Healthy liver in dogs with heptral prophylaxis. "Heptral" for cats: instructions for use Heptral for dogs dosage intravenously

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Pharmacological properties

Pharmacodynamics
Ademetionine belongs to the group of hepatoprotectors and also has antidepressant activity. It has choleretic and cholekinetic effects, has detoxification, regenerating, antioxidant, antifibrosing and neuroprotective properties.
Replenishes the deficiency of S-adenosyl-L-methionine (ademetionine) and stimulates its production in the body; it is found in all environments of the body. The highest concentration of ademetionine was observed in the liver and brain. Plays a key role in the metabolic processes of the body, takes part in important biochemical reactions: transmethylation, transsulfurization, transamination. In transmethylation reactions, ademetionine donates a methyl group for the synthesis of cell membrane phospholipids, neurotransmitters, nucleic acids, proteins, hormones, etc. In transsulfuration reactions, ademetionine is a precursor of cysteine, taurine, glutathione (providing a redox mechanism of cellular detoxification), coenzyme A (included in biochemical reactions of the tricarboxylic acid cycle and replenishes the energy potential of the cell).
Increases the content of glutamine in the liver, cysteine ​​and taurine in plasma; reduces the content of methionine in serum, normalizing metabolic reactions in the liver. After decarboxylation, it participates in aminopropylation reactions as a precursor of polyamines - putrescine (stimulator of cell regeneration and hepatocyte proliferation), spermidine and spermine, which are part of the ribosome structure, which reduces the risk of fibrosis. Has a choleretic effect. Ademetionine normalizes the synthesis of endogenous phosphatidylcholine in hepatocytes, which increases membrane fluidity and polarization. This improves the function of transport systems associated with hepatocyte membranes bile acids and promotes the passage of bile acids into the biliary tract.
Effective for intralobular cholestasis (impaired synthesis and flow of bile). Ademetionine reduces the toxicity of bile acids in hepatocytes by conjugating and sulfating them. Conjugation with taurine increases the solubility of bile acids and their removal from the hepatocyte. The process of sulfation of bile acids facilitates their elimination by the kidneys, facilitates their passage through the hepatocyte membrane and excretion in the bile. In addition, sulfated bile acids themselves additionally protect liver cell membranes from toxic effect non-sulfated bile acids (present in high concentrations in hepatocytes during intrahepatic cholestasis). In patients with diffuse liver diseases (cirrhosis, hepatitis) with intrahepatic cholestasis syndrome, ademetionine reduces the severity of skin itching and changes biochemical parameters, incl. concentration of direct bilirubin, alkaline phosphatase activity, aminotransferases, etc. The choleretic and hepatoprotective effect lasts up to 3 months after cessation of treatment. It has been shown to be effective against hepatopathy caused by various hepatotoxic drugs. Antidepressant activity appears gradually, starting from the end of the first week of treatment, and stabilizes within 2 weeks of treatment.
A number of studies have confirmed the effectiveness of ademetionine in the treatment of increased fatigue in patients with chronic diseases liver. A pooled analysis of data obtained in patients with symptoms of fatigue before treatment showed the effect of treatment with ademetionine in reducing symptoms of fatigue in combination with a number of other symptoms, such as depression, icterus skin and mucous membranes, malaise and itchy skin. Treatment with ademetionine significantly improved mood in patients with alcoholic liver disease, who simultaneously achieved a positive response to symptoms of increased fatigue. In addition, in patients with alcoholic liver disease and non-alcoholic fatty liver disease who achieved a response to treatment with ademetionine in terms of symptoms of increased fatigue, there was also a significant reduction in symptoms such as icterus of the skin and mucous membranes, malaise and itching.

Pharmacokinetics

The tablets are film-coated, dissolving only in the intestines, due to which ademetionine is released into the intestines. duodenum.
Suction
Bioavailability when taken orally is 5%, increases when taken on an empty stomach. The maximum concentrations (Cmax) of ademetionine in plasma are dose-dependent and are 0.5-1 mg/l 3-5 hours after a single oral dose of 400 to 1000 mg. Cmax of ademetionine in plasma decreases to the initial level within 24 hours.
Distribution
The connection with blood plasma proteins is insignificant, amounts to< 5 %.
Penetrates the blood-brain barrier. There is a significant increase in the concentration of ademetionine in the cerebrospinal fluid.
Metabolism
Metabolized in the liver. The process of formation, consumption and re-formation of ademetionine is called the ademetionine cycle. In the first step of this cycle, ademetionine-dependent methylases use ademetionine as a substrate to produce S-adenosylhomocysteine, which is then hydrolyzed to homocysteine ​​and adenosine by S-adenosylhomocysteine ​​hydrolase. Homocysteine, in turn, undergoes reverse transformation to methionine by transfer of a methyl group from 5-methyltetrahydrofolate. Eventually, methionine can be converted to ademetionine, completing the cycle.
Removal
Half-life (T½) - 1.5 hours. Excreted by the kidneys. In studies of healthy volunteers, ingestion of labeled (methyl 14 C) S-adenosyl-L-methionine showed 15.5 ± 1.5% radioactivity in urine after 48 hours and 23.5 ± 3.5% in feces. radioactivity after 72 hours. Thus, about 60% was deposited.

Indications for use

• Intrahepatic cholestasis in pre-cirrhotic and cirrhotic conditions, which can be observed in the following diseases:
  • fatty liver;
  • chronic hepatitis;
  • toxic liver damage of various etiologies, including alcoholic, viral, medicinal (antibiotics; antitumor, antituberculosis and antiviral drugs, tricyclic antidepressants, oral contraceptives);
  • chronic acalculous cholecystitis;
  • cholangitis;
  • cirrhosis of the liver;
  • encephalopathy, incl. associated with liver failure (alcohol, etc.).
• Intrahepatic cholestasis in pregnant women.
• Symptoms of depression.
• Increased fatigue in chronic liver diseases.

Contraindications

Pregnancy (1st trimester) and period breastfeeding(use is possible only if the potential benefit to the mother outweighs the possible risk to the fetus or child).
Simultaneous use with selective inhibitors serotonin reuptake drugs (SSRIs), tricyclic antidepressants (such as clomipramine), and plant origin and drugs containing tryptophan (see section “Interaction with other medicines»).
Elderly age.
Kidney failure.

Use during pregnancy and breastfeeding

Directions for use and doses

The recommended dose is 10-25 mg/kg/day orally.
Intrahepatic cholestasis/ increased fatigue for chronic liver diseases
Depression
The dose ranges from 800 mg/day to 1600 mg/day.
The duration of therapy is determined by the doctor.
Therapy with Heptral® can be started with intravenous or intramuscular injection followed by the use of the drug Heptral® in the form of tablets or immediately with the use of the drug Heptral® in the form of tablets.
Elderly patients
Clinical experience The use of the drug Heptral® did not reveal any differences in its effectiveness in elderly patients and younger patients. However, given the high likelihood of existing liver, kidney or cardiac dysfunction, other concomitant pathology or concomitant therapy with other drugs, the dose of Heptral® in elderly patients should be selected with caution, starting the use of the drug from the lower limit of the dose range.
Kidney failure
There are limited clinical data on the use of Heptral® in patients with renal failure Therefore, it is recommended to exercise caution when using Heptral® in such patients.
Liver failure
The pharmacokinetic parameters of ademetionine are similar in healthy volunteers and in patients with chronic liver diseases.
Children
The use of Heptral® in children is contraindicated (efficacy and safety have not been established).

Impact on the ability to drive a car and operate machinery

Some patients may experience dizziness while taking Heptral®. It is not recommended to drive a car or operate machinery while taking the drug until the patient is confident that the therapy does not affect the ability to engage in these types of activities.

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Registration Certificate Holder

“Heptral” is generally not intended for cats, since it is a human medicine. At the same time, this drug is actively used in veterinary practice, saving cats from ailments that affect the liver. This remedy is considered very effective and can cure an animal, even one in serious condition. The only disadvantage of this unique drug, which has no analogues in terms of effectiveness, is the low-budget cost. Below we will find out in what cases the purchase of this product is justified, when it is prescribed to cats, in what dosage and according to what scheme.

"Heptral" for cats: instructions for use

"Geprtal" is a remedy that treats a variety of diseases that affect the liver. Medicine is prescribed both in the initial stages of illnesses in order to significantly reduce the time of therapy, and in advanced cases. Veterinarians even say that if Heptral does not help the animal, then nothing will help.

"Heptral" is prescribed by veterinarians in cases where a cat is diagnosed with cirrhosis, cholecystitis, hepatitis, or cholestasis. If blood parameters such as bilirubin, urea, AST or ALT are simultaneously exceeded, then other medicinal drugs are added to Heptral.

The main active ingredient of Heptral is ademetionine.

As we found out, Heptral is a medicine from the group of hepaprotectors that has the following properties:

1. Cholestic (regeneration of bile ducts).
2. Cholekinetic (increasing the activity of bile secretion).
3. Antioxidant (removes toxins and other harmful substances from the liver and the whole body).
4. Regenerating, restoring organ cells.
5. Detoxifying.
6. Increases metabolic processes.
7. Plays an important role in many biochemical reactions, improving them and making them more productive.
8. Stimulates the production of L-methionine and S-adenosyl.

However, under no circumstances should you prescribe this strong medicine to your cat on your own. If an animal suffers from liver disease, it needs competent and qualified assistance a veterinarian, who will determine the dosage of Heptral, if it is necessary for treatment.

Only a zoo doctor can prescribe Heptral to a mustachioed patient

Veterinarians prefer to treat ailments affecting the liver of cats with Heptral, calling it universal. Its main advantage is that it is effective on initial stage illnesses, and in advanced cases (brings even hopeless animals back to life).

"Heptral" in tablets or injections: which is better?

"Heptral" is available in two classic form factors: tablet and liquid form. For cats, an injection solution is almost always used, which is injected intramuscularly (possibly at home) or intravenously (through a catheter, only in the clinic).

Despite the fact that it is easier to give a tablet to an animal, the injections act more quickly and effectively, and do not put a strain on other organs, since they do not enter the cat’s gastrointestinal tract. Treatment with the drug in tablet form is prescribed only when the owner does not have the opportunity to give the animal injections himself or take it to the veterinary clinic.

Dosage of Heptral for cats

Since Heptral is not designed for cats, the instructions for use contain only dosage data for humans. That is why a veterinarian should prescribe the drug to animals, based on the diagnosis of the cat, its weight, age and general clinical picture diseases.

For big cats or animals in a neglected state, the dosage of Heptral will be higher than for moustached patients with low body weight or at the initial stage of the disease. It is important to remember: you cannot prescribe Heptral to your cat on your own, since an excessive dose will not only not cure a self-diagnosed illness, but will also put a strong strain on the body.

Table. Approximate dosages of Heptral for cats

Important point! The data presented in the table is statistical information on dozens of animals that were treated with Heptral. In each individual case, the dosage can be changed up or down.

Typically, the course of therapy with Heptral lasts from a week to ten days, after which the animal needs to be tested again and have liver studies performed. Based on the results, the veterinarian can extend treatment up to a month.

"Heptral": side effects, contraindications

When using Heptral, cats rarely experience negative body reactions, but the owner must be prepared for the fact that both tablets and injections can provoke allergies in the pet (itching, swelling, skin reactions), restless behavior, stomach upsets, and vomiting. It is not permissible to take the drug to animals whose biochemical blood test showed a deficiency of vitamin B12; Heptral is also not prescribed to pregnant cats.

As for the interaction of Heptral with other drugs, there are no special contraindications. Caution should be used when combining a hepatoprotector with herbs and medications that contain tryptophan. Therefore, it is imperative to discuss with your veterinarian not only the current prescriptions, but also the advisability of taking other medications if they were previously prescribed to the animal.

"Heptral": storage, special information

"Heptral" in tablets and in "blanks" of solution for injection can be stored for two years if the packaging is intact. A tablet that has been opened from foil and is not needed for some reason cannot be stored. The solution for injection, already prepared, must be stored strictly in the refrigerator and for no more than two days. If the solution changes color to dark, then it has deteriorated.

Video - Preparation of Heptral solution

Analogues, cost of the drug

"Heptral" is the safest and effective medicine, which can help an animal at any stage of liver disease and with almost any form of illness. The advantage of Heptral is that it has no serious side effects, and cases of overdose are negligible. Therefore, it is believed that there are no analogues of this drug for cats. But it is possible to replace Heptral with the drug Heptor, which is similar in composition. In this case, you need to be more careful, since this domestic medicine is contraindicated if the animal has tumors or problems with gallbladder. If finances allow, it is better to purchase Heptral (its cost is about 1,800 rubles for a pack of five ampoules or twenty tablets).

"Heptor" - a partial analogue of "Heptral"

Summarizing

If you listen to the reviews veterinarians and cat owners, we can come to the conclusion: “Heptral” is extremely effective drug. People who treated their pets with this remedy note that already on the second day of therapy the cats feel better, and total percentage complete cure exceeds 95%.

Good afternoon, my good lovers animals and simply interested people!

In this review I want to tell you about human drug, which restored my Plush’s liver (in combination with other medications, where would we be without them, the treatment is complex).

The background is this- in my family there are two beautiful cats: Nika (Nikusya, Kus) - a Scottish straight cat, 6 years old, with all the documents, pedigrees, etc. Almost 5 kg. gray-marble happiness with a harmful character. And my youngest Tosha (Totofan), my doorstep, but no less beloved child, whose story I have already written - My little doorway snow queen Tosha!

If anyone has come across the Scottish Fold breed (straight ears are mandatory part of this breed), then he knows that lop ears are a genetic, cultivated defect of the cartilaginous system, which gives the cat beautiful, adjacent ears, making lop ears vulnerable aliens.

This breed originated in Scotland. The founder of this unusual breed was William Ross, who in 1861 noticed an unusual lop-eared cat, took one of the same kittens from her litter and began targeted crossbreeding to achieve the lop-eared effect.

But nevertheless, since initially it is a developmental defect, therefore, cats of this breed very often have problems with the musculoskeletal system.

As a result of recent in-depth studies, it turned out that mating with the aim of fixing the ear gene also fixed various defects of the musculoskeletal system.

As a result of crossing and mating, the offspring of Scottish cats appears with straight ears (straight) and fold ears (fold). Straight-eared straight cats are also carriers of the lop-eared gene.

So my furry happiness has problems with joints and spine. In this regard, at the beginning of March we went to the Kotonai veterinary clinic for an appointment and an x-ray. The doctor looked at us, the pictures, and prescribed medication. And in order not to take the cat to the veterinary clinic one more time (this is stressful for the animal), I asked us to take blood tests (biochemical and clinical) at the same time. A separate story is the blood draw, after which I found out that Nika is a big greedy person and not a donor at all. Blood was taken only from the third paw. This is where a “surprise” awaited us, which came as a shock to me personally. Liver parameters (AST and ALT) were off the charts, as can be seen from the tests.

After the ultrasound abdominal cavity We were given the following diagnosis: Triaditis syndrome, Liver lipidosis.

They said the condition is not critical, the liver is recovering, but we need to be treated and lose weight too (we were told this after being weighed on scales for adult dogs, since Nika tried to escape from ordinary ones with all the grace of an overgrown elf.

We were prescribed the following medications (with an expectation of almost 5 kg of weight), having stopped the drug for the joints (meloxicam, since it can negatively affect the liver if it is not healthy):

Sinulox(antibiotic for animals) - 1/4 tablet 2 times a day, 14-21 days (about 600 rubles).

Heptral or Heptor(I took Heptor, since giving injections at home is like death) - 1/4 tablet once a day, 14-21 days (900 rubles). This is, in fact, a hepatoprotector that restores the liver.

Ursofalk(suspension) - 1.24 ml. Once a day for 1 month (RUB 1,500). Additionally, I bought a couple of syringes to give the medicine, diluting it with water. Ursofalk is another one excipient for the liver, which normalizes the excretion of bile. Here is a review of Ursofalk:

Well, and the actual veterinary food Hepatik (we are on Hills l/d).

I came home with my shopping, took a sheet of A4 paper, and outlined a schedule for taking medications for a month so as not to get confused and not miss out. To be honest, with a bunch of bottles, pills and prescriptions, my head was threatening to explode. Therefore, the best thing in this case is to systematize the cries of your nervous cockroaches on paper so that they sit, read and follow the recommendations.

Compound Heptora next:

The tablets contain INN S-adenosylmethionine (in terms of ademetionine ). It also contains a number of additional substances: MCC, polyplasdon X El-10 (crospovidone), magnesium stearate, mannitol .

As follows from the instructions, it works Heptor as follows on the body:

Heptor is a hepatoprotective agent, which, moreover, has an antidepressant effect. This remedy has a regenerating, antioxidant, detoxifying, antifibrosing, and neuroprotective effect on the body.

I can’t say anything about the antidepressant; there were no dances with women around the apartment, but Nick started chasing the youngest around the apartment more. And steal all sorts of things from me, playing with them. From which I conclude that it gives vigor and increases the activity of the animal.

The active component of the product is ademetionine . This substance takes part in some biochemical processes in the human body and activates the production of endogenous ademetionine. This substance is found in tissues and also in biological fluids of the body. It participates in biochemical reactions. Ademetionine is also a precursor of polyamines, including putrescine, which stimulates cell restoration and hepatocyte proliferation.

Heptor At first I gave it to Nika, diluting the tablet (1/4) in a small amount of water and injecting it with a syringe (without a needle). The tablets are covered with a yellow insoluble coating, which I peeled off with a knife (in the photo, part of the tablet is daily dose, 1/4).

The cat spat foam at me and disappeared under the bed for a couple of hours, kicking me into karma. I tasted Heptor, it turned out that it was something sour and sour, which would probably make me foam.

I started mixing the daily dose into canned food, and we refused to eat canned food for the third time. Again, I don't care about karma. She sat and looked into my eyes with the air of someone condemned to execution unjustly.

The third attempt to reconcile the cat with Heptor, by trial and error, was to dilute the tablet in enough water to reduce the acidity. I took it with a syringe and poured it into my mouth through the side of my mouth, making 4-5 syringes. Judging by the fact that there was no more foam party at home, this is the most gentle option for giving this medicine. Although still not the most pleasant, judging by the fact that the cat tried to spit at me.

I gave Heptor 21 days, i.e. the maximum prescribed period (in agreement with the doctor, of course).

Two weeks after starting treatment, we went back for both blood tests. Again in the fixation bag and out hind paw. They lay there and screamed, not from pain, but from sincere bewilderment, how could such a thing even happen? beautiful cat you can put her in a straitjacket....I kissed her on the nose, said that this was a necessity, and felt like Judas).

But when the tests were sent to me by email in the evening, when I saw the AST and ALT readings, I howled with joy.

Although there was still inflammatory process, and the antibiotics were extended for another two weeks; we removed the most critical part. Thanks to all the drugs, and of course Heptor, as the main hepatoprotector in our treatment. And immense gratitude to the doctors of our clinic for their responsibility, participation and competent approach to treatment. But that's a different story.

In a couple of weeks we are going to lie in a straitjacket again to take a clinical blood test, but I think everything will be fine.

The drug does not have any serious contraindications, but still:

The drug is not prescribed if the patient has intolerance to a certain component medicine. Treatment with Heptor is carried out with caution in people diagnosed with cirrhosis of the liver, which is associated with hyperazotemia. In this case, treatment is carried out only if constant monitoring nitrogen content in blood plasma.

Be healthy yourself and may your pets be healthy and live long!!!

Hundreds of suppliers bring hepatitis C medications from India to Russia, but only M-PHARMA will help you buy sofosbuvir and daclatasvir, and professional consultants will answer any of your questions throughout the entire treatment.

If your cat has liver problems, it is worth trying a course of treatment with Heptral. Using Heptral for cats, you can achieve positive results quite quickly, despite the fact that this medicine is primarily intended for humans. When other drugs fail, veterinarians often prescribe Heptral, which can cure any liver disease.

When is Heptral prescribed and dosage of the drug?

You should not prescribe Heptral to your pet on your own, since for any liver disease, consultation with a specialist is extremely important. A veterinarian may prescribe this drug for the following diagnoses::

• Hepatitis;
• Cholestasis;
• Cholecystitis;
• Cirrhosis.

The medicine effectively helps at any stage of the disease, even the most advanced. Heptral is good for complex therapy when a cat needs several medications at once.

Of course, the dosage of Heptral for a cat differs from the norm for humans. Only a veterinarian should prescribe the exact dose of the drug for a cat. In many ways, the required amount of the drug depends on the weight of the animal and its condition. If the pet is heavy and has significant liver problems, an increased dose is needed. However, only a qualified specialist will be able to determine when the situation reaches a critical point and loading the body with a large dosage is dangerous.

If a cat weighs 3 kg, as a rule, the standard dose is 0.5-0.7 ml of Heptral intramuscularly 2 times a day. If you do not inject your cat yourself, and can only visit the veterinarian once a day, you can administer 1 ml of the drug once a day. In addition to the injection solution, Heptral is available in tablets, and for an animal weighing 3 kg, 1/5 of a tablet is needed 2 times a day.

If you need instructions for using Heptral for cats and dogs, it is better to contact your veterinarian, who will explain everything in detail. On average, the course of treatment with this drug is 7-10 days, however, depending on the course of the disease, it can last 1 month.

Features of using Heptral for cats

Since Heptral is available for sale in tablets and in solution for injection, pet owners are wondering which form is more convenient for use by animals. Most veterinarians recommend giving injections, since intramuscular or intravenous administration The drug helps improve your pet’s well-being much more effectively and quickly. In addition, using Heptral injections for a cat is much easier to calculate the dose. It is worth noting that the injection has less effect on gastrointestinal tract than a tablet.

However, it is worth considering that the prepared solution can only be stored in the refrigerator for 24 hours, so part of the drug will have to be disposed of. It is not recommended to use a solution for injection that has changed its color to a darker one. Opened tablets also need to be stored correctly so that they do not lose their properties. If the tablet has already been split, it should be wrapped tightly in foil. Unopened medication can be stored in packaging for 3 years at room temperature.

Among drugs similar in composition, Heptral is the safest and has virtually no side effects. Do not forget to consult a veterinarian before giving Heptral to your cat, but it is worth considering that there are no analogues this drug there are very few. Safe and effective drug Heptral is successfully used to treat liver diseases in pets, and you can notice the first results after 2 days of the course.

Source: KoshkaMurka.ru

If your cat has liver problems, it is worth trying a course of treatment with Heptral. Using Heptral for cats, you can achieve positive results quite quickly, despite the fact that this medicine is primarily intended for humans. When other drugs fail, veterinarians often prescribe Heptral, which can cure any liver disease.

When is Heptral prescribed and dosage of the drug?

You should not prescribe Heptral to your pet on your own, since for any liver disease, consultation with a specialist is extremely important. A veterinarian may prescribe this drug for the following diagnoses::

• Hepatitis;
• Cholestasis;
• Cholecystitis;
• Cirrhosis.

The medicine effectively helps at any stage of the disease, even the most advanced. Heptral is well suited for complex therapy when a cat needs several medications at once.

Of course, the dosage of Heptral for a cat differs from the norm for humans. Only a veterinarian should prescribe the exact dose of the drug for a cat. In many ways, the required amount of the drug depends on the weight of the animal and its condition. If the pet is heavy and has significant liver problems, an increased dose is needed. However, only a qualified specialist will be able to determine when the situation reaches a critical point and loading the body with a large dosage is dangerous.

If a cat weighs 3 kg, as a rule, the standard dose is 0.5-0.7 ml of Heptral intramuscularly 2 times a day. If you do not inject your cat yourself, and can only visit the veterinarian once a day, you can administer 1 ml of the drug once a day. In addition to the injection solution, Heptral is available in tablets, and for an animal weighing 3 kg, 1/5 of a tablet is needed 2 times a day.

If you need instructions for using Heptral for cats and dogs, it is better to contact your veterinarian, who will explain everything in detail. On average, the course of treatment with this drug is 7-10 days, however, depending on the course of the disease, it can last 1 month.

Features of using Heptral for cats

Since Heptral is available for sale in tablets and in solution for injection, pet owners are wondering which form is more convenient for use by animals. Most veterinarians recommend giving injections, since intramuscular or intravenous administration of the drug is much more effective and quickly helps improve the pet’s well-being. In addition, using Heptral injections for a cat is much easier to calculate the dose. It is worth noting that the injection has less effect on the gastrointestinal tract than the tablet.

However, it is worth considering that the prepared solution can only be stored in the refrigerator for 24 hours, so part of the drug will have to be disposed of. It is not recommended to use a solution for injection that has changed its color to a darker one. Opened tablets also need to be stored correctly so that they do not lose their properties. If the tablet has already been split, it should be wrapped tightly in foil. Unopened medication can be stored in packaging for 3 years at room temperature.

Among drugs with similar composition, Heptral is the safest and has virtually no side effects. Do not forget to consult a veterinarian before giving Heptral to your cat, however, it is worth considering that there are very few analogues of this drug. The safe and effective drug Heptral is successfully used to treat liver diseases in pets, and you can notice the first results after just 2 days of the course.

VETERINARIAN CONSULTATION REQUIRED. INFORMATION FOR INFORMATION ONLY.