Thiamine bromide indications for use. Results of the use of thiamine bromide in alcohol dependence. Contraindications for use

Pharmachologic effect:
It has a positive effect on the conduction of nervous excitation in synapses (at the sites of transmission of nervous excitation). Has moderate ganglion-blocking properties. With a reduced thiamine content in food, a person develops hypovitaminosis Bi (reduced intake of vitamin Bi into the body), and then vitamin deficiency Bi (lack of intake of vitamin Bi into the body) - Beri-Beri disease.

Thiamine method of application and dosage:
For medicinal purposes, thiamine chloride and thiamine bromide are used orally (after eating) and parenterally (bypassing the gastrointestinal tract).
Oral doses of thiamine chloride for adults are 0.01 g (10 mg) 1-3 (up to 5) times every day. Children under 3 years of age are prescribed 0.005 g (5 mg) every other day; 3-8 years - 0.005 g 3 times every day, every other day; over 8 years old - 0.01 g 1-3 times every day. The course of treatment is usually 30 days.
Thiamine bromide, due to its higher relative molecular weight (435.2), is used in slightly larger doses than thiamine chloride (relative molecular mass 337.27); 0.001 g (1 mg) of thiamine chloride corresponds in activity to 0.00129 g (1.29 mg) of thiamine bromide.
If absorption in the intestine is impaired and if there is a need to quickly create large concentrations of vitamin Bi in the blood, thiamine chloride or thiamine bromide is administered parenterally. Usually 0.025-0.05 g of thiamine chloride (1 ml of 2.5% or 5% solution) or 0.03-0.06 g of thiamine bromide (1 ml of 3% or 6% solution) is administered intramuscularly to adults (1 ml of 3% or 6% solution) 1 time each day every day; children are administered 0.0125 g (0.5 ml of a 2.5% solution) of thiamine chloride or 0.015 g (0.5 ml of a 3% solution) of thiamine bromide. The course of treatment is 10-30 injections.
The daily requirement for vitamin Bi is within 2 mg for an adult; With heavy physical work, the need for the vitamin increases slightly. Daily doses for babies: from 6 months of age. up to 1 year - 0.5 mg; from 1 year to 1.5 years - 0.8 mg; from 1.5 to 2 years - 0.9 mg; from 3 to 4 years - 1.1 mg; from 5 to 6 years - 1.2 mg; from 7 to 10 years - 1.4 mg; from 11 to 13 years - 1.7 mg; for boys 14-17 years old - 1.9 mg; for girls 14-17 years old - 1.7 mg.

Thiamine contraindications:
History of allergic diseases (previous).

Thiamine side effects:
In some cases, especially with parenteral administration, allergic reactions and even anaphylactic (allergic) shock are possible.

Release form:
Available in the form of thiamine bromide: powder 1 g; dragees of 0.002 g in a pack of 50 g; scored tablets of 0.0129 g in a pack of 50 pcs.; ampoules of 1 ml in a pack of 10 pcs. 3% and 6% solution and thiamine chloride: ampoules of 1 ml in packs of 50 pcs. 2.5% and 5% solution.

Synonyms:
Vitamin B, Vitamin B1, Aneurin, Aneuril, Benerva, Benevrin, Berin, Betabion, Betamine, Betanevrin, Betavitan, Betaxin, Betiamin, Bevimin, Bevital, Bevitin, Christovibex, Orizanin, Thiamine bromide, Thiamine chloride, Vitaplex Bi.

Storage conditions:
In a place protected from light.

Thiamine composition:
4-methyl-5-b-oxyethyl-N-(2-methyl-4-amino-5-methyl-pyrimidyl)-thiazolium bromide hydrobromide (or hydrochloride).
Thiamine bromide is a white or white powder with a slightly yellowish tint. The drug has a faint characteristic odor of yeast. Easily soluble in water. The solution (pH 2.7 - 3.6) is sterilized at +100 °C for 30 minutes.

Attention!
Before using the medication "Thiamin" You should consult your doctor.
The instructions are provided for informational purposes only. Thiamine».

(vitamin B1) belongs to the group of water-soluble B complex vitamins.

Thiamine bromide has a positive effect on the conduction of nerve excitation in synapses. Has moderate ganglion-blocking properties. With a reduced content of thiamine in food, a person develops hypovitaminosis B1, and then vitamin deficiency B1 (beriberi).

Vitamin B1 is found in yeast, germs and shells of cereals (rice, wheat, rye), nuts, almonds, carrots, egg yolks, liver, and milk. Rice bran, brewer's and baker's yeast, and black bread are especially rich in vitamins.

Daily requirement for thiamine

Daily requirement for thiamine: for an adult - 2 mg; during heavy physical labor, in pregnant women and nursing mothers - 2.5–3 mg; in children under 7 years old - 1 mg, from 7 to 14 years old - 1.5 mg.

Indications for use

The role of thiamine in metabolism and a number of body functions (especially the nervous system) determines a wide range of indications for its use, namely:

• Hypovitaminosis and vitamin B deficiency;
• Inflammatory and degenerative processes in peripheral nerves: various forms of neuritis, alcoholic and post-infectious polyneuritis, radiculitis, neuralgia, peripheral paresis and paralysis of various origins, Meniere's disease, Korsakoff's psychosis, poliomyelitis and encephalomyelitis, Wernicke's disease;
• Damage to the central nervous system as a result of trauma, concussions, especially with severe pain; autonomic neuroses, migraines;
• Cardiovascular neuroses accompanied by tachycardia, myasthenia gravis;
• Peptic ulcer of the stomach and duodenum, weakening of the secretory and motor functions of the gastrointestinal tract (intestinal atony, etc.);
• Deterioration of tissue regeneration after wounds, wound exhaustion;
• Eating disorders (nutritional dystrophy);
• Myocardial dystrophy, coronary circulation disorders in patients with angina pectoris;
• Thyrotoxicosis;
• Endarteritis;
• Neurogenic dermatoses. Shingles. Psoriasis. Eczema, itchy skin of various etiologies (diabetes, uremia, jaundice, etc.);
• Poisoning (carbon disulfide, tetraethyl lead, mercury, methyl alcohol, arsenic, etc.).

Rules of application

Thiamine bromide is prescribed orally in tablets and dragees, and is also administered intravenously and intramuscularly.

• For preventive purposes Thiamine bromide is prescribed orally - for adults, 0.01–0.06 g per day; for children 1–10 years old, a single dose is 0.001–0.01 g per day.
• For medicinal purposes adults are prescribed 0.06–0.12 g of thiamine bromide orally 1–3 times a day. Adults are administered intramuscularly with 0.5–1 ml of a 3% or 6% solution of thiamine bromide once a day. The course of treatment is 15–30 injections.

As preparations containing thiamine, 50–100 g of brewer's yeast (liquid and dry) and baker's yeast are prescribed orally.

Side effects

In some cases (especially with parenteral administration), allergic reactions and anaphylactic shock are possible.

Contraindications

History of allergic diseases.

Relative contraindications to the use of thiamine: hypertension, gastric ulcer.

Composition and release form

Issued:

Prescription for Thiamine Bromide

• Tablets with a score of 0.0129 g and 0.00645 g, in a package of 50 tablets.
• Tablets of 0.01 g, with 1 g of glucose, in a package of 10 tablets.
• Tablets of 0.00258 g, 0.005 g and 0.01 g in packages of 10, 40, 50 and 200 tablets.
• Dragee 0.002 g, in packs of 25 and 50 dragees.
• 3% and 6% solutions for parenteral administration (thiamine bromide - 30 g or 60 g, unithiol - 2 g, water for injection - up to 1 l) in ampoules of 1 ml, in packs of 10 ampoules.

Thiamine is included in numerous multivitamin preparations.

Shelf life and storage conditions

Store in a dry place, protected from light.

Shelf life of thiamine bromide: ampoules - 3 years, tablets - 4 years.

Properties

(Thiamini bromidum, Thiaminum bromatum) - 4-methyl-5-β-hydroxyethyl-N-(2-methyl-4-amino-5-methylpyrimidyl)-thiazolium chloride hydrobromide is a white crystalline powder with a faint characteristic odor. Hygroscopic, easily soluble in water.

Thiamine is phosphorylated in animals and humans and, in the form of thiamine pyrophosphate, functions as a coenzyme of decarboxylase, which plays an important role in intermediary metabolism.

A sufficient amount of thiamine in the body is associated with the normal course of carbohydrate, protein and water metabolism, secretory and motor function gastrointestinal tract, activity of the nervous system and cardiac muscle.

Thiamine deficiency in the body leads to impaired conversion of carbohydrates, accumulation of intermediate products of carbohydrate metabolism (lactic and pyruvic acids), and dysfunction of a number of organs and systems.

A deficiency of vitamin B1 occurs with prolonged monotonous nutrition with food poor in thiamine (especially rich in carbohydrates), with impaired absorption of the vitamin due to diseases of the gastrointestinal tract, or with a discrepancy between the amount of vitamin administered with food and the need for it.

In these cases, various forms of hypovitaminosis B1 may occur, manifested in loss of strength, loss of appetite, damage to the central and peripheral nervous systems, disruption of the heart, dysfunction of the gastrointestinal tract, hypothermia, and edema.

The complete absence of thiamine in food leads to the development severe form vitamin deficiency B1 - beriberi disease.

Analogs

Aneurin. Aneuril. Aneirin. Arkavit B1. Bevemin. Bevimin. Bevital. Bevitin. Bemunin. Benevrin. Benerva. Benol. Berin. Betabion. Betavel. Betavitan. Betaxin. Betalin. Betamin. Betaneurin. Betiazine. Bethiamin. Bitevan. Vitamin B1. Vitaplex B1. Vitapur B1. Christovibex. Oryzamin. Polyneuramine.

The drug Thiamine has a positive effect on the conduction of nervous excitation in synapses (at the sites of transmission of nervous excitation). Has moderate ganglion-blocking properties. With reduced content thiamine in food, a person develops hypovitaminosis Bi (reduced intake of vitamin Bi into the body), and then vitamin deficiency Bi (lack of intake of vitamin Bi into the body) - Beri-Beri disease.

Indications for use

Mode of application

Side effects

Contraindications

Release form

Storage conditions

Synonyms

Compound

Main settings

Thiamine bromide (vitamin B1) Can be taken orally and administered intramuscularly.

In tablet form prescribed 0.01 g in the morning, at lunch and in the evening, after meals.

Toddlers indicated 0.005 g every other day, preschool age – 0.005 g in the morning, at lunch and in the evening, every other day, schoolchildren– 0.01 g 3 times a day. The course of treatment is 1 month.

Solution for injection for adults:

1. 2.5% or 5% 1 ml intramuscularly, 20-50 mg 1 time per day.
2. 3% or 6% 1 ml intramuscularly, 30-60 mg 1 time per day.

Injection solution for children:

1. 2.5% 0.5 ml intramuscularly, 12.5 mg 1 time per day.
2. 3% 0.5 ml intramuscularly 15 mg 1 time per day.

The course of treatment is 1 month.

Dosage

Maximum daily dose the drug is 0.05 g per day. Preventively, Thiamine bromide is prescribed at 0.005 g per day.

Composition and release form

Active ingredient: thiamine pyrophosphate.
The drug is available in the form:

1. Powder 1000 mg.
2. Dragee 2 mg, pack of 50 pcs.
3. Score tablets: 2.58 mg, 6.45 mg, 12.9 mg, 50 pcs per pack.
4. Ampoules 2.5%, 3%, 5%, 6%, 1 ml, 10 or 50 pcs per pack.

Pharmacological properties

Thiamine bromide has the following effect on the body:

• Stimulates the transmission of nerve impulses, acting in the synaptic cleft.
• Blocks H-cholinergic receptors.
• Stimulates immunity.
• Positively affects metabolism.
• Has antioxidant properties.

Digestibility and stability

At oral administration absorbed into small intestine. When administered parenterally, it completely enters the bloodstream. Has a resorptive effect. Absorbed entirely. Poorly resistant to heat treatment.

Overdose

In case of an overdose of Thiamine bromide, the following reactions are possible:

• Liver damage.
• Kidney damage.

Indications

Indications for taking thiamine bromide:

• In endocrinology- excessive production of thyroid hormones.
• In gastroenterology- defects in the mucous membrane of the stomach and duodenum, decreased intestinal motility.
• In psychiatry and narcology- amnestic syndrome due to vitamin B1 deficiency.
• In otolaryngology- increase in the amount of endolymph in the cavity of the inner ear.
• In neurology- diseases of the roots of the spinal nerves, local pain along the nerve, incomplete paralysis, complete loss of conscious motor functions, acute upper hemorrhagic polioencephalitis.
• Lack of vitamin B1 in the body.
• At infectious diseases- polio, encephalomyelitis.
• In cardiology- damage to the heart muscle due to metabolic disorders in it, ischemic disease hearts.
• In dermatology - herpetic infection, dermatoses, scaly lichen, inflammation of the epidermis.
• In toxicology- in case of intoxication with carbon disulfide, tetraethylene lead, methanol, arsenic, mercury.

Contraindications

Hypersensitivity to the components of the drug.

Side effects

Immediate hypersensitivity.

special instructions

1. The preferred route of administration is oral. Parenteral administration is often complicated by allergic reactions, so it should be used only in cases where oral administration of the drug is impossible or inappropriate.
2. The drug should be combined with foods rich in B vitamins.
3. In case of upper acute hemorrhagic polioencephalitis, vitamin B1 must be taken before administering dextrose.

Interaction

1. Should not be taken simultaneously with alcohol.
2. Reduces the therapeutic effect of drugs that relax muscles.
3. Reduces the effect of penicillin antimicrobial agents and vitamin PP.
4. Should not be used in conjunction with vitamins B6 and B12.
5. Thiamine bromide loses its properties when in contact with sulfurous acid salts.

The drug contains the active substance thiamine .

An additional component can be water for injection.

Release form

Thiamine is available in the form of powder, capsules, tablets or ready-made solution for injection. The substance is packaged in bags, bottles or ampoules of 1 ml, 10 pieces per package.

pharmachologic effect

The drug has an effect that can compensate for the deficiency .

Pharmacodynamics and pharmacokinetics

Thiamine is synthetic analogue vitamin B1, which has good water solubility. Inside the body, during the process of phosphorylation, the substance is converted into cocarboxylase – coenzyme of most enzymatic reactions.

According to the pharmacopoeia, Thiamine Chloride, Thiamine Bromide, Thiamina Vial, Thiamine Hydrochloride- this is all trade names and vitamin B1 analogues. These medications are available as white crystalline powder, capsules, tablets, or solution.

They usually have a weak specific odor, are highly soluble in water, are resistant to acidic solutions, but are easily destroyed when exposed to alkaline and neutral environments.

Parenteral administration of drugs allows it to quickly penetrate into and be fairly evenly distributed throughout the body.

Phosphorylation of the substance occurs in the liver area. Accumulation of the vitamin is noted in the heart, liver, kidneys, brain and spleen. The main substance is excreted by the liver and kidneys.

Vitamin B1 or Thiamine is necessary for complete carbohydrate, protein and fat metabolism, normal functioning of the nervous, digestive, endocrine and cardiovascular systems.

Thiamine Mononitrate - what is it?

Thiamine Mononitrate has low hygroscopicity, but high resistance to exposure external factors. Therefore, it is actively used in the process of fortification of various food products.

Indications for use

Thiamine is prescribed for:

• hypovitaminosis and vitamin B1 deficiency;
• neuritis, radiculitis, peripheral paresis and paralysis, intestinal atony;
• fasting;
• chronic alcoholism;
• severe liver dysfunction;
• increased need for at .

Contraindications for use

The main contraindication to taking the drug is hypersensitivity.

Side effects

When taking Thiamine, side effects may develop in the form of: sweating, , allergic reactions – , skin, anaphylactic shock.

Thiamine, instructions for use (Method and dosage)

Instructions for use of Thiamine chloride indicate that this drug can be prescribed for both internal and parenteral administration. The dosage is determined by the doctor, but on average for adult patients it is 10 mg taken up to 5 times a day. For small patients under 3 years of age, the recommended dose is 5 mg taken every other day, for children 3-8 years old - 5 mg 3 times a day every other day, from 8 years old - 10 mg 1-3 times a day. The duration of treatment is about 30 days.

The instructions for Thiamine hydrochloride recommend using it for deep intramuscular injection. For adult patients and children over 7 years of age, a daily dosage of 25-50 mg is prescribed. Treatment begins with the introduction of a small amount of solution. If the drug is well tolerated by patients, the daily dosage is increased by 25 mg. In this case, the daily dose should not exceed 300 mg. The therapeutic course is 10-30 injections. Children under 3 months are prescribed 12.5 mg, from 4 months to 7 years – 25 mg taken once a day.

Overdose

In cases of overdose, the severity may increase side effects. Therefore, you must strictly adhere to the prescribed dose.

Interaction

Simultaneous use with solutions containing sulfites , and also reduces their activity.

With simultaneous parenteral administration of Thiamine and or Cyanocobalamin a significant increase in its effect is possible. In addition, it may complicate the conversion of Thiamine. It is prohibited to mix vitamin B1 with or, which may cause destruction , and also with nicotinic acid , which can destroy vitamin B1.

Combination with suxamethonium iodide, Redergama, some sympatholytics, for example: or Octadine – reduces them pharmachologic effect. Combination of Thiamine and sleeping pills can reduce their hypnotic and hypotensive activity.

Terms of sale

Over the counter.

Storage conditions

To store vitamin B1, you need a dark, cool place out of reach of children.

Best before date

Special instructions

What foods contain vitamin B1?

To prevent Vitamin B1 deficiency, you need to include foods that contain this substance in your diet. Most of this component is found in buckwheat, oatmeal, peas, nuts and fatty pork. Thiamine is also included in bread made from wholemeal flour, sprouted wheat, rice bran, green vegetables, some berries and fruits.

A sufficient amount of the vitamin is present in wild and garden greens, algae, brewer's yeast, poultry, beef, liver, eggs and fish.

Use of Thiamine chloride and its analogues for hair

Thiamine Vial in ampoules is intended for strengthening hair, which is not recommended for use pure form, due to the possibility of development .

Thiamine Vial - what is it?

It should be noted that this drug is an analogue of vitamin B1. You can significantly improve the condition of your hair if you use this product with shampoo. Before each wash of your hair, you need to add just a few drops of vitamin to your shampoo. The result of this will be beautiful and manageable hair.

In addition, you can add thiamine to hair masks or balms, which significantly strengthens them. positive influence on quality and structure. An excellent way to strengthen hair is wrapping, which makes it healthier, more beautiful and shiny.

To do this, make a mixture of two teaspoons of castor or burdock oil, an ampoule of thiamine, an ampoule , solution and lemon juice.

All this needs to be mixed well and rubbed into the hair roots. The rest of the product is distributed along the length of the hair. Wrap your head in a towel and leave for at least two hours. Then wash your hair well with shampoo. It is recommended to perform the procedure every other day for three weeks.

Analogs

The main analogues of this drug: Vitamin B, Aneuril, Aneurin, Benerva, Berin, Betabion, Benevrin, Betamin, Betanevrin, Betaxin, Betiamin, Bevital, Bevitin, Christovibex, Orizanin, Vitaplex Bi.

Also have a similar effect: , .

Alcohol

Simultaneous consumption of alcohol can significantly weaken the effect of vitamin B1 and speed up its elimination from the body.