Allergy medicine fenkarol. Fenkarol for children: instructions for use. Impact on the ability to drive vehicles and complex mechanisms

Hifenadine (quinuclidyl-3-diphenylcarbinol hydrochloride) is a derivative of quinuclidylcarbinol, a competitive blocker of H1 receptors. In addition, unlike classical antihistamines, it activates the enzyme diamine oxidase, which breaks down up to 30% of tissue histamine. This explains the effectiveness of Fenkarol in patients in whom the use of other antihistamines is ineffective. Fenkarol poorly penetrates the BBB and has little effect on the processes of serotonin deamination in the brain, and has little effect on MAO activity. The antihistamine properties of quinuclidine are associated with the presence of the quinuclidine cyclic nucleus in the structure and the distance between the diphenylcarbinol group and the nitrogen atom. In terms of antihistamine activity and duration of action, fenkarol is superior to diphenhydramine. Reduces the biological effect of histamine, in particular eliminates or weakens its bronchoconstrictor effect and spasmodic effect on intestinal smooth muscles, hypotensive effect and effect on capillary permeability, has a moderate antiserotonin and weak anticholinergic effect, and has pronounced antipruritic and desensitizing properties.
Unlike diphenhydramine and diprazine, quifenadine does not have a depressant effect on the central nervous system. The drug is low lipophilic and, compared to antihistamines that depress the central nervous system, its content in brain tissue is low (≤0.05%), which explains the lack of a depressant effect on the central nervous system.
It is quickly absorbed in the digestive tract (about 45%) and after 30 minutes the drug is detected in the tissues of the body. The maximum concentration in the blood serum is achieved after 1 hour. The highest concentration of the active substance is observed in the liver, lungs and kidneys, the lowest in brain tissue. Metabolized in the liver, excreted in urine, bile and through the lungs, the unabsorbed part of the drug is excreted in feces. Most of the unchanged quifenadine and its metabolites (about 44%) are excreted in the urine within 48 hours, another 1% over the next 48 hours.

Indications for use of the drug Fenkarol

Hay fever, food and drug allergies, other allergic diseases, acute and chronic urticaria, Quincke's edema, hay fever, allergic rhinopathy, dermatoses (eczema, psoriasis, neurodermatitis, itching), as well as infectious and allergic diseases of the upper respiratory tract with a bronchospastic component.

Use of the drug Fenkarol

Fenkarol is taken orally immediately after meals. Children aged 1 to 3 years - 5 mg 2-3 times a day (the daily dose should not exceed 15 mg); 3-7 years - 10 mg 2 times a day (the daily dose should not exceed 20 mg); 7-12 years old - 10-15 mg 2-3 times a day (daily dose should not exceed 50 mg), over 12 years old and adults - 20-25 mg 2-3 times a day (daily dose should not exceed 100 mg ). The duration of the course of treatment is 10-15 days. If necessary, the course is repeated.
If the next dose is not taken in a timely manner, the drug is continued without increasing the dose.

Contraindications to the use of the drug Fenkarol

I trimester of pregnancy, hypersensitivity to the drug

Side effects of the drug Fenkarol

In case of hypersensitivity or overdose of the drug, moderate dryness of the oral mucosa and dyspeptic symptoms are possible, which usually disappear when the dose is reduced or the drug is discontinued. The risk of side effects increases in people with diseases of the digestive tract.

Special instructions for the use of the drug Fenkarol

Caution should be exercised in case of severe diseases of the cardiovascular system, gastrointestinal tract or liver. There is no data on the penetration of the drug into breast milk, so caution should be exercised when prescribing it during breastfeeding.
Persons whose work requires quick physical or mental reactions (drivers of vehicles, etc.) should first determine (by short-term use) whether the drug has a sedative effect.

Interactions of the drug Fenkarol

Does not enhance the inhibitory effect of alcohol and hypnotics on the central nervous system. Fenkarol has weak M-anticholinergic properties, therefore, by reducing gastrointestinal motility, it is able to enhance the absorption of slowly absorbed drugs (for example, indirect coumarin anticoagulants).

Overdose of the drug Fenkarol, symptoms and treatment

At a dose of up to 300 mg/day it does not cause severe side effects. In a high dose, it can cause dry mucous membranes, headache, pain in the epigastric region, vomiting and other dyspeptic symptoms. There is no specific antidote. If necessary, carry out symptomatic treatment.

Storage conditions for the drug Fenkarol

In a dry place, protected from light, at a temperature not exceeding 25 ° C.

List of pharmacies where you can buy Fenkarol:

• Saint Petersburg

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Many people are interested in one question: “What are Fenkarol tablets for?” This remedy is designated by doctors as an antihistamine. That is, it reduces the amount of histamines affecting every human organ and system. Its unique description of action makes it very different from other drugs with the same mechanism.

Acting as a blocker of histamine Hi receptors inside each tissue, Fenkarol activates histaminase. Another name for it is the enzyme diamine oxidase. This is how the required level of histamine is achieved.

The effectiveness of using such a medicine for patients is difficult to overestimate, especially in cases where similar remedies have failed to cope with the task. When taken, each tablet will be quickly absorbed into the lining of the gastrointestinal tract. After half an hour, an improvement in the person’s condition is already observed. And after the same period of time, the maximum concentration in the blood is heard. This medication is metabolized only in the liver. Each metabolite is excreted through urine after two days.

Composition, active substance, release forms

There is only one active substance - quifenadine. He is the foundation. Of 100% of the substance there are 10 milligrams. The auxiliary components are water used for the injection solution, up to 1 milliliter, and glutamic acid, present in an amount of 6.26 milligrams. A solution is created in such proportions and administered intramuscularly.

The tablets are manufactured in these parameters. The active component does not change. His dose remains the same. Excipients will be the content of potato starch, the presence of sucrose, corn starch, calcium stearate. Together they should make up 100% of one tablet, minus the amount of quifenadine.

Gel and cream are dispensed in the form of a liquid, without any color and not containing anything. The tablets are white. Small cylinder shape. If the tablet has 10 mg of the active ingredient, then no special mark will be applied to it.

Dispensed only with a doctor's prescription!!!

How to take medicine for adults and children - dosage, instructions

Being decongestant, antiallergic, antipruritic, antiexudative, it is used as one of the best remedies against allergic reactions. It is the action of the active component that prevents the development and makes the course of the disease calmer. Also, when taken, a decrease in itching and inflammation in the tissues is noticed.

By making any action of histamine weaker, these products completely reduce its effect on blood vessels. They become more permeable, allowing blood to move faster.

There is also a decrease in bronchospastic effect and spasmogenic effect on intestinal smooth muscles. The hypotensive effects of histamine become less, which makes its amount in tissues less. All enzymes that activate it completely calm down and go away.

Even long-term treatment will not reduce the effectiveness of the main element. Mild antiserotonin actions do not affect cholimone blocking activity at all. In 100% of patients, no effects or effects on the central nervous system were observed.

Before use, you need to study Fenkarol; the instructions for use describe very rapid absorption with intramuscular injection. In this case, the peak value of the component in the blood is reached twice as fast. Since it has low lyophilicity, it crosses the blood-brain barrier very poorly. The highest concentration is observed in the human liver. The respiratory and fluid removal systems lag far behind in this indicator. The brain will contain the least of all. Therefore, when taking it, a person does not calm down or fall asleep. Excreted through urine.

In tablet form, almost half of the active substance is absorbed very quickly inside the stomach and intestines. Only after this action does the 30-minute countdown begin so that hifenadine reaches all its tissues throughout the body. The maximum amount in the blood will be only 60 minutes after taking it. All chemical properties are the same as for injections and balm, but in this case the unabsorbed part will be excreted by the liver.

As the abstract states, in both options, adults take 50 mg per day up to four times a day. Based on this indicator, calculate everything else! Always only after eating.

There is also a weaker Fenkarol, the instructions for children are the same as for adults, but the content of active components in it and the total dosage are much less than in the adult version.

Some parents, due to poor genetics, give their children this drug from birth, sometimes using ointment. Doctors have never been able to prove a negative effect, even in the absence of symptoms. But, it is better to undergo additional consultation with a pediatrician.

Children are given when they appear:

• Manifestations of urticaria on the skin;
• Various eczemas;
• Psoriasis;
• A runny nose that begins at the first sign of an allergy.

Fenkarol for children copes well with diseases such as:

• Hay fever;
• Neurodermatitis;
• Allergy with signs of suffocation.

Tablets of 10 milligrams are given to children when they have atopic dermatitis, severe allergic swelling, severe itching on the skin, and hay fever.

Immediately before vaccinations, taking Fenkarol is prohibited in cases where allergies are at their peak. The course must be completed before vaccination begins.

The pediatrician should calculate dosage according to the patient's age. Proper treatment greatly reduces the risk of swelling or rashes. The course always consists of a two-week period. Take after meals.

Features of use during pregnancy and lactation

Reception is prohibited throughout. If a woman is at the lactation stage, then the baby will have to drink formula. If these features are violated, side effects are possible not only for the mother, but also for the child. Namely: dry mucous membrane in the oral cavity, nausea, drowsiness, headaches.

Fenkarol's analogs

There is a fairly impressive list of similar medications to Fenkarol. Analogs even half may not have the same effect. But according to the principle of action, each substitute is similar:

• Aleric;
• Desal;
• Clarisens;
• Histaphen;
• Loratek;
• Telfast;
• Peritol.

Analogs of the medication can, of course, solve the problem, but not with the same effect. It all comes down to a strong core component.

Contraindications, side effects

In all dosage forms the use is prohibited:

• If the body completely refuses to take quifenadine. And also with strong sensitivity to other chemical elements of the drug.
• When a girl carries a fetus at any stage.
• DURING lactation.
• Any alcoholic drink.

With a little caution, it is possible for diseases of the digestive system, liver and kidney dysfunction.

Persons under 18 years of age are prohibited from any intravenous injections. The manual clearly describes that tablets are not given for sucrose deficiency or individual fructose intolerance in children. Their active component content should not exceed 10 mg for up to three years.

Compatibility of the drug with alcohol. Does not enhance the effects of alcoholic drinks. Careful use is possible!

Interaction with other drugs

With other sedatives they do not increase. But any combination with other drugs changes the concentration in the blood of slowly absorbing drugs. For example, coumarin. Compatible with alcohol in small doses.

Registration number: LP 002387-270214
Trade name of the drug: Fenkarol.
International nonproprietary name: hifenadine.
Dosage form: solution for intramuscular administration.

Composition per 1 ml of finished product:
Active substance: hifenadine (fenkarol base), calculated as 100% substance 10.00 mg;
Excipients: glutamic acid 6.26 mg, water for injection up to 1.0 ml.

Description: transparent colorless liquid.

Pharmacotherapeutic group: antiallergic agent - H1-histamine receptor blocker.

ATX code

Pharmacological properties

Pharmacodynamics
The active ingredient of the drug hifenadine is a blocker of H1-histamine receptors, prevents the development and facilitates the course of allergic reactions. It has antiallergic, antiexudative and antipruritic effects, preventing the development of allergic inflammation in the tissue. Weakens the effect of histamine, reduces its effect on vascular permeability (by reducing permeability, it has an anti-edematous effect), reduces its bronchospastic effect and spasmogenic effect on intestinal smooth muscles, weakens the hypotensive effect of histamine. Hifenadine reduces the content of histamine in tissues (associated with the ability to activate diamine oxidase, an enzyme that inactivates histamine). During a course of treatment, the antihistamine effect of quifenadine does not decrease. It has a moderate antiserotonin effect and exhibits weak m-anticholinergic activity. Does not have a depressing effect on the central nervous system.
Pharmacokinetics
After intramuscular (IM) administration, the solution is rapidly absorbed and the maximum concentration of quifenadine in the blood plasma is achieved after 30 minutes. Hifenadine has low lipophilicity and does not penetrate the blood-brain barrier well. The highest content of the active substance was observed in the liver, somewhat less in the lungs and kidneys, the lowest in the brain (less than 0.05%, which explains the absence of a pronounced sedative and hypnotic effect). The drug is metabolized in the liver, forming inactive metabolites, which are excreted primarily by the kidneys.

Indications for use

Hay fever, urticaria, angioedema (Quincke's edema) in case of severe disease and the need for intramuscular use of antihistamines.

Contraindications

Individual intolerance to quifenadine.
Hypersensitivity to any of the components of the drug.
Children under 18 years of age.
Pregnancy and breastfeeding period.

Carefully for decompensated diseases of the cardiovascular system, gastrointestinal tract, liver and kidneys.

Use during pregnancy and breastfeeding

Directions for use and doses

Intramuscularly. Subcutaneous administration is not used due to irritation.
Hay fever
2 ml (20 mg) 2 times a day for 3 days, then 2 ml (20 mg) 1 time a day for 2 days. The total duration of treatment is 5 days.

Urticaria and angioedema (Quincke's edema)
2 ml (20 mg) 2 times a day for 5 days, then 2 ml (20 mg) 1 time a day for 3 days. The total duration of treatment is 8 days.
The maximum single dose is 20 mg; the maximum daily dose is 40 mg.
After relief of acute allergic reactions, it is recommended to switch to the use of the drug Fenkarol in tablet form.

Side effect

The drug is well tolerated. Rarely possible adverse reactions: dryness of the oral mucosa, nausea, vomiting, drowsiness, allergic reactions, headache.

Overdose

Symptoms: dry mucous membranes, headache, vomiting, abdominal pain and other dyspeptic symptoms. Treatment is symptomatic. It is necessary to take activated carbon and consult a doctor immediately.

Interaction with other drugs

Does not enhance the inhibitory effect of alcohol and hypnotics on the central nervous system. Having weak M-anticholinergic properties, it can reduce gastrointestinal motility and increase the absorption of slowly absorbed drugs (for example, indirect anticoagulants - coumarin derivatives).

special instructions

The absence of a pronounced anticholinergic effect makes it possible to prescribe antihistamines with anticholinergic activity to patients who are contraindicated.
Impact on the ability to drive vehicles and maintain potentially dangerous mechanisms
Persons whose profession requires increased concentration and speed of psychomotor reactions should first determine (by short-term prescription) whether the drug has a sedative effect.

Release form
Solution for intramuscular administration 10 mg/ml.
1 ml or 2 ml of the drug in neutral glass ampoules.
10 ampoules are placed in a blister pack made of transparent polyvinyl chloride film. 1 blister pack along with instructions for use is placed in cardboard packs.

Fenkarol is a 1st generation antiallergic drug with an active antihistamine effect. Doctors prescribe tablets and solution for injection to relieve acute reactions. Medicines are used infrequently for the treatment of chronic diseases: there are new generation drugs with a smaller list of restrictions and negative reactions.

Fenkarol for children and adults: instructions for use, special instructions, effectiveness, reviews of the drug. Recommendations from allergists, nuances of treatment of various types of diseases against the background of high sensitivity of the body.

Compound

The active component of the drug Fenkarol is hifenadine hydrochloride. The active substance reduces the negative impact of a large amount of histamine, a powerful release of which occurs during the body’s immune response to the penetration of an allergen. Hifenadine activates diaminoskidase: the enzyme breaks down up to a third of histamine. This process provides a noticeable anti-allergic effect.

Hifenadine almost does not penetrate into the blood and brain cells, the negative effect on the heart and capillaries is weak. With a specific reaction to the active substance, in some patients the speed of psychomotor reactions is impaired and drowsiness occurs.

Release form

JSC company "Olainfarm" (Latvia) produces two types of antiallergic medicine based on hifenadine:

• pills. The content of the active component is 10 mg (for children) and 25 mg (for adults), there is a drug with a high concentration of quifenadine hydrochloride - 50 mg. Antiallergic medicine tablets are chamfered and the color of the pills is white. Pharmacies receive packages No. 15 and 20;
• solution for intramuscular administration. The colorless liquid is poured into ampoules (volume 1 or 2 ml), each package of Fenkarol contains 10 containers. The content of hifenadine hydrochloride in 1 ml of antihistamine composition is 10 mg.

Action

After intramuscular administration of the drug and taking tablets, the symptoms of allergic reactions noticeably weaken:

• itching decreases;
• spasm in the intestines disappears;
• swelling decreases;
• rashes on the body are less noticeable;
• hypotensive activity decreases;
• histamine release stops.

The highest concentration of hifenadine hydrochloride was observed an hour after consuming the tablet form, and when administering a medicinal solution - after half an hour.

On a note:

• an antiallergic drug is suitable for quickly eliminating a dangerous sign of an allergy: pronounced swelling, against the background of which the lumen of the larynx narrows, the functioning of internal organs is disrupted;
• the active component accumulates in the liver, lungs and kidneys, then quifenadine is metabolized, and the processed products are excreted from the body in the urine. For this reason, caution is required when prescribing antiallergic medications to patients suffering from kidney and urinary tract diseases.

Indications for use

• hay fever;
• dermatoses accompanied by skin itching;
• negative reaction to allergens, during which bronchospasm develops;
• , medicines, animal hair, food;
• urticaria of various forms;

Contraindications

The drug Fenkarol based on hifenadine hydrochloride is not suitable for allergy sufferers in the following cases:

• breast-feeding;
• the patient is under 18 years of age (Fenkarol in the form of a solution for intramuscular injection);
• allergic reactions to hifenadine hydrochloride;
• pregnancy (taking medication in the first trimester is strictly prohibited).

Moderate and severe forms of diseases of the liver, intestines, stomach, kidneys, heart and blood vessels are a reason for a more detailed examination of the patient before prescribing Fenkarol. Based on the test results, the doctor decides whether a drug based on quifenadine is suitable for a weakened patient or not. When prescribing Fenkarol to patients with acute and recurrent, indolent pathologies, it is important to reduce the dosage and frequency of administration

Instructions for use and dosage

The antiallergic drug is more often prescribed to adult patients; Diazolin (dragees) and Suprastin (tablets) are more common in pediatric practice. Fenkarol has a “softer” effect on the body than other 1st generation antihistamines, but uncontrolled use often worsens the allergy sufferer’s condition, causing skin reactions, problems with the digestive tract, severe drowsiness, and dizziness. Against the background of diseases of the gastrointestinal tract, the risk of negative effects increases.

Fenkarol tablets: features of therapy:

• adults. Doctors prescribe a medicine with a concentration of the antiallergic component of 25 or 50 mg per tablet. The optimal dosage is 1 or 2 tablets three to four times a day. The maximum daily dose of quifenadine is 200 mg. A course of therapy lasting 10-20 days is recommended;
• children. Young patients need tablets with a lower dosage - 10 mg of quifenadine. Age 3-7 years - 1 antiallergic tablet twice a day, 7-12 years - 10 mg. For patients over 12 years of age, doctors recommend taking the composition 2 or 3 times a day (a single dose is 2 tablets). Treatment lasts 10-15 days; you cannot take pills longer.

Intramuscular injections:

• for either the duration of therapy is 8 days: the first 5 days - in the morning and evening, administration of 2 ml of the medicinal solution, the next three days - once a day in the same volume (2 ml);
• when the duration of treatment is 5 days: three days - two injections of 2 ml, then two days of 20 mg per day.

Important! At one time, it is allowed to administer to the patient intramuscularly no more than 2 ml of the drug (concentration of quifenadine - 20 mg), the highest daily dosage is 40 mg of the active substance. After relieving severe signs of an allergic reaction, doctors strongly recommend that you stop using injections and switch to Fenkarol tablets.

Possible side effects

Compared to Suprastin, the drug based on hifenadine hydrochloride is less toxic to the body, penetration through the blood-brain barrier is less pronounced, and CNS depression is less pronounced. During treatment, normal capillary permeability is maintained, the negative effect on blood vessels and heart muscle is not as obvious as with other classic ones.

Despite the more delicate effect, Fenkarol still produces side effects:

• inhibition of reactions, drowsiness (rather mild manifestations);
• bitter taste;
• rarely - loss of consciousness;
• nausea;
• headache;
• dry mouth;
• vomit.

Overdose

The antiallergic agent acts “softer” than other 1st generation formulations; exceeding the daily norm is less likely to cause severe complications. In some cases, dry mouth, bloating, epigastric pain appear, the patient feels nauseous, vomiting, and dizziness. If negative symptoms appear, the patient should take (Enterosgel, Lactofiltrum) and consult a doctor to eliminate signs of overdose.

Description of the dosage form

Release form, composition and packaging

◊ Pills white or almost white, round, flat-cylindrical, chamfered.

Excipients: sugar, potato starch, calcium stearate.

10 pieces. - contour cell packaging (2) - cardboard packs.

Clinical and pharmacological group

pharmachologic effect

Histamine H1 receptor blocker. Reduces the effect of histamine, reduces its bronchospastic effect and spasmogenic effect on intestinal smooth muscles, weakens the hypotensive effect of histamine and reduces its effect on vascular permeability. Reduces the content of histamine in tissues, which is associated with the ability to activate diamine oxidase, an enzyme that inactivates histamine. It has a moderate antiserotonin effect and exhibits weak m-anticholinergic activity. Does not have a pronounced depressant effect on the central nervous system.

Pharmacokinetics

Suction and distribution

Hifenadine is absorbed from the gastrointestinal tract, absorption is 45%, and after 30 minutes it is found in the body tissues. Cmax in blood plasma is reached after 1 hour. The highest concentration of the active substance is found in the liver, somewhat lower in the lungs and kidneys, and the lowest in the brain (has lower lipophilicity). The content in brain tissue is low - less than 0.05% (which explains the lack of a depressant effect on the central nervous system; with individual hypersensitivity, a weak sedative effect is possible).

Metabolism and excretion

Hifenadine is metabolized in the liver.

Metabolites are excreted in urine, bile and through the lungs. The unabsorbed portion of the drug is excreted through the intestines.

Indications for use of the drug

- hay fever;

- acute and chronic urticaria;

- Quincke's edema;

- allergic rhinitis;

- dermatoses (including eczema, neurodermatitis, itchy skin).

Dosage regimen

The drug is taken orally after meals.

For adults Prescribe 25-50 mg 3-4 times/day. The maximum daily dose is 200 mg. The course of treatment is 10-20 days. If necessary, the course of treatment is repeated.

Children aged 2 to 3 years prescribed 5 mg 2-3 times/day; aged 3-7 years- 10 mg 2 times/day; aged 7-12 years- 10-15 mg 2-3 times/day; over 12 years old- 25 mg 2-3 times/day. The course of treatment is 10-15 days.

Side effect

From the digestive system: dryness of the oral mucosa, nausea, vomiting.

From the side of the central nervous system: drowsiness, headache.

Others: allergic reactions.

Contraindications to the use of the drug

- pregnancy;

- lactation period (breastfeeding);

- hypersensitivity to the components of the drug.

WITH caution should be used for diseases of the cardiovascular system, gastrointestinal tract, liver, kidneys.

Use of the drug during pregnancy and lactation

The use of the drug is contraindicated during pregnancy and lactation (breastfeeding).

special instructions

The absence of a pronounced m-anticholinergic effect allows the drug to be prescribed to patients for whom antihistamines with anticholinergic activity are contraindicated.

Impact on the ability to drive vehicles and operate machinery

If it is necessary to use it in patients whose profession requires rapid psychomotor reactions, it is necessary to determine whether the drug causes a sedative effect. To do this, the drug should be prescribed for a short period of time.

Overdose

Symptoms: dry mucous membranes, headache, dyspeptic symptoms, incl. vomiting, abdominal pain.

Treatment: gastric lavage, taking activated carbon, carrying out symptomatic therapy.

In case of overdose, the patient should consult a doctor.

Drug interactions

Does not enhance the inhibitory effect of alcohol and hypnotics on the central nervous system.

Having weak m-anticholinergic properties, the drug can reduce gastrointestinal motility, which helps increase the absorption of slowly absorbed drugs (for example, indirect anticoagulants - coumarins).

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions and periods

The drug should be stored out of the reach of children, in a dry place, protected from light. Shelf life - 4 years.