Sorbifer in ampoules instructions for use. Sorbifer Durules: instructions for use. Possible adverse reactions

Content

Our body cannot function normally without useful microelements and substances. Iron is the most essential element of many types of body cells. It is responsible for oxidative processes in tissues, is part of hemoglobin, and takes part in the deposition and transport of oxygen to organs and tissues. Iron deficiency may cause Iron-deficiency anemia. You can cope with the problem with the help of medications such as Sorbifer. It is worth understanding how to take the medicine and what contraindications there are to it.

Composition and release form

The pharmaceutical drug Sorbifer is produced by the Hungarian pharmaceutical plant EGIS. The drug is produced in the form of tablets for oral administration, which are packaged in 30 or 50 pieces in dark glass bottles. A similar composition of the product is presented in the table:

Pharmacological properties

Sorbifer is a tablet for normalizing iron levels in the body. Their therapeutic properties are due to the presence of two active components - iron and ascorbic acid, due to which an antianemic effect is achieved. Iron ions contribute to the formation of hemoglobin and the transport of carbon dioxide and oxygen. Ascorbic acid affects the rate of iron absorption by the body and ensures tissue regeneration. The drug is different high degree absorption, more than 90% of active iron is bound to plasma proteins.

The drug shell is made using Durules technology. The plastic matrix of the tablets is resistant to the influence of gastric juice, but is destroyed in the intestines under the influence of peristalsis. Due to this, a slow (5-6 hours) gradual release of iron ions into the intestines occurs. This avoids excess iron in the digestive organs and prevents the irritating effects of active substances on the mucous membrane of the digestive tract.

Indications for use

The drug is recommended for the treatment and prevention of iron deficiency anemia, but for anemia caused by other reasons, it is not effective. Before starting treatment, the level of iron in the blood and iron-binding activity are determined. Indications for the use of Sorbifer are:

• bleeding occurring long time and accompanying copious discharge of blood (uterine, nasal, gastrointestinal);
• the need to eliminate iron deficiency if its absorption in the intestines is impaired (diarrhea);
• compensation for iron deficiency in case of increased need for it: during donation, pregnancy and lactation, after serious illnesses, in postoperative period when intensive growth is observed in adolescents;
• prevention and treatment of iron deficiency diseases caused by various reasons.

How to take Sorbifer correctly

The treatment regimen and dosage of the drug is determined exclusively by the attending physician. The tablets should be taken orally. They should not be divided into parts or chewed so as not to destroy them. film shell. The medicine must be swallowed whole and washed down with plenty of water (no less than half a glass).. Many foods (eggs, milk, coffee, tea, juice, bread, herbs, vegetables) reduce the level of iron absorption, so it is better to take tablets 40-50 minutes before meals or 2 hours after a meal.

The duration of therapy depends on the doctor's decisions and periodic studies of hemoglobin levels. Instructions for use of Sorbifer suggest the following treatment regimen:

• For iron deficiency anemia, adults and children over 12 years of age are advised to take 1 pill twice a day. If side effects occur, it is recommended to reduce the dosage to 1 tablet per day. In case of severe anemia, the rate can be increased to 3-4 tablets in 2 doses. The duration of therapy is at least 3 months (until iron is completely replenished) and after the indicators return to normal, another 2 months.
• For low iron levels in pregnant women in the first 6 months of pregnancy and for the purpose of prevention, take 1 tablet per day.
• In the last three months of pregnancy and during lactation - 1 pill 2 times a day.

special instructions

Before taking the tablets, you must carefully study the instructions and pay attention to the special instructions:

• Take medicine with caution if you have Crohn's disease, peptic ulcer, inflammation of the small intestine,diverticulitis.
• Self-administration of medication without a doctor's prescription is prohibited.
• Darkening may occur while taking tablets feces, which is not a deviation from the norm.
• Tablets do not affect the functioning nervous system.

Sorbifer during pregnancy

Almost all women who will soon become mothers suffer from a lack of iron, a decrease in hemoglobin levels (below 110 g/l), and the development of anemia. This poses a danger to both the pregnant woman and the unborn child. To avoid possible complications During the second and third trimester of pregnancy, many doctors often prescribe the iron supplement Sorbifer to expectant mothers. This product provides a rapid increase in the level of essential substances.

Sorbifer during breastfeeding

Throughout the entire lactation period female body loses up to 1.4 g of iron, which can lead to serious complications. Sorbifer is effective in replenishing iron, but it can only be taken on the recommendation of a doctor. The daily dose is 2 tablets, divided into two doses. The course of therapy is 2-3 weeks. There is no need to stop breastfeeding your baby during this period, but you should closely monitor his health. If the baby feels unwell, Sorbifer should be stopped immediately and the child should be shown to the pediatrician.

In childhood

The drug Sorbifer is contraindicated for the treatment of children under 12 years of age due to the lack of clinical studies on the use of tablets in this age range. For adolescents over 12 years of age, Sorbifer is prescribed taking into account body weight (3 mg of medication is prescribed per 1 kg of weight). In the first few days of therapy, it is important to monitor the child’s health. If the slightest side effects You should immediately stop drug therapy and consult a doctor.

Drug interactions

Before treatment, the patient must warn his doctor about other medications he is taking to avoid unpredictable reactions. The combinations and effects are as follows:

• IN equally absorption of both decreases medicines when taking Sorbifer in combination with antibiotics from the group of tetracyclines or D-penicillamine.
• Antacids reduce iron absorption - medical supplies, which contain magnesium, calcium, aluminum.
• The drug Sorbifer may reduce the effect of Levofloxacin, Methyldopa, Enoxacin, Levodopa, Grepafloxacin, Clodronate, and thyroid hormones ( thyroid gland).
• Simultaneous treatment of Sorbifer Durules with Norfloxacin, Doxycycline, Ofloxacin, Ciprofloxacin is not recommended.

Side effects of Sorbifer

The likelihood of negative reactions increases with increasing dosage of the drug, but even in small quantities Sorbifer is capable of causing side effects. These include:

• abdominal pain;
• periodic vomiting;
• nausea;
• esophageal stenosis;
• bowel dysfunction (diarrhea, constipation);
• pale skin;
• dizziness;
• general weakness;
• periodic headache;
• thrombocytosis;
• leukocytosis;
• cardiopalmus;
• ulcerative lesions of the esophagus;
• allergic reactions - itching, skin rash.

Overdose

• abdominal pain;
• cold clammy sweat;
• temperature increase;
• fast fatiguability;
• weakness;
• vomit;
• weak pulse;
• diarrhea;
• paleness;
• loss of consciousness;
• decreased blood pressure;
• smell of acetone from the mouth;
• muscle cramps, coma (occur after 6-12 hours).

If signs of a drug overdose appear, you should immediately consult a doctor. At home, it is recommended to do a gastric lavage to bind iron ions in the gastrointestinal tract, you should drink a raw egg, a few glasses of milk. In a medical hospital, a solution of Deferoxamine is administered orally. In case of severe intoxication (state of shock, coma), the drug is administered intravenously, and in less severe cases - intramuscularly.

Contraindications

Take the tablets with extreme caution for stomach ulcers and inflammatory processes in the intestines (with enteritis, diverticulitis, ulcerative colitis). You should not take Sorbifer if you are hypersensitive to the components of the drug. TO medical contraindications tablets include the following body conditions:

• bleeding;
• children under 12 years of age;
• diseases associated with impaired iron utilization - hemolytic, aplastic, lead anemia (occurs from lead poisoning), sideroblastic anemia;
• after resection (removal) of the stomach;
• increased iron capacity in the body - hemochromatosis ( hereditary disorder iron metabolism), hemosiderosis (manifests itself with increased destruction of red blood cells);
• obstructive changes in the lumen of the esophagus (stenosis);
• urolithiasis disease.

Terms of sale and storage

The medicine is dispensed only with a doctor's prescription. Sorbifer should be stored in a dark place, out of reach of children, optimal temperature regime– 15-25 degrees. After 3 years from the date of manufacture, the tablets must be disposed of.

Sorbifer's analogues

To compensate for iron deficiency, your doctor may prescribe similar medications. These include:

• Ferroplex - the main purpose of the drug is the treatment and prevention of iron deficiency anemia, but with low hemoglobin levels the drug is not effective.
• Fenyuls 100 – has the form of capsules, contains iron and vitamin complex. The drug replenishes daily norm vitamin B1, B2, restores impaired metabolism, eliminates the causes of iron deficiency anemia.
• Actiferrin compositum is a German analogue of Sorbifer, has three release forms (capsules, syrup, drops). Approved for use by children from birth.
• Biofer - available in the form of chewable tablets. Recommended for the treatment and prevention of anemia caused by iron deficiency.
• Hemofer - drops can be prescribed to children from birth.

• Venofer is an anti-anemic drug administered intravenously or by drip.
• Gyno Tardiferon is a combination medicine that contains iron and violet acid.
• Ferretab - used for the prevention and treatment of anemia.
• Ferrogradumet - produced in the UK, has a lower percentage of iron absorption.
• Ferrinate – presented in capsules, is a dietary supplement.
• Heferol - hard gelatin capsules intended for the prevention and treatment of iron deficiency anemia.
• Ferronal - comes in the form of tablets (for adults) and syrup (for children over 3 years old), replenishes iron deficiency.

Sorbifer price

In Moscow, the drug is dispensed at any pharmacy with a doctor's prescription. The product can also be purchased in online pharmacies. The cost depends on the release form and packaging volume. The approximate price range in pharmacy chains is as follows.

Latin name: Sorbifer Durules
ATX code: B03AA07
Active substance:
Ferrous sulfate and ascorbic acid
Manufacturer: JSC "EGIS", Hungary
Conditions for dispensing from a pharmacy: On prescription

"Sorbifer Durules" is used in the treatment of iron deficiency anemia. Iron promotes the production of hemoglobin, which provides cells with oxygen. And the ascorbic acid contained in the composition helps the absorption of iron in the intestines.

Indications for use

"Sorbifer Durules" is used in the presence of iron deficiency anemia, when the amount of iron obtained from foods is too small, or there is a need to regularly replenish it during prolonged bleeding. And also as preventive measures during pregnancy and lactation, with heavy menstruation and blood donors. The drug is also prescribed if there is a need for increased amounts of iron - for children and the elderly.

Composition of the drug

One tablet contains: 320 mg ferrous sulfate (including 100 mg iron) and 60 mg ascorbic acid. It also contains: hypromellose, titanium dioxide, magnesium stearate, carbomer 934P, yellow iron oxide, paraffin, polyethylene powder, macrolog 6000 and povidone.

Medicinal properties

The plastic shell with which the tablets are coated is resistant to gastric juice, but is destroyed in the intestines, thereby providing a slow release of iron ions over a period of six hours. This prevents excessive concentration of iron in the intestines and the occurrence of irritating effects of active substances on its mucosa.

Thus, Sorbifer Durules is absorbed 30% better when compared with other iron-containing medications. More than 90% active substance binds to blood proteins. Partial elimination from the body occurs in approximately six hours.

Release forms

Price from 360 to 480 rub.

“Sorbifer Durules” is marketed in the form of convex yellowish tablets with the letter Z printed on one side. A grayish core is hidden under the shell. Tablets are packed in 30 pcs. or 50 pcs. in dark glass jars, closed with a plastic lid with a shock-absorbing accordion-shaped protrusion. The jar is included in a box along with instructions.

Mode of application

According to the manufacturer's instructions, Sorbifer Durules tablets should be swallowed, but not chewed or split in half, so as not to destroy the shell. It is better to drink them with half a glass of water. Milk, coffee, tea, eggs, juice, bread, vegetables and herbs impair the absorption of iron, so it is better not to take the medicine after meals.

In the presence of iron deficiency anemia, the daily dose for children over twelve years of age and adults is one tablet. twice a day. If side effects occur, you need to reduce the dosage to one tablet. in a day.

With reduced iron levels during pregnancy from one to six months and for preventive purposes, one tablet is used. in a day.

In the last three months of pregnancy and during breastfeeding, take one tablet. twice a day.

How many days to continue treatment depends on the decision of the doctor, who takes into account data from regularly prescribed studies on hemoglobin levels. Sufficiently high iron deficiency requires taking the drug for approximately three to six months. And after the indicators return to normal, you need to take the drug for at least two more months to form the necessary reserves of the element.

During pregnancy and breastfeeding

The use of "Sorbifer Durules" during pregnancy and lactation is permitted with regular measurement of the amount active substance in blood.

Contraindications

• Intolerance to any of its components
• Esophageal stenosis and other gastrointestinal pathologies
• Thrombophlebitis and thrombosis
• Iron levels above normal (with hemochromatosis or hemosiderosis)
• Diabetes mellitus
• Kidney stones and other serious disorders in their work
• Poor absorption of iron (with other types of anemia: sideroblastic, hemolytic and lead).

Sorbifer Durules should be used under strict control of hemoglobin levels and only as prescribed by a doctor for the following diseases:

• Gastric and duodenal ulcers
• Ulcerative colitis
• Enterite
• Crohn's disease
• Diverculitis.

Precautionary measures

Since Sorbifer Durules is effective only for the treatment of iron deficiency anemia, it is not advisable to take it if there is a lack of iron caused by impaired absorption. Prescribing the drug must be preceded by blood tests to check iron levels. You should also not take Sorbifer Durules together with other iron-containing medications.

Cross-drug interactions

Using the drug together with tetracyclines and D-penicillamine will reduce the absorption of the active element. The same effect will result from combining the drug “Sorbifer Durules” with antacids that contain magnesium, calcium and aluminum salts. Therefore, it would be best to take these drugs at least two hours apart. And simultaneous use of medication with ascorbic acid can, on the contrary, lead to exceeding normal levels.

Side effects

After taking the medicine, the functioning of the gastrointestinal tract may be disrupted, which is manifested by nausea, abdominal pain, diarrhea, and constipation.

Overdose

The consequences of exceeding prescribed doses are similar to the manifestations of side effects: nausea, vomiting, abdominal pain, bloody diarrhea, feeling tired, low pulse, cold sweat, pale skin, tachycardia.

Conditions and shelf life

As indicated in the instructions, the temperature at the place where the drug is stored should not exceed 25°C. Do not use after three years from the date of manufacture.

Analogs

"Ferrum Lek"

Lek, Slovenia
Price: 141–1100 rub.

Basics active remedy"Ferrum Leka" - iron hydroxide polymaltosate. Ferrum Lek is sold in the form of chewable tablets, syrup and solution for intramuscular injection.

Pros:

• Ferrum Lek syrup can be drunk with fruit and vegetable juices. The syrup can also be mixed with baby food, which makes taking the medicine more enjoyable for children
• Intramuscular injections ensure rapid entry of the Ferrum Lek drug into the blood. This is especially true in case of heavy blood loss.

Minuses:

• It is not recommended to use Ferrum Lek injection solution in the first twelve weeks of pregnancy. In subsequent stages of pregnancy and during breastfeeding - only if absolutely necessary
• Taking Ferrum Leka can lead to side effects: abdominal pain, nausea, diarrhea.

Vifor Inc, Switzerland
Price: RUR 252–932

The active component of the drug "Maltofer" is iron hydroxide polymaltosate. "Maltofer" is available in the form of chewable tablets with a heterogeneous white-brown structure, 10 tablets each. in blister, drops for oral administration and syrup.

Pros:

• "Maltofer" is used to normalize the level, even if anemia is not recorded
• You can take Maltofer during the entire period of pregnancy and lactation
• "Maltofer" can be drunk directly during meals or immediately after finishing them.

Minuses:

• After taking the tablets, side effects of the drug "Maltofer" may occur in the form of headache, nausea, diarrhea
• Chewable Maltofer tablets are not recommended for children under twelve years of age.
• Patients suffering from diabetes can take Maltofer under close supervision.

Ranbaxy Laboratories Ltd., India
Price: RUR 87–185

The active components of the drug "Fenuls" are divalent iron and multivitamins. "Fenuls" is available in the form of capsules of ten tablets. in a blister.

Pros:

• "Fenuls" replenishes the body's daily need for vitamin B1, which improves the contractile functions of the myocardium
• Vitamin B2 contained in Fenuls improves blood supply to the cells of the cornea and retina, activates the activity of the gastrointestinal tract
• "Fenuls" is allowed during pregnancy and lactation in compliance with the indicated dosages.

Minuses:

• The manifestation of side effects of Fenuls is expressed in the form of dizziness, dyspepsia and allergic reactions
• Fenuls is contraindicated for hemochromatosis and hemosiderosis.

Iron deficiency in the body, which occurs against the background of diseases, unbalanced nutrition or certain physiological conditions (during pregnancy), requires treatment, since it can seriously weaken the immune system, reduce the tone of the cardiovascular and other systems, and lead to other serious consequences for the body. According to experts, the antianemic drug Sorbifer Durules in tablets, thanks to a special manufacturing technology, helps to cope with this problem better than many of its analogues.

What is Sorbifer Durules

The antianemic drug Sorbifer (Sorbifer Durules) is a medical product that combines iron sulfate and ascorbic acid. Thanks to the second component, improved iron absorption is achieved digestive tract– Durules technology ensures slow absorption of iron ions by the intestines, not under the influence of digestive enzymes, but due to natural peristalsis.

Compound

The iron preparation Sorbifer is a drug that has an antianemic effect. Release form: yellow, film-coated tablets with the letter Z, 30 or 50 pieces in one package (bottle). Substance content per tablet:

• Ferrous sulfate (100 mg);
• ascorbic acid (60 mg);
• magnesium stearate;
• povidone;
• polyethylene powder;
• carbomer.

Indications for use

Sorbifer is prescribed for iron deficiency anemia, low blood hemoglobin, iron loss in certain physiological conditions (breastfeeding, late pregnancy, blood donation), for prevention, as an iron supplement food supplement. It involves prescribing long-term therapy or short-term use - it depends on each individual case; before the course of treatment, be sure to read the instructions, contraindications and recommended dosage to avoid possible negative consequences and side effects.

Contraindications

The use of medications containing the ferrous sulfate component is limited by the following contraindications:

• thrombosis;
• thrombophlebitis;
• thrombocytosis;
• stenosis of the digestive organs;
• iron absorption disorders;
• diabetes;
• urolithiasis disease;
• allergy to the components of the drug;
• hemosiderosis;
• hemochromatosis;
• children under twelve years of age.

Side effects

Among the side effects that occur primarily with an overdose of Durules, the manufacturer indicates disturbances in the functioning of the digestive system - nausea, diarrhea or constipation; headaches, hyperglycemia as a consequence of increased hemoglobin levels. If these symptoms appear, you must stop taking it and contact your doctor to adjust the dosage or select another drug.

Instructions for use Sorbifer Durules

The pharmacodynamics of the drug is aimed at restoring the required level of the microelement iron sulfate - the most important component of the body, serving for the formation of hemoglobin and promoting oxidative processes occurring in tissues. Thanks to special technology, different from the technologies used to produce other drugs containing ferrous sulfate, the pharmacokinetics of Sorbifer are improved, and when taking 100 mg twice a day, 25-30% more of its active substance is absorbed into the body than when undergoing a course of treatment with its analogues .

The pharmacological effect of the drug is not the only information contained in the instructions for use. In it you can find the answer to the question of how to take Sorbifer Durules - methods of application and recommended dosage. The manufacturer recommends taking 1 tablet 1-2 times with a sufficient amount of liquid (200 ml). The daily dose should not exceed 400 mg, the course duration is 3-4 months. Do not self-medicate and consult a doctor to undergo the necessary tests and select the correct dosage.

During pregnancy

During pregnancy, most expectant mothers suffer from iron deficiency and calcium deficiency. Therefore on later During pregnancy, at the end of the second and throughout the third trimester, the doctor prescribes ferrous sulfate. Information on how to properly take Sorbifer Durules for pregnant women can be found in the instructions for use; as a rule, one tablet is prescribed twice a day.

When breastfeeding

During lactation, it is important for a woman to take iron supplements in the same way as during pregnancy. Sorbifer Durules at breastfeeding prescribed at a dosage of 200 mg per day, divided into two doses. The absorption of the active components of the drug may be affected by the level of some hormones, so you should consult a specialist before starting the course.

Drug interactions

At joint use Sorbifer may impair the absorption of enoxacin, clodronate, grepafloxacin, levodopa, levofloxacin, methyldopa, penicillamine, tetracyclines and thyroid hormones. Concomitant use of this medicine and drugs containing magnesium carbonate may significantly reduce the absorption of iron sulfate. The required time interval between these medications should be three to five hours. Should not be taken in parallel with the following drugs:

• Ciprofloxacin;
• Doxycycline;
• Norfloxacin;
• Ofloxacin.

Price for Sorbifer Durules

You can buy the medicine in pharmacies in St. Petersburg, Moscow and other cities, or order through an online store (the price in this case will be significantly lower), because a prescription is not required for purchase. The answer to the question of how much the drug costs can be found in the pharmacy catalog on the relevant websites. The cost of Sorbifer in Moscow pharmacies ranges from 320-390 rubles per package of tablets (the number of tablets per package is 30 pieces).

Analogues of Sorbifer Durules

Effective analogues of this medicine for the active substance are Ferroplex, Fenyuls 100; Actiferrin compositum, Biofer, Hemofer, Venofer, Gino-Tardiferon are analogues in their mechanism of action. All of the listed products contain a lower dose of the main component and a deteriorated formula for its absorption, but can be effective for certain types of anemia. Therefore, only a doctor can select a medicine suitable for each individual case..

Aktiferrin compositum is a German analogue of Durules, containing iron sulfate and vitamin C. It contains amino acids that promote more efficient absorption of the active component and its entry into the blood. Indications for use:

• low hemoglobin;
• iron deficiency;
• pregnancy, breastfeeding;
• gastritis;
• poor nutrition;
• reduced immunity.

Biofer is a drug that has an antianemic effect and the ability to replenish iron deficiency. Folic acid, necessary for fetal development during pregnancy, is the second main component of the drug. Available in the form of lozenges. It is prescribed both for the prevention of anemia and for its treatment. Prescribed during pregnancy (second, third trimesters) and during breastfeeding.

Biofer is not prescribed to children under 12 years of age, with low hemoglobin caused not by anemia, but by other reasons. During treatment, you should regularly visit your doctor to monitor your hemoglobin levels. The recommended course is six to eight weeks. Like any other products containing complexes of vitamins or substances, it should not be combined with other medicines, as detailed in its instructions for use.

Video

Iron is one of the constituent elements of human blood. It promotes the production of hemoglobin in the blood, which, in turn, saturates the tissues with oxygen. This element is also necessary for metabolic processes in the body, to maintain immune system. Pregnant women especially need it. Iron is necessary for normal fetal development. You can compensate for its deficiency with the help of products, but this is not always possible, so medications are prescribed. One of these is Sorbifer. Side effects, indications, features of reception we will consider further.

Operating principle

The combined drug “Sorbifer” also contains ascorbic acid.

Iron plays a key role in binding and transporting oxygen and carbon dioxide. Absorbed into duodenum and proximal jejunum.

Vitamin C increases the absorption of iron in the stomach and intestines, and is also involved in redox processes.

And vitamin C promotes iron absorption.

The manufacturing technology of the drug ensures the continuous release of iron ions. Over 6 hours, the slow release of the active substance prevents dangerously high concentrations of iron. This avoids irritation of the intestines and stomach.

Once in the intestines, iron binds to apopheritin. One part enters the bloodstream, and the other remains in the intestine in the form of feritin, which is excreted in the feces or enters the bloodstream after 1-2 days. In the blood, iron binds to apotransferin or turns into transferrin. In this form, it enters the organs and through endocytosis into the plasma.

What does the drug contain?

"Sorbifer" is produced in the form of biconvex round tablets. Covered with a shell, they have a light yellow color. Z engraving is on one side. They have a peculiar smell. Gray inside.

One tablet contains:

Auxiliary components of the drug:

• magnesium stearate;
• povidone K-25;
• polyethene powder;
• carbomer 934R.

The shell contains:

• hypromellose;
• titanium dioxide;
• macrogol 6000;
• iron oxide yellow;
• paraffin paraffin

The tablets are packaged in dark glass bottles of 30 or 50 pieces.

Who is prescribed

The following indications exist for taking a drug such as Sorbifer:

• iron deficiency;
• Iron-deficiency anemia.

Prescribed as a prophylactic agent:

For pregnant women, if it is indicated to use Sorbifer, the side effects of the drug should not be ignored. If any unusual symptoms When taking, you need to consult a doctor.

Contraindications

The instructions for the drug contain a list of diseases for which it should not be prescribed. Pregnant women and anyone who is prescribed this medicine should pay special attention to it in order to exclude these conditions. The list of contraindications includes:

It is important to follow the instructions for the drug “Sorbifer”; in this case, there will probably be a minimum of side effects.

How to take the drug

For preventive purposes, Sorbifer is prescribed:

• Children over 12 years old: 1 tablet per day.
• Adults - 1 tablet per day.

In case of treatment of iron deficiency anemia, the drug is taken:

Pregnant women should use Sorbifer as follows:

• For the first 6 months, 1 tablet per day.
• In the last trimester of pregnancy, 1 tablet 2 times a day.

During lactation the following is prescribed:

• 1 tablet 2 times a day.

During the treatment period, the iron content in the blood plasma is monitored. The duration of therapy depends on this.

After the level of hemoglobin in the blood is restored, it is recommended to take the drug for another 2 months.

When treating iron deficiency anemia, it is necessary to take the drug for 3 to 6 months.

Before taking Sorbifer, contraindications and side effects of the drug should be discussed with your doctor.

Features of application

When carrying a child, a woman should be especially careful when taking any medications. Therefore, it is necessary to familiarize yourself with the features of taking Sorbifer.

When taking Sorbifer, side effects in women are more likely to occur if they have the following diseases:

• chronic liver and kidney diseases;
• leukemia;
• intestinal diseases;
• inflammatory pathologies gastrointestinal tract;
• ulcer of the stomach and duodenum.

Interaction with other drugs

The drug "Sorbifer" often exhibits side effects during pregnancy if the doctor prescribes several drugs.

Sorbifer should not be used together with the following medications:

• "Moxifloxacin";
• "Ciprofloxacin";
• "Levofloxacin";
• "Norfloxacin";
• "Ofloxacin"

The absorption of these medications is significantly reduced.

It is necessary to maintain an interval of at least 2 hours between taking Sorbifer and the following drugs:

• "Captopril";
• medications containing zinc, calcium, magnesium;
• "Clodronate";
• "Methyldopa";
• "Penicillinamine";
• "Risedronate";
• "Tocopherol";
• thyroid hormones;
• "Pancreatin";
• "Tetracycline";
• glucocorticosteroids;
• "Cimetidine"

Simultaneous use with the drug "Sorbifer" reduces the effect of ascorbic acid:

• oral contraceptives;
• fruit and vegetable juices;
• alkaline mineral water.

The drug "Deferoxamine" together with ascorbic acid increases iron toxicity, especially in the heart muscle.

Side effects

You should consider what side effects are possible when taking the drug Sorbifer.

It is also possible to disrupt the metabolism of zinc and copper in the body.

Sorbifer Durules is often prescribed during pregnancy. The doctor should warn the patient about the side effects of the drug.

Overdose

You need to know the symptoms of a drug overdose:

There is a risk of gastrointestinal perforation.

In severe cases, the health condition may improve for a period of time, but after 6-24 hours the situation worsens again. Convulsions, liver and renal failure, heart failure, coma.

It is also possible after a few weeks or months to develop cirrhosis of the liver and persistent narrowing of the pylorus of the stomach.

An overdose of vitamin C can lead to hemolytic anemia and severe acidosis.

It is very important to know the symptoms of overdose when taking Sorbifer Durules tablets. Side effects of the drug have similar symptoms, it is important to correctly assess the situation early stage. Timely provision of assistance is very important.

Providing assistance in case of overdose

In case of overdose, the following steps must be taken:

• Drink enough liquid to induce vomiting. You can use milk.
• Rinse the stomach with a solution of Desferoxamine 2 g/l.
• "Desferoxamine" 5 g + 50-100 ml of water enter the stomach and leave.
• An adult can take Sorbitol.
• It is necessary to take an x-ray of the stomach after lavage to identify the remaining tablets.
• In severe cases, maintenance therapy and intravenous Desferoxamine are prescribed.
• For less severe intoxication, Desferoxamine is administered intramuscularly.

The patient must be under constant monitoring. It is necessary to monitor serum iron levels.

Side effects during pregnancy

It is worth paying attention to the fact that most often the drug is prescribed to pregnant women. Therefore, let us pay attention to the side effects that are recorded in pregnant women:

• rash;
• constipation;
• diarrhea;
• nausea;
• heartburn;
• headache;
• sleep disturbance.

If women took Sorbifer, reviews of side effects during pregnancy included nausea and constipation.

As a rule, such deviations are very rarely noted. After consulting a doctor and adjusting the dose, the symptoms go away.

It is worth noting that many women appreciated the increase in hemoglobin in the blood in a short period of time when taking Sorbifer. Side effects, as noted in the reviews, did not appear in any way. The effectiveness of the drug is confirmed not only during pregnancy, but also during lactation.

Every fourth woman has iron deficiency anemia to one degree or another. This condition also occurs in men, but more often in girls, since their body is exposed to monthly blood loss. The modern drug "Sorbifer Durules" is effective for anemia of any etiology. This is modern combination drug, which contains ferrous sulfate and ascorbic acid. At the same time, it has a fairly reasonable price. Instructions, reviews of Sorbifer Durules, dosage and method of administration - everything is described in this article.

What is iron deficiency anemia and how does it manifest?

Previously, this diagnosis was known as anemia. People have long noticed that women sometimes experience symptoms that reduce the quality of life: pallor, weakness, lack of vital energy. With the development of microbiology, it became clear that anemia is a condition that occurs with prolonged iron deficiency.

Iron deficiency anemia is the most common form of all currently known anemia, which is due to a large number of reasons and circumstances that can lead to iron deficiency, which will lead to various disorders that are unsafe for the body.

Symptoms of iron deficiency anemia:

• constant weakness;
• lack of taste for life;
• asthenia, dysphoria, anhedonia;
• mental problems: increased vulnerability, anxiety, irritability;
• characteristic pallor skin(especially faces);
• alopecia (baldness);
• sphincter weakness (urinary and fecal incontinence);
• increased swelling of the limbs and face.

Why does a person need iron and what forms of this element exist in pharmacology?

In our body, the average indicator of the presence of iron is 3.5-4.5 g. Of this amount, approximately two-thirds are located in the blood, one-third is stored in the liver, muscle tissue, and spleen.

Iron is necessary for humans, since when it is deficient, the following processes are disrupted:

• cholesterol metabolism;
• liver function;
• hematopoiesis;
• hemoglobin synthesis;
• functioning of the immune system;
• various redox reactions;
• thyroid function.

It would not be an exaggeration to say that every process in human body to one degree or another passes through the influence of ferritin.

Not all iron from preparations is equally useful: very often the trivalent form is simply not absorbed and leaves the body along with feces. The instructions for use for Sorbifer Durules indicate that it contains a ferrous iron compound, which is better absorbed. In addition, in the manufacture of capsules, a special technology is used that allows the molecules of the element to be released gradually as they move through the gastrointestinal tract. This fact highlights this drug iron from all others.

Composition of the drug "Sorbifer Durules"

The drug is a large tablet in a special coating, which dissolves slowly and only under the influence of special enzymes. This technology allows iron to be completely absorbed by the body and bring maximum benefit to the patient. The release of element ions occurs for a total of six to seven hours after taking the tablet. This is the essence of the Durules technology: the name of the drug consists of two words, and the second is precisely the patented principle of slow absorption.

"Sorbifer Durules" after a meal may be absorbed a little slower than when taken on an empty stomach (the difference is about two hours).

The drug is sold in thick glass bottles, each containing 30 or 50 tablets.

Composition of one tablet:

• - 320 milligrams;
• ascorbic acid - 60 milligrams.

Manufacturers have enriched the composition of the drug with ascorbic acid (or vitamin C) for a reason. This component increases the absorption of iron. Thanks to Durules technology and ascorbic acid in the composition it was possible to achieve almost one hundred percent digestibility of ferrum.

Cost, where to buy

The drug can be purchased at any pharmacy without a doctor's prescription. The cost of a bottle with 30 tablets is about four hundred rubles, 50 tablets will cost 600 rubles. Depending on the region (place of purchase) and the markup of the pharmacy chain, the cost may vary. Packing include cardboard box, which contains a glass bottle with tablets and instructions.

The price of Sorbifer Durules and its effectiveness make the drug popular among a wide variety of categories of patients. Many people buy it after reading rave reviews about its effectiveness. Some patients are given a prescription for purchase by neurologists and endocrinologists.

Indications for use

Instructions for use of "Sorbifer Durules" (the price can be found above) states that the drug is active in the following conditions and pathologies:

• prolonged bleeding of different nature(uterine, after surgical interventions or injuries, etc.);
• Iron-deficiency anemia;
• intentional or unintentional fasting;
• impaired absorption of iron from food;
• malignant alopecia.

The drug is effective only for anemia caused by a lack or impaired absorption of ferritin (iron). If the causes of anemia are different, Sorbifer Durules is useless. How to take the drug so that it provides maximum benefit to the body will be described below.

Side effects

The drug quite often causes the following side effects:

• from the nervous system: insomnia, vigor, physical activity, nervous tics (rare);
• from the gastrointestinal tract: diarrhea, prolonged diarrhea, staining of stool black;
• from the endocrine system: loss of appetite, weight loss, fats may not be partially absorbed (rarely);
• Quite rarely, the drug can provoke ulceration and narrowing of the esophagus.

How to take Sorbifer Durules to avoid side effects? You should start taking it with a minimum daily dose. If the patient weighs less than forty kilograms and has diagnosed iron deficiency anemia of the third degree, you can start taking half a tablet (despite the fact that cutting the tablet is not recommended so as not to disrupt the integrity of the shell).

Contraindications for use

The drug has a number of contraindications:

• hemosiderosis;
• hemochromatosis;
• aplastic and hemolytic anemia;
• sideroblastic anemia;
• age up to twelve years;
• pathologies of the esophagus (iron can aggravate them).

Also, use is prohibited for certain diseases of the gastrointestinal tract. Often, before prescribing medications with iron, doctors play it safe and refer the patient to full examination to a gastroenterologist. This is done in order to avoid problems with the esophagus and stomach. Iron supplements can aggravate the course of erosion and ulcerative diseases of the esophagus, stomach, and intestines.

Drug interactions

With the simultaneous administration of Sorbifer Durules and tetracycline antibiotics, there is a significant decrease in the absorption of both drugs. Concomitant use of these drugs is not recommended.

Antacids (medicines with magnesium, aluminum, calcium) significantly reduce the absorption of iron ions.

The use of Sorbifer Durules reduces the absorption of Enoxacin, Methyldopa, Levofloxacin, Clodronate (and all drugs containing their metabolites), thyroid-stimulating hormones. If it is absolutely necessary to combine these drugs, you should wait at least three hours between taking therapeutic doses. The absorption of the drug is negatively affected by Chloramphenicol and oral contraceptives, as well as some foods and drinks (milk, eggs, tea, coffee, juices, bread).

The tablet should be taken whole without chewing. Drink with clean, cool water.

How should you use Sorbifer Durules: before meals or after? The opinion of doctors and the information from the instructions are unanimous: the tablet should be taken twenty to thirty minutes before meals. In rare cases, when taking it on an empty stomach causes severe nausea and vomiting, you can take the tablet immediately after eating. This intake will not reduce the effectiveness of the drug, but it may take longer to absorb iron.

One or two tablets should be taken per day, the amount depends on the hemoglobin and ferritin levels in the patient’s blood. If iron deficiency anemia is clearly expressed, you should take two tablets; after one or two months, as the patient’s condition improves, switch to a dosage of one tablet per day.

"Sorbifer Durules" during pregnancy: benefit or harm

The state of pregnancy imposes strict limits and restrictions on the list of medications taken. Alas, in an interesting situation, iron deficiency anemia most often develops and hemoglobin and ferritin levels decrease. The growing fetus takes a lot of vitamins and microelements for itself, which is why a deficiency of one or another substance often develops.

"Sorbifer Durules" is used during pregnancy in the absence of contraindications. As a rule, the patient is prescribed one tablet per day, twenty to thirty minutes before meals. Most often, hemoglobin levels increase significantly after two to three weeks from the start of therapy.