Gilman - A practical guide. Clinical pharmacology according to Goodman and Gilman - G. Gilman - Practical guide Clinical pharmacology according to Goodman and Gilman

Abstract to the book "Clinical pharmacology according to Goodman and Gilman. Volume 2"

"Clinical Pharmacology by Goodman and Gilman" is the leading guide to pharmacology, the only one of its kind, because it covers all areas of modern pharmacology - from molecular biology, genetics, biochemistry to physiology and clinical disciplines. This is a textbook, which sets out the basics of all the listed disciplines very clearly and concisely, and a monograph with the appropriate rigor of presentation and citation, and a practical guide suitable for use at the patient’s bedside, and an encyclopedia of modern pharmacology, written by leading scientists, including several Nobel laureates awards. One of them is the book's editor-in-chief, Alfred Goodman Gilman. “Clinical pharmacology according to Goodman and Gilman” is republished every five years, with each subsequent edition being radically updated. The reader is offered modern concepts that set the path for the development of science for many years to come. "Clinical pharmacology according to Goodman and Gilman" is the second part of the dilogy,...

"Clinical Pharmacology by Goodman and Gilman" is the leading guide to pharmacology, the only one of its kind, because it covers all areas of modern pharmacology - from molecular biology, genetics, biochemistry to physiology and clinical disciplines. This is a textbook, which sets out the basics of all the listed disciplines very clearly and concisely, and a monograph with the appropriate rigor of presentation and citation, and a practical guide suitable for use at the patient’s bedside, and an encyclopedia of modern pharmacology, written by leading scientists, including several Nobel laureates awards. One of them is the book's editor-in-chief, Alfred Goodman Gilman. “Clinical pharmacology according to Goodman and Gilman” is republished every five years, with each subsequent edition being radically updated. The reader is offered modern concepts that set the path for the development of science for many years to come. “Clinical pharmacology according to Goodman and Gilman” is the second part of a dilogy, the first part of which is “Internal Medicine according to Tinsley R. Harrison.”
Intended for doctors of all specialties and students of medical institutes.

Year of issue: 2006

Genre: Pharmacology

Format: DjVu

Quality: Scanned pages

Description: The tenth edition of Clinical Pharmacology by Goodman and Gilman is published in the year of the sixtieth anniversary of this book. The goals that L. Goodman and A. Gilman set for themselves when writing the first edition continue to serve as a guide to action for the authors of all subsequent editions of the book. These goals, clearly outlined in the following preface to the first edition, are: to relate the findings of pharmacology to those of related sciences, to continually review the mechanisms of action and clinical use of drugs in the light of recent scientific advances, and to place particular emphasis on the application of the principles of pharmacodynamics to drug therapy.
We are extremely grateful to both the regular and new contributors to this volume for their painstaking work in revising and updating the material in the relevant chapters in the light of the rapidly changing data of modern pharmacology. We are also grateful to the consultants, whose valuable comments helped to significantly improve the material presented. We also want to note the selfless work of three gifted women, without whom the publication of this publication would have been, if not impossible, then at least very difficult. Lorelei Edwards, Ph.D., carefully reviewed all pharmaceutical data and provided important assistance in the early stages of the book's preparation. Tracey Shields showed remarkable meticulousness in preparing the final chapters and checking references. Lynn Hutchinson took over the administrative work of producing this publication. Thanks to her extraordinary organizational skills, amazing ability to establish contacts with authors and publishers, high erudition and inexhaustible enthusiasm, the individual parts of this book were compiled carefully and on time. We are also grateful to John Morris and Kathleen McCullough of McGraw-Hill Publishing.
The very time of publication of the tenth edition of Clinical Pharmacology - the first edition in the new millennium - is symbolic. We live in an era of revolution in biology and medicine, inevitably associated with the inability to process the avalanche-like flow of information. We see how the contradiction between knowledge and thinking is growing. We try to combine them, but this is not always possible, especially when we are trying to write something or teach something. How will we be able to transfer all the accumulated knowledge in the future, while maintaining conceptuality and practical applicability? What will textbooks on theoretical and practical medicine be like in a few years? We can only say with confidence that they will not be replaced by databases - the printed word will retain its importance as a means of analysis and thinking.
The answers to many of these questions are given by the history of this book itself. It is often said that the publication of its first edition marked the emergence of clinical pharmacology as an independent discipline. The book owes such high praise not to a systematic presentation of individual facts, but to an attempt to generalize pharmacological knowledge and apply scientific concepts to clinical practice. The original authors of Clinical Pharmacology, Louis S. Goodman and Alfred Gilman, were outstanding scientists, brilliant teachers, and wise mentors, but many still consider this book their crowning achievement. The validity of this opinion is supported by the very fact that “Clinical Pharmacology” has already gone through 10 editions. The seventh edition (1985) was dedicated to Alfred Gilman, who died shortly before the book's publication. The eighth edition (1990) was dedicated to Louis Goodman, who had by then ceased his work as the book's primary editor. Louis Goodman died in November 2000. We will forever remember his brilliant mind, supreme erudition, sharp humor, impeccable taste and ability to captivate and lead.
We again dedicate the next edition of Clinical Pharmacology to Louis Goodman and Alfred Gilman, with gratitude for their wise mentorship and with the hope that the goals set for the first edition of the book will be achieved in this and subsequent editions. If the successors of these two eminent scientists maintain the foundations they laid, Clinical Pharmacology according to Goodman and Gilman will always be an invaluable guide for clinicians and researchers.

"Clinical pharmacology according to Goodman and Gilman"

ANTI-INFLAMMATORY AND ANTI-ALLERGIC MEDICINES
Histamine, kinins and drugs that suppress their action
Eicosanoids and platelet activating factor
Nonsteroidal anti-inflammatory drugs and drugs used for gout
Medicines used for bronchial asthma
DRUGS AFFECTING THE RECYCLING AND CARDIOVASCULAR SYSTEMS
Diuretics
ADH and drugs affecting water reabsorption in the kidneys
Agents acting on the renin-angiotensin system
Antianginal agents
Antihypertensive drugs
Drugs used for heart failure
Antiarrhythmic drugs
Lipid-lowering drugs
DRUGS AFFECTING THE DIGESTIVE SYSTEM
Medicines used for increased acidity of gastric contents, reflux esophagitis and peptic ulcers
Prokinetic and antiemetic agents. Medicines used for irritable bowel syndrome
Antidiarrheals and laxatives. Drugs used for chronic inflammatory bowel diseases. Pancreatic enzymes and bile acids

"Clinical pharmacology according to Goodman and Gilman" is the leading guide to pharmacology, the only one of its kind, because it covers all areas of modern pharmacology - from molecular biology, genetics, biochemistry to physiology and clinical disciplines. It is also a textbook in which it is extremely clear and concise sets out the fundamentals of all these disciplines, and a monograph with the appropriate rigor of presentation and citation, and a practical guide suitable for use at the bedside, and an encyclopedia of modern pharmacology, written by leading scientists, including several Nobel Prize laureates, one of them the editor-in-chief of the book, Alfred Goodman Gilman. "Clinical Pharmacology" is republished every five years, with each successive edition being radically updated. The reader is offered modern concepts that set the path for the development of science for many years to come. "Clinical Pharmacology" is the second part of the dilogy, the first part of which is “Internal Medicine by Tinsley R. Harrison.” Intended for doctors of all specialties and students of medical institutes. ISBN (Russian) - 5-89816-063-9 (volume 2), 5-89816-069-8 (edition) ISBN (English)-0-07-135469-7 This volume includes: ANTI-INFLAMMATORY AND ANTI-ALLERGIC REMEDIES DRUGS AFFECTING THE DIGESTIVE SYSTEM

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D GOODMAN AND GILMAN'S ARMACOLOGICA BASIS OF RA D CS Tenth edition Editors Joel G. Hardman, Ph.D. Professor of Pharmacology, Emeritus Vanderbilt University Medical Center Nashville, Tennessee Lee E. Limbird, Ph.D. Professor of Pharmacology Associate Vice Chancellor for Research Vanderbilt University Medical Center Nashville, Tennessee Consulting Editor Alfred Goodman Gilman, M.D., Ph.D., D.Sc. (Hon.; Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology Regental Professor and Chairman, Department of Pharmacology University of Texas Southwestern Medical Center Dallas, Texas McGraw-Hill Medical Publishing Division New York Chicago San Francisco Lisbon London Madrid Mexico City Milan New Delhi San Juan Seoul Singapore Sydney Toronto u EC KAYA ARMAKOLOSH by Goodman and Gilman Book Two Generally edited by A. G. Gilman Editors J. Hardman and L. Limberd Translation from English under the general editorship of Candidate of Medical Sciences N. N. Alipov Translation editors: T. V. Meleshenko, Candidate of Biological Sciences D. S. Benevolensky, E. M. Makarenko practice Moscow 2006 BBK 52.8 K 49 Medicine is a rapidly updating science. Research is underway, clinical experience is accumulating, new drugs and treatment methods are emerging. The authors and editor have done their best to ensure that the book includes the most up-to-date and comprehensive information. But due to the fact that no one is immune from errors, and medical science is constantly evolving, neither the authors, nor the editor, nor other persons who worked on the book can guarantee its absolute perfection and do not accept responsibility for any errors or omissions, as well as for the consequences of using the information given in the book. We strongly encourage readers to consult other sources of information in addition to this book. When prescribing medications, especially new or rarely used ones, carefully read the instructions included in the package. The editors would like to thank Dr. med. Zh. Yu. Alyabyev, Ph.D. n. M. A. Slinkina, Ph.D. n. E. R. Timofeev and N. A. Fedorov for their help in working on the book. Consultant Ph.D. U. S. Abdurakhmanov Technical editor D. V. Prishchepa Artists E. R. Gor, O. L. Lozovskaya Proofreaders N. N. Yudina, Yu. M. Gizatullina License LR No. 065635 dated 01/19/1998 Publishing house "Praktika", 119048, Moscow, PO Box 421. Tel.: 101-22-04, 203-97-62. Signed for publication on January 11, 2006. Format 84x108/16. Circulation 10,000 copies. Order No. 1658. Printed at JSC Printing House Novosti 105005, Moscow, st. Fr. Engelsa, 46 Series “Classics of Modern Medicine” No. 5 Clinical pharmacology according to Goodman and Gilman. Generally edited by A. G. Gilman, editors J. Hardman and L. Limbird. In four volumes. Per. from English - M.. Praktika, 2006. - 336 p. K 49 “Clinical Pharmacology according to Goodman and Gilman” is the leading guide to pharmacology, the only one of its kind, because it covers all areas of modern pharmacology - from molecular biology, genetics, biochemistry to physiology and clinical disciplines. This is a textbook, which sets out the basics of all the listed disciplines very clearly and concisely, and a monograph with the appropriate rigor of presentation and citation, and a practical guide suitable for use at the patient’s bedside, and an encyclopedia of modern pharmacology, written by leading scientists, including several Nobel laureates awards. One of them is the book's editor-in-chief, Alfred Goodman Gilman. “Clinical Pharmacology” is republished every five years, with each subsequent edition being radically updated. The reader is offered modern concepts that set the path for the development of science for many years to come. “Clinical Pharmacology” is the second part of a dilogy, the first part of which is “Internal Medicine according to Tinsley R. Harrison.” Intended for doctors of all specialties and students of medical institutes. © 2001 by The McGraw-Hill Companies, Inc. © Translation into Russian and design, Praktika Publishing House, 2006 ISBN (Russian) - 5-89816-063-9 (volume 2), 5-89816-069-8 (edition) TSRN *89816061 9 ISBN (English .)-0-07-135469-7 9 785898 160630 > CONTENTS Abbreviations and units of measurement VII Authors and translators IX Preface XII Preface to the first edition XIII Part IV ANTI-INFLAMMATORY AND ANTI-ALLERGIC DRUGS Introduction 502 2 5 Histamine, kinins and drugs that suppress their action 502 26 Eicosanoids and platelet activating factor 519 27 Non-steroidal anti-inflammatory drugs and drugs used for gout 533 28 Drugs used for bronchial asthma 566 DRUGS ACTING IN THE NUTRITIONAL AND CARDIACIOSIS 29 Diuretics 30 ADH and drugs , affecting the reabsorption of water in the kidneys 31 Drugs acting on the renin-angiotensin system 622 32 Antianginal drugs 649 33 Antihypertensive drugs 671 34 Drugs used for heart failure 694 35 Antiarrhythmic drugs 718 36 Lipid-lowering drugs 749 Part VI of the U.S. Drugs Acting on the Digestive System 37 Drugs used for increased acidity of gastric contents , reflux esophagitis and peptic ulcer 777 3 8 Prokinetic and antiemetic agents. Drugs used for irritable bowel syndrome 787 39 Antidiarrheals and laxatives. Drugs used for chronic inflammatory bowel diseases. Pancreatic enzymes 582 glands and bile acids 798 607 Subject index U-1 ABBREVIATIONS AND UNITS OF MEASUREMENT Abbreviations A AB AD ADG ADP ACTH Ala AlAT AMP ACE Apr AsAT Asn Asp ATP AChE ACTT BCYAS Val i/v vip HIV i/m WHO VPSP g G -6-PD GABA HDF His G-CSF Gly Gln Glu HMG-CoA reductase GM-CSF GMP GTP DAG two DDT DZLA DNA DOPA dTMP Gastrointestinal IBS IVL IL Ile IMP IF3 IGF cDNA CoA COMT CT CPK LH ldg adenosine Leu atrioventricular Lys blood pressure HDL antidiuretic hormone LDL adenosine diphosphate VLDL adrenocorticotropic hormone LDLP alanine LSD alanine aminotransferase adenosine monophosphate LPA angiotensin-converting enzyme MAC arginine MAO aspartate aminotransferase MBA asparagine Met aspartic acid MCB adenosine triphosphate M-CSF acetylcholinesterase activated partial thromboplastin-MHO time bacillus Calmette-Guérin MOD valine MIC intravenous mRNA vasoactive intestinal polypeptide MRI human immunodeficiency virus MSH intramuscular NAD World Health Organization NADP excitatory postsynaptic potential NSAID guanosine OPN glucose-6-phosphate dehydrogenase OPSS γ-aminobutyric acid guanosine diphosphate O CK histidine PV granulocyte colony-stimulating p/ to factor Pro glycine PTH glutamine PFC glutamic acid RDSV hydroxymethylglutaryl coenzyme A-reductase RNA granulocyte-macrophage columnar rRNA stimulating factor Serguanosine monophosphate GFR guanosine triphosphate CSF 1,2-diacylglycerol ESR disseminated intravascular coagulation GH dichlorodiphenyltrichloroethane T pulmonary wedge pressure arteries THPA deoxyribonucleic acid Tyr dioxyphenylalanine TMP deoxythymidine monophosphate TPSP gastrointestinal tract Tre ischemic heart disease tRNA artificial ventilation Trp interleukin TSH isoleucine TTP inosine monophosphate PE inositol-1,4,5-triphosphate U insulin-like growth factor UDP complementary DNA ^USI coenzyme A UMP cate hall -O-methyltransferase UTP computed tomography UV-A creatine phosphokinase luteinizing hormone lactate dehydrogenase leucine lysine high-density lipoproteins low-density lipoproteins very low-density lipoproteins intermediate-density lipoproteins lysergic acid diethylamide (LSD) exercise therapy minimum alveolar concentration monoamine oxidase minimum al bactericidal concentration methionine International classification of diseases macrophage colony-stimulating factor international normalized ratio minute respiration volume minimal inhibitory concentration messenger RNA (messenger RNA) magnetic resonance imaging melanocyte-stimulating hormone nicotinamide adenine dinucleotide nicotinamide adenine dinucleotide phosphate non-steroidal anti-inflammatory drugs acute renal failure total peripheral vascular resistance circulating blood volume prothrombin time subcutaneous proline parathyroid ny hormone area under the pharmacokinetic curve respiratory distress syndrome in adults radioimmunoassay ribonucleic acid ribosomal RNA series glomerular filtration rate cerebrospinal fluid erythrocyte sedimentation rate acquired immunodeficiency syndrome somatotropic hormone thymidine tetrahydrofolic acid tyrosine thymidine monophosphate inhibitory postsynaptic potential threonine transport RNA tryptophan thyroid-stimulating hormone thymidine triphosphate pulmonary embolism uridine uridine diphosphate ultrasound research uridine monophosphate uridine triphosphate long-wave ultraviolet radiation C20-400 nm) VII UV-B UV-C FDA Fen FIF2 TNF FSH CG COPD CRF C cAMP cGMP CCP Cys CMP CNS CTF FTC HR EDTA ECG EchoCG EEG AMPA DSM F F,O2 HLA IgA IgE IgG Ig M i LD50 NMDA PaCO2 PCO2 PH PO2 PUVA Rh sao2 shortwave ultraviolet B90-320 nm) ultrashortwave ultraviolet A00-290 nm) FDA (Food and Drug Administration) phenyl alanine phosphatidylinositol-4 ,5-diphosphate tumor necrosis factor follicle-stimulating hormone human chorionic gonadotropin chronic obstructive pulmonary diseases chronic renal failure cytidine cyclic adenosine monophosphate cyclic guanosine monophosphate cytidine diphosphate cysteine ​​cytidine monophosphate central nervous system cytidine triphosphate respiratory rate heart rate ethylenediaminetetraacetic acid electrocardiography (electrocardiogram) a, electrocardiographic) echocardiography electroencephalography a-amino- 3-hydroxy-5-methyl-4-isoxazole-propionic acid Guide to the diagnosis and statistics of mental illness catheter caliber according to the “French” scale (Charriere), 1 F = 1/3 mm fractional concentration of oxygen in the inhaled mixture

Hormones and their antagonists.

Vitamins.

Dermatological products.

Ophthalmic products.

Toxicology.

Modern pharmacology is a huge field of knowledge. It includes physiology, biochemistry, physics and chemistry - without them it is impossible to understand the mechanisms of action of drugs, molecular biology and genetics - without them physiology and biochemistry and, finally, clinical disciplines are unthinkable today.

Pharmacology is closely related to other, non-drug forms of treatment, since the doctor’s task is not to influence a specific cellular receptor, but to lead the patient to recovery, using all available means.

“Clinical pharmacology according to Goodman and Gilman” is a unique book of its kind, because it comprehensively and organically embraces all these aspects. This is a textbook, which very clearly and at the same time concisely sets out the fundamentals of all the listed disciplines, and a monograph with the appropriate rigor of presentation and citation, a rich bibliography and critical analysis of modern data, and a practical guide suitable for use at the patient’s bedside, and an encyclopedia modern pharmacology, whose articles were written by leading scientists, including several Nobel Prize laureates. One of them is the book's editor-in-chief, Alfred Goodman Gilman.

In the “Historical Background” subsections, rigor and academicism are combined with a fascinating presentation of vivid episodes from the history of science, cults, rituals - everything that is associated with the use of medicinal substances.

The sections devoted to the mechanisms of action of drugs present modern genetic, physiological and biochemical theories; Thus, the part of the book devoted to vegetotropic drugs begins with a chapter on the physiology of the autonomic nervous system, which examines both classical ideas about this system and the latest achievements in this area. Mechanisms of action are followed by pharmacokinetics and drug interactions—the most important information from a practical point of view, which is not always given due attention.

Finally, sections devoted to practical issues - indications for the use of drugs, their doses and modes of administration, are written with direct practical application in mind, these sections rely primarily on data from controlled trials, but at the same time give the doctor the breadth of outlook that is necessary for freedom of action.

The most sophisticated and modern therapy will not achieve its goal if the patient does not follow medical instructions, so measures aimed at creating a convenient regimen for taking medications are constantly being discussed.

Pharmacology is one of the most rapidly developing areas of medicine.

By the time major monographs are published, many of the data presented in them begin to become outdated, but such monographs are still necessary - not every doctor is able to navigate the huge flow of information published in original articles and reviews. To compensate for this shortcoming, Clinical Pharmacology is republished every five years, with each successive edition being radically updated. This update is not limited to listing new facts, because facts quickly become outdated - the reader is offered modern concepts that set the path for the development of science for many years to come.

Many of the data presented in the book, especially from the field of molecular and cellular biology, at the time of writing the book had not yet led to the development of new drugs, but their appearance is a matter of the near future, and the doctor, after reading the book, will be ready for this. “Clinical pharmacology according to Goodman and Gilman” is the second part of the most popular dilogy among Western doctors, and the first is “Internal Medicine according to Tinsley R. Harrison.”

By publishing the book, the Praktika publishing house completes the cycle of work on this dilogy, providing the reader with a complete description of the foundations of modern medicine.

Hormones and antihormonal drugs. Hormones of the pituitary gland and hypothalamus. Thyroid hormones and antithyroid drugs. Estrogens and progestogens. Androgens. Adrenocorticotropic hormone, glucocorticoids and their antagonists. Insulin and other pancreatic hormones. Oral hypoglycemic agents. Drugs affecting calcium metabolism and bone metabolism
Vitamins. Water-soluble vitamins. Fat-soluble vitamins
Dermatological products
Ophthalmic products
Clinical toxicology. Heavy metal poisoning. Other poisonings