Wobenzym is a systemic enzyme therapy drug. Instructions for use Wobenzym Wobenzym interaction with diuretics

Instructions

Enzyme therapy is considered a new direction in medicine. One of the drugs based on a combination of enzymes of natural origin that act systemically is Wobenzym. It is included in therapeutic regimens for chronic and complicated diseases.

Latin name

Release forms and composition

The drug is available only in the form of enteric tablets. This suggests that the components of the drug do not participate in the digestion process in the stomach, but dissolve in the small intestine, from the walls of which enzymes are actively distributed, bind to blood proteins and have a biological effect.

Round tablets of complex composition have a biconvex shape, covered with a smooth red-orange coating. Sold in 40, 100 or 200 pcs. (each blister contains 20 tablets), bottles contain 800 tablets. Medicine packaging (cardboard packs or polyethylene bottles) is red and white.

The substances that make up the dosage form are distributed as follows:

1. The active ingredients are concentrated in the core. Enzyme volumes are presented in units adopted by the Federation International Pharmaceutical - FIP/FIP. Each tablet contains:
   • 100 mg of pancreatin (300 proteolytic units) - necessary to compensate for the lack of enzymes and improve digestion;
   • 18 mg of papain (90 FIP units) - inhibits the growth and reproduction of bacteria, improves immunity, has an antipyretic and analgesic effect;
   • 50 mg rutoside trihydrate (vitamin P) - prevents fragility and improves capillary permeability, improves blood flow;
   • 12 mg of trypsin (360 FIP units) - provides an immunomodulatory effect, accelerates wound healing, prevents thrombosis, reduces swelling (inflammatory and lymphatic);
   • 45 mg bromelain (225 FIP units) - improves immunity, removes toxic substances from the body, enhances the anti-inflammatory response, accelerates tissue repair and wound healing, reduces inflammatory and lymphatic edema;
   • 10 mg each of lipase (34 FIP units) and amylase (50 FIP units) - both enzymes are necessary to improve metabolism and absorption of vitamins;
   • 0.75 mg of chymotrypsin (300 FIP units) - necessary to optimize the anti-inflammatory response and improve blood flow.
2. Lactose monohydrate, pregelatinized starch, stearic acid, magnesium stearate, anhydrous colloidal silicon dioxide, and talc are used as excipients in the production of the drug.
3. The composition of the film shell includes a copolymer of methacrylic acid and methyl methacrylate, sodium lauryl sulfate, triethyl citrate, macrogol 6000, talc, dyes, wax, clay, etc.

pharmachologic effect

Pharmacokinetics

The multicomponent medicine (7 enzymes and vitamin P) is a carefully selected proportion of highly active enzymes of plant (papain, bromelain) and animal (pancreatin, trypsin, lipase, amylase, chymotrypsin) origin, carefully selected in quality and quantity. The systemic effect is realized through anti-inflammatory, immunomodulatory, antiplatelet, fibrinolytic, and decongestant effects. Most enzymes also have secondary analgesic properties.

It has a positive effect on the body’s immunological reactivity, limits the pathological manifestations of autoimmune and immune complex processes, and stimulates antitumor immunity.

Under the influence of the drug composition, the activity of monocytes-macrophages is stimulated and regulated, which absorb, neutralize and eliminate viruses and cells infected by them, and cytotoxic T-lymphocytes, which are responsible for the lysis of damaged cells.

Helps normalize lipid metabolism and reduce cholesterol synthesis. As a result of the action of the components of the tablets, the concentration of thromboxane is reduced, the number of platelets is normalized, blood microcirculation and oxygen supply to tissues are improved.

The effectiveness of the therapeutic effect is improved due to the fact that the composition contains bromelain. This enzyme ensures the penetration and increase in the concentration of the antibiotic in the blood plasma and the site of inflammation.

The drug reduces the severity of side effects that occur while taking antibiotics or hormonal drugs.

The drug ensures maximum recovery of the body, regulates the mechanisms of production of interferons that provide antiviral immunity.

Indications for use of Wobenzym

The list of diseases and pathological conditions for which enzyme medications are included in complex therapy is practically unlimited. It is prescribed to women and men:

• in urology in the treatment of chronic and acute diseases such as cystitis, prostatitis, STDs, urinary tract infections;
• in gynecology for endometriosis, adnexitis, mastopathy, uterine fibroids, gestosis, genital infections;
• in angiology in the treatment of thrombophlebitis (including acute thrombophlebitis), obliterating endarteritis, postphlebitic syndrome, atherosclerosis of the arteries of the legs, lymphatic edema, thrombosis and other arterial lesions;
• in gastroenterology (hepatitis, pancreatitis);
• in cardiology - to improve the rheological properties of blood, which is important for patients with myocardial infarction and angina pectoris;
• in nephrology for patients with pyelonephritis or glomerulonephritis;
• in rheumatology (arthritis, ankylosing spondylitis, etc.);
• in pulmonology (pneumonia, bronchitis, sinusitis);
• in endocrinology (thyroiditis, diabetic retinopathy and angiopathy);
• in dermatology;
• in surgery (including plastic surgery) to prevent postoperative complications;
• in traumatology (burns, injuries, bruises, hematomas, etc.);
• in pediatrics for any infectious and inflammatory processes;
• in ophthalmology (including ophthalmic surgery).

In most areas of medicine, the drug is prescribed for prophylactic purposes, because the combination of enzymes has a beneficial effect on the immune system and helps to avoid infectious complications after surgery, chemotherapy and radiation therapy for oncology, and adhesive disease.

It is used as a prophylactic for recurrent phlebitis and viral respiratory tract infections. Helps reduce side effects if the patient is prescribed a course of hormone replacement therapy.

Contraindications

The tablets contain enzymes only of natural origin, so there are few contraindications, but they do exist. Patients cannot use the medication:

• having diseases with a high likelihood of bleeding (for example, hemophilia or thrombocytopenia);
• undergoing hemodialysis;
• having individual intolerance to any component;
• under 5 years old.

How to take Wobenzym

To include a drug in a treatment course, it is necessary to take into account the type and severity of the disease, therefore, only the attending physician should prescribe dosages and duration of administration. Preventive courses are also prescribed by the doctor according to indications and taking into account the patient’s condition.

Pills

The duration of the course can be from 2 weeks to several months, which is explained by the peculiarities of absorption of components from the small intestine. Every day the patient should drink from 9 to 15 tablets (this recommendation is average; the doctor can increase the dosage according to the indications). The number of tablets is divided into 3 doses. The tablets are swallowed whole, without chewing, and washed down with a glass of water.

Before or after meals

For urological diseases

Enzyme therapy is prescribed by urologists for most genitourinary diseases and is considered an indispensable part of complex treatment. These can be chronic and acute pathologies, infectious and bacterial. Systemic enzyme therapy helps to precisely concentrate antibiotics in areas of inflammation and reduce intoxication in organs and tissues.

With prostatitis, enzymes help reduce pain, prevent its spread, and have a positive effect on sexual function.

For cystitis, enzymes speed up recovery, prevent relapses and the disease becoming chronic.

The course can last from 3 to 6 months with 3-5 tablets taken 3 times daily.

For mastopathy

The course of treatment must be comprehensive. The gynecologist also prescribes the described drug, which in the course of research has shown not only the ability to eliminate the symptoms of the disease, but also its effect on its cause. With long-term use (at least 3 months, 15 tablets per day), the drug can prevent the growth of cysts and pathological neoplasms in the breast tissue.

For pancreatitis

Side effects from taking Wobenzym

Most patients tolerate long-term enzyme therapy well, without side effects, addiction or withdrawal symptoms. Only in some cases, as a result of taking the tablets, changes in stool (consistency, smell) were noted.

Children over 5 years of age are prescribed a daily dose of 1 tablet for every 6 kg of body weight. If the child is over 12 years old, then adult dosages are used when prescribing the drug.

Effect on concentration

It does not have a negative effect on activities associated with the manifestation of psychomotor reactions and is not doping.

Drug interactions

With other drugs

Cases of incompatibility with other drugs have not been recorded. Increases the effectiveness of antibacterial drugs of the main groups:

• penicillins (including semisynthetic);
• cephalosporins;
• aminoglycosides;
• lincosamides;
• macrolides;
• tetracyclines;
• fluoroquinolones.

Alcohol compatibility

Any treatment course loses its meaning if the patient drinks alcohol, because... ethanol reduces the effectiveness of drugs. In addition, enzymes are prescribed as an addition to complex treatment, so alcohol may be contraindicated in combination with other drugs.

Storage conditions and periods

The tablets are included in list B, which requires storage in a dry place at +15...+25°C. Children should not have access to the place where the medicine is stored. The drug can be used for 30 months if storage conditions have been met.

Conditions for dispensing from pharmacies

Is it sold without a prescription?

Over-the-counter medication.

Price

Depends on the number of tablets. Minimum prices: for 40 pcs. — 411 rub., for 800 pcs. — 5800 rub.

Analogs

Finding cheap Russian drugs that can replace the German enzyme complex is not so easy. Other drugs do not have the same wide range of indications.

A doctor who is familiar with the patient’s medical history will help you select a complete replacement based on enzyme content or immunomodulatory properties.

Systemic enzyme therapy is a method of treatment using targeted mixtures of highly active plant and animal enzymes that affect inflammation, immune reactions, and reparative processes. One of these complex enzyme preparations is “ Wobenzym» ( Wobenzym) - a set of enzymes of animal and plant origin with the addition of rutoside. Wobenzym is used as part of complex therapy for many diseases and improves the health of the body.
In a number of countries, Wobenzym is registered as a dietary supplement (dietary supplement) and its distribution as a medicine is prohibited (for example, in the USA). Wobenzym was registered as a medicine in Russia in 2010. Manufacturer: Mucos Emulsions GmbH, Germany.

Indications for use of Wobenzyma

The main indications for the use of Wobenzym are post-traumatic edema, inflammatory processes in surgical pathology and in the postoperative period, lymphedema of various etiologies, post-thrombophlebitis syndrome, superficial thrombophlebitis, some autoimmune and immune complex diseases (rheumatoid arthritis, multiple sclerosis, glomerulonephritis, vasculitis), chronic and recurrent inflammatory processes of the upper and lower respiratory tract, ear, genitourinary system, digestive tract, joints, etc.
It should be remembered that in case of infectious and inflammatory processes, Wobenzym does not replace antibacterial agents, but increases their effectiveness.

Method of use of Wobenzym and dose

The dose of Wobenzym is selected individually, taking into account the nature and severity of the disease. First, 5-10 tablets are prescribed 3 times a day, the maintenance dose is usually 3 tablets 3 times a day. It is recommended to take the tablets 30 minutes before meals, without biting them, and wash them down with plenty of liquid (at least 250 ml).

For thrombophlebitis and postthrombophlebitis syndrome, Wobenzym is prescribed, depending on the severity of the disease, 5-10 tablets per dose 3 times a day for 7-14 days until swelling and inflammation are eliminated, then the dose is reduced to 3-5 tablets per dose. Usually the effect occurs on the 4th day. To achieve good results, it is recommended to carry out treatment for 1–2 months. For obliterating endarteritis of the vessels of the lower extremities, the therapeutic dose and duration of treatment are selected individually, but not less than 15 tablets per day. For the treatment of grade II-III lymphedema after mastectomy, Wobenzym is prescribed 7 tablets 3 times a day simultaneously with tocopherol (100 mg 3 times a day) for 4 weeks, then the drug is used in a maintenance dose.

For rheumatoid arthritis and ankylosing spondylitis, Wobenzym is prescribed 8-10 tablets 3 times a day, after achieving remission they switch to a maintenance dose - 5 tablets 3 times a day for a year or more. If necessary, to quickly eliminate pain, the drug is taken simultaneously with indomethacin or other non-steroidal anti-inflammatory drugs. For patients with reactive arthritis, Wobenzym is prescribed 5 tablets 3 times a day for 3–4 weeks in combination with antibacterial and non-steroidal anti-inflammatory drugs.

In gynecology and obstetrics, Wobenzym is usually prescribed 5 tablets 3 times a day for 16–17 days; for inflammatory processes, Wobenzym is taken simultaneously with antibiotics.

For the treatment of venous diseases (thrombophlebitis, postthrombophlebitis syndrome), it is recommended to prescribe 10 Wobenzym tablets 3 times a day for 2 weeks.

In traumatology for large-scale surgical interventions (endoprosthetics, complex reconstructive operations, transplantation and replantation), Wobenzym is prescribed according to a special regimen: 1st week - 10 tablets 3 times a day, 2nd week - 7 tablets 3 times a day , then 5 tablets 3 times a day for 1–1.5 months. In the conservative and surgical treatment of patients with minor injuries to soft tissues and muscles, as well as with isolated fractures of individual segments, the duration of therapy may be limited to 2–3 weeks.

In sports medicine, Wobenzym is prescribed for prophylactic purposes during sports competitions (5 tablets 3 times a day), as well as for injuries (10 tablets 3 times a day).

Contraindications to the use of Wobenzym

Contraindications to the use of systemic enzyme therapy are severe disorders of the blood coagulation system (with hemophilia or severe liver failure). When prescribing the enzyme drug "Wobenzym" to patients in the pre- and postoperative period, its fibrinolytic effect should be taken into account. Wobenzym should be prescribed with caution during pregnancy.
Side effects, even with long-term treatment with Wobenzym, are rare, mainly changes in the color, consistency and smell of stool. Rarely, allergic reactions occur that disappear after discontinuation of the drug.

Pharmacokinetics of the drug "Wobenzym"

The pharmacokinetics of the polyenzyme drug has been studied in detail " Wobenzym", which includes papain(plant enzyme from papaya). After ingestion, enzymes are absorbed in the small intestine in an active form, maintaining hydrolytic activity. Absorption in the small intestine of some enzymes reaches 20%. In the blood, enzyme macromolecules bind to the antiproteases α1-antitrypsin and α2-macroglobulin. Thanks to this, antigenic determinants of proteases are screened, which do not cause sensitization of the body. The maximum concentration of the components of polyenzyme preparations is achieved after 2 hours, is maintained at a stable level for 4 hours, and then decreases within 2 hours. The half-life is 8 hours. Enzymes circulating in the blood are partially captured by stellate reticuloendotheliocytes of the liver and other cells of the mononuclear phagocyte system. About 10% of Wobenzym is excreted in the urine, about 45% in feces. The drug, which is not absorbed in the intestine, participates in the digestive process.

Clinical trials of the drug "Wobenzym"

Numerous clinical trials have shown that complex enzyme preparations comply with general therapeutic principles - they are characterized by reliability and high efficiency with good tolerability, which determines a wide range of their clinical use. The method of systemic enzyme therapy has been introduced in various areas of clinical medicine (the complex enzyme preparation Wobenzym is most often prescribed for this purpose).

In pulmonology Wobenzym is used in combination with antibiotics and other drugs for the treatment of inflammatory diseases of the respiratory system: acute and chronic bronchitis, pneumonia, bronchiectasis. It has been established that the use of enzymes in complex therapy helps to increase the concentration of antibiotics in the pathological focus, reduces the viscosity of secretions, improves bronchial clearance and regeneration of the respiratory epithelium. The dissolution of microthrombi in pathologically altered parenchyma improves microcirculation and promotes saturation of tissues with antibacterial drugs, cleanses the alveoli of fresh fibrin clots, and activates lymph absorption. Enzyme drugs (including Wobenzym) are prescribed until recovery or stable remission of the disease is achieved. They are an effective means of preventing congestive bronchitis and pneumonia in elderly patients who are on bed rest.
Timely administration of enzyme therapy has a beneficial effect on the course of pulmonary infarction or infarction pneumonia.
The use of Wobenzym for sinusitis and laryngitis helps cleanse the mucous membrane and eliminate the source of inflammation.
A positive effect of systemic enzyme therapy has been noted for hepatitis, ulcerative colitis, Crohn's disease, and chronic pancreatitis.

In rheumatology The enzyme preparation "Wobenzym" is used in the complex treatment of rheumatoid polyarthritis, deforming osteoarthritis, ankylosing spondylitis (ankylosing spondylitis), juvenile rheumatoid arthritis, systemic vasculitis, there is evidence of a good clinical effect in systemic lupus erythematosus.
In rheumatoid arthritis, Wobenzym, with long-term (12 months) continuous use, showed the same effectiveness as oral gold preparations, which suggests a possible basic effect of the drug. During treatment with enzyme preparations, there is a rapid decrease in clinical and laboratory signs of immune inflammation activity, restoration of joint mobility, and a decrease in morning stiffness and pain.

In case of ankylosing spondylitis, the effectiveness of enzyme preparations is higher in a number of parameters than indomethacin. Enzyme therapy is used to treat reactive arthritis (especially in resistant and recurrent forms), tenosynovitis, bursitis, periarthritis, and myositis. In osteoarthritis, especially complicated by secondary synovitis, the therapeutic effectiveness of Wobenzym is comparable to the effect of diclofenac. During monotherapy and complex treatment of rheumatic diseases with Wobenzym, no significant adverse reactions were observed. In this regard, the drug can be used continuously for 12 months or more without special laboratory control. Prescribing Wobenzym to patients with rheumatoid arthritis improves tolerability and reduces the dose of cytostatics, non-steroidal anti-inflammatory drugs and glucocorticoids by 30–50%, which is a significant success in preventing the side effects of these drugs.

The use of Wobenzym in the complex treatment of chronic patients reduces the time required for the elimination of clinical symptoms and laboratory indicators of the activity of the inflammatory process in the kidneys, due to the normalization of immune reactivity, rheological properties of blood and restoration of balance between the state of lipid peroxidation and the body's antioxidant defense system. The effectiveness of systemic enzyme therapy in the complex treatment of glomerulonephritis has been established. In kidney diseases, the fibrinolytic (thrombolytic) effect of combined enzyme preparations promotes the disappearance of cylinders and restores the patency of the renal tubules.

In urological practice systemic enzyme therapy gives good clinical results for prostatitis, cystitis, orchitis and epididymitis. It accelerates the process of transurethral drainage of the prostate for chronic obstructive lesions. Systemic enzyme therapy helps to lyse the plugs of the excretory ducts, reduce the viscosity of the secretion and the number of leukocytes in the aspirate obtained during transurethral drainage. The patients showed important positive clinical dynamics: pain and dysuria disappeared, sexual function was restored ( Guskov A. R. et al., 1998).

Prescribing Wobenzym at a dose of 5–7 tablets 3 times a day for 3–4 weeks together with two intermittent 10-day courses of antibiotics (Tarivid or Vibramycin) allows one to achieve clinical recovery with complete elimination of the pathogen in urogenital chlamydia and ureaplasmosis in 87. 5% and 96% of cases respectively. With mycoplasmosis, clinical recovery was observed in 100% of patients.

In gynecology and obstetrics Systemic enzyme therapy is used in the complex treatment of mastopathy, adnexitis, recurrent miscarriage, cancer, as well as venous pathology and pyelonephritis in pregnant women. It is advisable to include Wobenzym in complex treatment regimens for vaginitis, cervicitis, acute and chronic endometritis, salpingo-oophoritis, parametritis, pelvic peritoneal joints, tubal infertility, and cervical dysplasia. Systemic enzyme therapy is the most effective conservative method of treating fibrocytous mastopathy; it is indicated for the treatment of mild and moderate forms of preeclampsia in pregnant women. Wobenzym is also prescribed for late toxicosis of pregnant women.

The administration of Wobenzym in the postoperative period for infective endocarditis (in two courses: the first - 2 weeks, 8 tablets per day, the second - for a month during the rehabilitation period, 6 tablets per day) promotes sustainable correction of impaired immunological parameters. Normalization of most immunological parameters occurred on the 45th day (after the second course of systemic enzyme therapy) and persisted for 6 months ( Vorobyova A. M. et al., 1998).

The use of Wobenzym for a month after myocardial infarction in a daily dose of 9 tablets helps normalize the plasma lipid profile (reliably reduces the level of cholesterol and cholesterol-containing low-density lipoproteins (by 24 and 31%, respectively), lipid peroxidation processes (reduces the level of malonic acid by 34%). dialdehyde), normalizes the number of circulating immunocompetent cells. Under the influence of Wobenzym, the level of circulating immune complexes and antibody titers to the affected myocardium significantly decreased in most patients.

In angiology systemic enzyme therapy is widely used to treat diseases of peripheral arteries and veins, including varicose veins of the superficial and deep veins of the lower extremities, thrombophlebitis (effectiveness is more than 90%), postthrombophlebitic syndrome, phlebothrombosis. By improving capillary permeability and reducing blood viscosity, in patients with venopathy, hyperemia and swelling in the affected area, relapses of thrombosis, muscle cramps are quickly relieved, and the feeling of fatigue and severity of pain are reduced. During treatment with Wobenzym, there was no progression of blood reflux through the veins of the affected limbs. In 28.3% of patients, complete recovery occurred when using systemic enzyme therapy. Wobenzym helps prevent blood clots. For vein pathology, local application of enzymes in the form of ointments is effective.

Numerous studies have proven that under the influence of systemic enzyme therapy with Wobenzym, inhibition of the processes of sclerosis (atherogenesis) in the vascular wall is observed, improvement of endothelial function by reducing the degree of adhesion of blood cells and cytokine damage, splitting of deposits of immune complexes, which is important in patients with autoimmune damage to the vascular wall, for example, with systemic vasculitis, etc.).
For diabetic angiopathies complicated by disseminated intravascular coagulation syndrome, the use of Wobenzym, in addition to reducing pain and swelling of the extremities, accelerates the healing of trophic ulcers and reduces the percentage of patients who required amputations, significantly improves coagulogram parameters, and normalizes fibrinogen content in the blood.
Elimination of disseminated intravascular coagulation syndrome by Wobenzym in patients with purulent-necrotic complications of diabetic angiopathy significantly improves wound healing. By improving impaired microcirculation, Wobenzym significantly reduces the risk of thromboembolic complications.

Enzyme preparations are prescribed for the prevention and treatment of secondary lymphedema that develops against the background of erysipelas, after oncological operations. In patients constantly taking " Wobenzym“over 2 years, after surgical treatment of breast cancer, lymphedema was 5 times less common.

There has been positive clinical experience with the use of Wobenzym in hemorrhagic vasculitis (Henoch-Schönlein disease), autoimmune thrombocytopenia, Wegener's disease and Behçet's syndrome.

Enzyme therapy is becoming increasingly popular in dentistry. It is indicated for all inflammatory processes in the oral cavity, as well as after tooth extraction and root surgery.
Systemic enzyme therapy is used for preventive and therapeutic purposes in plastic surgery - it promotes the healing of cosmetic sutures and the formation of invisible, delicate scars.

There have been good, although not always stable, results of treatment with Wobenzym for sciatica.

Systemic enzyme therapy helps withstand training loads of increased volume and intensity and helps achieve stable athletic shape. Taking Wobenzym does not cause disruption of adaptation mechanisms and depletion of the immune system during intense training; the level of sports performance increases significantly according to control biochemical and psychofunctional tests. The effect after a month's course of systemic enzyme therapy lasts for 10–14 days. Taking Wobenzym by athletes before competitions reduces the possibility of traumatic damage to ligaments and muscles and promotes their rapid healing. According to numerous studies, prescribing Wobenzym 10 tablets 3 times a day from 10–14 days to 4–6 weeks allows you to begin sports training after injuries, on average 2–2.5 times faster compared to patients receiving traditional therapy.

There is extensive experience in the use of enzyme preparations in oncology. Enzyme therapy for cancer can be effective if treatment is started in the early stages of the disease, the drug is used in large doses and treatment is continued even after visible remission is achieved. Unlike cytostatics, enzyme therapy does not cause adverse reactions, and there is no danger of overdose. The drug “Vobe-Mugos” is widely used in oncology.
The drugs "Vobezim" and "Vobe-Mugos" were used to treat lymphogranulomatosis and non-Hodgkin's lymphomas. In combination with irradiation, enzyme preparations (2 tablets 4 times a day) made it possible to achieve significant resorption of a large mass of tumors, a pronounced normalization of hematological parameters, and reduce the time of subsequent irradiations.

In experimental nutritional hypercholesterolemia in rabbits, it was confirmed that the drug “Wobenzym” exhibits a pronounced and antiatherogenic effect. Along with reducing serum cholesterol levels, it inhibits by 2.8–3.2 times the intensity of the uptake of plasma lipoproteins by a culture of mouse macrophages.

Based on articles by B. M. Zuzuk, R. V. Kutsik, L. M. Kurovets, G. T. Nedostup,
Ivano-Frankivsk State Medical Academy

Compound

pharmachologic effect

Indications for use

Mode of application

Side effects

Contraindications

Release form

Storage conditions

Nosological classification (ICD-10)

Acute hepatitis A (B15)

Acute hepatitis B (B16)

Acute hepatitis C (B17.1)

Chronic viral hepatitis B without delta agent (B18.1)

Chronic viral hepatitis C (B18.2)

The work of the body is based on enzymes, which are directly involved in almost all its life processes. Wobenzym compensates for the lack of such enzymes in the body, having a positive effect on the course of the inflammatory process, limiting the pathological manifestation of immune complex processes, and also reacting positively to the indicators of the body’s immune system.

Such a versatile effect in the body is achieved due to the active components that predominate in Wobenzym. These are bromelain, papain, pancreatin, trypsin, amylase, lipase, chymotrypsin, rutoside. And the excipients are purified water, magnesium stearate, lactose, talc, colloidal silicon dioxide, corn starch, stearic acid, sucrose.

Wobenzym is produced in the form of convex, red, film-coated tablets.

Among the analogues of Wobenzym are known: Immunofan, Normoven, Ginsomin, Heparin ointment, Immunovit C and others.

Indications and contraindications for the use of Wobenzym

Wobenzym is widely used in the treatment of Sjögren's and Degtyarev's diseases, as well as extra-articular rheumatism, post-thrombotic syndrome, vasculitis, thrombophlebitis, prostatitis, mastopathy, adnexitis and lymphedema. Also, indications for the use of Wobenzym are inflammatory processes of the genitourinary system and infectious diseases in a chronic form.

In addition, Wobenzym is recommended for complications after operations, limb fractures, bruises, bronchitis and sinusitis. To the listed pathologies you can also add hepatitis, bronchial asthma, colitis, pancreatitis, pancreatitis, pyelonephritis, and cardiac ischemia.

However, we should also not forget about the preventive properties of Wobenzym, which are especially in demand during radiation and chemical therapy, stress conditions and cancer.

The use of Wobenzym is prohibited during pregnancy and lactation, when the body is hypersensitive to its individual components, in the presence of thrombosis or a predisposition to such, as well as in childhood.

Side effects and overdose during treatment with Wobenzym

Wobenzym quietly adapts to a sick body, without provoking an exacerbation of side effects, but these are still known. In some cases, minor changes in the smell and consistency of feces, skin rashes in the form of redness and urticaria are noted.

Cases of overdose have not been recorded in practice.

Instructions for use of the drug Wobenzym

The daily dose of Wobenzym is calculated based on the specifics of the disease and the age of the typical patient.

Moderate intensity of the disease: adults three tablets three times a day.

Average intensity of the disease: adults up to seven tablets three times a day.

Severe intensity of the disease: adults up to ten tablets three times a day.

The duration of the treatment course with Wobenzym depends on the nature of the pathology and can range from a couple of weeks to six months.

To enhance the activity of antibiotics and prevent dysbacteriosis, Wobenzym should be used throughout the entire course of antibacterial therapy at a dose of five pills three times a day, and to restore intestinal microflora - three tablets three times a day for a couple of weeks. Prevention lasts up to two months with a daily intake of three Wobenzym tablets.

The drug is taken half an hour before meals, not chewed and washed down with water.

Features of using the drug Wobenzym

Wobenzym is not prescribed to children, but it also does not affect the central nervous system, so driving and active work are allowed.

When taken together with antibiotics, Wobenzym increases their predominance in the inflammation site and blood plasma. No negative reactions were found when combined with other medications.

Reviews about the drug Wobenzym

Oddly enough, the vast majority of reviews about the effectiveness of Wobenzym are negative. Of course, there are also positive notes about its work in the body, but, unfortunately, they remain in the minority.

Thus, former patients report that such treatment with Wobenzym turned out to be absolutely useless, even if the specialist’s recommendations were followed, and did not produce any changes in the body: neither for the better nor for the worse. Although it is fair to note that the side effects also did not worsen, which is good news.

This once again emphasizes that it is better to think again and consult with a doctor before resorting to his “services,” and superficial self-medication will not give the desired result.

The price of Wobenzym n200 tablets is 1,490 rubles.

03:14 Wobenzym: instructions, application, reviews -

If we talk about the group affiliation of the drug Wobenzym, it is important to clarify that it is a complex of highly active enzymes of animal and plant ethnology with decongestant, immunomodulatory, anti-inflammatory, fibrinolytic and secondary analgesic effects, in other words, it is an immunomodulator. General description of the drug Wobenzym The body's work is based on enzymes that are directly involved in almost all its life processes. The shortage of such [...]

A medicine that has anti-inflammatory, immunostimulating, fibrinolytic, anti-edematous and secondary analgesic effects is Wobenzym. Instructions for use prescribe taking the tablets for gynecology, urology, cardiology and other areas of medicine. Reviews from patients and recommendations from doctors report that this drug helps in the treatment of cystitis, thrombophlebitis and STIs.

Release form and composition

Wobenzym is produced in the form of tablets coated with a protective film coating of orange color with a pronounced specific odor.

Each tablet contains the following active ingredients:

• Lipase.
• Amylase.
• Rutin.
• Papain.
• Trypsin.
• Chymotrypsin.
• Bromelain.

pharmachologic effect

The medicine Wobenzym is a complex of highly active animal and plant enzymes (enzymes). These enzymes are carefully selected, optimally combined and included in Wobenzym tablets, which gives them a fairly wide range of clinical applications.

Taking the medication has a positive effect on the course of the inflammatory process, reduces the pathological symptoms of immunocomplex and autoimmune reactions, and has a positive effect on the immunological reactivity of the human body.

Under the influence of the active ingredients of the drug, the number of immune complexes circulating in the blood decreases and their membrane deposits are removed from the tissues. The drug activates and corrects the functionality of natural killer cells (lymphocytes) and monocytes-macrophages, stimulates phagocytic cellular activity, cytotoxic T-lymphocytes and antitumor immunity, for which Wobenzym is often prescribed as an immunomodulator.

Prescribing a medication enhances the effectiveness of antibiotic therapy by increasing the level of antibacterial agents in the inflammation site and their plasma concentrations, triggers the process of nonspecific defense of the body (production of interferons), thereby exhibiting antimicrobial and antiviral effects, and also eliminates the symptoms of dysbiosis.

The drug also reduces the severity of side effects that occur when taking hormonal medications (including hypercoagulation).

Why is Wobenzym (tablets) prescribed?

Indications for use of the drug include therapy and prevention of the following conditions:

• In gynecology and obstetrics: inflammatory diseases of the uterus and appendages, frequent miscarriages due to vitamin deficiency and general weakness of the body, mastopathy, lactostasis, recurrent vaginal candidiasis.
• In cardiology: prevention of myocardial infarction in patients at risk, coronary heart disease, atherosclerosis, aortic aneurysm.
• In traumatology: numerous fractures, dislocations, sprains, bruises, traumatic brain injuries.
• In urology: inflammatory diseases of the urinary organs - cystitis, urethritis, pyelonephritis, glomerulonephritis, urolithiasis.
• In gastroenterology: acute and chronic diseases of the stomach and duodenum, colitis, pancreatitis, Crohn's disease.
• In neurology: multiple sclerosis, neuroses, complex treatment of vegetative-vascular dystonia with panic attacks.
• In dermatology: complex treatment of dermatitis of various etiologies, eczema, neurodermatitis, acne, carbuncles, boils.
• In surgery: treatment of adhesions against the background of previous surgical interventions, treatment and prevention of postoperative complications (suppuration of wounds, secondary bacterial infection, inflammation, thrombosis).
• In pulmonology: chronic and acute bronchitis as part of complex therapy, laryngitis, pneumonia, bronchopneumonia, bronchial asthma.
• In rheumatology and angiology: as part of complex therapy for rheumatoid arthritis, ankylosing spondylitis, rheumatism, vasculitis, thrombophlebitis, inflammatory processes of lymphatic vessels.

Wobenzym tablets are prescribed to patients as part of complex therapy for viral and infectious diseases in order to speed up recovery and reduce the risk of complications. The medicine is also prescribed to patients undergoing chemotherapy or radiation therapy to prevent the development of severe side effects.

Under the influence of the drug, the risk of developing side effects during hormonal therapy, including oral contraceptives, is significantly reduced.

Instructions for use

Wobenzym is prescribed in a dosage that is set individually depending on the severity of the disease. Adults, depending on the activity and severity of the disease, are prescribed a dose of 3 to 10 tablets 3 times a day. In the first 3 days of taking the drug, the recommended dose is 3 tablets 3 times a day.

With average disease activity, the drug is prescribed in a dose of 5-7 tablets 3 times a day for 2 weeks. In the future, the dose of the drug should be reduced to 3-5 tablets 3 times a day. Course - 2 weeks. If the disease activity is high, the drug is prescribed in a dose of 7-10 tablets 3 times a day for 2-3 weeks. In the future, the dose should be reduced to 5 tablets 3 times a day. Course - 2-3 months.

For chronic long-term diseases, Wobenzym can be used according to indications in courses of 3 to 6 months or more. In order to increase the effectiveness of antibiotics and prevent dysbacteriosis, Wobenzym should be used throughout the entire course of antibiotic therapy at a dose of 5 tablets 3 times a day. After stopping the course of antibiotic therapy to restore the intestinal microflora, Wobenzym should be prescribed 3 tablets 3 times a day for 2 weeks.

During radiation and chemotherapy, Wobenzym should be used in a dose of 5 tablets 3 times a day until the completion of the course of radiation and chemotherapy in order to prevent infectious complications, improve the tolerability of basic therapy and improve the quality of life.

For preventive purposes, Wobenzym is prescribed 3 tablets 3 times a day for 1.5 months, repeating the course 2-3 times a year.

Children aged 5-12 years are prescribed a daily dose at the rate of 1 tablet per 6 kg of body weight. For children over 12 years of age, the drug is prescribed according to the regimen intended for adults. The duration of treatment is determined individually. The drug should be taken at least 30 minutes before meals, without chewing, with water (200 ml).

Contraindications

• Hypersensitivity to the components of the drug.
• Diseases associated with an increased likelihood of bleeding (thrombocytopenia, hemophilia).
• Children's age up to 5 years.
• Carrying out hemodialysis.

Side effects

Wobenzym is usually well tolerated, provided that the basic recommendations for its use are followed: tablets should not be crushed, and it is also necessary to observe intervals between taking the drug and food (30 minutes before or 2 hours after meals).

In some cases, during therapy, the development of such side effects as: minor changes in the smell and consistency of feces, vomiting, nausea, heaviness in the stomach, diarrhea, skin rashes in the form of urticaria, allergies to the components included in the drug were noted.

These symptoms disappear when the dose is reduced or the drug is discontinued. The syndrome of addiction and withdrawal was not detected even with prolonged therapy with high doses. If adverse reactions not noted in the instructions develop, it is recommended to discontinue treatment and consult a doctor.

Children, pregnancy and breastfeeding

It is possible to prescribe the drug during pregnancy and lactation. The appointment is carried out under strict medical supervision. Contraindicated under the age of 5 years.

special instructions

It must be taken into account that when you start taking Wobenzym, the symptoms of the disease may worsen. Treatment should not be interrupted in such cases; it is recommended to temporarily reduce the daily dose of the drug.

In infectious diseases, Wobenzym does not replace antibiotics, but increases effectiveness by increasing their concentration in microbial colonies, tissues and the site of inflammation. The drug is not a doping and does not have a negative effect on driving a car or performing work that requires a high speed of physical and mental reactions.

Drug interactions

When taking Wobenzym tablets in combination with other drugs belonging to various drug groups, no negative interactions were found.

Analogues of the drug Wobenzym

Analogs have a similar effect:

1. Wobe-mugos E.
2. Phlogenzyme.
3. Engystol.
4. Galavit.
5. Immunal.
6. Broncho-Vaxom.
7. Imudon.
8. Ribomunil.
9. Neuroferon.

Vacation conditions and price

The average price of Wobenzym (40 tablets) in Moscow is 410 rubles. The drug is sold in pharmacies without a doctor's prescription.

Post Views: 579