Use of the antimicrobial properties of nitroxoline in the treatment of urological diseases. Nitroxoline: instructions for use and what it is needed for, price, reviews, analogues Nitroxoline do I need a prescription

In many countries of the world the drug is not used, but in the post-Soviet space it is included in second-line drugs for the treatment of urinary tract infections. There have been no reliable modern clinical trials of its effectiveness, so we can say that it is often used the old fashioned way, based on the experience of previous generations.

Features of the drug

Nitroxoline tablets are available in a dosage of 50 mg. Perhaps it owes its popularity to its low price - from 80 rubles for 50 tablets. Analogs “5-NOK” and “Nitroxoline-UBF” are a little more expensive - about 190 rubles for 50 tablets. (Data as of February 2018).

The composition of the drug suggests that it is a synthetic antibiotic with a wide spectrum of action. It is capable of inhibiting the synthesis of DNA molecules in microbial cells, which leads to a bacteriostatic effect.

Nitroxoline exhibits activity against the following pathogens:

staphylococci;
streptococci;
Corynebacterium diphtheria;
coli;
proteas;
salmonella;
shigella;
enterobacter;
Mycobacterium tuberculosis;
Trichomonas;
candida.

The medicine is quickly absorbed and excreted unchanged by the kidneys. Therefore, it is able to act directly in the organs of the urinary system.

Instructions for use of "Nitroxoline": effectiveness for thrush, inflammation of the appendages, cystitis

What is the drug taken for and how to take it? The metabolic features of the substance determined the scope of its use. Indications for the use of Nitroxoline include diseases caused by sensitive microbes:

cystitis;
urethritis;
epididymitis;
pyelonephritis;
infected prostate adenoma;
prostate carcinoma with infection.

It can also be used for prophylaxis during operations and invasive diagnostic studies on the urinary organs. Sometimes it is prescribed in gynecology during catheterization of the bladder before surgery for uterine fibroids. But it is ineffective against inflammation of the appendages.

For the treatment of thrush, which is caused by fungi of the genus Candida, the prescription of the drug is unreasonable. Its effectiveness may be insufficient, and side effects may be severe. There are safer remedies for candidiasis, for example, Fluconazole, Clotrimazole, Butaconazole.

Even in the presence of kidney inflammation, contraindications for taking the medicine include the following conditions:

individual intolerance;
cataract;
neuritis;
polyneuritis;
liver failure;
chronic renal failure;
deficiency of glucose-6-phosphate dehydrogenase.

Taking Nitroxoline during pregnancy is not recommended. This is especially true in the first trimester. In the second and third cases, when the fetus is already formed, treatment with Nitroxoline is allowed, but only if the benefits for the mother outweigh all the risks for the child. It is also not recommended to use it for treatment while breastfeeding. Some maternity hospitals practice prescribing medication for possible infectious complications of the bladder or kidneys. Especially with urolithiasis.

When treating during pregnancy, it is necessary to monitor the presence of edema and increased blood pressure. These symptoms may be in addition to the frequent urination that occurs with cystitis. If swelling does not go away overnight, then you need to tell your doctor about it. Perhaps this is a sign of gestosis.

How to use

The method of application depends on the age of the patient.

Adults. The prescribed dosage of Nitroxoline per day is 600-800 mg, which must be divided into four doses. Take each dose of the medicine after six to eight hours. The course of treatment lasts 10-14 days.
Children . Dosing is based on body weight. For each kilogram, take 10-30 mcg per day. The required dose is distributed over the course of the day into three to four doses.

The treatment regimen for urinary tract infections, in addition to Nitroxoline, includes antispasmodics and diuretics with a weak effect. Reviews from doctors about using this approach are positive. Similar reviews about Nitroxoline-UBF tablets, which are a complete analogue.

Considering the side effects of the drug, it is taken not before, but during or immediately after meals. This helps avoid unpleasant nausea.

Unpleasant consequences

Side effects vary in severity. These may be the following manifestations:

nausea;
vomit;
a sharp decrease in appetite;
allergies in the form of skin rash;
increased heart rate;
ataxia;
headache;
polyneuropathy;
feeling of "crawling" and other paresthesias;
liver dysfunction.

With very long-term use, a single case of optic neuritis has been observed. You also need to take into account the compatibility of the drug with other medications.

Special instructions: therapy and alcohol

In case of severe renal impairment, the medication should be discontinued. As with renal colic, disruption of the outflow of urine will lead to the accumulation of medicine in the blood and increased unpleasant effects.

Patients with diabetes or impaired glucose tolerance should also be careful. The medicine shell contains sucrose and glucose, which can lead to the appearance of sugar in the urine.

An overdose of the drug leads to increased side effects. In such cases, you need to induce vomiting or perform gastric lavage.

You should not take alcohol at the same time as Nitroxoline. Alcohol has a negative effect on nervous tissue. Nitroxoline has a similar effect, which manifests itself in the possibility of developing polyneuropathy and neuritis. Combining the two will only enhance the unpleasant effects.

The use of Nitroxoline for cystitis should be under supervision and on the recommendation of a doctor. More effective and less toxic drugs have been identified for this disease. But this antibiotic must be kept in reserve, and besides, you cannot buy it without a prescription.

Reviews: “There are no reminders of the disease left...”

Nitroxoline is very good in the treatment of cystitis. And if you don’t hope for instant miracles, but show persistence and treat it for at least two weeks, then the results will be very impressive. I have a feeling that cystitis is gone forever. Let's see how long this effect really lasts.

Lilya, https://www.piluli.ru/product/Nitroksolin

Periodically produces a pronounced anti-inflammatory effect. Low efficiency, side effects. The drug is quite toxic. The drug was actively used about twenty years ago. Over time, the effectiveness decreased. Although in some cases it still gives a pronounced effect. In a word, it can still be used today.

Nedoshkulo K. T., urologist https://protabletky.ru/nitroxoline/

I had to take Nitroxoline after an accidental swim in an ice hole. I can judge objectively. The pain was quite significant. After the first day of taking this medicine, I felt significantly better. I drank three times a day. He healed quite quickly. In about ten days. I did not observe any troubles during the appointment. Only the urine is slightly colored. After a full course of treatment and following all the doctor’s recommendations, the disease did not recur. There are no reminders left.

Sergey R., https://protabletky.ru/nitroxoline/

Instructions for use classify Nitroxoline tablets as antibacterial agents. The medicine is prescribed for the treatment of genitourinary tract infections and for the prevention of infectious processes after operations on the kidneys and genitourinary tract. Reviews from patients and recommendations from doctors report that this medication helps in the treatment of cystitis, pyelonephritis and urethritis.

Release form and composition

The drug Nitroxoline is available in the dosage form of film-coated tablets for oral administration (oral administration). They have a round shape, a biconvex surface and an orange color.

The main active ingredient of the drug is nitroxoline, its content in one tablet is 50 mg. Nitroxoline tablets are packaged in blister packs of 10 pieces. A cardboard pack contains 1 or 5 blisters, as well as instructions for use of the drug.

pharmachologic effect

Nitroxolin shows activity against gram -positive and gram -negative bacteria (hay wand, enterococci, streptococci, causative agents of gonorrhea and diphtheria, Klebsiella, salmonella, staphylococci, shigella, enterobacter), vaginal trichomonas, mycobacteria of tuberculosis, dermatophytes, and dermatophytes, and mushrooms of the family of candidate and plesy and plesy and plesy and plesy and pleseni Some deep pathogens mycoses.

After oral administration, Nitroxoline is highly absorbed from the gastrointestinal tract. This drug is excreted unchanged by the kidneys. High concentrations of the drug are detected in the urine.

Indications for use

What does Nitroxoline help with? Tablets are prescribed:

prevention of infectious complications during diagnostic and therapeutic procedures (catheterization, cystoscopy) in the postoperative period during surgical interventions on the kidneys and genitourinary tract;
infectious and inflammatory diseases mainly of the genitourinary tract (including pyelonephritis, cystitis, urethritis, epididymitis, infected adenoma or prostate carcinoma), caused by microorganisms sensitive to nitroxoline.

Instructions for use

Nitroxoline tablets are taken orally during meals or immediately after meals. Adults are prescribed 100 mg 4 times a day. In severe cases, the single dose is increased to 150-200 mg, the frequency of use is 4 times a day.

The maximum permissible daily dose is 800 mg. The duration of treatment depends on the type and severity of the disease. On average, the course of therapy is 2-3 weeks. If there is a need for repeated courses, 2-week breaks are taken between them.

Children over 5 years old are prescribed 50-100 mg 4 times a day, children under 5 years old - no more than 200 mg per day. Duration of treatment is 2-3 weeks. For chronic urinary tract infections, the drug is prescribed in courses of 2 weeks with a 2-week break.

For preventive purposes after surgery on the urinary tract or kidneys, 100 mg is prescribed 4 times a day for 2-3 weeks.

Contraindications

pregnancy, lactation;
neuritis;
impaired renal function, which may be accompanied by oligo- or anuria;
severe liver diseases;
cataracts;
high sensitivity to quinolines;
deficiency of glucose-6-phosphate dehydrogenase.

Side effects

When using Nitroxoline tablets, side effects from various organs and systems may develop:

Allergic reactions - skin rash, itching.
Nervous system - ataxia (gait disturbance), paresthesia (impaired skin sensitivity), polyneuropathy (metabolic disorders in the nerves), headache, isolated cases of the development of optic neuritis have been described.
Cardiovascular system – tachycardia (increased heart rate).
Digestive system - nausea, vomiting, loss of appetite, rarely a functional disorder of the liver may develop.

The need to stop taking Nitroxoline tablets is determined by the doctor, depending on the nature and severity of the side effects.

Children, pregnancy and breastfeeding

Nitroxoline is contraindicated for use during pregnancy and lactation (breastfeeding).

Application is possible according to the dosage regimen.

special instructions

During treatment, urine may turn saffron yellow. When taking Nitroxoline, it is possible to develop side effects from the central nervous system (dizziness, headache), therefore, during the course of treatment, it is recommended to be careful when driving vehicles and performing potentially dangerous work that requires increased concentration and immediate psychomotor reactions.

Drug interactions

Taking Nitroxoline together with drugs from the tetracycline group can enhance the effect of each drug. The simultaneous use of Nystatin and Levorin can potentiate their effect. Combination with nitrofurans causes a negative neurotropic effect, so it is better not to take them together.

Analogues of the drug Nitroxoline

Analogues are determined by structure:

Noxin.
Nikinol.
Nikopet.
Nitroxoline Akos.
Noxibiol.
5 Nitrox.
Nitroxoline UBF.
5 NOK.
Uritrol.
Niuron.
Nibiol.

Vacation conditions and price

The average price of Nitroxoline (50 mg tablets No. 50) in Moscow is 89 rubles. Sold according to prescription.

The shelf life of Nitroxoline tablets is 4 years from the date of manufacture. The drug should be stored in a dark, dry place, out of reach of children, at an air temperature no higher than +25 C.

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Release forms: film-coated tablets, 50 mg of the active ingredient Nitroxoline.

What are these pills for? The drug belongs to systemic antibiotics. The main purpose is to suppress gram-negative bacteria of the Enterobacteriaceae family (E.coli, Salmonella spp., Shigella spp., Proteus spp.) and fungi of the genus Candida.

After using the product, it is quickly absorbed into the blood from the alimentary canal, the active substance is excreted unchanged by the kidneys (urine turns intense yellow). With a single dose of 2 tablets of 50 mg each, the minimum bacteriostatic concentration in the urine lasts up to 3 hours, after taking 400 mg - up to 7 hours.

What does nitroxoline help with? The drug is effective for prostate adenoma, carcinoma-infected prostatitis, pyelonephritis, epididymitis, urethritis, cystitis and other acute and chronic infections of the kidneys and genitourinary tract caused by antibiotic-sensitive microorganisms.

Additionally, Nitroxoline is used to prevent infections after surgery on the kidneys and genitourinary tract, and to prevent complications (infectious) during diagnostic procedures (catheterization or cystoscopy). Prevention of recurrent urinary tract infections in children and adults.

Is Nitroxoline an antibiotic or not? It is an antimicrobial agent derived from 8-hydroxyquinoline. The mechanism of action is associated with selective inhibition of bacterial DNA synthesis. Yes, a systemic antibiotic.

Nitroxoline - instructions for use and dosage

Use of nitroxoline tablets for adults: the recommended daily dose is 400–800 mg, divided into 4 doses.

The average daily dosage is 400 mg (2 tablets 4 times a day before meals).

In severe forms of infection, the daily dosage of nitroxoline can be increased to 800 mg (4 tablets 4 times a day), but the total daily dose should not exceed 800 mg (16 tablets of nitroxoline 50).

Some chronic recurrent diseases require longer (several months) therapy.

Should I take Nitroxoline 50 before or after meals? It is recommended to use during or after meals with the amount of clean water required for swallowing.

The use of nitroxoline for cystitis

Instructions for using nitroxoline for cystitis depend on the form of the disease (acute, chronic). If cystitis is acute and symptoms appear for the first time, it is usually enough to take a course of two weeks, and it is recommended to take two tablets every six hours.

For cystitis, it is important to take Nitroxoline at regular intervals in the doses recommended above. In special cases, the daily dosage can be adjusted depending on the age category of the patient, the severity and severity of the infection and, accordingly, on the doctor’s prescription.

The dosage for cystitis for adults is 600-800 mg/day. The frequency of administration is 3-4 times a day with an interval of 6-8 hours. The course of treatment is 10-14 days.
Even if you feel relief and the pain has disappeared, you still need to take the pills for the entire course of treatment for cystitis. The benchmark is the normalization of three urine tests over three consecutive days.

For children, the dose is 10-30 mg/kg/day in 3-4 doses and should be calculated by a doctor. Don't self-medicate! Children over five years of age are allowed to take no more than 400 mg per day. Children under 5 years old should not take pills.

Nitroxoline should not be taken together with alcoholic beverages. Strictly observe the time and frequency of taking the drug.

Precautionary measures

In most cases, the development of side effects occurs when patients take the drug without even knowing what nitroxoline helps with. On the advice of friends, what helped him with cystitis..

In general, the product is well tolerated and its effectiveness has been proven in clinical trials, but there are some peculiarities.

Renal failure with impaired nephron function can cause excessive accumulation of the active substance nitroxoline, which will lead to undesirable side effects.

Tablets should not be used in case of individual intolerance or hypersensitivity to the main/auxiliary components of nitroxoline.

It is prohibited to take when:

deficiency of glucose-6-phosphate dehydrogenase;
neuritis;
cataracts;
pregnancy, breastfeeding;
high sensitivity to quinolines.

Side effects Nitroxoline

appetite disorders;
dyspeptic disorders;
rash and other manifestations of allergies;
headaches, sensory disturbances;
increased heart rate (rare).

Rarely, with prolonged use, optic neuritis and myelopathy may occur.

In most cases, negative reactions are associated with violation of the instructions for use of Nitroxoline 50. So, if you miss a dose of the drug, you should not take a double dose (!).

Nitroxoline during pregnancy

The drug is not prescribed during pregnancy or lactation due to the lack of data regarding the effectiveness and safety of use.

Nitroxoline analogues, list

Analogues of nitroxoline according to the active substance:

5-NOK,
Uritrol,
5-Nitrox,
Nikopet,
Nibiol.

Please note that the instructions for use of nitroxoline 50 and analogues may not be the same, due to differences in the concentration of the active antibacterial substance and other differences. Read the instructions for the drug and take it only after a doctor’s prescription! Replacement with a similar antibiotic should not be unauthorized!

Storage conditions and shelf life
In a place protected from light, at a temperature not exceeding 20°C. Shelf life - 2 years.

ATX classification:
J Antimicrobials for systemic use
J01 Antimicrobials for systemic use
J01X Other antibacterial drugs
J01XX Other antibacterial drugs

To solve problems associated with inflammatory processes in the urinary tract, doctors often prescribe nitroxoline tablets. This is a well-known drug in the pharmaceutical market and is produced by a large number of companies. How and when to take it correctly?

General characteristics of nitroxoline

If you have been prescribed nitroxoline, is it an antibiotic or not - the first question that you will probably have. The fact is that pharmaceutical companies producing the drug often add the abbreviation of their production to the name to give the drug “authority.” However, no matter what words are used, nitroxoline remains a drug with a fixed content:

magnesium stearate;
silicon dioxide and titanium;
magnesium carbonate;
tropeolin O;
macrogol 6000;
potato and corn starches;
lactose, talc, granulated sugar and red dye 2C.

Nitroxoline is not an antibiotic, although, like them, it has an antimicrobial effect. The difference lies in the degree of impact on microorganisms: with antibiotics it is more radical, so the microbes needed by the human body also fall under its influence.

If you have been prescribed nitroxoline, you need to know what these tablets are for. This drug is indicated for patients:

with infectious or other diseases of the urinary and genital tract, which are provoked by harmful microbes - with cystitis, urethritis, pyelonephritis;
with an infected adenoma or other inflammation of the prostate gland;
with epididymitis;
for preventive treatment of the urinary tract;
during postoperative restoration of the genitourinary system and kidneys.

General principles of action of nitroxoline

The antimicrobial effect of nitroxoline is to block the DNA of pathogenic microorganisms, due to which the infected cells die and further spread of the infection is blocked. A set of certain enzymes in the structure of the drug allows a selective approach to the destruction of pathogenic cells without having a negative effect on other tissues and systems of the human body. Here are the microorganisms that “succumb” to the effects of nitroxoline:

staphylococci;
streptococci;
diphtheria bacillus;
gonococci;
Proteus;
Klebsiella;
Trichomonas;
thrush;
microbacteria tuberculosis;
fungi related to molds;
enterobacteria;
Streptococcus hemolytic type beta.

Due to the wide spectrum of effects of the drug, nitroxoline is prescribed for any disease caused by a pathogen from this list.

Features of taking nitroxoline for cystitis

Nitroxoline is often prescribed for cystitis. It is imperative to take into account the severity of the disease, because it determines the dosage of the drug and the effectiveness of treatment. If cystitis is acute and symptoms appear for the first time, then it is enough to take a course of two weeks, and it is recommended to take two tablets every six hours. Treatment is considered complete if the patient's urine test three times in a row does not contain pathogenic microorganisms.

For the treatment of chronic cystitis, nitroxoline is taken according to the same scheme. But, if the symptoms do not disappear, the dose is increased to six tablets per one-time dose every 12 hours. This treatment lasts three weeks, and then you need to take a detailed urine test. If the infection still exists, antibiotics are prescribed.

Antibiotic nitroxoline or not - in any case, it is a drug that is considered an effective means of getting rid of ailments of the urinary and reproductive systems. As a rule, the problem is successfully solved in one step. However, a number of patients complain about a rather long course of therapy. In addition, changes in urine color are sometimes noted. In each specific case, the patient’s attending physician should tell the patient in detail about possible side effects and how to take nitroxoline.

The drug contains the active component - nitroxoline.

Additional ingredients: sucrose, , aerosil, basic aqueous magnesium carbonate, talc, titanium dioxide pigment, paraffin, beeswax, yellow-orange dye.

Release form

The main form of release of the drug is coated tablets, packaged in 10 pieces. in blister packs, 5 per pack.

pharmachologic effect

Nitroxoline tablets have antibacterial action.

Pharmacodynamics and pharmacokinetics

This drug is antibacterial an 8-hydroxyquinoline derivative. Its action is due to the selective inhibition of bacterial DNA production. The activity of Nitroxoline is manifested against known gram-positive bacteria and gram-negative bacteria, and some types of fungi.

As a result of oral administration, Nitroxoline-UBF is absorbed from the gastrointestinal tract to a fairly high degree. Excretion occurs through the kidneys, almost unchanged. In this case, high concentrations of the main substance are predominantly determined in the urine.

Indications for use of Nitroxoline

Main indications for use of Nitroxoline:

treatment of infectious and inflammatory diseases of the genitourinary tract, for example: , epididymitis, infected prostate adenoma or carcinoma ;
carrying out the prevention of infectious complications during diagnostics and treatment procedures – catheterization or cystoscopy , as well as after or during operations in the area of the kidneys and genitourinary tract.

Contraindications

impaired renal function, which may be accompanied by oligo- or anuria;
severe liver diseases;
deficiency of glucose-6-phosphate dehydrogenase;
neuritis;
, ;
high sensitivity to quinolines.

Side effects

In most cases, the development of side effects occurs when patients take the drug without even knowing what the pills help with. In this case, deviations in the functioning of the digestive system may be observed, for example, nausea, vomiting , loss appetite , and sometimes disturbances in liver function.

Disturbances in the activity of the nervous system occur somewhat less frequently, manifesting themselves ataxia, . Long-term use can cause optic neuritis.

In general, as is known, Nitroxoline is, therefore, undesirable effects affecting the functioning of various organs and systems, including the cardiovascular system, cannot be ruled out.

Nitroxoline tablets, instructions for use (Method and dosage)

According to the instructions for use of Nitroxoline-UBF, the tablets are taken orally, preferably after meals. The dosage of the drug is determined by the attending physician. On average, adult patients are prescribed 0.1 g per day, 4 times a day. In this case, the duration of treatment can be 2-3 weeks.

If necessary, repeat courses are given after 2 weeks. The tablets are also prescribed to prevent postoperative infections in the kidney or urinary tract, and it is recommended to take 0.1 g of the drug 4 times a day for 2-3 weeks.

Overdose

Cases of drug overdose may be accompanied by symptoms such as vomiting, nausea or general weakness. Treatment includes gastric lavage, taking enterosorbents and carrying out symptomatic therapy.

Interaction

Taking Nitroxoline together with drugs from the tetracycline group can enhance the effect of each drug. Simultaneous use and Levorin can potentiate their action. Combination with nitrofurans causes a negative neurotropic effect, so it is better not to take them together.

Terms of sale

On prescription.

Storage conditions

Tablets are stored in a dry, dark place protected from children.

Best before date

Nitroxoline analogs

Level 4 ATX code matches:

The main analogues are represented by the following drugs: 5-Nitrox, Nibiol, Nikinol, Nikopet, Niuron, Noxibiol, Noxin, Uritrol.

Reviews of Nitroxoline

As reviews of Nitroxoline show, many patients use this drug for cystitis. It should be noted that this remedy is well known to women. However, some of them are interested in Nitroxoline tablets - what they are for and how to take the medicine correctly.

In most cases, reviews of Nitroxoline with confirm the fairly high effectiveness of these tablets. But there are also reports when the medicine did not help quickly eliminate the unpleasant symptoms of the disease.

There are especially frequent discussions about how to take Nitroxoline during pregnancy, although its use is contraindicated during this period. However, sometimes women wonder whether these pills can be taken during pregnancy, and what the consequences might be? At the same time, experts do not recommend self-medication, and if symptoms of the disease appear, immediately consult a doctor.

Sometimes this medicine is prescribed to children, but most parents, after carefully studying the annotation, doubt whether patients can take the pills at an early age. They also find out whether Nitroxoline is an antibiotic or not, and at what age is it prescribed for cystitis?

Experts recommend that before starting to take these tablets, get tested and find out how sensitive the pathogen microorganisms are to the effects of this antibiotic. Thanks to this, you can understand how effective this treatment will be.

Until patients receive test results, taking antibiotics is not recommended. But you can use local antimicrobial agents, not forgetting to drink plenty of fluids, for example, herbal decoctions.

In addition, you should discuss possible replacement options with your doctor, and if this drug is not suitable for treatment, find out how you can quickly find an effective treatment. Only with this approach can we hope that health will be restored fully and in a short time.

Nitroxoline price, where to buy

The price of Nitroxoline in tablets is approximately 60 rubles.

Online pharmacies in Russia Russia
Online pharmacies in Ukraine Ukraine
Online pharmacies in Kazakhstan Kazakhstan

ZdravCity

Nitroxoline tablets p.o 50 mg No. 50 Anzhero-Sudzhensky HFZLLC Anzhero-Sudzhensky Chemical Plant

Nitroxoline tablets p.o 50 mg No. 50 IrbitskyOJSC Irbitsky Chemical Plant