When will Sinaflan ointment help, and what can replace it? Sinaflan - instructions for use of ointment Sinaflan ointment non-hormonal analogues

1 g of liniment or ointment contains 0.25 mg of active ingredient.

The auxiliary ingredients in liniment include:

• propylene glycol;
• anhydrous;
• pentanol;
• stearic acid;
• nipagin;
• nipazole;
• purified water.

Excipients in the ointment:

• benzyl alcohol;
• propylene glycol;
• soft white paraffin;
• ceresin;
• lanolin.

Release form

Available in the following dosage forms:

• Ointment Sinaflan. Characterized by a homogeneous consistency. Color from light yellow to deep yellow.
• Liniment light yellow color.
• Cream Sinaflan.
• Gel Sinaflan.

Both liniment and ointment are placed in aluminum tubes of 10 g and 15 g. Each tube is placed in a separate cardboard box.

pharmachologic effect

Refers to glucocorticosteroids . Apply externally to eliminate inflammatory processes, .

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

You can often hear the question of whether Sinaflan is hormonal or not. This is a hormonal drug, but this is the reason for its high effectiveness.

Fluocinolone acetonide binds to specific receptors in the cytoplasm of cells, which provokes an increase in mRNA synthesis. The result of exposure affects all metabolic processes in the cell.

From clinically significant effects The following aspects of influence on the cell can be named:

• inducing the synthesis of lipocort proteins, including lipomodulin, which leads to inhibition of the activity of phospholipase A2, which is one of the factors in the progression of the inflammatory response;
• stabilizes the cell membrane, which helps prevent;
• increases the rate of protein catabolism;
• reduces the migration of B and T lymphocytes and disrupts the interaction of these cells;
• inhibits the accumulation of leukocytes and macrophages at the site of inflammation;
• suppresses the effect of hyaluronidase, reduces the level of formation of arachidonic acid and leukotrienes;
• affects the regulation of carbohydrate metabolism, reducing glucose consumption by tissues, which can lead to an increase in its concentration in;
• promotes the retention of sodium and water ions, provokes the excretion of potassium and calcium, reduces the ability to absorb calcium;
• increases the synthesis of erythrypoietins.

This effect on metabolic processes in the cell contributes to a noticeable effect in those cases for which the medicine is used - for acne and other inflammatory skin lesions.

Pharmacokinetics

Fluocinolone acetonide easily penetrates into all layers of the skin, but accumulates in the stratum corneum (can be detected even 15 days after completion of treatment). It enters the bloodstream in small quantities.

Biotransformation occurs in the liver. In this case, inactive ones are formed. Excretion occurs mainly due to the work of the kidneys.

Absorption of the drug occurs more intensely when treating children, when applied to large areas of skin, when used regularly, when applied to the face or damaged skin.

Indications for use

Why use Sinaflan ointment and dosage forms drug? For the treatment of various inflammatory skin lesions of non-infectious etiology.

What does Sinaflan ointment help with in most cases? You can list the following indications for the use of ointment, gel, cream and liniment:

• various localizations;
• body and scalp;
• red flat;
• itching skin of unknown etiology;
• discoid shape;
• allergic rashes;
• multiform;
• small;
• inflammation at the site of an insect bite.

Contraindications

It is prohibited to use ointment or liniment in such cases;

• hypersensitivity to the active substance or auxiliary components of the drug;
• skin diseases caused by an infectious agent: bacteria, virus or fungus;
• skin lesions that are a manifestation;
• wound surface;
• diaper rash ;
• precancerous skin conditions;
• presence on the area of ​​skin where the medicine needs to be applied;
• psoriasis , which has progressed to plaque formation;
• (using Sinaflan for acne, which is actually acne, can cause an exacerbation of the disease);
• trophic ulcers on lower limbs caused by varicose veins;
• any use for children under 2 years of age;
• use in ophthalmology and on the skin of the mammary glands is prohibited;
• and period.

Side effects

The question of whether the ointment is hormonal or not is often due to the fact that it is known that hormonal drugs actively affect the entire body. This also applies to Sinaflan. Side effects are not very common, but they can be quite varied.

On the part of the skin and subcutaneous fatty tissue, the following may appear:

• skin irritation;
• peeling of the skin or rashes in the form of papules or spots at the site of application of the medicine;
• hyperkeratosis ;
• furunculosis ;
• exacerbations pathological conditions skin that was present at the start of treatment;
• atrophic changes in the skin;
• burning sensation ;
• itching ;
• steroid blackheads ;
• folliculitis ;
• hair loss or excessive growth in the area where Sinaflan was applied;
• pigmentation disorders .

From the outside digestive system(occurs when used on large areas of the skin):

• steroid

From the endocrine organs:

• increased blood glucose levels;
• glucosuria ;
• in children – slower growth and development;
• when applied to large areas of skin, it may develop adrenal insufficiency , Itsenko-Cushing syndrome , steroid.

• hypersensitivity reactions;
• decline ;
• exacerbation of chronic diseases;
• generalization of infectious lesions;
• slowing down repair processes.

From the heart and blood vessels:

• promotion ;

When applied to the outer surface of the eyelids, there is a risk of developing And .

Instructions for use of Sinaflan (Method and dosage)

Sinaflan ointment, instructions for use

The ointment is applied to the affected area 1 or 2 times a day and lightly rubbed in. The course of treatment for adults is up to 10 days, for children – no more than 5 days, for facial skin – no more than 1 day.

It is not advisable to use ointment under a bandage, with the exception of only some forms psoriasis . But in this case, it is very important to change it regularly.

Liniment Sinaflan, instructions for use

Liniment can be applied 2-4 times a day. The course of treatment is the same in duration as when using the ointment.

Do not use under a closed bandage, but can be applied to a small area of ​​skin under an occlusive one.

It is advisable to use on dry dermatoses .

How to use Sinaflan cream or gel

Apply to affected areas 1-4 times a day. The course lasts no more than 2 weeks.

The cream is most often used in damp dermatoses , and the gel - for lesions of the scalp.

Overdose

An overdose can easily occur when the medicine is applied to large areas of the skin, in case of long-term treatment, or when applied to particularly sensitive areas, such as the skin of the face. Also high risk when treating children with Sinaflan.

Possible symptoms of overdose:

• swelling ;
• promotion blood pressure ;
• burning , itching at the site of application of the drug;
• increased levels of glucose in the blood and urine;
• Itsenko-Cushing syndrome .

Treatment for overdose is symptomatic. In this case, gradual withdrawal of Sinaflan is indicated.

Interaction

The drug interacts with many other medications, so caution is necessary when using at the same time:

• with systemic glucocorticosteroids – the effectiveness of Sinaflan increases and the likelihood of developing side effects from its use;
• with non-hormonal anti-inflammatory medications – the risk of developing both local and systemic adverse reactions of the body to each of the drugs increases;
• with antihypertensive, antirhythmic drugs, diuretics, potassium supplements - the effectiveness of these medications decreases;
• with diuretics (except potassium-sparing ones) – the likelihood of developing hypokalemia ;
• with vaccines - an inadequate immune response is possible due to the fact that the immune system is weakened and is not able to synthesize the necessary antibodies in normal quantities;
• with immunosuppressants – enhances the effect;
• with immunostimulants - suppresses the effect of these drugs on the immune system.

Terms of sale

On prescription.

Storage conditions

Store in a cool place, but do not allow it to freeze.

Best before date

The ointment is stored for 5 years, liniment for 2 years.

special instructions

When treating with Sinaflan, you must adhere to the following recommendations:

• avoid getting the medicine into your eyes;
• do not apply to wounds or breast skin;
• it is strictly forbidden to exceed the recommended duration of treatment;
• do not use with other topical medications;
• it is undesirable to use under a bandage, since in this case the adsorption of the drug and the risk of developing systemic side effects increases;
• If necessary, undergo a course of treatment several times, you need to take tests to monitor the functioning of the adrenal glands.

For children

Prohibited for use by children under 2 years of age.

After 2 years, Sinaflan for children is prescribed with caution, for a short period of time and only under the supervision of a doctor.

When used in the treatment of children, it is prohibited to apply the medicine to the skin of the face.

During pregnancy and lactation

Prohibited use when pregnancy and in lactation period , since there is not enough research on the effect of the drug on the child’s body.

Sinaflan's analogs

Analogues of Sinoflana:

• ointment Sinoflan-Fitofarm (an analogue with an identical composition, manufactured by the manufacturer PJSC Fitofarm);
• Flutsar-Darnitsa ;
• Flucederm ;
• (gel and ointment).

Instructions for use. Contraindications and release form.

Composition and release form

Ointment for external use

100 g of ointment contains the active substance fluocinolone acetonide 25 mg.

Tube 10 g; 15

pharmachologic effect

Sinaflan is a glucocorticosteroid for topical use. It has anti-inflammatory, antiallergic, antiexudative and antipruritic effects. Reduces symptoms and eliminates inflammatory skin reactions.

Indications

Inflammatory and allergic skin diseases of non-microbial etiology:
- Seborrheic dermatitis.
- Eczema of various origins and localization.
- Neurodermatitis.
- Skin itching.
- Psoriasis.
- Sunburn.
- Insect bites.
- Other chronic forms inflammatory and allergic diseases skin accompanied by dry skin.

Contraindications

Hypersensitivity to the components of the drug.
- Bacterial, viral, fungal skin diseases.
- Anogenital itching, pyoderma, skin tumors.
- Infectious diseases skin: skin manifestations of syphilis, skin tuberculosis, diaper rash, rosacea.
- Extensive psoriatic rashes (plaques).
- Trophic ulcers of the leg associated with varicose veins veins
- Pregnancy and lactation period.
- Childhood(up to 1 year).
Use with caution in girls during puberty.

Directions for use and doses

Externally. A small amount of the drug is applied to the skin, previously wiped with a swab moistened with an antiseptic liquid, 2-4 times a day and lightly rubbed. The duration of treatment depends on the nature of the disease and is usually 5-10 days, with a long course of the disease - up to 25 days. For limited lesions, the ointment can be used under an occlusive dressing to enhance the effect. It is not allowed to use more than 2 g of ointment per day under a bandage. The ointment is preferable to use for dry forms of dermatoses.

special instructions

Use only in short courses on small areas of skin. The drug should not be applied to the face. Avoid getting the drug into your eyes. The duration of administration in children should not exceed 5 days. It is recommended to wear loose clothing during treatment. In patients with acne vulgaris or rosacea, the disease may worsen during treatment. To warn local infectious complications It is recommended to prescribe in combination with antimicrobial agents.

Drug interactions

Compatible with antimicrobial agents. Reduces the activity of antihypertensive, diuretic, antiarrhythmic drugs, potassium supplements. Diuretics (except potassium-sparing drugs) increase the risk of hypokalemia.

Overdose

Symptoms: itching, burning of the skin at the site of application of the ointment, hyperglycemia, glucosuria, Itsenko-Cushing syndrome.
Treatment: symptomatic with gradual withdrawal of the drug.

Storage conditions

In a dry, cool place.

Keep out of the reach of children.

Best before date

If you go to the doctor with a rash, itching or inflammation on the skin, you will be recommended a healing ointment. There are a lot of them now, and they all act differently and have different effectiveness. Many experts recommend the use of Sinaflan ointment because it is effective in treating various epidermal problems.

This product must be handled with care and caution. Let's look at why Sinaflan ointment is used and in what cases it can cause harm.

Sinaflan ointment - hormonal or not?

The active ingredient of the ointment is a glucocorticosteroid. This is a hormone produced by the adrenal cortex. This hormone relieves skin inflammation and itching. In cases of severe damage, it is applied topically to the affected area, in the form of an ointment. It must be used with extreme caution, strictly following the instructions and directions of the doctor. Otherwise, you can provoke a malfunction in the body with serious consequences.

Release form and composition of Sinaflan ointment

Sinaflan ointment is a yellowish, slightly greasy substance that is easy to apply. Metal tubes are available in two sizes: 10 g and 15 g. B cardboard box In addition to the tube of ointment, there is a sheet with instructions and other necessary information. The product is popular, so it is easy to find in pharmacies.

The active substance of the ointment is a synthetic hormone glucocorticosteroid. In addition to it, it contains:

• Petrolatum.
• Lanolin.
• Propylene glycol.
• Ceresin.

The main function of these substances is to ensure the correct concentration of the active component and facilitate its application to the skin.

Blood plasma, liver and kidneys are involved in excretion from the body.

What does the ointment help with: instructions for use

Sinaflan ointment fights skin inflammations, except those caused by pathogenic microorganisms, eliminates the manifestations of allergies on the skin, and eliminates itching. Indications for use of Sinaflan are associated with skin damage:

• seborrhea;
• dermatitis;
• lichen planus;
• toxicoderma;
• psoriasis;
• lupus;
• erythrema multiforme;
• eczema;
• neuroallergodermatosis;
• hives.

Effective against itching and inflammation makes possible use Sinaflan ointment after insect bites. It is often prescribed for the treatment of minor burns.

The drug Sinaflan is not able to affect bacteria and fungi, so it is often used in tandem with drugs specializing in them. This allows you to comprehensively protect the affected area from infection and worsening of the condition.

Before use, be sure to read the instructions for Sinaflan and follow them thoroughly.

Instructions for use and dosage

Sinaflan ointment is used externally only. The affected area of ​​skin needs to be wiped disinfectant, then apply ointment. If possible, massage for a couple of minutes until absorbed. Usually the treatment is repeated 2-4 times a day. In some cases, a bandage is applied after treatment, this enhances the effectiveness of the drug.

The duration of treatment is determined by the doctor, guided by the severity of skin damage and the speed of recovery. It is not recommended to delay the use of Sinaflan ointment. Treatment with it is safe for up to 2 weeks. More long treatment sometimes carried out, but only in emergency cases and under the close supervision of a doctor.

Contraindications and side effects

Sinaflan hormonal ointment is very effective if you are constantly monitored by a doctor during treatment. But carelessness in its use can provoke a deterioration in the patient’s condition:

• re-infection of tissues;
• itching, feeling of dryness;
• folliculitis;
• steroid acne;
• allergies and decreased immunity.

When used over a large area of ​​skin, more serious violations are possible:

• disorders of the adrenal glands;
• slower rehabilitation;
• stomach ulcer;
• diabetes;
• gastritis.

There are also risks with prolonged contact with the drug:

• secondary immunodeficiency;
• alopecia;
• varicose veins;
• purpura;
• violation of the protective function of the skin.

If complications arise, you must stop applying Sinaflan ointment to the skin - sometimes this is done immediately, sometimes the amount is gradually reduced. In some cases, symptomatic treatment of individual symptoms is required, but more often the condition improves simply with the cessation of exposure to the hormone.

Did you know that to restore hormonal balance when menstrual cycle The drug Utrozhestan may help. Doctors often prescribe this remedy during pregnancy.

Use during pregnancy

Sinaflan ointment is very dangerous for a baby. Sometimes it still has to be used - in these cases, the doctor assesses the prospects and authorizes treatment if the benefit to the mother outweighs the harm to the child. Analogues of Sinaflan ointment often come to the rescue.

Most doctors avoid using Sinaflan ointment at all costs during pregnancy, as this will inevitably affect the development of the fetus.

During lactation, they also try to avoid the use of this ointment, and if this fails, they stop breastfeeding the baby and switch to formula.

special instructions

Sinaflan is almost never prescribed to children under 12 years of age. Before puberty, it is forbidden to use the product for longer than 5 days in a row - with longer exposure, the risk of side effects is very high.

An opened tube of the drug can be stored for no more than 5 years; after this period the product cannot be used.

Name:

Sinaflanum

Pharmacological
action:

Sinaflan– a drug from the group of topical glucocorticosteroids.
Fluocinolone acetonide– a substance obtained synthetically, which has pharmacological activity similar to glucocorticosteroids, has high glucocorticoid activity and has virtually no mineralocorticoid effect.

The drug molecule contains additional 2 fluorine atoms, which help reduce local absorption and enhance the anti-inflammatory effect.

A drug at local application provides:
- antipruritic effect;
- antiallergic and anti-inflammatory effect;
- promotes local vasodilation.

The main mechanism of action of the drug is the inhibition of phospholipase A2. Inhibition of the activity of this enzyme prevents the conversion of arachidonic acid to its pharmacologically active form.
By reducing the activity of arachidonic acid there is a decrease in the amount of leukotrienes and prostaglandins, which are the main mediators of inflammation.

A drug by reducing histamine release from mast cells inhibits the development of hypersensitivity reactions.

When using the drug Sinaflan the risk of developing exudative reactions is reduced, because active substance The drug helps to narrow the lumen of blood vessels.

The drug affects protein metabolism, in particular, leads to a decrease in protein synthesis and collagen deposition.

When applied topically, the drug is well absorbed through the stratum corneum of the epidermis and accumulates in the dermis; pharmacologically significant concentrations of fluocinolone are determined in the dermis 15 days after application.

The drug is not biotransformed in the skin.
Systemic absorption is negligible However, it intensifies when the drug is applied to areas of the skin that are hypersensitive, including the face, skin folds, and damaged areas of the epidermis.
Systemic absorption increases also when applying the drug Sinaflan under an occlusive dressing and with long-term use of the drug on large areas of the skin.
In children and adolescents, systemic absorption of topical glucocorticosteroids is higher than in adults.

Indications for
application:

A drug used for skin diseases that require glucocorticosteroid therapy, including:
- psoriasis;
- lichen planus and discoid lupus erythematosus;
- seborrhea of ​​the skin;
- eczematous lesions of various localizations;
- neurodermatitis;
- allergic skin diseases and itchy skin of various etiologies;
- first degree burns, including sunburn;
- insect bites.

Mode of application:

Externally. A small amount of the drug is applied to the skin, previously wiped with a swab moistened with an antiseptic liquid, 2-4 times a day and lightly rubbed.
Duration of treatment depends on the nature of the disease and is usually 5-10 days, with a long course of the disease - up to 25 days.

For limited lesions To enhance the effect, the ointment can be used under an occlusive dressing. It is not allowed to use more than 2 g of ointment per day under a bandage. The ointment is preferable to use for dry forms of dermatoses.

Avoid getting the drug into your eyes. The duration of administration in children should not exceed 5 days. It is recommended to wear loose clothing during treatment.

In patients with acne vulgaris or rosacea During treatment, an exacerbation of the disease is possible. To prevent local infectious complications, it is recommended to prescribe in combination with antimicrobial agents.

Side effects:

Telangiectasia;
- post-steroid vascular purpura;
- skin atrophy;
- skin stretching;
- hirsutism;
- hypertrichosis;
- perioral dermatitis;
- secondary infectious skin lesions.

For long-term use and/or when applied to large surfaces possible systemic side effects.

Contraindications:

Hypersensitivity to the components of the drug.
- Bacterial, viral, fungal skin diseases.
- Anogenital itching, pyoderma, skin tumors.
- Infectious skin diseases: skin manifestations of syphilis, skin tuberculosis, diaper rash, rosacea.
- Extensive psoriatic rashes (plaques).
- Trophic ulcers of the leg associated with varicose veins.
- Pregnancy and lactation period.
- Children's age (up to 1 year).

Use with caution in girls during puberty.

Interaction
other medicinal
by other means:

Compatible with antimicrobial agents.
Reduces activity antihypertensive, diuretic, antiarrhythmic drugs, potassium supplements. Diuretics (except potassium-sparing drugs) increase the risk of hypokalemia.

Sinaflan ointment is a thick, homogeneous glucocorticosteroid gel of a light yellow hue for external use. It is produced in the form of an ointment at a concentration of 0.025% in an aluminum tube with a volume of 10 or 15 g. The tube is also additionally packaged in a small cardboard box with instructions included. What is Siaflan ointment needed for: instructions for use and how much does Sinaflan cost?

The product is not intended for internal use, strictly for external use! What is Sinaflan-phytofarm ointment used for:

• chronic inflammatory processes on the skin;
• various dermatitis;
• Sinaflan relieves symptoms of psoriasis;
• severe burns;
• insect bites;
• severe itching of the skin;
• non-infectious skin diseases.

Sinaflan ointment in the photo:

Fluocinolone acetonide is the main active substance(1 g of product is equivalent to 250 mcg of fluocinolone acetonide). There are additional components such as medical petroleum jelly, lanolin, propylene glycol and ceresin.

Sinaflan ointment contains a hormone produced by the adrenal glands - glucocorticoid. It is the hormonal composition of the drug that provides quick results. However, their use may not go unnoticed:

• change in hair growth in the area treated with ointment (both upward and downward);
• formation of spider veins;
• skin pigmentation, etc.

That is why this product should be used strictly as prescribed by a doctor, despite its free sale in retail pharmacies.

Sinaflan ointment for external use is indicated for use from three years of age.

The rules for using the product are determined only by the attending physician personally for his patient, based on the illness and age of the patient.

Sinaflan gel must be applied in a thin layer to a clean, dry skin covering with a frequency of 2-4 times a day. Average duration treatment with Sinaflan is 5−7 days. If you do not achieve the expected result, you should contact your doctor.

For more severe dermatological diseases, it is allowed to use dressings and then change them at intervals of 2 times a day.

When using the product for a long time on large areas of skin, the following symptoms of overdose appear:

• disruption of the endocrine system;
• active growth of unwanted hair growth in the area where the ointment is applied;
• adrenal insufficiency.

If you notice the symptoms described above, you must immediately stop using the product and contact your doctor. As a rule, after stopping the use of the drug, all negative signs go away on their own.

Sinaflan liniment should not be used simultaneously with other glucocorticosteroids, as this increases the appearance of side effects and overdose.

For severe dermatological diseases, Sinaflan can be combined with the use of antimicrobial and anti-inflammatory drugs orally.

Is it possible to smear Sinaflan on the face if there are rashes on it? Not recommended. But in some exceptions it is possible. Before using the product, you must wash your hands to avoid infection. After using the product, you should also wash your hands well with soap to avoid getting any residue. medicine in the eyes. If the ointment gets into your eyes, rinse them immediately with water and consult an ophthalmologist as soon as possible.

Before use, for children from 2 to 5 years old, Sinaflan ointment must first be mixed with “Children’s” cream in a 50:50 ratio to reduce the likelihood of side effects and overdoses.

The end of using the product should not be abrupt. When applied, the volume of the ointment should be reduced every day or mixed with the “Children’s” cream, while the proportion of the cream should be increased daily and the ointment reduced accordingly.

Sinaflan ointment should not be used by pregnant women, since the main substance can enter the uterus through the placenta. There are no studies on the effect of the drug on the potential child of a pregnant woman., so it’s better not to risk your health and the health of your future children.
During lactation, it is also prohibited to use Sinaflan, since its components can be absorbed into the blood and excreted in small, but still, quantities in breast milk. If there is an urgent need for its use, breastfeeding is stopped and the child is transferred to artificial feeding.

• itching and burning at the application site;
• the appearance of acne at the application site;
• alopecia;
• active growth of hair growth at the application site;
• the appearance of various pigmentation of the skin;
• hypertrichosis.

When using the product for a long time and over large areas of skin, the following side effects may be observed:

• gastritis;
• the appearance of ulcers in the digestive tract;
• Itsenko-Cushing syndrome;
• adrenal insufficiency;
• diabetes.

The cost of the product ranges from 40 to 80 rubles, depending on the manufacturer and the weight of the tube. The average cost is 60 rubles (prices are given for Moscow).

This one has medical product there are analogues:

• Flucinar ointment;
• Synoderm cream;
• Flunolone ointment.

All of the above analogues of Sinaflan belong to the group of glucocorticosteroids, therefore they are hormonal. Each remedy has its own contraindications, therefore self-replacement Extremely not recommended, only with the permission of the attending physician.

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Before using medicinal ointment, it is imperative to read the instructions to exclude cases of contraindications:

• age up to two years;
• individual intolerance to the components of the product or allergies;
• purulent processes on the skin;
• streptoderma;
• diaper dermatitis;
• tuberculosis of the skin.
• pregnancy and lactation.

Teenagers need to be especially careful when using this product to relieve skin problems during puberty.

The product is sold in almost any retail pharmacy and is dispensed without a doctor’s prescription. Sinaflan should be stored in a cool, dark place (the refrigerator is best suited for this purpose). After use, screw the cap tightly.

The shelf life of the product is 5 years, pay attention to the date of manufacture and packaging, as medicines cannot be returned.

At the end of the shelf life of the medicine, stop using it, and it is better to get rid of the expired product immediately.

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