The contraceptive drug Logest. Menstruation when taking Logest: how do they change? Logest on what day does your period come?

Hormonal contraceptives today are the main way to protect against unwanted pregnancy. But the effect of various drugs differs significantly from each other, so many women are interested in how their periods proceed during logest.

The drug in question meets the two main requirements of modern gynecology in the field of contraception: to minimize the hormonal load on a woman’s body and to use selective progestins to achieve a contraceptive effect. These substances correspond to the main hormones produced in the female body in the second phase of the menstrual cycle.

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Reasons for using hormonal contraception

The main purpose of prescribing this drug is to prevent pregnancy. The contraceptive effect of Logest is due to a pronounced suppression of ovulation in the patient and a change in the physiological properties of loose mucus located in the cervical canal.

Sometimes it happens that after Logest there are no periods, but this drug has a number of positive qualities. It is recommended for use in the following pathological conditions:

The role of this medicine in reducing the risk of developing benign and malignant tumors of the female genital area has been clinically proven.
Logest is widely used to prevent heavy periods and the possible occurrence of iron deficiency anemia in such patients.
If a woman uses drugs with a high content of hormones for contraception, then there is a high probability of her having an ectopic pregnancy or the formation of cystic changes in the ovaries. Logest reduces such risks by 2-3 times.

When Logest is used, a delay in menstruation becomes normal, however, when the drug is discontinued, the woman’s menstrual cycle is quickly restored.

Rules for taking the drug

Before starting to take a hormonal contraceptive, a woman should receive appropriate advice from specialists. Like any hormonal drug, Logest changes the patient’s hormonal background, so independent use of this drug can lead to various problems with a woman’s health.

First experience using hormonal contraceptives

Experts recommend using Logest in patients who have not previously encountered hormonal pills to prevent pregnancy. The drug is prescribed 1 capsule per day, preferably in the evening 2 - 3 hours before bedtime.

The course of treatment is indicated on the package itself and is 21 days, followed by a week break. Usually during this period, women note the presence of bloody discharge from the vagina, but there are situations when, after stopping Logest, there is no menstruation.

This option is possible, but most often the bleeding does not stop even after 2 - 3 days of taking medications from the next package. In case of any such dysfunctions, you should contact a specialist to correct the drug intake or discontinue it.

Prescribing the drug after removal of the IUD or stopping the use of other OCs

Most experts agree that by interrupting tablet hormonal birth control, a woman runs the risk of conceiving a child. This is due to hormonal changes in the female body when using such drugs.

Therefore, Logest is prescribed to this group of patients the very next day after stopping other contraceptives. There are options when, before switching to the drug in question, the doctor recommends that the woman take a week-long break.

Such recommendations are usually associated with certain menstrual irregularities. If the patient does not take hormonal drugs for conception for some period of time, then it is advisable not to have sexual intercourse or use a condom.

Since menstruation does not always begin on a specific day when taking Logest, after removal of the IUD it is advised to take special pills immediately. To achieve a full contraceptive effect, it is recommended to combine the use of this contraceptive with other methods of birth control for 7-10 days.

The use of hormonal pills for conception after childbirth or miscarriages

The use of a similar method of birth control after childbirth can begin after 3 - 4 weeks. Typically, during this period, women avoid sexual intercourse, but the characteristics and national traditions of some peoples should be taken into account.

For patients who are breastfeeding, the use of hormonal contraceptives is not indicated, since the high level of female sex hormones in the body of a nursing mother is a physiological protective mechanism. When artificially feeding a baby, Logest is prescribed immediately after the woman’s menstrual cycle has normalized and her first period has passed.

If the patient suffered a long-term miscarriage, the mechanism for using the drug in question corresponds to the scheme for postpartum birth control. A regular abortion performed before 11 - 12 weeks of pregnancy allows the drug to be prescribed the next day after abortion surgery.

A woman should know that after termination of pregnancy, situations occur when she regularly takes Logest, but her periods do not stop. This option requires contacting a specialist. Possible disruption of menstrual function due to the use of the drug after an abortion.

Watch the video about the action of hormonal contraception:

Contraindications and possible side effects

Logest is far from the most harmless drug. The active substances included in its composition can cause quite serious changes in the internal organs of a woman. Experts note the following:

The drug has a significant effect on the central nervous system. Its use is often accompanied by headaches and sudden mood changes. Anxiety, unreasonable fear, and sexual dysfunction may occur.
Gastrointestinal problems when using Logest most often manifest themselves as various dyspeptic manifestations. These are nausea, vomiting, spasmodic pain in the stomach, and stool disorders.
A fairly common consequence of using this contraceptive can be the appearance of various rashes on a woman’s body. Severe itching and redness of the mucous membranes and skin are possible.
Any hormonal drug affects the normal functioning of the female reproductive system. This product is no exception. Often women note that they are taking Logest, their periods have not come, their mammary glands have become enlarged and discharge from the nipples has begun to bother them.

All these side effects from the use of Logest are described in the annotation and should be taken into account by specialists before recommending a similar method of contraception to a young woman.

Among other things, this drug also has a large number of various contraindications. These include problems with the blood coagulation system, diseases of the cardiovascular system, and various oncological processes in the female genital organs.

Logest is 90% absorbed in the intestines and is excreted from the woman’s body with toxins, so it is not recommended for use in chronic diseases of the liver and stomach. Absolute contraindications for this method of contraception are acute and chronic pancreatitis, diabetes mellitus of the first and second types, and the patient’s individual intolerance to this type of female hormones.

Features of the menstrual cycle when taking the drug

Taking any hormonal drugs to prevent unwanted pregnancy, and especially Logest, deals a fairly strong blow to a woman’s hormonal background. In this case, any fluctuations in the menstrual cycle are possible.

Delay of menstruation

Most often, ladies notice when taking this contraceptive. Usually this condition manifests itself as bloody vaginal discharge on the 3rd to 5th day of using the medicine. Normal periods in such a case can begin on the 14th - 16th day of such pregnancy protection. The literature describes cases of loss of several cycles at once when taking Logest.

It's not worth taking risks in such a situation. Since the recommendations for using this method of contraception consider a delay in menstruation to be possible only in 5 - 10% of women, you should immediately consult a doctor. Although experts suggest that this medicine guarantees protection against pregnancy in 98% of cases, various conflicts are possible. Any tests may give incorrect results, and the woman risks becoming pregnant.

Absence of menstruation while taking Logest

According to many authors, the use of this method of contraception can cause a complete absence of menstruation in the patient. In most cases, such a disorder is simply a coincidence, and such a disruption of the menstrual cycle is caused by various inflammatory diseases of the female genital area.

Moreover, many women noted that if they took Logest, their periods began ahead of schedule. This is explained by the presence in the drug of artificial analogues of female sex hormones - gestodene and ethinyl estradiol. It is these substances that fully correspond in their mechanism of action in the female body to progesterone, which is responsible for regulating the menstrual cycle.

Thanks to this composition, Logest is used to treat various menstrual dysfunctions, although some women believe that using this drug they can regulate the time of the next menstruation. This is a dangerous misconception. Such techniques do exist, but their use is only possible under the supervision of a doctor.

Most representatives of the fair sex should be reminded that hormonal contraceptives are quite serious medications. Their impact on the female body can affect the functioning of most organs and systems of patients. Independent use of these drugs, which help a woman avoid unwanted pregnancy, can cause irreversible disturbances in the hormonal system, lead to severe poisoning and provoke a wide variety of pathologies. Any experiments with female hormones can permanently deprive a woman of the opportunity to have children.

Pharmacology

Logest ® is a low-dose monophasic oral combined estrogen-progestogen contraceptive drug.

The contraceptive effect of Logest is carried out through complementary mechanisms, the most important of which include suppression of ovulation and changes in the state of cervical mucus.

In women taking combined oral contraceptives, the cycle becomes more regular, the pain and intensity of menstrual bleeding decreases, resulting in a reduced risk of iron deficiency anemia. In addition, there is evidence that the risk of developing endometrial and ovarian cancer is reduced.

When used correctly, the Pearl index (an indicator reflecting the frequency of pregnancy in 100 women during a year of using a contraceptive) is less than 1. If the pills are used incorrectly, including when pills are missed, the Pearl index may increase.

Pharmacokinetics

Gestoden

Absorption. After oral administration, gestodene is quickly and completely absorbed, its maximum serum concentration of 3.5 ng/ml is reached after about 1 hour. Bioavailability is approximately 99%. Distribution. Gestodene binds to serum albumin and sex hormone binding globulin (SHBG). Only about 1.3% of the total concentration in the blood serum is found in free form; about 69% are specifically associated with SHBG. The induction of SHBG synthesis by ethinyl estradiol affects the binding of gestodene to plasma proteins.

Metabolism. Gestodene is almost completely metabolized. Serum clearance is approximately 0.8 ml/min/kg.

Excretion. The content of gestodene in the serum undergoes a two-phase decrease. The half-life in the terminal phase is about 12 hours. Gestodene is not excreted unchanged, but only in the form of metabolites, which are excreted by the kidneys and through the intestines in a ratio of approximately 6:4 with a half-life of about 24 hours.

Equilibrium concentration. The pharmacokinetics of gestodene is affected by the concentration of SHBG in the blood serum. As a result of daily administration of the drug, the concentration of the substance in the serum increases approximately 4 times during the second half of the contraceptive cycle.

Ethinyl estradiol

Absorption. After oral administration, ethinyl estradiol is rapidly and completely absorbed. The maximum concentration in the blood serum, equal to approximately 65 pg/ml, is achieved in 1-2 hours. During absorption and “first passage” through the liver, ethinyl estradiol is metabolized, as a result of which its bioavailability when taken orally averages about 45%.

Distribution. Ethinyl estradiol is almost completely (approximately 98%), although nonspecifically, bound by albumin. Ethinyl estradiol induces the synthesis of SHBG. The apparent volume of distribution of ethinyl estradiol is 2.8-8.6 l/kg. Metabolism. Ethinyl estradiol undergoes presystemic conjugation, as in the thin mucosa. intestines and in the liver. The main route of metabolism is aromatic hydroxylation. The clearance rate from blood plasma is 2.3 -7 ml/min/kg.

Excretion. The decrease in the concentration of ethinyl estradiol in the blood serum is biphasic; the first phase is characterized by a half-life of about 1 hour, the second - 10-20 hours. It is not excreted from the body unchanged. Ethinyl estradiol metabolites are excreted in urine and bile in a ratio of 4:6 with a half-life of about 24 hours.

Equilibrium concentration. Equilibrium concentration is reached after approximately one week.

Release form

White coated tablets, round in shape.

Excipients: lactose monohydrate - 37.155 mg, corn starch - 15.5 mg, polyvidone 25,000 - 1.7 mg, magnesium stearate - 550 mcg, sucrose - 19.66 mg, polyvidone 700,000 - 171 mcg, macrogol 6000 - 2.18 mg, calcium carbonate - 8.697 mg, talc - 4.242 mg, mountain glycolic wax - 50 mcg.

21 pcs. - blisters (1) - cardboard packs.
21 pcs. - blisters (3) - cardboard packs.

Dosage

The tablets should be taken orally in the order indicated on the package, every day at approximately the same time, with a small amount of water. Take one tablet per day continuously for 21 days. The next package begins after a 7-day break from taking pills, during which withdrawal bleeding usually develops. Bleeding usually begins 2-3 days after taking the last tablet and may not stop until you start taking a new pack.

How to start taking Logest

If you have not taken any hormonal contraceptives in the previous month.

Taking Logest begins on the first day of the menstrual cycle (i.e., on the first day of menstrual bleeding). It is allowed to start taking it at 2-5 menstrual cycles, but in this case it is recommended to additionally use a barrier method of contraception during the first 7 days of taking tablets from the first package .

When switching from other combined oral contraceptives, vaginal ring or contraceptive patch.

It is preferable to start taking Logest the day after taking the last hormone-containing tablet from the previous package, but in no case later than the next day after the usual 7-day break (for drugs containing 21 tablets) or after taking the last inactive tablet (for drugs containing 28 tablets per package). Taking Logest should begin on the day the vaginal ring or patch is removed, but no later than the day when a new ring is to be inserted or a new patch is applied.

When switching from contraceptives containing only gestagens (mini-pills, injection forms, implant), or from a gestagen-releasing intrauterine contraceptive (Mirena ®).

A woman can switch from a mini-pill to Logest on any day (without a break), from an implant or intrauterine contraceptive with gestagen - on the day of its removal, from an injection form - from the day when the next injection is due. In all cases, it is necessary to use an additional barrier method of contraception during the first 7 days of taking the pills.

After an abortion in the first trimester of pregnancy.

A woman can start taking the drug immediately. If this condition is met, the woman does not need additional contraceptive protection.

After childbirth or abortion in the second trimester of pregnancy.

It is recommended to start taking the drug 21-28 days after birth, if the woman is not breastfeeding, or after an abortion in the second trimester of pregnancy. If use is started later, it is necessary to use an additional barrier method of contraception during the first 7 days of taking the pills. However, if a woman has already been sexually active, before starting to take Logest, pregnancy should be excluded or she must wait until her first menstruation.

Taking missed pills

If the delay in taking the drug is less than 12 hours, contraceptive protection is not reduced. The woman should take the pill as soon as possible, and the next one should be taken at the usual time.

If the delay in taking the pills is more than 12 hours, contraceptive protection may be reduced. The more pills are missed, and the closer the missed pill is to the 7-day break in taking pills, the greater the likelihood of pregnancy. In this case, you can be guided by the following two basic rules:

The drug should never be interrupted for more than 7 days.

7 days of continuous tablet use are required to achieve adequate suppression of hypotapamic-pituitary-ovarian regulation.

Accordingly, the following recommendations can be given if the delay in taking the pills is more than 12 hours (the interval since the last pill was taken is more than 36 hours).

First week of taking the drug

A woman should take the last missed pill as soon as she remembers (even if this means taking two pills at the same time). The next tablet is taken at the usual time. Additionally, a barrier method of contraception (for example, a condom) should be used for the next 7 days. If sexual intercourse took place within a week before missing a pill, the possibility of pregnancy must be taken into account.

Second week of taking the drug

A woman should take the last missed pill as soon as she remembers (even if this means taking two pills at the same time). The next tablet is taken at the usual time.

Provided that the woman has taken the pills correctly for the 7 days preceding the first missed pill, there is no need to use additional contraceptive measures. Otherwise, as well as if you miss two or more tablets, you must additionally use barrier methods of contraception (for example, a condom) for 7 days.

Third week of taking the drug

The risk of decreased reliability is inevitable due to the upcoming break in taking the pills. A woman must strictly adhere to one of the following two options. Moreover, if in the 7 days preceding the first missed pill, all pills were taken correctly, there is no need to use additional contraceptive methods.

1. A woman should take the last missed pill as soon as she remembers (even if this means taking two pills at the same time). The next tablets are taken at the usual time until the tablets in the current pack are gone. The next pack should be started immediately. Withdrawal bleeding is unlikely until the second pack is finished, but spotting and breakthrough bleeding may occur while taking the tablets.

2. A woman can also stop taking pills from the current package. She should then take a break for 7 days, including the day she missed the pills, and then start taking a new pack.

If a woman misses taking pills and then does not have withdrawal bleeding during the break, pregnancy must be ruled out.

If a woman has vomiting or diarrhea within 4 hours of taking the tablets, absorption may be incomplete and additional contraceptive measures should be taken. In these cases, you should follow the recommendations when skipping pills.

Changing the days of the onset of menstrual-like bleeding

In order to delay the onset of menstrual bleeding, a woman should continue taking pills from a new Logest package immediately after taking all the pills from the previous one, without interruption in taking. The tablets from this new pack can be taken for as long as the woman wishes (until the pack runs out). While taking the drug from the second package, a woman may experience spotting or breakthrough uterine bleeding. You should resume taking Logest from a new pack after the usual 7-day break.

In order to move the day of the onset of menstrual bleeding to another day of the week, a woman should shorten the next break in taking pills by as many days as she wants. The shorter the interval, the higher the risk that she will not have withdrawal bleeding, and will continue to have spotting and breakthrough bleeding while taking the second package (just as in the case when she would like to delay the onset of menstrual-like bleeding).

Additional information for specific patient groups

Elderly patients

Not applicable. The drug Logest is not indicated after menopause.

Patients with liver disorders

Logest is contraindicated in women with severe liver disease until liver function tests return to normal. See also the section “Contraindications”.

Patients with kidney disorders

Overdose

No serious adverse events have been reported following overdose. Symptoms that may occur in case of overdose: nausea, vomiting, spotting or metrorrhagia.

There is no specific antidote; symptomatic treatment should be carried out.

Interaction

Interaction of oral contraceptives with other drugs may lead to breakthrough bleeding and/or decreased contraceptive effectiveness. Women taking these drugs should temporarily use barrier methods of contraception in addition to Logest, or choose another method of contraception. The following types of interactions have been reported in the literature.

Effect on hepatic metabolism: the use of drugs that induce liver microsomal enzymes can lead to an increase in the clearance of sex hormones. Such drugs include: phenytoin, barbiturates, primidone, carbamazepine, rifampicin; There are also suggestions regarding oxcarbazepine, topiramate, felbamate, griseofulvin and drugs containing St. John's wort.

HIV proteases (eg, ritonavir) and non-nucleoside reverse transcriptase inhibitors (eg, nevirapine) and combinations thereof also have the potential to affect hepatic metabolism.

Effect on enterohepatic recirculation: According to individual studies, some antibiotics (for example, penicillins and tetracyclines) may reduce the enterohepatic recirculation of estrogens, thereby reducing the concentration of ethinyl estradiol.

While taking medications that affect microsomal liver enzymes, and for 28 days after their discontinuation, you should additionally use a barrier method of contraception.

While taking antibiotics (such as penicillins and tetracyclines) and for 7 days after their discontinuation, you should additionally use a barrier method of contraception. If the period of using a barrier method of contraception ends later than the tablets in the package, you need to move on to the next package of Logest without the usual break in taking the tablets.

Oral combination contraceptives may affect the metabolism of other drugs, resulting in an increase (eg, cyclosporine) or decrease (eg, lamotrigine) in plasma and tissue concentrations.

Side effects

When taking Logest, like other combined oral contraceptives, irregular bleeding (spotting or breakthrough bleeding) may occur, especially during the first months of use. While taking combined oral contraceptives, women experienced other undesirable effects, the connection of which with taking the drugs has not been confirmed, but has not been refuted.

Organ system	Often (>1/100)	Uncommon (>1/1000 and<1/100)	Rarely (<1/1000)
Organ of vision			intolerance to contact lenses (unpleasant sensations when wearing them)
Gastrointestinal tract	nausea, abdominal pain	vomiting, diarrhea
The immune system			hypersensitivity
General symptoms	weight gain		weight loss
Metabolism		fluid retention
Nervous system	headache	migraine
Mental disorders	decreased mood, mood swings	decreased libido	increased libido
Reproductive system and mammary glands	breast tenderness, breast engorgement	mammary hypertrophy	vaginal discharge, breast discharge
Skin and subcutaneous tissues		rash, hives	Erythema nodosum, erythema multiforme

The following serious adverse events have been reported in women using combined oral contraceptives. Additional information about possible side effects of oral combined contraceptives, including Logest, is presented in the “Special Instructions” section:

Venous thromboembolic disorders

Arterial thromboembolic disorders

Cerebrovascular disorders

Increased blood pressure

Hypertriglyceridemia

Changes in glucose tolerance or effects on peripheral insulin resistance

Liver tumors (benign and malignant)

Impaired liver function parameters

Chloasma

The onset or worsening of conditions for which an association with the use of combined oral contraceptives has not been proven: jaundice and/or itching associated with cholestasis; formation of gallstones; porphyrin disease; systemic lupus erythematosus; hemolytic-uremic syndrome; chorea; herpes during pregnancy; hearing loss associated with otosclerosis; Crohn's disease; ulcerative colitis; cervical cancer.

The incidence of breast cancer diagnosis in women using oral contraceptives is increased only slightly. Breast cancer is rarely observed in women under 40 years of age, the excess incidence is insignificant in relation to the overall risk of breast cancer. The cause-and-effect relationship between the occurrence of breast cancer and the use of combined oral contraceptives has not been established. For more information, see the “Contraindications” and “Special Instructions” sections.

Indications

oral contraception.

Contraindications

Logest should not be used if you have any of the conditions/diseases listed below. If any of these conditions/diseases develop for the first time while taking the drug, the drug should be discontinued immediately;

thrombosis (venous and arterial) and thromboembolism currently or in history (including deep vein thrombosis, pulmonary embolism, myocardial infarction), cerebrovascular disorders;
conditions preceding thrombosis (including transient ischemic attacks, angina) currently or in history;
the presence of pronounced or multiple risk factors for venous or arterial thrombosis may also be a contraindication (see section “Special instructions”);
migraine with focal neurological symptoms currently or in history;
diabetes mellitus with vascular complications;
pancreatitis with severe hypertriglyceridemia currently or in history;
liver failure and severe liver disease (until liver tests return to normal);
liver tumors (benign or malignant) currently or in history;
identified or suspected hormone-dependent malignant neoplasms (including genital organs or mammary glands);
bleeding from the vagina of unknown origin;
pregnancy or suspicion of it;
breast-feeding;
hypersensitivity to any of the components of the drug Logest.

Carefully:

If any of the conditions/diseases/risk factors listed below currently exist, the potential risks and expected benefits of combined oral contraceptives should be carefully weighed in each individual case:

risk factors for the development of thrombosis and thromboembolism: smoking; thrombosis, myocardial infarction or cerebrovascular accident at a young age in one of the immediate family; obesity; dyslipoproteinemia, arterial hypertension; migraine without focal neurological symptoms; heart valve diseases; heart rhythm disturbances, prolonged immobilization, serious surgical interventions, extensive trauma;
other diseases in which peripheral circulatory disorders may occur: diabetes mellitus without vascular complications; systemic lupus erythematosus; gsmolytic-uremic syndrome; Crohn's disease and non-specific ulcerative colitis; sickle cell anemia; as well as phlebitis of the superficial veins;
hypertriglyceridemia;
liver diseases;
diseases that first appeared or worsened during pregnancy or against the background of previous use of sex hormones (for example, jaundice, cholestasis, gallbladder disease, otosclerosis with hearing impairment, porphyria, pregnancy herpes, Sydenham's chorea);
In women with hereditary angioedema, exogenous estrogens may cause or worsen symptoms of angioedema.

Features of application

Use during pregnancy and breastfeeding

Logest ® is contraindicated during pregnancy and breastfeeding. If pregnancy is detected while taking Logest ®, the drug should be discontinued immediately. However, numerous epidemiological studies have found no increased risk of developmental defects in children born to women who received sex hormones before pregnancy or teratogenic effects when sex hormones were taken inadvertently in early pregnancy.

Taking Logest, like other combined oral contraceptives, can reduce the amount of breast milk and change its composition, therefore, their use is not recommended during lactation. Small amounts of sex hormones and/or their metabolites may be excreted in breast milk.

Use for liver dysfunction

Logest is contraindicated in women with severe liver disease until liver function tests return to normal. See also section Contraindications.

Use for renal impairment

Logest has not been specifically studied in patients with renal impairment. Available data do not suggest adjustment of the dosage regimen in such patients.

Use in children

The drug Logest ® is indicated only after the onset of menarche.

special instructions

If any of the conditions/diseases/risk factors listed below currently exist, the potential risks and expected benefits of using combined oral contraceptives, including Logest, should be carefully weighed in each individual case and discussed with the woman before how she decides to start taking the drug/ If any of these conditions or risk factors worsen, intensify, or appear for the first time, the woman should consult with an obstetrician-gynecologist, who may decide whether to discontinue the drug.

Diseases of the cardiovascular system

The results of epidemiological studies indicate a relationship between the use of combined oral contraceptives and an increased incidence of venous and arterial thrombosis and thromboembolism (such as deep vein thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular disorders) when taking combined oral contraceptives. These diseases are rare.

The risk of developing venous thromboembolism (VTE) is greatest in the first year of taking such drugs. An increased risk is present after initial use of combined oral contraceptives or resumption of use of the same or different combined oral contraceptives (after a dosing interval of 4 weeks or more). Data from a large prospective study involving 3 groups of patients suggest that this increased risk is predominantly present during the first 3 months. The overall risk of VTE in patients taking low-dose combined oral contraceptives (< 50 мкг этинилэстрадиола) в два-три раза выше, чем у небеременньгх пациенток, которые не принимают комбинированные пероральные контрацептивы, тем не менее, этот риск остается более низким по сравнению с риском ВТЭ при беременности и родах.

VTE can be fatal (in 1-2% of cases).

VTE, manifested as deep vein thrombosis or pulmonary embolism, can occur with the use of any combined oral contraceptives. It is extremely rare that when using combined oral contraceptives, thrombosis of other blood vessels occurs, for example, hepatic, mesenteric, renal, cerebral veins and arteries or retinal vessels. There is no consensus regarding the relationship between the occurrence of these events and the use of combined oral contraceptives.

Symptoms of deep vein thrombosis (DVT) include the following: unilateral swelling of the lower extremity or along a vein in the leg, pain or discomfort in the leg only when standing up or when walking, localized warmth in the affected leg, redness or discoloration of the skin on the leg. Symptoms of pulmonary embolism (PE) include: difficulty or rapid breathing; sudden cough, including with hemoptysis; sharp pain in the chest, which may intensify with deep inspiration; sense of anxiety; severe dizziness; fast or irregular heartbeat. Some of these symptoms (eg, shortness of breath, cough) are nonspecific and may be misinterpreted as signs of other more or less severe complications (eg, respiratory tract infection).

Arterial thromboembolism can lead to stroke, vascular occlusion, or myocardial infarction. Symptoms of a stroke include: sudden weakness or loss of feeling in the face, arm or leg, especially on one side of the body, sudden confusion, problems with speech and comprehension; sudden unilateral or bilateral vision loss; sudden disturbance in gait, dizziness, loss of balance or coordination; sudden, severe or prolonged headache for no apparent reason; loss of consciousness or fainting with or without an epileptic seizure. Other signs of vascular occlusion: sudden pain, swelling and slight blue discoloration of the limbs, “acute” abdomen.

Symptoms of myocardial infarction include: pain, discomfort, pressure, heaviness, a feeling of squeezing or fullness in the chest, arm, or chest; discomfort radiating to the back, cheekbone, larynx, arm, stomach; cold sweat, nausea, vomiting or dizziness, severe weakness, anxiety or shortness of breath; fast or irregular heartbeat.

Arterial thromboembolism can be fatal.

The risk of developing thrombosis (venous and/or arterial) and thromboembolism increases:

With age;

For smokers (the risk increases with increasing number of cigarettes or increasing age, especially in women over 35 years of age);

in the presence of:

Family history (for example, venous or arterial thromboembolism ever in close relatives or parents at a relatively young age). In the case of a hereditary or acquired predisposition, the woman should be examined by an appropriate specialist to decide on the possibility of taking combined oral contraceptives;

Obesity (body mass index more than 30 kg/m2);

Dyslipoproteinemia;

Arterial hypertension;

Migraine;

Heart valve diseases;

Atrial fibrillation;

Prolonged immobilization, major surgery, any leg surgery or major trauma. In these situations, it is advisable to stop using combined oral contraceptives (in the case of planned surgery, at least four weeks before it) and not to resume use for two weeks after the end of immobilization.

The possible role of varicose veins and superficial thrombophlebitis in the development of venous thromboembolism remains controversial. The increased risk of thromboembolism in the postpartum period should be taken into account.

Peripheral circulatory disorders may also occur in diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis), and sickle cell anemia.

An increase in the frequency and severity of migraine during use of combined oral contraceptives (which may precede cerebrovascular events) may be grounds for immediate discontinuation of these drugs.

Biochemical indicators indicating a hereditary or acquired predisposition to venous or arterial thrombosis include the following: resistance to activated protein C, hyperhomocysteinemia, antithrombin III deficiency, protein C deficiency, protein S deficiency, antiphospholipid antibodies (anticardiolipin antibodies, lupus anticoagulant). When assessing the risk-benefit ratio, it should be taken into account that adequate treatment of the relevant condition may reduce the associated risk of thrombosis. It should also be taken into account that the risk of thrombosis and thromboembolism during pregnancy is higher than when taking low-dose oral contraceptives (< 0,05 мг этинилэстрадиола).

The most significant risk factor for developing cervical cancer is persistent human papillomavirus infection. There are reports of a slight increase in the risk of developing cervical cancer with long-term use of combined oral contraceptives. The connection with the use of combined oral contraceptives has not been proven. Controversy remains regarding the extent to which these findings are related to screening for cervical pathology or to sexual behavior (lower use of barrier methods of contraception).

A meta-analysis of 54 epidemiological studies found that there is a slightly increased relative risk of developing breast cancer diagnosed in women currently taking combined oral contraceptives (relative risk 1.24). The increased risk gradually disappears within 10 years of stopping these drugs. Because breast cancer is rare in women under 40 years of age, the increase in breast cancer diagnoses in women currently or recently taking combined oral contraceptives is small relative to the overall risk of breast cancer. Its connection with the use of combined oral contraceptives has not been proven. The observed increased risk may also be a consequence of earlier diagnosis of breast cancer in women using combined oral contraceptives. Women who have ever used combined oral contraceptives are diagnosed with earlier stages of breast cancer than women who have never used them.

In rare cases, during the use of combined oral contraceptives, the development of benign, and in extremely rare cases, malignant liver tumors, which in some cases led to life-threatening intra-abdominal bleeding, was observed. If severe abdominal pain, liver enlargement, or signs of intra-abdominal bleeding occur, this should be taken into account when making a differential diagnosis.

Other states

Women with hypertriglyceridemia (or a family history of this condition) may have an increased risk of developing pancreatitis while taking combined oral contraceptives.

Although mild increases in blood pressure have been described in many women taking combined oral contraceptives, clinically significant increases have rarely been reported. However, if a persistent, clinically significant increase in blood pressure develops while taking combined oral contraceptives, this drug should be discontinued and treatment of arterial hypertension should be initiated. Taking combined oral contraceptives can be continued if normal blood pressure values are achieved with antihypertensive therapy.

The following conditions have been reported to develop or worsen both during pregnancy and while taking combined oral contraceptives, but their relationship with taking combined oral contraceptives has not been proven: jaundice and/or pruritus associated with cholestasis; formation of gallstones; porphyria; systemic lupus erythematosus; hemolytic-uremic syndrome; chorea; herpes during pregnancy; hearing loss associated with otosclerosis. Cases of Crohn's disease and ulcerative colitis have also been described during the use of combined oral costraceptives.

In women with hereditary forms of angioedema, exogenous estrogens may cause or worsen symptoms of angioedema. Acute or chronic liver dysfunction may require discontinuation of combined oral contraceptives until liver function tests return to normal. Recurrent cholestatic jaundice, which develops for the first time during pregnancy or previous use of sex hormones, requires discontinuation of combined oral contraceptives.

Although combined oral contraceptives may have an effect on insulin resistance and glucose tolerance, there is no need to change the therapeutic regimen in diabetic patients using low-dose combined oral contraceptives (<0,05 мг этинилэстрадиола). Тем не менее, женщины с сахарным диабетом должны тщательно наблюдаться во время приема комбинированных пероральных контрацептивов. Иногда может развиваться хлоазма, особенно у женщин с наличием в анамнезе хлоазмы беременных. Женщины со склонностью к хлоазме во время приема комбинированных пероральных контрацептивов должны избегать длительного пребывания на солнце и воздействия ультрафиолетового излучения. Каждая таблетка препарата Логест содержит 35 мг лактозы. Пациенты с редкими наследственными заболеваниями - непереносимостью галактозы, дефицитом лактазы, глюкозо-галактозной мальабсорбцией, находящиеся на диете с исключением лактозы, должны принимать во внимание информацию о содержании лактозы в препарате.

Laboratory tests

Taking combined oral contraceptives may affect the results of some laboratory tests, including liver, kidney, thyroid, adrenal function, plasma transport protein levels, carbohydrate metabolism, coagulation and fibrinolysis parameters. Changes usually do not go beyond normal values.

Reduced efficiency

The effectiveness of combined oral contraceptives may be reduced in the following cases: missed pills, vomiting and diarrhea, or as a result of drug interactions.

Effect on bleeding pattern

While taking combined oral contraceptives, irregular bleeding (spotting or breakthrough bleeding) may occur, especially during the first months of use. Therefore, any irregular bleeding should be assessed only after an adaptation period of approximately three cycles.

If irregular bleeding recurs or develops after previous regular cycles, careful evaluation should be performed to rule out malignancy or pregnancy.

Some women may not develop withdrawal bleeding while off the pill. If combined oral contraceptives are taken as directed, the woman is unlikely to be pregnant. However, if combined oral contraceptives have not been taken regularly before or if there are no two withdrawal bleedings in a row, pregnancy should be ruled out before continuing to take the drug.

Medical examinations

Before starting or resuming the use of the drug Logest, it is necessary to familiarize yourself with the woman’s life history and family history, conduct a thorough general medical examination (including measuring blood pressure, determining body mass index) and gynecological examination (including examination of the mammary glands and cytological examination of the cervical epithelium), and exclude pregnancy. The scope of additional studies and the frequency of follow-up examinations are determined individually. Typically, follow-up examinations should be carried out at least once every 6 months.

A woman should be warned that drugs like Logest do not protect against HIV infection (AIDS) and other sexually transmitted diseases!

Impact on the ability to drive vehicles and operate machinery

01/09/2002, Ilona
Last September, I was in the hospital with a diagnosis of salpingo-oophoritis. During treatment, I took a hormone test to select OK, but the gynecologist told me to choose from Femoden, Logest, Mercilon. The pharmacy said that of these the lowest hormonal is Logest. I took it according to the instructions until July of this year; on vacation I needed to extend my periods by almost two weeks, because... their onset coincided with the beginning of rest, as a result, menstruation began on August 16 and itching, brownish discharge. 26 went to the doctor and was diagnosed with thrush. I am now drinking Trichopolum and putting Clotrimazole suppositories, but at the same time, from 25 onwards, according to the scheme, I drank another pack of Logest, but missed two tablets (forgot to take them) and had sexual intercourse during treatment, but protected myself with a condom and now I am on the 6th day of treatment from 7, discharge began, large blood clots, and pain in the side, like during menstruation. I had to go to the doctor on Monday. Please answer what this is: this bleeding was caused by the fact that I violated the prescription and had contact the night before the bleeding started or because I missed taking 2 tablets; what to do now, finish the pack or wait for the bleeding to stop; how to continue to protect yourself; After what time should I take a break from taking OK.

Bleeding is caused by several factors: violation of the pill regimen, sexual intercourse on the eve of menstrual bleeding, and the influence of infection. In addition to the treatment you have given, I recommend taking Orungal for 3 days, this is a new highly effective antifungal drug. You should take 2 capsules daily.

01/09/2002, Dina
My gynecologist said that if you don’t want your period to come, you can just start a new pack of pills. I have been taking Novinet for a long time. But for how long can you take pills like this without a 7-day break? Is it possible, for example, to drink 3 packs without a break for 3 months, and only then do it? Or even more.

In principle, nothing bad can happen, only spotting and bleeding may appear, which will last from several hours to 10 days. So it's better to take a break.

02/09/2002, Alena
There was a 10-day delay, an ultrasound on the 6th day of the delay, they didn’t give an answer, they asked me to come back in a week. Pregnancy tests (domestic) show 2 stripes, one is slightly pink, imported tests show nothing. For 7 days now there has been a dark, bloody, slightly spotting discharge. I feel very good. I saw the doctor and said come back after the ultrasound. She was not given a referral to take tests for hCG. Can not wait. The discharge is very disturbing. What could it be? (ectopic, inflammation of the uterus or miscarriage).

Unfortunately, these may also be symptoms of an ectopic pregnancy. It is urgent to undergo an ultrasound using a vaginal sensor. With a week's delay, the fertilized egg should already be clearly visible. If it is found in the uterus, then the symptoms indicate a threat of miscarriage.

03/09/2002, Oksana
In 1996, I had to have an abortion (I have a son born in 1988). After this, some disturbances began: every few months, menstruation became very heavy, especially for several hours on the second or third day. The doctor advised me to take Logest. I took Logest for 3 years (with two breaks - on the advice of a doctor). Menstruation became weaker, but the peak of discharge now occurred on the third and fourth day (menstruation lasted 4 days), and some increases still occurred, although weaker. In April I stopped taking Logest (another break). The first three menstruation after stopping treatment were normal, even somewhat weaker. On June 18 (the first day of the fourth menstruation) I had an operation - they removed a polyp of the cervical canal and made a small conization at the site of the former (10 years ago) cauterization of erosion. After this, the nature of menstruation changed greatly (there were already four menstruation) - they became very heavy, more painful, blood came out in clots, almost without stopping during the second and third days, although the duration did not change (4 days). The last menstruation began on September 1st. (I must say that on August 28 I arrived from the south, maybe this has some influence) On this day I started taking Logest again. Starting from September 2, menstruation is very heavy (stronger than previous ones), at night the intensity has not decreased and continues to this day - for almost a day (September 3). I took Dicinon 2 times, but did not notice any significant changes. After the operation, I was examined by a doctor, had ultrasound scans twice (July and August) and no pathologies were noted. I would very much like to receive your advice on the following questions: 1. What is the reason for such an increase in menstruation, what can be done to weaken it? 2. Should I continue to take Logest? 3. What to do during such enhancements?

At your age, excuse me, Logest is already too weak to regulate menstruation. Switch to Rigevidon, containing 3 packs of 21 tablets in 1 pack. Start by taking 3 tablets at a time to stop bleeding, the next day - 2 tablets, then 1 tablet. at night, for a total of 21 days, along with taking Logest. Rigevidon can continue to be taken, but the duration of continuous use of OCs should not exceed 5 years.

03/09/2002, Tanya N.
I haven't had my period for 3 months. The pregnancy test is negative. Sometimes there are attacks of fever and sweating, recently I have gained a lot of weight, although my diet has remained the same. I often feel tired and drowsy. Could these all be signs of menopause at my age?

Yes, unfortunately, the picture you painted is very reminiscent of early menopause. To finally clarify this, you need to take an analysis for the pituitary hormones FSH, LH. Currently, functionally weak ovaries and early cessation of their activity are increasingly common. If the hormones are within the menopausal range, the diagnosis is 100% certain. You will need to undergo an ultrasound, an examination by a gynecologist, and some tests. If no abnormalities are found during this examination, it is necessary to carry out HRT - hormone replacement therapy. I recommend the drug Trisequence from the Danish company Novo-Nordisk.

03/09/2002, Anonymous
I hope very much for your help. This is the situation. Actually, I have an irregular menstrual cycle, sometimes there are delays of up to 7 days. This is now the 9th day of delay. The test showed a negative result. BT - 36.8. Over the course of a month, I had to take several long-haul flights and change time zones radically and frequently. Tell me, can a delay in menstruation be caused by this? If this is still a pregnancy, what kind of abortion is better to do at my age (at the same time there are problems with gynecology, there was an operation to remove an ovarian cyst)? I have heard many negative opinions about medical abortion, as if it often leads to emergency hospitalization with uterine bleeding. What can you say about this?

Logest is a low-dose mixed oral contraceptive estrogen - progestin medication. You can learn more about taking Logest in the instructions for use, which will be described below.

The drug is produced in the following forms:

Pills. Treated with a protective layer, they have a biconvex shape. Packaged in blisters, the number of tablets is 21 pieces.
Dragee. They have a round shape, the color of the tablets is white. It is packaged in the same way as tablets - 21 pieces in a blister.

Gestodene – 0.075 mg;
Ethinyl estradiol – 0.02 mg.

Additional components:

Polyvidone 25,000;
Sucrose;
Polyvidone 700,000;
Macrogol 6000;
Mountain glycol wax;
Talc.

Action

The structure of the tablets includes gestodene and enthinylestradiol, which interfere with the development of the follicle and stops the ovulation process. Because of this, the endometrium is not configured to accept a fertilized egg. In addition, the influence of Logest is concentrated on increasing the stickiness of cervical mucus, and this complicates the process of sperm entering the uterus.

The active components of the drug are gestodene and ethinyl estradiol. Gestodene is completely and rapidly absorbed into the body's systems when taken. An hour later, the largest amount of gestodene (4 ng/ml) is already visible in the bloodstream. There it combines with proteins: globulin, which combines sex hormones and albumin.

Indications for use

The drug is used for oral contraception.

Contraindications

Among the contraindications, there are the following:

With caution, having thoroughly considered the predicted benefits and possible dangers to well-being, it is recommended to prescribe Logest for women who have risk factors:

Myoma;
Fibrocystic mastopathy;
Tobacco smoking;
Thrombosis;
The presence of a heart attack in someone close to you;
Pathologies in the cerebral blood supply;
Malignant breast tumors;
Excessive obesity, which is classified as obesity;
Disturbances in the functioning of the heart valves;
Pathologies in heart rhythm;
Major surgery.

In addition, it is necessary to consult a doctor before starting to take this drug for those women whose condition from the following disorders in the body appeared or worsened during previous use of hormones: cholestasis, jaundice, gallbladder disease, Sydenham's chorea, herpes in pregnant women.

Instructions for use

The tablets should be taken once a day for 3 weeks in accordance with the dosage system shown on the package. It is recommended to take the tablets at the same time, with a small amount of water. Taking the next pack of tablets must begin a week after completing the tablets from the previous pack. During the week-long pause between taking pills, a menstrual-like response from the body (bleeding) may begin. As a rule, it occurs 2-3 days after a week-long pause. At certain points there is no bleeding stops by the time you take pills from another package.

How to start taking it?

The pills should be taken from the 1st day of the monthly cycle (1st day of critical days). When using tablets on days 2-5, auxiliary methods of contraception should be used during the first 7 days of using Logest.

When switching from the previous method to taking Logest, it is necessary to take mini-pills on any day. When using various injections or implants, the first tablet is used on the day the implant is removed or the effects of the injections are completed. All described methods require taking auxiliary contraceptive protection for a week, as Logesta is taken.

It is recommended to take the drug during the initial termination of pregnancy immediately after the abortion. Backup contraception is not required.

Taking the drug after childbirth or late termination of pregnancy allows you to start using Logest after a three-week period after childbirth, or after termination of pregnancy in the second trimester.

If the use of the drug is delayed for less than 12 hours, a decrease in the contraceptive effect is not observed. It is necessary to take the missed pill as soon as possible. Then carry out the reception in the same way, at the same time.

If the use of the drug is delayed for more than 12 hours, a decrease in the contraceptive effect can be observed. It is especially risky when the interval is more than a week, since the effect will only be observed if the pills are taken continuously.

What to do if you miss a pill?

If you miss a dose of the drug, you should know the following principles:

If a pill is missed within the first 7 days, you should take the missed pill as soon as possible. It is allowed to take 2 tablets if it is time for the next tablet. After this, the tablets are used as usual. You need to understand that if you miss the pill for a week, you can get pregnant if you have had sexual intercourse.
A missed pill occurred during the 2nd week. As in the first option, you should immediately take the missed pill. You are allowed to take two tablets, then continue taking them at your usual pace. If you miss more than one tablet, you should take extra precautions during sexual intercourse.
I missed a pill in the 3rd week. If you miss this period, the risk of a decrease in the contraceptive effect significantly increases. But, subject to the guidelines set out below, auxiliary measures are not required (under the circumstances that this omission was the only one for the entire period of use of the tablets). Otherwise, auxiliary assistance is required by other methods of protection (for example, the barrier method). The pill should be taken as soon as possible, after which the usual pill intake is allowed. As soon as you finish taking the last tablet, you should not stop; you should immediately take the tablets from the next package.

If menstruation does not come while taking the pills, you should be examined for possible pregnancy. If you take the pills correctly, pregnancy should not occur. This issue should be taken very seriously.

Side effects

The following secondary results from the use of the drug Logest are identified:

Other reasons: probably a slowdown in the removal of fluid from the body, the formation of allergies.

average price

The average cost of the drug ranges from 770 rubles. The price depends on the number of tablets in the package.

Analogs

artisia,
Gestarella,
Lindinet 20,
Lindinet 30,
Femoden.

Reviews from gynecologists

Irina Aleksandrovna, obstetrician-gynecologist

I have been a doctor for a long time; my work experience is more than 15 years. From a medical point of view, Logest can be concluded to be the most suitable contraceptive for most women. This drug has the characteristics of excellent contraceptive action, side effects occur extremely rarely (however, they do occur!). If you are personally sensitive or intolerant to the composition of the drug, you should consult a gynecologist to replace this drug with another one.

It is very important to constantly use Logest in order to achieve the best result. Even one gap in intake can cause an unplanned pregnancy. It must be borne in mind that when using an oral contraceptive with other medications (for example, antibiotics), the effectiveness of the contraceptive may be reduced.

Elena Gennadievna, gynecologist of the highest category

As a doctor, I would like to highlight the following: the drug is considered the most effective drug from the group of oral contraceptives. Logest can not only get rid of an unwanted pregnancy, but also postpone the period of your critical days. In addition, the pills certainly benefit those women who suffer from painful and excessive discharge during menstruation, since the pain becomes minimal.

The secondary effects, which are mentioned by a large number of women and girls, go away after some time (as the body gets used to the drug). In general, the drug is quite good, but I still recommend consulting with your treating gynecologist. Only in this case can you correctly and competently choose a contraceptive for yourself.

Features of the menstrual cycle after use and withdrawal
The use of any hormone-containing drug to prevent unplanned pregnancy, and especially the drug Logest, causes a rather powerful blow to the hormonal background of every woman. All sorts of deviations in the menstrual cycle are possible.

Delayed menstrual cycle

Often, women experience a delay in menstruation while using this contraceptive. IN
especially this condition is expressed by bleeding on the 3-5th day of using Logest. Normal menstruation in this case can occur after two weeks of this protection. The literature talks about episodes of loss of several cycles.

According to numerous authors, the use of this method of contraception can cause the absolute absence of a woman’s period. In most situations, this pathology is considered a coincidence, and such disturbances in menstruation are provoked by various inflammatory diseases “female-style”. In addition, numerous women noted that when taking this drug, their periods came ahead of time. This fact is explained by the presence in the tablets of analogues of female sex hormones - gestodene and ethinyl estradiol. Progesterone is directly responsible for the timely onset of menstruation.

One of the effective means of contraception of the new generation is the Logest contraceptive pill. These contraceptives contain a minimal level of hormones. In addition to protecting against unwanted pregnancy, this contraceptive has the ability to have a therapeutic and prophylactic effect on the development of female cancer.

The mechanism of action of the contraceptive Logest.
The tablets contain gestodene (progestogen) and enthinyl estradiol, which interfere with the maturation of the follicle and prevent ovulation, as a result of which the endometrium is not prepared for implantation of the fertilized egg. In addition, the effect of the drug is aimed at increasing the viscosity of cervical secretions, which makes it difficult for sperm to penetrate the uterus and their implantation.

Logest tablets are recommended for women over 35 years of age to prevent pregnancy and restore the menstrual cycle. After using these contraceptives, menstrual bleeding normalizes, becomes less painful and scanty, which reduces the risk of developing iron deficiency anemia. Scientific studies have proven that this contraceptive drug significantly reduces the risk of endometrial and ovarian cancer, breast diseases, inflammatory diseases of the reproductive system and ovarian cysts.

Contraceptive Logest is in the form of tablets, available in a blister with a calendar scale. The tablets should be taken at the beginning of the menstrual cycle, on the first day of menstruation. You should take one tablet daily (in accordance with the arrows on the blister), it is recommended at the same time, for twenty-one days. After this, a seven-day break is provided (as with other new generation oral contraceptives). Usually during this break menstrual-like bleeding is observed. At the end of the seven-day break, you should start a new package of the drug according to the same scheme, even if your period has not yet ended.

It should be noted that while taking the contraceptive drug Logest, side effects very rarely occur; mostly, if they appear, they occur at the very beginning of use. In the future, all unpleasant manifestations disappear on their own.

Side effects of the contraceptive Logest.

headache, migraine, abdominal pain, depressed mood;
nausea, vomiting, diarrhea, changes in body weight;
changes in vaginal secretion;
enlargement and soreness of the mammary glands, the appearance of discharge from the mammary glands, decreased libido, various skin reactions due to increased sensitivity (allergies, rash, urticaria, etc.), fluid retention.

If, while taking the drug, severe frequent headaches, hearing or vision impairment, signs of thrombophlebitis or thromboembolism, increased blood pressure, hepatitis, itching, severe abdominal pain, as well as increased frequency of epileptic seizures, you should immediately stop taking it. and contact a specialist.

Contraindications.

diabetes mellitus with vascular complications;
breast or endometrial cancer;
hypersensitivity or individual intolerance to the components of the drug;
migraine;
risk of developing venous or arterial thrombosis;
liver tumors;
presence of blood clots;
vaginal bleeding of unknown origin;
severe liver disease;
hormone-dependent oncological diseases of the genital organs or mammary glands;
pancreatitis;
pregnancy (increases the risk of developing congenital pathologies), lactation period (components of the drug penetrate into mother’s milk).

It is also worth noting that these contraceptives in the presence of cardiovascular diseases should be taken with caution and only after consultation with a doctor. The presence of arterial hypertension, atrial fibrillation, obesity, systemic lupus erythematosus, ulcerative colitis, as well as the presence of surgical pathology (a month before surgery and for two weeks after the drug is contraindicated) makes it impossible to take the drug. In addition, you should remember the high risk of thromboembolism during the postpartum period while taking Logest.

Concomitant use of these oral contraceptives with rifampicin, ampicillin, griseofulfin, phenylbutazone, phenytoin, phenobarbital, carbamazepine significantly reduces the contraceptive effect. Therefore, during this period and within a week after their discontinuation, it is recommended to use additional methods of contraception (within 28 days after discontinuation of rifampicin).

Use of the drug during pregnancy and breastfeeding.
This drug is strictly contraindicated for use during pregnancy and breastfeeding. If treatment with Logest is necessary during lactation, breastfeeding should be stopped, since the substances contained in the drug pass into breast milk and enter the child’s body.

Method of use and dosage of the contraceptive.
As mentioned earlier, the drug is started on the first day of menstruation. If the treatment was started from the second to the fifth day of the cycle, it is recommended to use additional methods of contraception during the week of taking the drug.

If you decide to switch to taking Logest from another hormonal contraceptive, it is recommended to do this the next day after taking the last active tablet/dragée of the previous contraceptive.

You can switch to Logest contraceptives from a mini-pill any day after they are discontinued. If injections or implants were used as contraception, then the first Logest tablet should be taken on the day the implant is removed or the injection ends. However, in all cases of transition, the first week of taking Logest must use an additional barrier method of contraception.

After artificial termination of pregnancy in the early stages, the drug is taken on the same day, immediately after the operation. Additional means of protection against unwanted pregnancy are not required.

After childbirth or late-term abortion, the drug should be started on days 21-28 of the postpartum period or after the abortion. In the latter case, additional protection is required for a week. Before starting to use the drug, you must make sure that you are not pregnant.

Skipping a drug dose.
If for some reason you missed taking an oral contraceptive, but the delay was no more than twelve hours, then you should take the pill immediately, and the next dose will be carried out according to the same schedule. In this case, the contraceptive effect of the drug is not reduced, and additional protection is not required. If the drug was delayed for more than twelve hours, a decrease in the contraceptive effect is observed. In this case, a decrease in contraceptive effectiveness may be observed. The danger is represented by a break of seven days or more, since the effect of the drug is based on its continuous use for at least a week.

Remember, the likelihood of conception increases with the number of pills missed per cycle, especially closer to the seven-day break. If a pill was missed during the first week of taking the drug, you must take the pill immediately (as soon as you remember). If by this time it is time to take the next pill, you are allowed to take two pills. Next, the drug should be taken according to the usual regimen.

If you missed a dose in the second week, you should also take it as soon as possible. If it is time to take the next pill, you can take two tablets. Then the drug should be taken as usual, but additionally use a condom for a week.

If you missed a pill in the third week of taking it, you should also take the pill as quickly as possible; if necessary, you can take two pills if it’s time to take the next pill after the missed pill. Then the drug is taken according to the usual regimen, but in this case there is no seven-day break; you should immediately start taking the pills from the next package. In this case, menstrual-like bleeding is unlikely, but bleeding may be observed while taking pills from a new package.

Before starting to use Logest contraceptives, a woman must undergo a thorough general medical and gynecological examination, in addition, it is advisable to examine the mammary glands and do a cytological examination of cervical mucus. It is very important to exclude pregnancy and blood clotting disorders.