Hepatoses. Hepatoses Fatty hepatosis in the ICD classification

Liver cancer (ICD 10 - code C22 Malignant neoplasm of the liver and intrahepatic bile ducts) is considered a serious pathology, the outcome of which is fatal, especially if treatment is not started in a timely manner. If you start therapy in time, you can significantly increase life expectancy, or even cure cancer.

Why does liver cancer occur?

There are many reasons contributing to the occurrence of liver cancer with code C22 according to ICD 10 (International Classification of Diseases, 10th revision). The most common of them are:

1. The development of viral hepatitis type B or C, which has a chronic course. This inflammatory disease is accompanied by mutation of organ cells, which contributes to their degeneration from benign to malignant.
2. Development of liver cirrhosis. The disease occurs with the replacement of organ cells with connective tissue, thereby causing a malfunction in its functioning.
3. Human consumption of foods that can produce aflatoxin B1, especially under the influence of a specific fungus. These include soybeans, wheat, and low-quality rice.
4. Increased levels of iron in the body.
5. The development of gallstone disease in the body can also increase the risk of malignant neoplasms in the liver.
6. Alcohol abuse.

Men, as well as people who abuse steroids and have diabetes, are at risk for developing liver cancer.

Symptoms of the disease

All symptoms of liver cancer (code C22 according to ICD 10) can be divided according to the stages of development of the disease.

Stage 1. The neoplasm is just beginning to form, increasing in size. The vessels and surrounding tissues are not yet damaged, but the first symptoms already appear, which are often mistaken for the development of completely different pathologies: general malaise, rapid mental fatigue.

Stage 2. The tumor spreads to nearby blood vessels, and the following symptoms occur: general malaise, a feeling of heaviness, pain in the abdominal area above the level of the liver, which increases with physical activity, digestive dysfunction (nausea, vomiting, diarrhea), loss of interest in food.

Stage 3. The neoplasm is significantly increased in size, which can be detected by palpation. The following symptoms also occur: swelling, signs of jaundice, nosebleeds, disruption of the endocrine system, severe pain in the liver area, general malaise.

Stage 4. At this stage of tumor development, cancer cells metastasize to other organs in the body. Unfortunately, it is impossible to cure a disease occurring at this stage. The result is quick death.

How to treat liver cancer?

At an early stage of cancer development, the doctor may prescribe a resection, an operation during which part of the organ is removed. Exactly those areas that are affected by malignant neoplasms are subject to removal. The doctor may also prescribe an operation such as hemihepatectomy, during which the half of the organ on which the tumor is localized is removed.

The half of the liver that remained intact during the operation functions normally for some time, and subsequently, the organ self-regenerates to its previous size.

Chemotherapy is actively used in the treatment of such neoplasms. It is immediately worth noting that such treatment can cause addiction to the body, after which the effect of chemotherapy will be zero. For this reason, researchers have developed a different method - infusion, which involves introducing the drug into the body through the hepatic artery.

Any disease, including liver cancer, can be cured. To do this, it is enough to consult a doctor at the first symptoms indicating an illness.

The development of fatty hepatosis is based on a violation of metabolic processes in the human body. As a result of this liver disease, healthy organ tissue is replaced by fatty tissue. At the initial stage of development, fat accumulates in hepatocytes, which over time simply leads to degeneration of the liver cells.

If the disease is not diagnosed at an early stage and appropriate therapy is not carried out, then irreversible inflammatory changes occur in the parenchyma, which lead to the development of tissue necrosis. If fatty hepatosis is not treated, it can develop into cirrhosis, which can no longer be treated. In the article we will look at the reasons for which the disease develops, methods of its treatment and classification according to ICD-10.

Causes of fatty hepatosis and its prevalence

The reasons for the development of the disease have not yet been precisely proven, but factors are known that can confidently provoke the occurrence of this disease. These include:

• completeness;
• diabetes;
• disturbance of metabolic processes (lipid);
• minimal physical activity with a nutritious daily diet high in fat.

Doctors register most cases of the development of fatty hepatosis in developed countries with an above-average standard of living.

Important! The disease affects all age groups, from overweight children to old people with diabetes.

There are a number of other factors associated with hormonal imbalances, such as insulin resistance and blood sugar. The hereditary factor cannot be ignored; it also plays a big role. But still the main reason is poor diet, sedentary lifestyle and excess weight. All the causes have nothing to do with the consumption of alcoholic beverages, which is why fatty hepatosis is often called non-alcoholic. But if we add alcohol dependence to the above reasons, then fatty hepatosis will develop much more rapidly.

In medicine, it is very convenient to use coding of diseases to systematize them. It’s even easier to indicate a diagnosis on a sick leave certificate using a code. All diseases are coded in the International Classification of Diseases, Injuries and Related Health Problems. At this time, the tenth revision option is in effect.

All liver diseases according to the International Classification of the Tenth Revision are encrypted under codes K70-K77. And if we talk about fatty hepatosis, then according to ICD 10, it falls under the code K76.0(fatty liver degeneration).

Treatment of fatty hepatosis

The treatment regimen for non-alcoholic hepatosis is to eliminate possible risk factors. If the patient is obese, then you need to try to optimize it. And start by reducing the total mass by at least 10%. Doctors recommend using minimal physical activity in parallel with dietary nutrition to achieve the goal. Limit the use of fats in your diet as much as possible. It is worth remembering that sudden weight loss will not only not bring benefits, it can, on the contrary, cause harm, aggravating the course of the disease.

Important! Drug therapy consists only of correcting impaired carbohydrate metabolism.

For this purpose, the attending physician may prescribe thiazolidinoids in combination with biguanides, but this line of drugs has not yet been fully studied, for example, for hepatotoxicity. Metformin can help correct the process of metabolic disorders in carbohydrate metabolism.

As a result, we can confidently say that by normalizing the daily diet, reducing body fat mass and giving up bad habits, the patient will feel an improvement. And only in this way can one fight a disease such as non-alcoholic hepatosis.

This may be useful to you:

Hundreds of suppliers bring hepatitis C medications from India to Russia, but only M-PHARMA will help you buy sofosbuvir and daclatasvir, and professional consultants will answer any of your questions throughout the entire treatment.

We invite you to read the article on the topic: “Viral cirrhosis of the liver ICD 10” on our website dedicated to liver treatment.

Excluded:

• alcoholic liver fibrosis (K70.2)
• cardiac sclerosis of the liver (K76.1)
• cirrhosis of the liver):
  • alcoholic (K70.3)
  • congenital (P78.3)
• with toxic liver damage (K71.7)

Liver fibrosis in combination with liver sclerosis

Primary biliary cirrhosis

Chronic non-purulent destructive cholangitis

Secondary biliary cirrhosis

Biliary cirrhosis, unspecified

Other and unspecified cirrhosis of the liver

Cirrhosis of the liver): . NOS. cryptogenic. large-knot. small-knotted. mixed type. portal. postnecrotic

ICD is a system of classification of various diseases and pathologies.

Since its adoption by the world community at the beginning of the 20th century, it has gone through 10 revisions, so the current edition is called ICD 10. For the convenience of automating the processing of diseases, they are encrypted with codes, knowing the principle of their formation, it is easy to find any disease. Thus, all diseases of the digestive system begin with the letter “K”. The next two digits identify a specific organ or group of organs. For example, liver diseases begin with combinations of K70–K77. Further, depending on the cause, cirrhosis may have a code starting with K70 (alcoholic liver disease) and K74 (fibrosis and cirrhosis of the liver).

With the introduction of ICD 10 into the system of medical institutions, the registration of sick leave began to be carried out according to new rules, when instead of the name of the disease, the corresponding code is written. This simplifies statistical accounting and allows the use of computer technology to process data sets both in general and for various types of diseases. Such statistics are necessary for analyzing morbidity on a regional and national scale, when developing new drugs, determining their production volumes, etc. To understand what a person is sick with, it is enough to compare the entry on the sick leave certificate with the latest edition of the classifier.

Classification of cirrhosis

Cirrhosis is a chronic liver disease characterized by liver failure due to tissue degeneration. This disease tends to progress and differs from other liver diseases in its irreversibility. The most common causes of cirrhosis are alcohol (35–41%) and hepatitis C (19–25%). According to ICD 10, cirrhosis is divided into:

• K70.3 – alcoholic;
• K74.3 – primary biliary;
• K74.4 – secondary biliary;
• K74.5 – biliary, unspecified;
• K74.6 – different and unspecified.

Alcoholic cirrhosis

Liver cirrhosis caused by alcohol is coded K70.3 in ICD 10. It was specially identified as a group of individual diseases, the main cause of which is ethanol, the damaging effect of which does not depend on the type of drinks and is determined only by its quantity in them. Therefore, a large amount of beer will cause the same harm as a smaller amount of vodka. The disease is characterized by the death of liver tissue, which transforms into scar tissue in the form of small nodes, while its correct structure is disrupted and the lobules are destroyed. The disease leads to the fact that the organ ceases to function normally and the body is poisoned by decay products.

Our regular reader recommended an effective method! New discovery! Novosibirsk scientists have identified the best remedy for CIRRHOSIS. 5 years of research!!! Self-treatment at home! After carefully reviewing it, we decided to offer it to your attention.

EFFECTIVE METHOD

Primary biliary cirrhosis

Primary biliary cirrhosis is an immune-related liver disease. According to ICD 10 it has code K74.3. The causes of the autoimmune disease have not been established. When it occurs, the immune system begins to fight the liver’s own bile duct cells, damaging them. Bile begins to stagnate, which leads to further destruction of organ tissue. Most often, this disease affects women, mainly 40–60 years old. The disease is manifested by skin itching, which at times intensifies, leading to bleeding scratching. This cirrhosis, like most other types of disease, reduces performance and causes depressed mood and lack of appetite.

Secondary biliary cirrhosis

Secondary biliary cirrhosis occurs due to exposure to bile, which, having accumulated in the organ, cannot leave it. According to ICD 10 it has code K74.4. The cause of obstruction of the bile ducts may be stones or the consequences of surgery. This disease requires surgical intervention to eliminate the causes of obstruction. Delay will lead to continued destructive effects of bile enzymes on liver tissue and the development of the disease. Men suffer from this type of disease twice as often, usually at the age of 25-50 years, although it also occurs in children. The development of the disease most often takes from 3 months to 5 years, depending on the degree of obstruction.

Biliary cirrhosis, unspecified

The word "biliary" comes from the Latin "bilis", which means bile. Therefore, cirrhosis associated with inflammatory processes in the bile ducts, stagnation of bile in them and its effect on liver tissue is called biliary. If it does not have the distinctive features of primary or secondary, then it is classified according to ICD 10 as biliary unspecified cirrhosis. The cause of these types of disease can be various infections and microorganisms that cause inflammation of the intrahepatic bile ducts. In the 10th edition of the classifier, this disease has code K74.5.

Causes of liver cirrhosis

Other and unspecified cirrhosis

Diseases that, in terms of etiology and clinical characteristics, do not coincide with those previously listed are assigned a general code K74.6 according to ICD 10. Adding new numbers to it allows for their further classification. So, in the 10th edition of the classifier, unspecified cirrhosis was assigned the code K74.60, and the other - K74.69. The latter, in turn, can be:

• cryptogenic;
• micronodular;
• macronodular;
• mixed type;
• postnecrotic;
• portal.

Who said that it is not possible to cure liver CIRRHOSIS?

• Many methods have been tried, but nothing helps...
• And now you are ready to take advantage of any opportunity that will give you the long-awaited well-being!

An effective treatment for the liver does exist. Follow the link and find out what doctors recommend!

The abbreviation ICD is the system by which all diseases and pathologies known to science are classified. Today, the ICD 10 system is in force. The name change is associated with a dozen revisions and additions since its adoption by the world community at the dawn of the 20th century.

Each ICD 10 code carries an encrypted name for a specific disease or pathology. Knowing how the system works, you can easily find any disease. In this article we will look at examples of encryption, and we will dwell in more detail on the cirrhosis of their classification and description.

Why is an encryption system needed?

The introduction of the ICD 10 system made it possible to automate the treatment of diseases. If you understand the principle of assigning letters and numbers, you can find the desired disease in a matter of minutes.

Today we’ll talk about the problems of the digestive organs, which in the above-described system are encrypted under the letter “K”. Next, the code displays the numbers that are responsible for a specific organ or their combination and the pathologies that are associated with them. Diseases that affect liver function are indicated by a combination of letters and numbers in the range K70-K77.

After doctors began to use such a system, the process of maintaining sick leave became much easier, because instead of the name of the disease, a code according to ICD 10 was simply written down. This solution will simplify as much as possible the recording of a large mass of data on a variety of diseases in electronic form, which is simply an ideal method analyzing the volume of cases of individual diseases on a large scale of cities, countries, etc.

Classification of liver cirrhosis according to ICD 10

Cirrhosis is a chronic liver disease in which the cells of the organ degenerate and can no longer fulfill their intended purpose. If this disease is not diagnosed at the initial stage and treated, it progresses rapidly and is irreversible. Most often, the catalysts for the development of cirrhosis are excessive alcohol consumption and the presence of the hepatitis virus in the body.

Important! The future prognosis for people diagnosed with cirrhosis is not very good. Surprisingly, with alcoholic cirrhosis the survival rate is higher compared to viral cirrhosis. If the patient completely stops taking alcoholic beverages and takes treatment seriously, then within 5 years he can become one of 70% of those cured.

According to the ICD 10 system, cirrhosis is divided into several separate groups:

• alcoholic cirrhosis (K70.3). Liver problems caused by excessive consumption of alcoholic beverages are specifically included in the group of individual diseases. Cirrhosis develops under the destructive influence of ethanol and it does not matter in what drinks it enters the body. Liver cells die and are replaced by scar tissue, forming small nodules. As the disease develops, the structure of the liver changes completely and reaches the point where it simply stops functioning;
• primary biliary cirrhosis (K74.3). It occurs as a consequence of the development of an autoimmune disease, when the immune system begins to fight against its own cells and destroys the bile ducts in the liver. As a result, the process of bile stagnation is activated, which ultimately poisons the liver cells. Basically, this type of cirrhosis is diagnosed in the female half of the population after 50 years;
• secondary biliary cirrhosis (K74.4). It occurs during the aggressive action of bile, which cannot be released due to clogged ducts. The bile ducts can become obstructed after surgery or as a result of the formation of stones that block the ducts. The causes of obstruction are removed only during the operation, otherwise the destructive process will lead to irreparable consequences;
• biliary cirrhosis, unspecified (K74.5). This group includes cirrhosis of viral etiology or infectious in the case when the disease differs in characteristics from the primary or secondary biliary form;
• unspecified cirrhosis (K74.6). If the etiology of the disease and its symptoms do not fit into any of the above groups, then it is classified as unspecified cirrhosis. Additional digits after the period allow further classification of each case.

The etiology of cirrhosis can be of definite, uncertain or mixed origin. Doctors often register several causes that influence the development of cirrhosis, for example, viral hepatitis with alcohol dependence. By the way, let’s say that alcohol abuse is the most common reason why patients are diagnosed with the development of cirrhosis.

It was the ICD system that became the international standard for classifying not only diseases, but also epidemiological purposes. With its help, the World Health Organization can analyze and monitor the health status of each population group with its help. The ICD 10 accounting system makes it possible to record the frequency of certain diseases or pathologies and their relationship with various factors.

Liver cirrhosis from ICD 10 is a complex disease that is characterized by the replacement of parenchymal tissue with fibrous tissue. Men over 45 years of age are most susceptible to this disease. But this does not mean that women do not suffer from this pathology. In modern medicine, cirrhosis is diagnosed even in young people.

About the disease

The human liver is a kind of filter that passes through itself and removes all substances dangerous to the body. Toxins destroy liver cells, but this unique organ is able to recover. But in cases where the body is constantly poisoned, the natural filter does not cope with its task. As a result, a severe disease, cirrhosis (ICD 10), develops.

The liver is the largest gland of the human body, and it performs the following functions:

• Detoxification. The organ processes and removes all harmful substances from the body. Alcohol intoxication very often disrupts this function.
• Bile production. Violation of this function leads to digestive problems.
• Synthetic. Proteins, fats, and carbohydrates are formed with the help of this important organ.
• The gland is responsible for blood clotting.
• Antibodies are formed in the liver.
• It is this organ that acts as a “storehouse” for vitamins and nutrients that enter the body as needed.

This is not a complete list of the functions of our filter. It is involved in almost all important processes, and disruption of work threatens failures in other organs and systems.

There are a number of causes that cause liver disease, including cirrhosis (ICD 10).

The main reasons include:

1. Chronic hepatitis C. About 70% of people suffering from cirrhosis have previously had hepatitis C. It does not matter what etiology the disease is: toxic, viral or autoimmune.
2. Alcohol intoxication. The disease develops after 10-15 years of regular alcohol abuse. In women, this process can occur twice as fast.
3. The influence of drugs. When treating diseases of any etiology, it is very important to follow the doctor’s recommendations and not prescribe medications yourself. With long-term therapy, hepatoprotectors may be required, which will reliably protect the liver from the negative effects of drugs.
4. Obesity. Poor nutrition leads to many health problems; the disease included in the international classifier (code 10) is no exception. Therefore, it is very important to eat right, lead an active lifestyle and monitor your weight.
5. Viruses and infections. Many pathological organisms contribute to the destruction of the liver, so it is important to consult a doctor at the first signs of illness.

There are reasons for other etiologies, there are quite a lot of them, and only a specialist can identify why the pathology developed and how to get rid of the provoking factors.

How to determine the disease

For a long time, cirrhosis (ICD 10) does not make itself felt, the person continues a normal life, noting some fatigue, which is most often attributed to heavy workload. An organ begins to hurt when the disease has already reached a certain stage.

In order to timely diagnose the onset of the development of pathology, it is necessary to know the signs that cirrhosis has:

• A state of chronic fatigue and weakness, constantly makes you sleepy, and there is no desire to do anything.
• The presence of spider veins, which can often be seen on the back and palms.
• Skin itching and peeling. This may indicate increased cholesterol.
• Yellowness of the skin.
• Sudden weight loss.

If a person notices some of the listed symptoms, it is necessary to urgently consult a doctor. Since such symptoms can be observed for 5-10 years, and after that there is a sharp deterioration in health and the disease becomes irreversible.

The disease has 3 stages, each of which has its own characteristics:

1. The first initial stage may not have external manifestations. Even a biochemical analysis may show no obvious abnormalities.
2. Subcompensation stage. Symptoms become obvious, and the disease can be diagnosed using tests and ultrasound.
3. Decompensation. At this stage, liver failure and portal hypertension develop. The patient's condition is very serious and requires hospitalization.

As the pathology moves from one stage to another, a person’s well-being worsens and treatment becomes more difficult. The sooner medical assistance is provided, the greater the chance of life. At the third stage, the only salvation is liver transplantation. But if alcohol addiction is not cured, there is no point in such an operation; the organ may simply not take root.

Classification of cirrhosis

Cirrhosis in the International Classifier 10 has a code of 70-74 depending on the type, and refers to severe irreversible processes; it is divided into five types of the disease.

Alcoholic

About 40% of people with cirrhosis abused alcohol. This type of disease has code 70.3 ICD 10. Alcohol disrupts the functioning of the organ and the body is poisoned with toxins. The gland tissue becomes scarred, the cells cease to perform their functions. Alcoholic cirrhosis develops regardless of the type of alcohol consumed; the alcohol content is important. So a large amount of beer or wine is just as harmful as a smaller amount of vodka or cognac.

Primary biliary

The reason for this form of development of pathology is disruption of the immune system. Liver cells are affected by their own immune cells, bile stagnation occurs and the organ is destroyed. Most often, this form is diagnosed in women after 40 years of age. Signs include severe itching, decreased performance, drowsiness, and lack of appetite.

Secondary biliary

This type of disease has code 74.4 and is characterized by obstruction of the bile ducts. This can happen if stones are present or after surgery. Bile, not receiving an outlet, destroys liver cells and thereby causes the death of the organ. In this case, urgent surgical intervention is required. Most often, young men suffer from this form; several months are enough for development; in some cases, the process lasts up to 5 years.

Biliary unspecified

Most often, this form is caused by viruses and infections. If the pathology does not have signs of primary or secondary biliary, it is classified according to the classification as unspecified.

Other and unspecified

This type of disease is divided into:

• Cryptogenic
• Macronodular
• Micronodular
• Mixed type
• Post-necrotic
• Portal

Treatment is prescribed depending on the type of pathology and the causes of development. An experienced doctor will prescribe the necessary therapy based on the examination.

Not so long ago, the diagnosis of liver cirrhosis sounded like a death sentence. But medicine is developing, and today many patients can live quite a long time with this diagnosis.

Before talking about the chances of survival, the doctor orders a full examination.

1. General blood and urine analysis.
2. Biochemical blood tests.
3. Needle biopsy.
4. Endoscopy.

Having assessed the indicators of these studies, the specialist can prescribe additional diagnostics, which will identify complications of the disease:

• Internal bleeding. If this complication is not detected in a timely manner, the patient faces death.
• Development of ascites. This condition most often develops in the second or third stage.
• Hepatic coma. If the liver does not perform its functions, the body, including the brain, is poisoned. As a result, loss of consciousness and disruption of the basic processes of the human body occur.
• Infectious complications. A severe decrease in immunity caused by disruption of the gland leads to poor resistance to pathogenic organisms. A person gets sick often and in severe form.
• Portal vein thrombosis.
• Presence of cancer cells. In this case, only an organ transplant can save a life, and then in the absence of metastases.

Unfortunately, therapy at the stage of decompensation is only supportive. After three years, 12-40% of patients remain alive.

A set of drugs is prescribed by a doctor, taking into account the stage of the pathology and the presence of concomitant diseases.

1. Take medications according to the regimen prescribed by your doctor.
2. Follow a diet. It is important to exclude fatty and fried foods. Vegetables and fruits should be consumed without heat treatment. Limit consumption of dairy products.
3. Avoid drinking alcohol, which causes alcoholic cirrhosis. Even if the pathology is of viral etiology, you need to give up alcohol and nicotine.
4. Limit physical activity. Sports and hard work will have to be canceled.
5. Maintaining optimal temperature conditions. Both hypothermia and high air temperatures can be dangerous.

Treatment of this serious illness should be carried out by a doctor. It is very dangerous to rely on traditional medicine. If you consider it necessary to use medicinal plants, consult your doctor. Perhaps it will allow them to be used as an addition to the main therapy.

Even if the doctor diagnoses cirrhosis of the liver, do not despair. Although not high, there is still a chance to survive. If you follow your doctor's recommendations, you can extend your life by years. Take care of your health, it is priceless!

There are many known reasons for the development of hepatosis, but they are all divided into two groups: exogenous factors and hereditary pathologies. External causes include toxic influences and diseases of other organs and systems. With excessive alcohol consumption, thyroid diseases, diabetes mellitus, and obesity, fatty liver hepatosis develops. Poisoning with toxic substances (mainly organophosphorus compounds), drugs (most often tetracycline antibiotics), poisonous mushrooms and plants leads to the development of toxic hepatosis.
In the pathogenesis of non-alcoholic fatty hepatosis, the leading role is played by necrosis of hepatocytes with subsequent excessive deposition of fat both inside and outside the liver cells. The criterion for fatty hepatosis is the content of triglycerides in the liver tissue of more than 10% of the dry mass. According to studies, the presence of fatty inclusions in most hepatocytes indicates at least 25% fat content in the liver. Non-alcoholic fatty hepatosis is very common among the population. It is believed that the main cause of liver damage in non-alcoholic steatosis is exceeding a certain level of blood triglycerides. Basically, this pathology is asymptomatic, but occasionally it can lead to liver cirrhosis, liver failure, and portal hypertension. About 9% of all liver biopsies reveal this pathology. The total share of non-alcoholic fatty hepatosis among all chronic liver diseases is about 10% (for the population of European countries).
Alcoholic fatty hepatosis is the second most common and relevant liver disease after viral hepatitis. The severity of the manifestations of this disease is directly dependent on the dose and duration of alcohol consumption. The quality of alcohol does not affect the degree of liver damage. It is known that complete abstinence from alcohol, even at an advanced stage of the disease, can lead to regression of morphological changes and clinical manifestations of hepatosis. Effective treatment of alcoholic hepatosis is impossible without giving up alcohol.
Toxic hepatosis can develop when the body is exposed to chemically active compounds of artificial origin (organic solvents, organophosphorus poisons, metal compounds used in production and everyday life) and natural toxins (most often poisoning with stitches and toadstool). Toxic hepatosis can have a wide range of morphological changes in liver tissue (from protein to fat), as well as various course options. The mechanisms of action of hepatotropic poisons are diverse, but they are all associated with impaired detoxification function of the liver. Toxins enter hepatocytes through the bloodstream and cause their death by disrupting various metabolic processes in the cells. Alcoholism, viral hepatitis, protein starvation and severe general diseases enhance the hepatotoxic effect of poisons.
Hereditary hepatosis occurs against the background of impaired metabolism of bile acids and bilirubin in the liver. These include Gilbert's disease, Crigler-Najjar, Lucy-Driscoll, Dubin-Johnson, and Rotor syndromes. In the pathogenesis of pigmentary hepatosis, the main role is played by a hereditary defect in the production of enzymes involved in the conjugation, subsequent transportation and release of bilirubin (in most cases, its unconjugated fraction). The prevalence of these hereditary syndromes in the population ranges from 2% to 5%. Pigmentary hepatoses proceed benignly; if the correct lifestyle and nutrition are followed, no pronounced structural changes occur in the liver. The most common hereditary hepatosis is Gilbert's disease; other syndromes are quite rare (the ratio of cases of all hereditary syndromes to Gilbert's disease is 3:1000). Gilbert's disease, or hereditary non-hemolytic unconjugated hyperbilirubinemia, predominantly affects young men. The main clinical manifestations of this disease occur when exposed to provoking factors and dietary errors.
Crises with hereditary hepatosis are caused by fasting, a low-calorie diet, traumatic surgery, taking certain antibiotics, severe infections, excessive physical activity, stress, drinking alcohol, and using anabolic steroids. To improve the patient’s condition, it is enough to eliminate these factors, establish a daily routine, rest and nutrition.