time as nonsteroidal anti-inflammatory drugs, tetracyclines, or antihistamines.

special instructions

The drug should not be used for bleeding, as well as on open wounds, mucous membranes and purulent processes.

Release form

Gel for external use 1000 IU/g. 10, 20, 30, 40, 50 g in aluminum tubes or polyethylene laminate tubes. Each tube along with instructions for medical use The drug is placed in a cardboard pack.

Storage conditions

At a temperature not higher than 25 °C.

Keep out of the reach of children.

Best before date

3 years. Do not use the drug after the expiration date.

Vacation conditions

Over the counter.

OJSC "Nizhpharm", Russia

603950, Nizhny Novgorod,

GSP-459, st. Salganskaya, 7

The information on the page was verified by physician-therapist E.I. Vasilyeva.

DETAILS: What is heparin ointment used for?

Manufacturer of the drug - JSC Chemical and Pharmaceutical Plant AKRIKHIN Russia

Heparin Acrigel 1000 is a heparin-based gel. This means that the composition includes the active substance - sodium heparin, in a dosage of 1000 IU - this is a direct-acting anticoagulant, a component that slows down blood clotting and also dissolves existing blood clots.

In addition to heparin, the composition also contains:

• Methyl parahydroxybenzoate (has an inhibitory effect on yeast and fungi).
• Carbomer 940, 980 (stabilizer for gel/cream).
• Trometamol (prevents the appearance of edema, has a diuretic effect).
• Ethanol.
• Lavender oil (can have anticonvulsant, bactericidal, antiseptic and restorative effects). Thanks to it, microcirculation improves.
• Nerol oil (can have anticonvulsant, antispasmodic and decongestant effects).
• Purified water.

Release form – heparin gel/ointment for external use is available in tubes of 20, 30, 40 or 50 g.

Description of the drug

– Direct anticoagulant, belongs to the group of medium molecular heparins. In blood plasma, it activates antithrombin III, accelerating its anticoagulant effect. Disturbs the transition of prothrombin to thrombin, inhibits the activity of thrombin and activated factor X, reduces platelet aggregation to some extent.

For unfractionated standard heparin, the ratio of antiplatelet activity (antifactor Xa) to anticoagulant activity (APTT) is 1:1.

Increases renal blood flow; increases cerebral vascular resistance, reduces the activity of cerebral hyaluronidase, activates lipoprotein lipase and has a hypolipidemic effect. Reduces the activity of surfactant in the lungs, suppresses excessive synthesis of aldosterone in the adrenal cortex, binds adrenaline, modulates the ovarian response to hormonal stimuli, and increases the activity of parathyroid hormone.

There is evidence that heparin has immunosuppressive activity.

In patients with coronary artery disease (in combination with ASA) it reduces the risk of developing acute thrombosis coronary arteries, myocardial infarction and sudden death. Reduces frequency repeated heart attacks and mortality of patients who have had myocardial infarction. IN high doses effective against thromboembolism pulmonary artery And venous thrombosis, in small cases - for the prevention of venous thromboembolism, incl. after surgical operations.

With intravenous administration, blood coagulation slows down almost immediately, with intramuscular injection - after 15-30 minutes, with subcutaneous administration - after 20-60 minutes, after inhalation the maximum effect is within a day; the duration of the anticoagulant effect is respectively 4-5, 6, 8 hours and 1-2 weeks, the therapeutic effect - prevention of thrombus formation - lasts much longer. Deficiency of antithrombin III in plasma or at the site of thrombosis may reduce the antithrombotic effect of heparin.

When applied externally, it has a local antithrombotic, antiexudative, and moderate anti-inflammatory effect. Blocks the formation of thrombin, inhibits the activity of hyaluronidase, and activates the fibrinolytic properties of the blood. Heparin penetrating through the skin reduces the inflammatory process and has an antithrombotic effect, improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and blood clots and reducing tissue swelling.

Pharmacotherapeutic action

Heparin-Acrigel, thanks to its active component, is able to suppress the formation of blood clots. The cream can also be used for swelling and inflammatory processes on the early stages diseases.

• When used externally, the cream enhances microcirculation in tissues and activates metabolic processes. In this regard, doctors often recommend this gel for veins against bruises, as it effectively resolves hematomas and improves lymphostasis.
• If you use this drug according to the regimen for a long time (only on the recommendation of a doctor), you can get rid of varicose veins in already advanced conditions. Such treatment, in some cases, allows you to get rid of the disease without surgery.

DETAILS: Ziman analogues are cheaper. Ziman - instructions for use

This drug is also effective for hemorrhoids. It is allowed to be used both during exacerbation and during chronic forms diseases. During an exacerbation, Heparin-Acrigel reduces the risk of cavernous vein thrombosis, reduces inflammation, relieves swelling and pain.

1. To obtain a positive effect, doctors recommend using the gel according to the scheme. It must be applied in a thin layer to the anal area 3 times a day. The duration of treatment is at least 3 days. As a rule, treatment is carried out for 2 weeks.
2. Instructions for use indicate the use of Heparin-Acrigel for acute hemorrhoidal thrombosis, as it is able to quickly resolve blood clots and hematomas.
3. For internal hemorrhoids, the drug can be injected into the anus. To do this, you need to smear it on a cotton swab and insert it into the anus. If this treatment option is not suitable for you, you can purchase suppositories containing heparin at the pharmacy.
4. If the patient has an external form of the disease, the gel is applied to a gauze pad and applied to the external bumps using an adhesive plaster.
5. During the acute phase of hemorrhoids, rubbing the gel is prohibited, since this type of application of the cream can provoke a breakthrough of the vascular wall and severe bleeding.

In addition to the above properties, this drug thanks to heparin in the composition, it is often indicated to be used after surgical removal proctological pathologies.

List of analogues

Note! The list contains synonyms for Heparin-Akrikhin 1000, which have a similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from of Eastern Europe: KRKA, Gedeon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

How to apply the gel?

Heparin-Acrigel should be applied to previously clean and dry skin. It is recommended to rub the cream in light circular movements until it is completely absorbed. You are allowed to apply the product no more than 3 times per day.

The course of treatment is several days. As soon as there is an improvement, the swelling and inflammation will go away - the use of the drug must be stopped.

If the patient has a trophic ulcer, the product cannot be applied over it. In this case, the gel is applied to the surface around the wound.

DETAILS: Suppositories for hemorrhoids - inexpensive and effective candles for hemorrhoids with bumps

Side effects

As a rule, the gel is well tolerated and allergies do not occur. In some cases, when applying the cream, the area of ​​application may burn.

1. Patients who use Heparin-Acrigel should know that this gel cannot be used simultaneously with certain medications. Eg:
2. Simultaneous use of this gel with other anticoagulants and NSAIDs can enhance the reduction in blood clotting.
3. Simultaneous use of Heparin-Acrigel with antihistamines, thyroxine, tetracycline group drugs, ergot and nicotine alkaloids significantly reduces their effect.

The product "Heparin-Acrigel 1000", the price of which starts from 124 rubles, is an anticoagulant with a direct effect. The drug promotes the activation of antithrombin III in the blood plasma and the acceleration of its anticoagulant effect. The medication disrupts the transformation of prothrombin into thrombin and inhibits the activity of the latter. To some extent, the drug reduces platelet aggregation.

Mechanism of action

The drug "Heparin" (unfractionated standard) has antiplatelet and anticoagulant activity. The effects appear in a 1:1 ratio. The drug "Heparin-Acrigel 1000" helps to increase renal blood flow. The medication increases cerebral vascular resistance and reduces hyaluronidase activity. The medicine has a lipid-lowering effect. The drug activates lipoprotein lipase and reduces the activity of pulmonary surfactant (a mixture lining the alveoli). The drug suppresses the process of aldosterone synthesis occurring in the adrenal cortex, modulates the ovarian response to steroid stimuli, and binds adrenaline. The medication increases the activity of parathyroid hormone. The medicine interacts with enzymes. Due to this, the activity of pepsinogen, brain tyrosine hydroxylase, and DNA polymerase may increase. At the same time, the effect of pepsin, RNA polymerase, and pyruvate kinase decreases. During use, some degree of immunosuppressive activity of the drug was observed.

Description of effects

In patients with ischemic heart disease (in combination with acetylsalicylic acid) the medicine "Heparin-Acrigel 1000" reduces the likelihood of acute thrombosis in the coronary arteries and myocardial infarction. The medication reduces the incidence of deaths. The drug helps reduce the likelihood of a recurrence of a heart attack in those who have had it. When taken in a higher dosage, the drug is effective for venous thrombosis and thromboembolism in the pulmonary artery, and in a small dosage - for the prevention of these conditions, including postoperative period. When used externally, local antithrombic, antiexudative and anti-inflammatory (to a moderate extent) effects are noted. The medicine "Heparin" (gel) activates fibrinolytic properties in the blood. Penetrating through the skin, the medication reduces inflammation and exhibits an antithrombotic effect. The medicine improves microcirculation and stabilizes metabolic processes in tissues. This, in turn, helps to accelerate the processes of resorption of blood clots and hematomas and reduce swelling.

Pharmacokinetics

When Heparin is administered into a vein, blood clotting is observed almost immediately, into a muscle - after 15-30 minutes, subcutaneously - 20-60 minutes, inhalation - the maximum effect occurs after a day. The duration of the anticoagulant effect is according to the above figures: 4-5, 6, 8 hours and 1-2 weeks. The therapeutic effect, manifested in the prevention of thrombosis, lasts much longer. If there is a deficiency of antithrombin III in the body, the antithrombotic effect may decrease. After subcutaneous administration, the maximum concentration is observed after 3-4 hours. The drug "Heparin" penetrates the placenta quite poorly. This is due to its large molecular weight. The medication is not found in breast milk.

Indications

The drug "Heparin" is prescribed for the treatment and prevention of deep vein and coronary artery thrombosis, pulmonary embolism (against the background of peripheral vascular pathologies, including), thrombophlebitis. Indications include atrial fibrillation (accompanied by embolism), myocardial infarction (acute type), unstable angina, DIC syndrome. The medication is prescribed for the treatment and prevention of microcirculation disorders and microthrombosis, thrombosis in the renal veins, hemolyticouremic syndrome, mitral disease heart (to prevent thrombosis). Indications also include lupus nephritis, glomerulonephritis, and bacterial endocarditis. The medication is used in the prevention of blood clotting during surgery using extracorporeal blood circulation methods during forced diuresis, cytapheresis, peritoneal dialysis, hemosorption, hemodialysis, as well as when flushing venous catheters.

Heparin-Acrigel 1000 product: instructions

The medication in the form of liniment is applied externally. Heparin-Acrigel 1000 is applied in a thin layer to the affected area. 3-5 cm of liniment is designed for an area of ​​3-5 cm in diameter. The product is gently rubbed into the skin. Frequency of use: 1-3 times a day, every day. The medication "Heparin-Acrigel 1000" is applied until the inflammatory manifestation completely disappears. Average duration therapeutic course - 3-7 days. The dosage of other forms of medication is determined individually.

Interaction with other drugs

When used in combination with NSAIDs, antiplatelet agents, and anticoagulants, the anticoagulant effect of the drug Heparin is enhanced. Antihistamines, ergot alkaloids, and the drug “Tetracycline” reduce the activity of the drug. Nicotine also slows down the effect of the drug.

Side effects

TO negative consequences Local use of the drug should include irritation, hyperemia, and soreness. Some patients had allergic reactions when taking Heparin-Acrigel 1000. Feedback from experts, however, is generally positive. Doctors note that side effects rarely occur. Patients generally tolerate therapy well.

Contraindications

Heparin is not recommended for any dosage form with hypersensitivity to its components. Contraindications for the use of liniment include reduced blood clotting and thrombocytopenia. The drug is not recommended for ulcerative-necrotic changes or violations of the integrity of the skin in the intended areas of application. The medication is contraindicated for severe lesions in the liver parenchyma, cirrhosis complicated by esophageal varicose veins. The drug is not prescribed for malignant neoplasms. The medication is contraindicated after recent operations on biliary tract and liver.

special instructions

Caution must be exercised with patients suffering from polyvalent allergies (with bronchial asthma including), arterial hypertension, diabetes mellitus, endocarditis, pericarditis. Dose adjustment may be required for active tuberculosis, liver failure, or during radiation therapy. The medication is prescribed with caution to elderly patients (over 60 years of age), especially women. Dose adjustment may be required in case of renal failure in chronic course. During treatment, blood clotting parameters should be monitored. Caution should also be observed when used externally against the background of bleeding and conditions of increased bleeding, thrombocytopenia. During pregnancy and lactation, the drug is prescribed strictly in accordance with the indications. During therapy, patients should be under constant medical supervision.

Heparin-Acrigel 1000 is one of the few drugs that is actively used in phlebology to strengthen the walls of blood vessels and prevent the formation of blood clots. It shows good results not only during treatment, but also as universal remedy prevention of phlebitis, thrombophlebitis, trophic ulcers and others possible complications varicose veins of the lower extremities.

Let's look at more detailed information about the drug Heparin-Acrigel 1000: instructions for use, composition, indications and contraindications, compatibility with other medications.

Composition of the drug

Main active substance is heparin sodium (dosage 1000 IU), the action of which is aimed at slowing down the process of blood clotting and breaking down the resulting blood clots.

Additional substances in the composition of the drug:

• Trometamol is a diuretic that has the ability to eliminate swelling.
• Methyl parahydroxybenzoate – has the ability to inhibit yeast and mold fungi.
• Carbomer - acts as a stabilizer and thickener in the gel.
• Ethanol.
• Lavender oil has an anticonvulsant effect and a positive effect on microcirculation, and is also an excellent antiseptic with increased bactericidal and restorative properties.
• Nerol oil – has the ability to prevent tissue swelling, relieve spasms and cramps.

Release form

For the convenience of consumers, the medicine is available in the form of a gel in tubes of 20, 30, 40 or 50 grams and is recommended only for external use during therapy. Release forms - the ointment is not provided by the manufacturer.

pharmachologic effect

The main functional ability of Heparin-Acrigel (dosage 1000 IU) is blocking the formation of blood clots, as well as an anti-inflammatory and decongestant effect. These functions are provided through:

1. Decreased hyaluronidase activity.
2. Increasing the activity of fibronilistic properties of blood.
3. Blocking thrombin formation.

When used locally, Heparin-Acrigel can enhance microcirculation and metabolic processes in tissues. Thanks to this, the rate of resorption of blood clots and bruises increases several times, hematomas disappear within a few days.

In addition to the main functions, Heparin-Acrigel performs a number of related functions:

• Reduces blood clotting during operations when extracorporeal methods are used.
• It is one of the components of treatment for hemodialysis, hemosorption, and forced diuresis.
• Has the ability to activate lipoprotein lipases.

Indications for use

Indications for use are the presence of diseases such as:

1. Deep vein thrombosis of the lower extremities.
2. Thrombophlebitis of superficial veins.
3. Impaired blood microcirculation.
4. Microthrombosis.
5. Injuries to tendons, muscle tissue, joints that do not violate the integrity of the skin.
6. Other diseases of the circulatory and cardiovascular systems.

Contraindications

Contraindications to gel treatment are:

• Individual intolerance to one or more components of the drug.
• Blood clotting disorders.
• Frequent bleeding.
• Possibility of internal bleeding.
• Aneurysm of the aorta or cerebral vessels.
• Diseases of the gastrointestinal tract and liver.
• Ischemia of the brain or heart.
• Recent surgical interventions.
• Arterial hypertension.
• Childbirth, menstruation or threatened miscarriage.

For people who suffer from diabetes, tuberculosis, acute renal or liver failure, as well as certain types of cardiovascular diseases, treatment with Heparin-Acrigel is recommended under regular and constant monitoring level of blood clotting, which should be carried out in laboratory conditions. If the level of coagulation decreases by 2 times, then the use of the drug should be stopped.

Before 12 years of age and after 60 years of age, treatment with Heparin-Acrigel is not recommended and can be prescribed by a specialized specialist only in case of urgent need under constant supervision and control.

In the 2nd and 3rd trimester, treatment with the drug is often approved by doctors, but the 1st trimester and the last weeks before childbirth are obvious contraindications. The decision to use the gel during therapy remains with the attending physician and is carried out only under his supervision.

Mechanism of use

The correct technique for using the gel is indicated in the instructions for use:

1. The gel is applied to previously cleansed and dry skin.
2. The dosage of the drug is 0.5-1 grams per 10-20 cm2 of the affected skin area - this figure is average and can be adjusted by the attending physician depending on the indications.
3. Application of the product should be carried out with light movements in a circle (without patting) until completely absorbed.
4. The frequency of use is a maximum of 3 times within 24 hours.
5. The course of treatment lasts several days (on average 3-7 days) and is stopped immediately after swelling, inflammation or other symptoms of the disease disappear (in some cases, the treatment period can be extended by the attending physician based on individual indications).
6. Application of the product to open trophic ulcers is not recommended; the best option is to treat the wound with gel around the perimeter.

After the drug enters the body, a slowdown in blood clotting begins to be observed almost immediately.

Compatibility with other tools

The use of Heparin-Acrigel together with NSAIDs (non-steroidal anti-inflammatory drugs) and anticoagulants can reduce blood clotting many times over. And parallel use with antihistamines and drugs of the tetracycline group, thyroxine, and ergot alkaloids has the completely opposite effect - the decrease in blood clotting occurs much more slowly.

Smoking tobacco products with a high nicotine content can also slow down the direct effect of Heparin.

Overdose and adverse reactions

Explicit adverse reactions from the use of the drug during clinical studies was not noted, since its effect is local, and the level of absorption into the blood is minimal. Because of this, an overdose from the use of this drug is also excluded.

In some cases, a slight burning sensation may be observed at the site of use, which quickly passes without leaving any traces.

Price

The average price of a 30 gram tube of gel in the Russian Federation is 250-270 rubles and can vary depending on the city, the form of ownership of the pharmacy and the manufacturer.

Conclusion

More detailed information regarding indications, contraindications, methods of use and side effects is provided in the manufacturer's instructions.

Correct use of Heparin-Acrigel 1000 can provide positive effect and eliminate not only the symptoms of varicose veins, often accompanied painful sensations, but also the disease itself, which occurs in different stages. But this is only possible if the drug is prescribed by a specialized specialist according to a special scheme, based on the patient’s individual indications.

Self-medication with this drug is not recommended, since not every person understands the danger that may be hidden in the medicine if there are hidden or obvious contraindications.

In this article you can read the instructions for use of the drug Heparin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Heparin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Heparin analogues in the presence of existing structural analogues. Use for the treatment of thrombophlebitis, hemorrhoids, varicose veins in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Heparin- direct-acting anticoagulant, belongs to the group of medium molecular heparins. In blood plasma, it activates antithrombin 3, accelerating its anticoagulant effect. It disrupts the transition of prothrombin to thrombin, inhibits the activity of thrombin and activated factor 10, and to some extent reduces platelet aggregation.

For unfractionated standard heparin, the ratio of antiplatelet activity (antifactor 10a) to anticoagulant activity (APTT) is 1:1.

Increases renal blood flow; increases cerebral vascular resistance, reduces the activity of cerebral hyaluronidase, activates lipoprotein lipase and has a hypolipidemic effect. Reduces the activity of surfactant in the lungs, suppresses excessive synthesis of aldosterone in the adrenal cortex, binds adrenaline, modulates the ovarian response to hormonal stimuli, and increases the activity of parathyroid hormone. As a result of interaction with enzymes, it can increase the activity of brain tyrosine hydroxylase, pepsinogen, DNA polymerase and reduce the activity of myosin ATPase, pyruvate kinase, RNA polymerase, pepsin.

There is evidence that heparin has immunosuppressive activity.

In patients with coronary artery disease (in combination with ASA), it reduces the risk of acute coronary artery thrombosis, myocardial infarction and sudden death. Reduces the frequency of recurrent infarctions and mortality in patients who have had myocardial infarction. In high doses it is effective for pulmonary embolism and venous thrombosis, in small doses it is effective for the prevention of venous thromboembolism, incl. after surgical operations.

At intravenous administration blood clotting slows down almost immediately, with intramuscular injection - after 15-30 minutes, with subcutaneous injection - after 20-60 minutes, after inhalation the maximum effect is within a day; the duration of the anticoagulant effect is respectively 4-5, 6, 8 hours and 1-2 weeks, the therapeutic effect - prevention of thrombus formation - lasts much longer. Deficiency of antithrombin 3 in plasma or at the site of thrombosis may reduce the antithrombotic effect of heparin.

When applied externally, it has a local antithrombotic, antiexudative, and moderate anti-inflammatory effect. Blocks the formation of thrombin, inhibits the activity of hyaluronidase, and activates the fibrinolytic properties of the blood. Heparin penetrating through the skin reduces the inflammatory process and has an antithrombotic effect, improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and blood clots and reducing tissue swelling.

Compound

Heparin sodium + Excipients(injections).

Heparin sodium + Benzocaine + Benzyl nicotinate + excipients (heparin ointment).

Heparin sodium 1000 IU + excipients (gel Akrikhin 1000).

There are no other forms, such as tablets.

Pharmacokinetics

Heparin penetrates the placenta poorly due to its high molecular weight. Not excreted in breast milk.

Indications

Prevention and therapy:

• deep vein thrombosis;
• pulmonary embolism (including in diseases of peripheral veins);
• coronary artery thrombosis;
• thrombophlebitis;
• unstable angina;
• acute myocardial infarction;
• atrial fibrillation (including those accompanied by embolism);
• DIC syndrome;
• prevention and therapy of microthrombosis and microcirculation disorders;
• renal vein thrombosis;
• hemolyticouremic syndrome;
• mitral heart disease (prevention of thrombosis);
• bacterial endocarditis;
• glomerulonephritis;
• lupus nephritis;
• prevention of blood clotting during operations using extracorporeal circulatory methods;
• preparation of non-clotting blood samples for laboratory purposes and blood transfusions
• prevention and treatment of superficial vein thrombophlebitis;
• post-injection and post-infusion phlebitis;
• external hemorrhoids;
• inflammation of postpartum hemorrhoids;
• trophic ulcers of the leg;
• elephantiasis;
• superficial periphlebitis;
• lymphangitis;
• superficial mastitis;
• localized infiltrates and edema;
• injuries and bruises without violating the integrity of the skin (including muscle tissue, tendons, joints);
• subcutaneous hematoma.

Release forms

Ointment for external use.

Solution for intravenous and subcutaneous administration (injections in injection ampoules).

Gel for external use.

Instructions for use and dosage

Ampoules

Intravenously (infusion or injection) or subcutaneously (famous injections in the abdomen), initial dose - intravenously (injection) 5000 IU, maintenance: continuous IV infusion - 1000-2000 IU/h (20000-40000 IU/day), pre- diluting in 1000 ml of isotonic NaCl solution; regular IV injections - 5000-10000 IU every 4-6 hours; subcutaneously (deep) - 15,000-20,000 IU every 12 hours or 8,000-10,000 IU every 8 hours.

Ointment

Apply externally. The ointment is applied in a thin layer to the affected area (at the rate of 0.5-1 g (2-4 cm of ointment) per area with a diameter of 3-5 cm) and the ointment is carefully rubbed into the skin. The ointment is used 2-3 times a day every day until the inflammation disappears, on average from 3 to 7 days. The possibility of a longer course of treatment is determined by the doctor.

In case of thrombosis of external hemorrhoids, the ointment is applied to a calico or linen pad, which is applied directly to the thrombosed nodes and fixed. The ointment should be used daily until symptoms disappear, on average from 3 to 14 days; for the same purpose, you can use a tampon soaked in heparin ointment, which is inserted into the anus.

Side effect

• bleeding of the gastrointestinal tract and urinary tract;
• bleeding at the injection site, in areas exposed to pressure, from surgical wounds;
• hemorrhages in organs;
• hematuria;
• thrombocytopenia;
• nausea, vomiting;
• decreased appetite;
• diarrhea;
• skin hyperemia;
• drug fever;
• hives;
• rhinitis;
• itchy skin and feeling of heat in the soles;
• bronchospasm;
• collapse;
• anaphylactic shock;
• thrombocytopenia (can be severe up to fatal outcome) with the subsequent development of skin necrosis, arterial thrombosis, accompanied by the development of gangrene, myocardial infarction, stroke;
• osteoporosis;
• spontaneous fractures;
• soft tissue calcification;
• irritation, pain, hyperemia, hematoma and ulceration at the injection site;
• transient alopecia;
• hypoaldosteronism.

Contraindications

• bleeding;
• diseases accompanied by impaired blood clotting processes;
• suspected intracranial hemorrhage;
• cerebral aneurysm;
• hemorrhagic stroke;
• dissecting aortic aneurysm;
• antiphospholipid syndrome;
• malignant arterial hypertension;
• subacute bacterial endocarditis;
• erosive and ulcerative lesions of the gastrointestinal tract;
• severe damage to the liver parenchyma;
• cirrhosis of the liver with varicose veins of the esophagus;
• malignant neoplasms in the liver;
• states of shock;
• recently held surgical interventions in the eyes, brain, prostate gland, liver and bile ducts;
• condition after spinal cord puncture;
• menstruation;
• threatened miscarriage;
• childbirth (including recent);
• hypersensitivity to heparin.

Use during pregnancy and breastfeeding

Use during pregnancy is possible only according to strict indications, under close medical supervision.

Can be used during lactation ( breastfeeding) according to indications.

special instructions

Use with caution in patients suffering from polyvalent allergies (including bronchial asthma), with arterial hypertension, dental procedures, diabetes mellitus, endocarditis, pericarditis, in the presence of an intrauterine contraceptive device, with active tuberculosis, radiation therapy, liver failure, chronic renal failure, in elderly patients (over 60 years old, especially women).

Use externally with caution for bleeding and conditions of increased bleeding, thrombocytopenia.

During treatment with heparin, monitoring of blood clotting parameters is necessary.

To dilute heparin, only saline solution is used.

If severe thrombocytopenia develops (a decrease in the platelet count by 2 times the initial number or below 100,000/μl), it is necessary to urgently stop using heparin.

The risk of bleeding can be minimized with careful assessment of contraindications, regular laboratory monitoring of blood clotting, and adequate dosing.

The ointment or gel is not applied to open wounds or mucous membranes, and is not used for ulcerative-necrotic processes.

Drug interactions

The anticoagulant effect of heparin is enhanced by the simultaneous use of anticoagulants, antiplatelet agents and nonsteroidal anti-inflammatory drugs (NSAIDs).